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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES BANGALORE, KARNATAKA PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION Sunil Kumar 1. NAME OF THE CANDIDATE AND ADDRESS Smt M.C Vasantha College of Nursing Naubad Bidar 2. NAME OF THE INSTITUTION 3. COURSE OF THE STUDY AND SUBJECT 1st year M.sc nursing, Medical DATE OF ADMISSION TO THE COURSE 12/10/2010 4. Surgical Nursing “A STUDY TO ASSESS THE KNOWLEDGE AND METHODS 5. TITLE OF THE STUDY AND PRACTICES OF HEMODIALYSIS CLIENTS (3060 YEARS) REGARDING PREVENTION AND CARE OF ARTERIOVENOUS FISTULA IN NEPHROLOGY UNIT OF SELECTED HOSPITALS BIDAR WITH A VIEW TO DEVELOP HEALTH INSTRUCTIONAL MODULE.” 6. BRIEF RESUME OF THE INTENDED WORK 6.1 INTRODUCTION There is a pair of organs, which are always compared with “the Mother of a family”. They show the significance of sacrifice. Very precious, valued during and after life; not considered when intact but receives more concern when dysfunctional. So care when it is intact. They are nothing but the retroperitoneal “kidneys”. The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid-base balance, and regulation of blood pressure (via maintaining salt and water balance). They serve the body as a natural filter of the blood, and remove wastes which are diverted to the urinary bladder. In producing urine, the kidneys excrete wastes such as urea and ammonium; the kidneys also are responsible for the reabsorption of water, glucose, and amino acids. produce hormones including calcitriol, renin, and erythropoietin. The kidneys also Located at the rear of the abdominal cavity in the retroperitoneum, the kidneys receive blood from the paired renal arteries, and drain into the paired renal veins. Each kidney excretes urine into a ureter, itself a paired structure that empties into the urinary bladder. They play a role in the acid-alkaline (PH) balance and help to control blood pressure. They produce hormones that regulate the production and release of red blood cells from bone marrow. They filter about 200 quarts of blood a day. They produce about two quarts of water and waste every single day.1 Proper functioning of urinary function is essential to life. Dysfunction of the kidney may occur at any age and with varying levels of severity. Renal failure is the severe impairment or total lack of kidney function. In renal failure there is an inability to excrete metabolic waste products and water as well as functional disturbances of all body systems. Renal failure is classified as acute or chronic. Among them Chronic Renal Failure (CRF) develops insidiously overtime and necessitates the initiation for long term survival.2 The global scenario of End Stage Renal Disease (ESRD) patients shows that the incidence is increasing by an average of 7.8% per year. Before 1970s glomerulo nephritis was the most common cause for CRF worldwide. But currently diabetic mellitus and hypertension are the leading causes for CRF. In 2005, the overall incidence of ESRD was at the rate of 347 per million populations i.e., 77000 of the new ESRD patients lived in urban areas and 26000 in rural settings (world statistics) which is 3% higher than in 2002. The incident counts and rates by gender have not been changing dramatically in recent years. The number of males beginning ESRD therapy in 2005 was 1.2 times (281 per million) greater than the number of females, and their incidence rate was 1.5 times higher (434 per million population) than males in 2007. According to USRDS (United States Renal Data System), there will be 7,85,000 ESRD patients in the world by 2020. According to Metropolitan Statistical Area (MSA), the incidence rates of ESRD in high density areas for whites exceed 300 per million populations in the Los Angeles and the lowest rate is found in the Tampa (St. Peter’s Berg) at 199 per million population.3 The focus in CRF has changed from treating a terminally ill patient, to dealing with a person who has a manageable chronic disease that requires long term care. The changes in focus are the result of the technical advances in dialysis and improved surgical techniques. Dialysis is used to remove fluid and uremic waste products from the body when the kidneys are not able to do so. It is proved that life could be saved in patients dying of renal failure with dialysis. The two important types include hemodialysis and peritoneal dialysis. Acute dialysis is indicated when there is a significant high level of serum potassium, fluid over load, increasing acidosis and pericarditis. Hemodialysis is the most commonly used method of dialysis. 