Download Neurocognitive Impairment Chapter

Neurocognitive Impairments
Richard S. E. Keefe, Ph.D.
Charles E. Eesley, B.S.
Dr. Richard Keefe
Associate Professor
Duke University
Box 3270
Duke University Medical Center
Durham, NC 27710 USA
Fax: 1-919-684-2632
[email protected]
Charles E. Eesley, B.S.
Duke University
Box 3270
Duke University Medical Center
Durham, NC 27710 USA
919-471-0054
[email protected]
1
Neurocognitive Impairments Chapter
I. What is the cognitive impairment in schizophrenia?
A. Cognition as a Core Feature of Schizophrenia
B. Profile and Magnitude of Cognitive Impairment Associated with Schizophrenia
1. 7 divisions of cognition
II. What is the natural history of neurocognitive impairment?
A. Deficits in children at risk for schizophrenia and follow-back studies
B. The course of cognitive impairment from prodrome to end-stage illness.
Prodrome Studies
First Episode of Psychosis Studies
Cognitive Changes in Patients Recovering from Acute Exacerbation
Longitudinal Change in Cognitive Function
Cognitive Functioning in Elderly Patients
C. Summary
III. Relationship of neurocognitive impairment to positive, negative and extrapyramidal
symptoms.
A. Pseudospecificity
B. Cross-sectional studies.
C. Longitudinal studies.
IV. Clinical importance of neurocognitive impairment.
A. Cross-sectional correlations with function
B. Relationship of Neurocognitive Impairment to Functioning
V. Conclusion
2
SECTION I. Cognitive Impairment in Schizophrenia
Cognition as a Core Feature of Schizophrenia
Cognitive impairment associated with schizophrenia is now viewed as a potential
psychopharmacological target for treatment (Hyman and Fenton 2003). While cognition is not a
formal part of the current diagnostic criteria for schizophrenia, the Diagnostic and Statistical
Manual of Mental Disorders, volume IV (DSM-IV-TR 2000) includes seven references to
cognitive dysfunction in the description of the disorder. Diagnostic and scientific experts have
increasingly expressed the idea that neurocognitive impairment is a core feature of the illness,
and not simply the result of the symptoms or the current treatments of schizophrenia.
Profile and Magnitude of Cognitive Impairment Associated with Schizophrenia
Severely impaired performance on cognitive tests is the strongest evidence for the
importance of cognitive deficits in schizophrenia. In several cognitive domains, the average
impairment can reach 2 standard deviations below the healthy control mean (Harvey and Keefe
1997; Heinrichs and Zakzanis 1998; Saykin et al. 1991). While only about 27% of patients with
schizophrenia (and 85% of the general population) are not rated as “impaired” by clinical
neuropsychological assessment (Palmer 1997), these patients tend to have the highest levels of
premorbid functioning (Kremen 2000), and demonstrate cognitive functioning that is
considerably below what would be expected of them based upon their premorbid levels and the
educational level of their parents. Recent analyses of data from 150 patients with schizophrenia
suggest that up to 98% of patients perform more poorly on cognitive tests than would be
predicted by their parents level of education (Keefe, Eesley, and Poe submitted for publication).
In addition, comparisons of monozygotic twins discordant for schizophrenia suggest that almost
all affected twins perform worse than their unaffected twin on cognitive tests (Goldberg et al.
3
1990). Therefore, it is likely that almost all patients with schizophrenia are functioning below the
level that would be expected in the absence of the illness.
Neurocognitive tests often assess more than one domain of functioning, and many tests
do not fit neatly into a single domain. Thus, descriptions of the profile of cognitive deficits in
schizophrenia have varied across literature reviews. The domains that are most consistently cited
as being severely impaired in schizophrenia are verbal memory, executive functions, attention or
vigilance, verbal fluency, and motor speed (Harvey and Keefe 1997). Deficits in social cognition
also appear to be severe, but this is a relatively new area of research, with fewer studies to
support this finding (Pinkham et al. 2003). The opinion of a group of experts who served on the
Neurocognition Subcommittee for the Measurement and Treatment Research to Improve
Cognition in Schizophrenia (MATRICS) Project is that the most important domains of cognitive
deficit in schizophrenia are: working memory, attention/vigilance, verbal learning and memory,
visual learning and memory, reasoning and problem solving, speed of processing, and social
cognition (Green et al., in preparation www.matrics.ucla.edu).