4 Hemodialysis is the method for removing waste products from the blood when the kidneys are in failure. Hemodialysis is one of the three renal replacement therapies, the other two being renal transplant and peritoneal dialysis. Hemodialysis can be an outpatient or inpatient therapy. Routine hemodialysis is conducted in a dialysis outpatient facility.5 History may have played a role in developing dialysis as a practical treatment for renal failure, starting with Thomas Graham of Gasgow, who first presented the principles of solute transport across a semi permeable membrane in 1854. The artificial kidney was first developed in Baltimore by Abel, Rountree and Turner in 1913. The first hemodialysis in a human being was done by a German physician Dr.Hass in 1924 and the artificial kidney was developed into a clinically useful apparatus by a Dutchman Dr.Willem Kolff in 1943 to 1945. The first successfully treated patient was a 67 year old woman in uremic coma who gained consciousness after 11 hours of hemodialysis with Kolff’s dialyzer in 1945. As the original Kolff’s kidney was not able to remove excess fluid, Dr: Nils Alwall encased a modified version of this dialyzer in 1946.6 Access to the patient’s vascular system must be established to allow blood to be removed, cleansed and returned to the patient’s vascular system at rates between 200 and 800 ml/min. A most permanent access is created surgically (usually in forearm) known as fistula, by joining an artery to vein either side to side or end to side. The arterial segment of the fistula is used for arterial flow and venous segment for reinfusion of the dialyzed blood. Fistula takes four to six weeks to mature or become patent before it is ready to use. This gives time for healing and for the venous segment of fistula to dilate to accommodate two large-bore (14-16gauge) needles. As for CRF patients, hemodialysis should be repeated three times a week for at least three to four hours per dialysis; it is the best method to use arteriovenous fistula (AVF) as a vascular access. Compared to other vascular access such as venous catheter and a synthetic graft, arteriovenous fistula is most commonly used method as it has fewer complications.7 An arteriovenous fistula is a preferred access at any age group as stated by Dr. Andrew R Foraner, MD, an interventional radiologist. He says that elderly patients’ arteriovenous fistulae respond just as well as those in younger patients.8 A report given by North-West Renal Network states that there were 54% increase in the use of arteriovenous fistula for hemodialysis between 2001 and 2003, 73% increase between 2001 and 2004, 80% increase between 2001 and 2005 and 86% increase between 2001 and 2006.9 In UK the rate of AV fistula in use were 51.6% with an increased rate of 6.4% between 2007 and 2008. In France, Germany, Italy, Japan and Spain it was 62%, 83%, 60%, 62% and 69% respectively.10 In India the 1st nephrology department was started on 1st of March 1981 at Sir Ganga Ram hospital in New Delhi and was the first hospital to provide maintenance hemodialysis in North India. The HOD of nephrology here has pioneered the art of vascular access by nephrologists in India, which has now being taken over by the nephrologists all over the world. In this hospital, more than 1200 patients are undergoing hemodialysis per month and a few thousand successful surgeries of arteriovenous fistula are being performed here. This unit is among the centers with largest experience in vascular access surgery anywhere in the world.11 An article on increasing use of arteriovenous fistula reveals that in Karnataka the incidence rate of arteriovenous fistula is increasing with a rate of four to five percentage per year. One of the major hospitals in Bidar reports that around 1250 patients are undergoing hemodialysis in their institution per year. Among them around 1000 are CRF patients, with arteriovenous fistula as vascular access.12 It is important to take care of the vascular access to prevent complications. Complications can occur even if we are