The most striking aspect of the profile of cognitive deficits in patients with schizophrenia
is that so few cognitive functions remain similar to healthy controls (Harvey and Keefe 1997;
Saykin et al. 1994). In fact, an estimate of the severity of neurocognitive impairment in patients
with schizophrenia, based upon an examination of the most methodologically sound studies
completed, suggests that many important cognitive functions are in the severely impaired range
(2 to 3 standard deviations below the normal mean) or moderately impaired range (1 to 2
standard deviations below the normal mean). A review and meta-analysis of 204 studies shows a
consistent and stable difference between patients with schizophrenia (N = 7420) and healthy
controls (N = 5865) in a wide range of domains of cognitive functioning (Heinrichs and Zakzanis
4
1998). Examples of tests that measure the most important components of cognitive impairment
in schizophrenia are briefly reviewed here.
Attention/Vigilance. Many neurocognitive tests require vigilance functions, even if the
test itself is not a measure of “pure” vigilance. Vigilance refers to the ability to maintain
attention over time. A standard vigilance test used in many studies is the Continuous
Performance Test, or CPT. The “A-X” version of the CPT, requires that patients attend to a
series of letters presented one at a time on a computer screen at a rate of one per second. Patients
respond with a button-press on the computer mouse or keyboard each time an “A” is followed by
an “X”. This type of CPT reveals severe vigilance impairments in patients with schizophrenia
(Cornblatt and Keilp 1994).
Impairments in vigilance can result in difficulty following social conversations, inability
to follow important instructions regarding treatment, therapy or work functions, and simple
activities like reading or watching television become labored or impossible. Reviews of the
literature have suggested that vigilance deficits in patients with schizophrenia are related to
various aspects of outcome, including social deficits, community functioning, and skills
acquisition (Green 1996; Green 2000).
Verbal Learning and Memory. Several different types of abilities involved in memory
functioning include, but are not limited to, abilities associated with learning new information,
retaining newly learned information over time, and recognizing previously presented material. In
general, patients show larger deficits in learning than in retention. The findings for recognition
are more equivocal, with most studies suggesting relatively mild deficits (Calev 1984; Saykin et
al. 1991) yet large deficits have also been reported (Mohamed et al. 1999). The tests used to
measure learning typically involve the ability to learn lists of words or written passages. Verbal
5
list learning tasks usually require the patient to listen to 12 to 16 words, then immediately recall
as many of the words as possible. Using the California Verbal Learning Test, normal controls
can recall about 8 of 16 words after the first trial; patients with schizophrenia can recall only
about 5 (Paulsen et al. 1995). After 5 consecutive trials of the same word list, most controls can
recall at least 13 of the words, while patients with schizophrenia, on average, can recall only 9.
Thus, patients are not only impaired in their ability to immediately recall verbal material, they
are also impaired compared to controls in their ability to learn over time. Patients are also
impaired in recalling more interesting verbal material, such as stories (Hoff et al. 1992).
Much empirical evidence points to the connection between verbal memory impairment
and social deficits in patients with schizophrenia (Green 1996).
Visual Learning and Memory. Since visual information is not as easily expressed as
verbal information, fewer tests sensitive to the deficits of schizophrenia have been developed,
and this area of cognitive function has generally been found not to be as impaired as verbal
memory (Heinrichs and Zaksanis 1998). Most tests require subjects to draw figures from
memory or to indicate which among an array of figures was previously presented.
Studies of the relationship between poor visual memory and functional outcome have
yielded mixed findings. Visual memory has been found to correlate modestly with employment
status (Gold et al. 2003), job tenure (Gold et al. 2002), psychosocial rehabilitation success
(Mueser et al. 1991), social functioning (Dickerson et al. 1999), quality of life ratings (Buchanan
et al. 1994), and strongly with functional capacity (Twamley et al. 2003). Other studies have
reported no significant correlations (Addington and Addington 2000; Addington et al. 1998;
Ertugrul and Ulug 2002; Velligan et al. 2000).
6
Reasoning and Problem-solving. While there are numerous tests of reasoning and
problem solving, the most well-known and most frequently utilized in schizophrenia research is
the Wisconsin Card Sorting Test (Heaton 1981). In this test, patients are given a deck of cards
with various numbers of colored shapes on them, and are asked to match their cards to four
“key” cards that have shapes on them that differ by color, form, and number. The first principle
to which the subject needs to learn to sort the cards is color. After a patient demonstrates that he
has learned that color is the correct sorting principle, the principle changes to form without
warning. Repeated sorting attempts by the previously correct principle are referred to as
perseverations, and patients with schizophrenia, like patients with frontal lobe damage, often
make many of these errors. In fact, the very poor performance of patients with schizophrenia on
the Wisconsin Card Sorting Test (Goldberg et al. 1987), and the reduced activity of the
dorsolateral prefrontal cortex during performance of this test (Weinberger et al. 1987) led to
widespread pursuit of the hypothesis of frontal hypoactivation in schizophrenia. It is important to
note, however, that the Wisconsin Card Sorting Test measures a variety of cognitive functions
and is not a “pure” measure of executive functions (Keefe 1995)
The rules of society and the workplace change regularly, and success in these arenas is
often measured by one’s ability to adapt to changes. Patients with schizophrenia who are
impaired on measures of executive functions have difficulty adapting to the rapidly changing
world around them.
Speed of processing. Many neurocognitive tests require subjects to process information
rapidly and can be compromised by impairments in processing speed. A standard example of this
type of task is the Wechsler Adult Intelligence Scale Digit Symbol Test (Wechsler et al. 1997).
Each numeral (1 through 9) is associated with a different simple symbol. Subjects are required to
7
copy as many of the symbols associated with the numerals as possible in 90 seconds. This
nonspecific cognitive impairment has been found to correlate with a variety of clinically
important features of schizophrenia, such as daily life activities (Evans et al. 2003), job tenure
(Gold et al. 2002), and independent living status (Brekke et al. 1997). It is also sensitive to
medication side effects such as somnolence and extrapyramidal symptoms (Galletly et al. 2000).
Reduced processing speed can impair ability to keep in step with the task-oriented jobs
that are frequently held by patients with schizophrenia. Increased response latency in social
settings may hamper social relationships.
Verbal Fluency. Most cognitive assessments in treatment studies of schizophrenia have
included measures of verbal fluency as a separate domain of functioning (Harvey and Keefe
2001; Keefe et al. 1999; Meltzer and McGurk 1999). Most of these tests measure either
phonological fluency (also referred to as letter fluency) or semantic fluency. Phonological
fluency refers to a patient’s ability to produce as many words as possible beginning with a
particular letter within for instance 60 seconds. Semantic fluency refers to the ability to produce
words within a particular meaning-based category, such as “vegetables.” Not only do
schizophrenia patients produce fewer words than normal controls, but they often produce
inappropriate examples, such as examples of fruits instead of vegetables. Impaired verbal fluency
can damage functioning in social and vocational settings by making communication difficult and
awkward.
Immediate / Working Memory. Immediate memory refers to the ability to hold a limited
amount of information "on-line" for a brief period of time (usually a few seconds). Repeating a
string of digits (Digits Forwards) is an example of immediate memory. The definition of working
memory, on the other hand, is more complex and varies across studies. Some investigators
8
consider working memory to be synonymous with immediate memory, whereas others describe
that it should require some manipulation of the information being held on-line. For example,
repeating a series of digits in the reverse order than they were presented (Digits Backward)
requires an active manipulation because the information needs to be both held on-line and then
subsequently re-ordered. Patients typically show deficits on both tasks. These visual tasks
involve keeping a visuospatial stimulus, such as a dot on a computer screen, or series of visual
objects in mind while working on a related or unrelated task (reviewed in Keefe 2001).
Working memory has been described by various authors as a core component of the
cognitive impairment in schizophrenia (Goldman-Rakic 1994; Keefe 2001; Silver et al. 2003),
and is related to functional outcomes such as employment status (McGurk and Meltzer 2000),
and job tenure (Gold et al. 2002). Much of the clinical relevance of working memory deficits in
schizophrenia comes from strong correlations that working memory measures have with a
variety of other cognitive domains impaired in schizophrenia, such as attention, planning,
memory (reviewed in Keefe 2001), and intelligence (Baddeley 1992), as well as the advanced
understanding of the neuroanatomy of working memory functions in human and non-human
primates. This neuroanatomical work has suggested that neural circuitry that includes prefrontal
cortical regions mediates aspects of working memory functions (Callicott et al. 1999; GoldmanRakic 1987), and that this circuitry may be impaired in schizophrenia (Callicott et al. 1999).