careful, but are much less common if you take a few precautions such as wash the access with soap and warm water each day, and always before dialysis, do not scratch the area or try to remove scabs, check the area daily for signs of infection, including warmth and redness, take care to avoid traumatizing the arm where the access is located, check that there is blood flow in the access daily. There should be a vibration (called a thrill) over the access. If this is absent or changes, notify your healthcare provider.13 A prospective cohort study was conducted among 470 hemodialysis patients in USA on knowledge about the effective self management measures to care their fistula site. The knowledge was measured using a Chronic Hemodialysis Knowledge Survey. The median score was 65% and lower scores were associated with older age and fewer years of education. They concluded that the patients with less knowledge may be less likely to get involved in the care of their arteriovenous fistula. The author concludes that additional educational interventions are needed in improving their knowledge14. The CRF clients are more prone to develop complications related to their arteriovenous fistula such as infection, clotting, rupture, pseudo aneurism formation and stenosis. Moreover, the investigator felt that post-operative care of arteriovenous fistula is very important nowadays that there is increase in number of complications due to improper knowledge of patients and their care givers regarding care of arteriovenous fistula. They need guidance on prevention of these complications. So the investigator felt a need to examine the knowledge and attitude of hemodialysis clients regarding care of their fistula site. 6.2 NEED FOR THE STUDY The arteriovenous fistula has marked important advance allowing effective treatment of ESRD for longer periods of time. It is proved that the quality and length of life with chronic kidney disease can be improved by dialysis through a good vascular access. Arteriovenous fistula has proven to be the best kind of vascular access for people whose veins are large enough, not only because it lasts longer but it also less likely than other types of access to form clots or become infected. A primary AV fistula should be the access for at least 50% of all new patients initiating hemodialysis. A native fistula is the primary access for 40% of prevalent patients undergoing hemodialysis.15 As many studies have proven that the use of arteriovenous fistula is increasing day by day, the importance of care for it, also become unavoidable. Complications can also occur with this arteriovenous fistula. The most frequent complication in arteriovenous fistula is related to the vascular access site where needles are inserted. This can include infection around the access area or the formation of clots in the fistula. The greatest danger is that the clots may block the fistula and would have to be removed surgically. Frequent clotting may require creating a back up fistula at another site to allow dialysis when one access is blocked.16 The mean maturation time of a new arteriovenous fistula is about two to four months which should be properly informed to the patients and relatives. Moreover the patients, whose arteriovenous fistula fails to mature adequately to be used for dialysis, require subsequent interventions to promote fistula maturation. Otherwise there will be poor blood flow, frequent thrombosis and malfunction.17 Factors influencing fistula maturation include adequacy of vessels and type of fistula. Several changes are critical for the successful maturation of a new arteriovenous fistula. First, it must dilate to a caliber large enough to be cannulated repeatedly with two large bore dialysis needles. Second, the blood flow rate in the draining vein must increase sufficiently to accommodate the dialysis blood flow required to deliver adequate dialysis. Third, the wall of the draining vein must hypertrophy sufficiently to seal after withdrawal of the dialysis needle. Finally the fistula must be superficial enough for the land marks to be appreciated and permit safe cannulation without infiltration.18 The patients and relatives should be properly educated regarding the care of arteriovenous fistula at home. There is a list of reminders that the patients should follow strictly to