Social Cognition. Theory-of-mind skills and social perception have been the general
focus of the literature on social cognition in schizophrenia. Theory-of-mind is the ability to infer
about another’s intentions and/or to represent the mental states of others. Individuals with
schizophrenia perform poorly on measures of theory-of-mind abilities (Corcoran, Mercer, and
Frith 1995; Drury, Robinson, and Birchwood 1998; Sarfati et al. 1997). The evidence regarding
9
whether impairments in theory-of-mind skills are independent of a general cognitive deficit is
mixed (Doody et al. 1998; Pinkham et al. 2003). Facial affect recognition and social cue
perception are the two general areas into which studies of social perception in schizophrenia can
be broken down. Reviews of the literature on facial affect recognition (Morrison, Bellack, and
Mueser 1988; Penn et al. 1997) suggest that individuals with schizophrenia have stable deficits
on tests of facial affect perception compared with healthy controls and psychiatric controls, and
that perception of negative emotions and fear may be particularly impaired (Addington and
Addington 1998; Edwards et al. 2001; Gaebel and Wolwer 1992). Tests of social cue perception
use more dynamic stimuli that require multiple sensory modalities, such as watching videotapes
of persons interacting. Patients with schizophrenia show consistent impairments on these tasks
(Bell, Bryson, and Lysaker 1997; Corrigan, Davies-Farmer, and Stolley 1990). In particular, they
have more difficulty discerning other individuals’ goals and intentions than what they are
wearing or saying.
A variety of reports have described the strong relationship between cognitive function
and social deficits in schizophrenia (reviewed by Trumbetta and Meuser 2000). Even so, there is
growing evidence that social cognition is related to social impairments in schizophrenia, even
after controlling for performance on neurocognitive tasks (Penn et al. 1996).
Summary
Experts in cognition and schizophrenia have come to a clear consensus that cognitive
impairment is a core feature of the illness. The profile of deficits is broad, severe, and is likely
present in most if not all patients. Neurocognitive impairment has clear clinical relevance, as
cognitive impairment interferes with the everyday lives of patients in various important ways,
from limiting social relationships to reducing the likelihood of employment.
10
SECTION II. Natural History of Neurocognitive Impairment
Evidence shows that the time course of the development of cognitive deficits in
schizophrenia patients appears to follow a predictable pattern. Some deficits may be present in
childhood, followed by a decline in cognitive function prior to the first episode. The severity of
neurocognitive impairments becomes even more severe once psychosis develops. The long-term
stability of neurocognitive impairment over time is not clear, but evidence for progression in
non-elderly patients is lacking.
Deficits in Children at Risk for Schizophrenia and Follow-back Studies
Individuals who are genetically vulnerable to schizophrenia have notable cognitive
impairments (Cornblatt and Keilp 1994), while individuals who are examined with cognitive
assessments before they develop schizophrenia are found to have impairments in a variety of
areas (Davidson et al. 1999). High-risk studies of children with one or two biological parents
with schizophrenia (Cornblatt et al. 1999) have suggested that attention deficits can predict
which children will develop schizophrenia in the future.
Several studies have utilized the “follow-back” method of identifying adult patients with
schizophrenia, and then linking these patients with their records of cognitive assessments
performed while they were children or adolescents (Fuller et al. 2002; Jones et al. 1994;
Davidson et al. 1999). In the UK National Survey of Health and Development study, data from
5,362 people indicated that children who went on to develop schizophrenia as adults differed
significantly from the general population in a wide range of cognitive and behavioral domains
(Jones et al. 1994). Low educational test scores in verbal, non-verbal, and
mathematics/arithmetic at all ages assessed were significant risk factors. Similar findings were
generated from a population-based study that investigated the risk of schizophrenia in a sample
11
of 50,000 18-year-old males conscripted into the Swedish Army between 1969 and 1970 (David
et al. 1997). In the U.S., scores from grades 4, 8, and 11 on the Iowa Tests for 70 children who
later developed schizophrenia show no significant differences from controls at grades 4 and 8.
However, for children who developed schizophrenia, test scores dropped significantly between
grades 8 and 11, corresponding to the onset of puberty (Fuller et al. 2002). Yet limitations of
this study including small sample size and a non-random sample restrict the generalizability of
these results.
Several studies have utilized a link between the Israeli Draft Board Registry and the
National Psychiatric Hospitalization Case Registry. Israeli law requires that all adolescents
between the ages of 16-17 undergo pre-induction assessment to determine their intellectual,
medical, and psychiatric eligibility for military service. This assessment is compulsory and is
administered to the entire, unselected, population of Israeli adolescents. It includes individuals
who will be eligible for military service, as well as those who will be excused from service based
on medical, psychiatric, or social reasons. The results suggest that cognitive functions are
significantly impaired in those adolescents who are later hospitalized for schizophrenia. These
deficits thus precede the onset of psychosis in young people destined to develop schizophrenia,
and along with social isolation and organizational ability, cognitive deficits are a significant
predictor of which young people will eventually develop a psychotic disorder (Davidson et al.
1999). One study from this series examined the cognitive performance of 44 patients with a first
episode of schizophrenia who had previously undergone cognitive assessment as part of their
registration with the Israeli Draft Board. The stability of the deficits in these patients suggests
that most of the cognitive impairment seen occurs prior to the first psychotic episode (Caspi et al.
12
2003). These follow-back studies consistently demonstrate that cognitive impairment precedes
the onset of illness in schizophrenia and schizoaffective illness.
Prodrome Studies
Cognitive deficits are also found in individuals who are identified as being at “ultra-high”
risk (Yung and McGorry 1996) for schizophrenia by virtue of their family history of
schizophrenia and/or the manifestation of mild signs and symptoms consistent with the
prodromal symptoms of schizophrenia. While several research groups are gathering data on this
question, results have only recently begun to be reported (Brewer et al. 2003; Hawkins et al.
2004). Preliminary data also suggests that olfactory identification deficits predict which
individuals at ultra-high risk will develop schizophrenia (Brewer et al. 2003).
First Episode of Psychosis Studies
Once psychosis develops, cognitive deficits are severe (Mohamed et al. 1999; Bilder et
al. 2000; DeLisi et al. 1995; Hoff et al. 1999; and Stirling et al. 2003). Patients with a first
episode of schizophrenia who have never taken antipsychotic medication, already exhibit
cognitive impairment (Brickman et al, in press; Mohamed et al. 1999; Saykin et al. 1994). Motor
functions and language functions may be more mildly impaired prior to medication treatment
(Brickman et al, in press). Initial treatment with first-generation antipsychotic medications does
little to change these cognitive deficits (Bilder et al. 2000).
Cognitive Changes in Patients Recovering from Acute Exacerbation
Several studies have investigated the longitudinal course of cognitive deficits in
schizophrenia by repeatedly assessing cognition in samples that combine first episode patients
and those who have had an acute exacerbation of their symptoms. Patients recovering from an
acute exacerbation of illness do not appear to demonstrate substantial changes in the severity of
13
their cognitive impairment despite clear improvements in symptoms with treatment (Hughes et
al. 2003; Nopoulos et al. 1994; Gold S. et al. 1999; Sweeney et al. 1991).
Longitudinal Change in Cognitive Function
There are many age-related changes in cognitive functioning in the normal population,
especially in motor speed and memory functions (Moss and Albert 1988). The magnitude of
change in long-term memory and ability to access and utilize previously learned material is more
modest. Reading and vocabulary are tests of “old learning” therefore baseline functioning can be
estimated from performance on these tests which show minimal aging-related changes. The
possibility of detecting cognitive decline with aging is diminished due to floor effects on
numerous tests. The types of cognitive functions that change with normal aging, such as new
learning and recall, attention, and processing speed are related to the deficits most commonly
observed in schizophrenia patients early in life. Thus, aging-related changes are likely to affect
those functions that are already severely impaired in adults with schizophrenia (Harvey
1999).The notion of neurodegeneration in schizophrenia has been controversial. Evidence has
been presented suggesting that schizophrenia is a neurodegenerative process, and some have
concluded that schizophrenia is progressive (Lieberman 1999). Supportive evidence for this
theory derives from the greater cognitive impairment reported in chronic patients compared with
first episode patients (Saykin et al. 1994). However, with a few notable exceptions (Bilder et al.
1992; Davidson et al. 1995; O’Donnell et al. 1995), cross-sectional studies generally have not
found evidence of increased cognitive impairment in association with duration of illness, and
older non-elderly patients do not manifest greater impairment than younger patients (Goldberg et
al. 1993b; Heaton et al. 1987; Hyde et al. 1994; Zorrilla et al. 2000). Definitive answers to
questions regarding possible progression of cognitive impairment in schizophrenia must come
14
from longitudinal studies. The available studies, however, have a variety of methodological
limitations such as small or unrepresentative samples, no controls, limited assessment, or
relatively short follow-up periods. One recent longitudinal study traced 111 first-episode
schizophrenia patients over 10-12 years and finding that Visuospatial function while spared in
the first episode may deteriorate over time while executive deficits do not (Stirling et al. 2004).