prevent the complications of arteriovenous fistula. Never touch the area that the needle enters after skin disinfection and during dialysis, never carry heavy loads across or on the fistula, never sleep on the fistula, always keep the access clean. Moreover, these guidelines provide information like how to watch for the signs of complications.19 Hemodialysis patients are frequently encouraged to perform regular hand exercises to promote maturation of a new fistula. Exercises means squeezing a rubber ball for forearm fistula in order to increase the size of the vessels and thereby to accommodate the large-bore needles used in hemodialysis.20 A descriptive study was conducted among 120 hemodialysis patients in London to assess their practice in caring their fistula site. They used an observational method to assess the practice and found that more than 50% of them are following malpractices. Then a self instructional module was prepared to enhance their knowledge regarding the importance of proper care of the arteriovenous fistula.21 The investigator from her personal experience while working in nephrology unit at Calicut observed that rupture, clotting among dialysis patients with arteriovenous fistula have occurred due to improper caring of the fistula site. The investigator found that the clients had less knowledge on care aspect as well as complications of arteriovenous fistula. This has motivated her to assess the existing knowledge and practice of hemodialysis clients towards the care of their arteriovenous fistula. 6.3 STATEMENT OF THE PROBLEM A Study to Assess the Knowledge and methods and practices of Hemodialysis Clients (30-60 years) regarding prevention and Care of Arteriovenous Fistula in Nephrology unit of Selected Hospitals, Bidar with a View to Develop Health Instructional Module. 6.4 OBJECTIVES OF THE STUDY 1. To assess the existing knowledge of hemodialysis clients regarding care of arteriovenous fistula. 2. To assess the existing practice of hemodialysis clients on care of their fistula site. 3. To associate the knowledge and practice of hemodialysis clients regarding care of arteriovenous fistula with selected demographic variables. 6.5 OPERATIONAL DEFINITIONS 1. KNOWLEDGE: It refers to the awareness and understanding of hemodialysis clients regarding care of their fistula site such as hygiene, prevention of accidents, and complications (infection, clotting, rupture), Do’s and Don’ts with arteriovenous fistula elicited with the help of a structured interview schedule. 2. PRACTICE: It refers to the actions or measures taken by the hemodialysis clients regarding care of their arteriovenous fistula site such as hygienic care, prevention of accidents, injuries and prevention of complications like infection, rupture, clotting; Do’s and Don’ts with arteriovenous fistula as elicited by a non-observational checklist. 3. HEMODIALYSIS: It refers to the process in which a stream of blood taken from an artery is circulated through a dialyzer on one side of a semi permeable membrane and by which the water and waste products from the client’s blood is filtered through the membrane and the purified blood is then returned to the client’s body through a vein. 4. CLIENTS: It refers to the hemodialysis patients of 20-70 years with arteriovenous fistula in their forearm attending the nephrology unit of selected hospitals in Bidar. 5. ARTERIOVENOUS FISTULA: An arteriovenous fistula is a surgically created connection of a vein and an artery, usually in the forearm, to allow access to the vascular system for hemodialysis. The fistula usually becomes patent over a period of three months to undergo hemodialysis. 6. CARE OF ARTERIOVENOUS FISTULA: It refers to the actions taken by the clients with arteriovenous fistula in care of fistula site such as keeping the access site clean at all times, preventing accidents, preventing complications like infection, clotting, rupture; Do’s and Don’ts. 7. HEALTH INSTRUCTIONAL MODULE: It refers to an instructional unit which contains a set of information regarding care of arteriovenous fistula. 6.6 ASSUMPTIONS 1) Hemodialysis clients may have knowledge regarding care of arteriovenous fistula to some extent. 2) The level of knowledge of hemodialysis clients regarding care of their fistula site can have an impact on their practice. 