These longitudinal studies of neurocognitive impairment suggest that it is a stable, enduring
feature of the illness, with very little change in chronic patients between assessment periods of
up to 5 years duration (Heaton et al. 2001; Rund 1998)
Cognitive Functioning in Elderly Patients
There is some evidence that neurocognitive impairment in schizophrenia may worsen
over time in at least a subgroup of elderly patients with schizophrenia. In older schizophrenic
patients with a lifetime of poor functional outcome, prominent cognitive impairments resembling
dementia have been reported (Arnold et al. 1995; Davidson et al. 1995; Harvey et al. 1997).
Based upon cross-sectional studies, elderly patients with schizophrenia appear to show
some decline in cognitive function toward the end of life. However, this decline may be
restricted to those patients who had an early onset of illness followed by a lifetime of poor
functioning (Heaton et al. 1994; Hyde et al. 1994; Jeste et al. 1995; Zorrilla et al. 2000). Some of
the inconsistency of these results may derive from the subject selection processes in these
studies. Finally, cognitive decline in some elderly patients with schizophrenia has been found to
be associated with tardive dyskinesia (Waddington and Youssef 1996) and neurological
dysfunction (Goldstein and Zubin 1990).
Summary
Several studies have demonstrated that neurocognitive impairment is present in a mild
15
form prior to the onset of psychosis in young people destined to develop schizophrenia.
Neurocognitive impairment is severe in patients who have experienced their first psychotic
episode, even before antipsychotic treatment is initiated. While some early phase patients may
demonstrate a slight improvement in neurocognitive impairment with treatment, many patients
do not improve at all. Following this early phase, neurocognitive impairment appears to be
remarkably consistent, even in the presence of positive and negative symptom change, although
few longitudinal studies have had follow-up periods of longer than 5 years. The course of
neurocognitive impairment in elderly patients in uncertain, but some studies suggest that patients
with the most chronic courses of illness may manifest a further, albeit gradual, cognitive decline
in the latest years of life.
Early treatment with second generation antipsychotics could potentially improve long
term cognitive and functional outcome and change the longitudinal course of illness described
above. We will return to this topic of a greater cognitive enhancing effect of second generation
antipsychotics in the section entitled Impact of Second Generation Antipsychotics on Cognition.
III. Relationship of Neurocognitive Impairment to Schizophrenia Symptoms
Overview and Introduction of Pseudospecificity
This section will address the relationship between neurocognitive impairment and
symptoms. If neurocognitive deficits were the result of the symptoms of the illness, then the
deficits would disappear when the symptoms do. However, this is usually not the case in patients
with schizophrenia. In contrast to patients with psychotic bipolar illness whose performance on
cognitive tests may improve when their psychotic symptoms remitted, the performance of the
patients with schizophrenia does not change when psychosis remits (Harvey et al. 1990).
16
The impact of first generation antipsychotics on cognition is very weak (Blyler and Gold
2000). The recalcitrance of neurocognitive impairment in the context of substantial symptom
improvement is one of the most compelling lines of evidence of the independence of these
symptom domains. However, recent studies investigating second-generation antipsychotics raise
an important question about the potential “pseudospecificity” of cognitive improvement: If
second-generation antipsychotics improve cognition and symptoms, is the cognitive
improvement explained by the improvement in symptoms? While substantial improvements in
symptoms and mild improvements in cognition may be found with some second-generation
drugs, the correlations between these two domains of improvement have largely been found not
to be statistically significant (Bilder et al. 2002).
Cross-sectional Studies of the Relation to Symptoms of Schizophrenia
Neurocognitive deficits are largely separate from both the positive and negative
symptoms of the disorder. Cross-sectional relationships between neurocognition and positive
symptoms, particularly for hallucinations and delusions, are usually quite weak (Addington and
Addington 2000; Hughes et al. 2003; Strauss 1993). Generally, the variance shared by these
variables is less than 10 percent. Relationships tend to be slightly stronger between
neurocognition and negative or ‘deficit’ symptoms (Addington and Addington 2000; Buchanan
et al. 1997; Hughes et al. 2003; Tamlyn et al. 1992).