3) The health instructional module may enhance the knowledge and practice of dialysis clients in caring their arteriovenous fistula site. 6.7 HYPOTHESES H1: There is a significant correlation between knowledge and practice of hemodialysis clients regarding care of arteriovenous fistula. H2: There is a significant association of knowledge and practice of hemodialysis clients with their selected demographic variables. 6.8 REVIEW OF LITERATURE A literature review is an integral component of any study of research product; it enhances the depth of knowledge and provides a clear understanding regarding a topic or a research aspect. Literature reviews are secondary sources, and as such, do not report any new or original experimental work. It is a critical analysis of a segment of a published body of knowledge through summary, classification and comparison of prior research studies and theoretical articles.22 A study was conducted to find out the incidence of CRF, among dialysis patients at Central Military Hospital in Yemen in the nephrology department. The study was done among 334 patients and found that 260 were CRF patients who are receiving dialysis treatment. They concluded that in Cuba, CRF is becoming one of the major health problems.23 A study was conducted among adults on the prevalence of CRF in India. The background was that CRF is a debilitating condition responsible for high morbidity and mortality and is a financial burden for the Government and the society. Because of its costs and complexity of the treatment proper care is available to a very few patients in India. A total of 4972 persons were contacted for the study. Their mean age was 42 ± 13 years and 56% were males. And it was found that 37 of them are having chronic renal failure. They concluded that the prevalence of CRF in India makes it a serious problem in need of urgent efforts to contain it.24 An editorial published in an American journal in the year 2004 says that maintenance of patients with ESRD on long term dialysis is a triumph of modern medicine. In US alone more than 2, 50,000 persons with ESRD are surviving because of the availability of hemodialysis and peritoneal dialysis. And there is increasing the incidence with ESRD who are receiving hemodialysis.25 The National Kidney Foundation Kidney-Dialysis Outcome Quality Initiative ((K/DOQI) clinical practice guidelines recommended native AV fistulas as optimal hemodialysis vascular access. The article describes that there is much evidence that native AV fistulae, compared to arteriovenous graft or catheters, provide longer patency rates, require fewer interventions, have less complications and subsequently lower mortality rates for the patient.26 A comparative study was conducted among 200 hemodialysis patients in Netherlands to assess the effectiveness of AV fistula with regard to AV graft on decreasing the thrombosis rates. Among study participants 100 were having arteriovenous fistula and rest with arteriovenous graft. They found that AV fistulae have a positive impact on decreasing future thrombosis rates and the percentage of AV fistulae in the dialysis population increased from 28% to 65% between 1990and 2003.27 A community-based study conducted among 1000 hemodialysis patients in US revealed that 660 of hemodialysis patients are having AV fistula as vascular access. Annual expenditure were also estimated and found that it is less in AV fistula based access as compared to other modalities. They concluded that AV fistula placement is cost-effective and so they are providing financial incentives in the form of higher reimbursement to encourage wider use of AV fistula placement.28 An international journal recommended national guide lines to promote fistula use among hemodialysis patients. Increasing hemodialysis prevalence requires increasing fistula placement, improving maturation of new fistulae and enhancing long term patency of mature fistulae for dialysis. Whether a mature fistula achieves long term patency, depends on the ability to prevent rupture of the fistula thrombosis and to correct it as early as possible.29 A quasi experimental study was done on incidence of micro inflammation of AV fistula among 47 patients with maintenance hemodialysis. They were divided into three groups such as patients with initial hemodialysis and new fistula, patients treated with hemodialysis for long term with well functioning vascular access, and maintenance hemodialysis patients with vascular dysfunction under group one, two and three respectively. Biomedical parameters were determined and found that patients in group 3 had a thicker internal layer of vessels. They concluded that vascular access dysfunction including micro inflammation is a major clinical complication in the hemodialysis population and has a direct effect on dialysis outcome. 