Positive Symptoms
It has been repeatedly reported that neurocognitive ability is not strongly correlated with
severity of psychotic symptoms in patients with schizophrenia (Addington et al. 1991; Bilder et
al. 1985; Strauss 1993). In acute exacerbation, the severity of positive symptoms has been found
to be significantly correlated with better performance on select domains of cognitive function.
17
Although some exceptions exist, such as isolated reports of significant correlations of positive
symptoms with working memory (Bressi et al. 1996; Carter et al. 1996), source monitoring
(Keefe et al. 2002), and auditory distractibility (Walker and Lewine 1988), the overall trend is
for general neurocognitive impairment not to be correlated with positive symptoms. This low
correlation across various patient samples, including first episode (Mohamed et al. 1999),
chronic (Addington, Addington, and Maticka-Tyndale 1991; Tamlyn et al. 1992), and elderly
(Davidson et al. 1995) samples, suggests that positive symptoms are clearly not the sole cause of
the cognitive impairment found in patients with schizophrenia.
The low reliability of positive symptom assessment is a crucial factor (Strauss 1993). The
subjective report of a psychotic patient may not reflect the true level of the patient’s psychosis.
Another factor may be that the exclusion of patients who are too psychotic to be tested may serve
to weaken any potential correlation between the severity of psychosis and neurocognitive
impairment. Finally, those patients who have more intact cognitive abilities may be better able to
recall and express their internal state including detailed delusions and hallucinations. These
patients would thus receive higher scores on positive symptom rating scales, resulting in a
reduction in any potential correlation between positive symptoms and neurocognitive
impairment. Clearly, there are limitations to the assessment of positive symptoms, and the
absence of cross-sectional correlations between positive symptoms severity and neurocognitive
impairment is complex.
Negative Symptoms
Cognitive dysfunction is significantly correlated with various types of negative symptoms
(Addington, Addington, and Maticka-Tyndale 1991; Cuesta et al. 1995; Morris et al. 1995;
Strauss 1993; Summerfelt et al. 1991; Tamlyn et al. 1992). The greater variance shared between
18
neurocognition and negative symptoms compared with positive symptoms may result from
measurement overlap. For instance, the neurocognitive variable verbal fluency and the negative
symptom variable poverty of speech both measure the speed at which a patient generates speech.
A patient who generates speech at a slow rate will do so during a test of verbal fluency as well as
in an interview during which he is being rated for poverty of speech.
Empirical studies suggest that motor functions are strongly correlated with negative
symptoms (Cuesta et al. 1995; Manschreck et al. 1985), job success (McGurk et al. 2003) and
outcome (Bilder et al. 1985). Deficient motor skills are represented in both the negative symptom
and the cognitive dysfunction domain, since symptoms such as blunted affect and motor
retardation are observational measures of motor functioning (Alpert 1985; Andreasen 1989).
Thus, impaired motor skills in many ways lie at the core of negative symptoms in schizophrenia.
Whether the negative symptom of reduced motivation underlies the poor performance of
patients with schizophrenia on cognitive tests is controversial. Though monetary reinforcement
has been shown to improve performance on effortful cognitive tests such as the WCST in some
studies (Summerfelt et al. 1991), especially in less difficult tasks, others have not (Green et al.
1990). Increases in pupil size are associated with increased cognitive processing demands
(Granholm et al. 1996). Therefore, pupillary response can measure engagement in a task. If the
cognitive deficits of schizophrenic patients were due to lack of interest or motivation, their
pupillary response would be low throughout the period of cognitive assessment. Only during
high processing conditions do patients have abnormal pupillary responses, suggesting they put
forth a normal amount of effort when being given cognitive tests, yet their decreased processing
capacity leads them to be unable to engage in difficult tasks (Granholm et al. 1997).
19
On the contrary, cognitive deficits may cause reduced motivation. Individuals with
cognitive deficits are less likely to be motivated to have goals and pursue them (reviewed by
Deci and Flaste 1996). Patients with neurocognitive impairment are likely to be met with failure
if they attempt to pursue employment, social, and even recreational avenues that require
cognitive skill. Repeated failures are likely to cause discouragement and reduced motivation in
people with schizophrenia.
In sum, a cross-sectional correlation of negative symptoms and neurocognitive
impairment has been consistently reported, but the magnitude of this relation is modest.