30 A study was conducted among 15 patients to investigate the effect of venous stenosis on early patency by examining the peri-operative arterial and venous pressures of the fistula. A thrill was palpable over the anastomosis in 10 patients and absent in 5 patients. In conclusion, patients with venous obstruction the fistula had a much higher venous pressure than those with a patent fistula. If venous stenosis is suspected, measurement of fistula pressures may be useful for determining the early patency of AV fistulae.31 An article published in Oxford journals reveals the complications of a neglected AV fistula. Creation of fistulae provides readily available vascular access for hemodialysis in patients with ESRD. However it is associated with various potentially serious complications if left unattended. They report a case of 63-yr old male presenting with forearm fistula who was admitted in the emergency department of St. George hospital, London, following the rupture and severe hemorrhage after a fall. They concluded that if it is not attended properly it may lead even to death due to excessive bleeding.32 An article emphasizes on the importance of keeping the vascular access clean. Cleanliness is one way someone on hemodialysis can keep their fistula uninfected. Keep an eye out for infections, which can often be detected when there is pain, tenderness, swelling or redness around the access area and also be aware of any fever or flu-like symptoms. The article also instructs the patients to contact health professional if they get an infection to catch it early and treat it properly.33 A study was conducted among 55 hemodialysis patients with CRF who are having AV fistula. It revealed that a simple, incremental resistance, exercise training program can cause a significant increase in the size of the cephalic vein commonly used in the creation of an AV fistula. The increase in size and the resultant probable increase in blood flow might accelerate the maturation of native AV fistula, thereby lessening the morbidity associated with vascular access.34 An information booklet narrates the care of arteriovenous fistula as follows: place ice cubes put in a plastic bag and covered in a towel over the fistula site for pain or swelling, carefully wash the stitches or staples with soap and water when the patients are allowed to take bath, change your bandage any time it gets dirty or wet, do not keep the limb with fistula bent for a long time.35 A patient education book gives information on ‘care of your AV fistula’ which acts as a patient education guide to protect the AV fistula. The instructions are follows: do not allow anyone to take BP in the affected limb, do not allow anyone to stick or take blood from the affected limb, avoid sleeping on the affected limb, do not wear tight straps, jewels or clothes that restrict the movement of the limb, do not carry any heavy objects or lift heavy objects greater than 5 pounds with the affected limb. It also explains how to watch for signs of clotting.36 A nurse-led clinic focusing on education and self-care for patients with advanced renal failure was introduced in a renal outpatient clinic in Sweden. The purpose was to enhance patients' disease-related knowledge, involvement, and self-care ability. The participants in the nurse-led clinic chose and started dialysis in a self-care alternative and also had a functioning, permanent dialysis access to a greater extent than the patients in the comparison group. Those choosing home-hemodialysis rated their self-care ability higher. The participants rated self-care and effects of treatment options on family and everyday life as the most important disease-related areas of knowledge.37 7. MATERIALS AND METHODS 7.1 SOURCE OF DATA The data will be collected from the hemodialysis clients with arteriovenous fistula attending the nephrology unit of selected hospitals, Bidar 7.2 METHOD OF DATA COLLECTION I. RESEARCH DESIGN The research design will be Non-experimental; Descriptive Correlational design. II. RESEARCH VARIABLES A) STUDY VARIABLE The knowledge and practice of hemodialysis clients regarding care of arteriovenous fistula. B) DEMOGRAPHIC VARIABLES The demographic variables of the clients such as age, gender, educational status, occupation, family income, religion, previous exposure to any information, duration of illness, duration of treatment(hemodialysis), site of fistula, schedule of hemodialysis. III. SETTING The setting will be the nephrology unit of the selected hospitals in Bidar IV. POPULATION In this study the target population is the clients with arteriovenous fistula, between the age group of 30-60 years undergoing hemodialysis at nephrology unit of selected hospitals, Bidar. V. SAMPLE Hemodialysis clients who are fulfilling the inclusion criteria will be the sample. Sample size will be 90. VI. CRITERIA FOR SAMPLE SELECTION INCLUSION CRITERIA 1. Clients admitted with diseases like CRF or ESRD undergoing hemodialysis in nephrology unit of selected hospitals. 2. Clients of both IPD and OPD undergoing hemodialysis in selected hospitals, Bidar. 3. Clients with arteriovenous fistula undergoing dialysis for a minimum period of six months. 4. Clients who are willing to participate in the study. 5. Patients between the age group of 20 and 70. 6. Clients who are able to read and understand Kannada or English. EXCLUSION CRITERIA 1. Clients having vascular access other than AVF such as AV graft, catheters or cannula undergoing hemodialysis in nephrology unit of selected hospitals Bidar. 2. Clients who are emotionally unstable and those with behavioral disorders. 3. Clients whose vital signs are unstable or fluctuating. 4. Clients who have undergone arteriovenous fistula recently within three months. VII. SAMPLING TECHNIQUe. Non-probability sampling technique. 35 hemodialysis patients will be selected based on purposive sampling method. VIII. TOOLS FOR DATA COLLECTION. Section A: A structured interview schedule will be used to assess the demographic data (age, gender, educational status, occupation, family income, religion, previous exposure to any information, duration of illness, duration of treatment(hemodialysis), site of fistula, schedule of hemodialysis). Section B: A structured interview schedule will be used to assess the knowledge among hemodialysis clients regarding the care of arteriovenous fistula. Section C: The practice of hemodialysis patients with arteriovenous fistula towards the care of AV fistula will be elicited by a non-observational check list. IX. METHODS OF DATA COLLECTION. After obtaining formal permission from the concerned authority and getting informed consent from samples, assuring about confidentiality of information, the investigator will administer the structured interview schedule to assess demographic variables, knowledge and non-observational check list to assess the practice regarding care of arteriovenous fistula among hemodialysis clients. X. PLAN FOR DATA ANALYSIS. The data collected will be analyzed using descriptive and inferential statistics. DESCRIPTIVE STATISTICS: Frequency, Percentage distribution, Mean and Standard Deviation will be used to assess the knowledge and practice of hemodialysis clients with arteriovenous fistula regarding care of arteriovenous fistula. INFERENTIAL STATISTICS: Correlation Coefficient formula will be used to determine the correlation between knowledge and practice regarding care of arteriovenous fistula. Chi-square test will be used to determine the association of knowledge and practice with demographic variables. XI. PROJECTED OUTCOME. The investigator will assess the level of existing knowledge and practice on care of arteriovenous fistula among hemodialysis clients with AV fistula. Based on the findings obtained, the investigator will prepare a health instructional module regarding care of arteriovenous fistula, which will help the clients to improve their knowledge and follow proper practices in the care of arteriovenous fistula. 8. LIST OF REFERENCE: 1. http://en.wikipedia.org/wiki/Kidney 2. Suzanne C Smeltzer, Brenda G Bare. Brunner and Suddharth’s Text Book of Medical-Surgical Nursing. 10th ed. Philadelphia: Lippincott publishers; 2000; 1285, 1321, 1326. 3. Incidence ESRD 2005. Available from http://www.usrds.com 4. Lewis SM, Collier IC, Heitkemper MM. Medical Surgical Nursing-Assessment and Management of Clinical Problem. 7th ed. Missouri: Mosby publications; 2002; 1372, 1379, 1392. 5. Renal Replacement Therapies. Available from http://www.kidney.org. 6. Dialysis history. Available from http://www.niddk.nih.gov. 7. Joyce M Black, Jane H Hawks, Annabelle M Keene. Medical Surgical Nursing. 6th ed. Philadelphia: W.B. Saunders Company; 2001; 891-894. 8. Andrew R Foraner. For Old and Young Dialysis Patients Arteriovenous Fistula Remain Pure Gold. 2009 Mar; Available from http://esciencenew.com 9. Fistula First. Available from http://www.nwrenalnetwork.org. 10. ESRD Network Results 2002-2007. Available from http://www.nkudic.niddk.nih.gov. 11. Department of Nephrology India. Available from http://www.sgrh.com. 12. Increasing Incidence Rate- Arteriovenous Fistula. 2007 Oct; Available from http://www.issuu.com. 13. Berns M. Patient Information- Hemodialysis. Available from http://www.uptodate.com. 14. Clavanaugh KL, Wingard RL. Patient Dialysis Knowledge is Associated with Permanent Arteriovenous Access Use in Chronic Hemodialysis. Clin J Am Soc Nephrol. 2009 May; 4(5): 950-56. 15. ESRD Clinical Performance Measures Project. Annual Report 2007. Available from http://www.cms.hhs.gov. 16. Stewen MH. Increasing Arteriovenous Fistula in Hemodialysis Patients: Problems and Solutions. Official Journal of ISN. 2007 Jul 15; 22(2): 522-528. 17. Voormolen, Eduard HJ. Non-maturation of arm AVF for HD access: a systematic review of risk factors and results of early treatment. J Vasc Surg. 2009 May; 49(5): 1325-36. 18. Guidelines for Vascular Access. 2008 June; Available from http://www.kidney.org/professionls/KDOQI/guidelines. 19. Vascular Access for Hemodialysis: How should I Care of my Vascular Access 2008. Available from http://en.wikipedia.org. 20. Oder TF, Uribarri J. Effect of exercise on maturation of AVF in HD dialysis patients. ASAIO Journal. 2003 Sep; 49(50): 554-55. 21. Mendelssohn DC. Ethier J. Assessment of Practice on Care of Fistula 2005. Available from http://www.ncbi.nlm.gov 22. Literature Review: Writing Audio Duke University. http://uwp.aas.duke.edu/wsstudio. 2001. Available from 23. Dr. Jose Luis, Dr. Roberto. A Study of Chronic Renal Failure. English Medical Journal. 2007 Sep; 51:251-54. 24. Sanjay Kumar Agarwal, Suresh Chand. Prevalence of Chronic Renal FailureAdults in Delhi. Oxford Journals. 2005 Apr; 20(8): 1638-1642. 25. Norman G Levinsly. Specialist Evaluation in CKD. Am J Int Med. 2004 Apr; 137:542-543. 26. K/DOQI Clinical Practice Guidelines for Vascular Access. Am J Kidney Dis. 2002 Mar; 37(2):137–181. 27. Sands J, Miranda CL. Increasing Number of AVF for HD Access. Clin Neph J. 2003 Mar; 52:114-117. 28. Donald Schon, Steven W. Increasing the Use of Arteriovenous Fistula in Hemodialysis Patients- Economic Benefits. Clin J Am Soc Neph. 2008 Nov; 3(6): 1736-1732. 29. Allon M, Robbin ML. Increasing AVF in Hemodialysis Patients- Problems and Solutions. Kidney Int J. 2007 Oct; 62(40): 1109-24. 30. Lin-Bi-Cheng, LiLi. Micro Inflammation is Involved in the Dysfunction of AVF in Patients with Maintenance HD. Chinese Med J-Peking. 2008 Mar; 121(21): 2157-61. 31. Kubilay Korkut, Faruk H. Patency and Venous Pressure of AVF for HD. Asian annals. 2006 Aug; 13(2): 131-133. 32. Wayne Lam, Dibendu Betal. Neglected AVF- Problems. Oxford Journals. 2008 Jul; 103:52-57. 33. Vascular Access-Your Life Line to Hemodialysis. Available from http://www.davita.com/dialysis/treatment. 34. Leaf DA, Grant E. Isometric Exercise Increases the Size of Forearm Veins in Patients with CRF. Am J Med. 2003 Mar; 325(3):115-9. 35. Arteriovenous Fistula Care. 2007 Oct; Available from http://www.healthsquare.com/mc/fgmc6005.htm. 36. Conti S. A Vascular Access Unit- Patient Education Book. Associates; 1997 Jun; 13. W.L Gore and 37. Pagels AA, Wang M, Wengstrom Y. The Impact of A Nurse-led Clinic on Self care Ability- Disease Specific Knowledge. Nephrology Journal. 2008 May; 35(3): 242-8. 9. SIGNITURE OF THE CANDIDATE 10. REMARKS OF THE GUIDE 11. NAME AND DESIGNATION OF PRINCIPAL (IN BLOCK LETTERS) 11.1 GUIDE 11.2 SIGNITURE 11.3 CO GUIDE (IF ANY) 11.4 SIGNITURE 11.5 HEAD OF THE DEPARTMENT 11.6 SIGNITURE 12 REMARKS OF PRINCIPAL 12.2 SIGNITURE THE CHAIRMAN AND