Formal Thought Disorder
Deficits in semantic memory may lie at the heart of the cognition—thought disorder
relation (Elvevag et al. 2002). This argument has recently been supported by empirical data
suggesting that the difference between semantic fluency (the number of names of animals
produced in 60 seconds) and phonological fluency (the number of words beginning with “F”
produced in 60 seconds), an indication of the severity of the impairment of the “semantic
network” in schizophrenic patients, predicted the severity of their formal thought disorder
(Goldberg et al. 1998). Thus, a patient’s ability to have verbal information available (referred to
as “semantic priming”) may be the most important cognitive factor in formal thought disorder.
Affective symptoms
Since many patients with schizophrenia also report depressed mood (Jin et al. 2001) if
not a full depressive disorder, and since depression is associated with some cognitive impairment
(Goldberg et al. 1993a), the role of depressed mood in neurocognitive impairment is important.
Very few studies have examined this relationship directly. Furthermore, the distinction between
depressive symptoms and negative symptoms is sometimes difficult for raters and clinicians to
20
make (McKenna et al. 1989; Goldman et al. 1992), yet factor analyses suggest that they are
separate dimensions of schizophrenia (Lindenmayer et al. 1995; Van der Does et al. 1995).
Higher depression scores were significantly correlated with worse verbal memory task
performance, which remained even when psychomotor retardation and processing speed
performance were controlled statistically (Brebion et al. 2001). Thus, depression may influence
the association between negative symptoms and cognitive impairments, and it may also have a
direct deleterious effect on some aspects of neurocognitive impairment.
In conclusion, the cross-sectional correlations between neurocognitive impairment and
symptoms are weaker than might be expected, and vary depending upon symptom domain. The
consistency of this finding strongly supports the idea that neurocognitive impairment is not
caused by psychosis.
Longitudinal Studies
The relative independence of neurocognitive impairment and symptoms in crosssectional studies appears to be supported by longitudinal studies. When patients with
schizophrenia are successfully treated with first-generation antipsychotics, the severity of their
symptoms is substantially reduced (Lieberman et al. 2003). However, if neurocognitive function
improves with first-generation antipsychotic treatment, the effects are small (Blyler and Gold
2000; DeLisi et al. 1995; Gold S. et al. 1999; Hoff et al. 1999).
It is important to emphasize here that the stability of neurocognitive impairment occurs in
the context of frequent variability of the symptoms of schizophrenia, especially the positive
symptoms (Bilder et al. 2000). For example, in a study of patients tested during a psychotic
exacerbation and then again when symptoms had improved considerably one to two years later,
cognitive function was found to be very stable over time (Nopoulos et al. 1994). In a longitudinal
21
study over a one-year interval, cognitive and negative symptoms were correlated at each of the
assessments, but there was no predictive relationship between these variables over time (Harvey
et al. 1996). If negative symptoms were somehow causing poor performance on cognitive tests,
then a longitudinal relationship between these variables would have been expected. Second,
when the differential relationship between cognitive and negative symptoms and adaptive
functioning deficits has been examined, cognitive impairments have been found to be more
strongly correlated with functional deficit than negative symptoms (Harvey et al. 1996; Harvey
et al. 1998). Third, in those patients whose functional status worsens over time, changes in
cognitive impairment predicts the level of change while changes in negative symptoms do not
(Harvey et al. 1998). These data suggesting a variable relationship of symptoms and
neurocognitive impairment provide yet another line of support for the relative independence of
these domains.
Another way to investigate the longitudinal relationship between neurocognitive
impairment and symptoms is to calculate the correlation between change in neurocognitive
impairment and symptom change. This approach addresses the issue of ‘pseudospecificity’.
Several studies have performed such analyses and though results are mixed, the findings have
generally suggested that symptom change does not contribute substantially to cognitive change
(Addington, Addington and Maticka-Tyndale 1991; Hoff et al. 1999).
Impact of Second Generation Antipsychotics on Cognition
Patients with schizophrenia were treated with excessive doses of conventional
antipsychotic medication for years. This may have had direct adverse cognitive effects and led
clinicians to use anticholinergic medications to control side effects. Lowering dosages of
conventional antipsychotic medications has some modest cognitive benefit (Seidman, Pepple,
22
and Faraone 1993) which suggests that use of excessive doses may have led to some of the
failures of conventional medications to improve cognition (Harvey et al., in press).
When compared with first generation antipsychotics, second generation antipsychotics
have some cognitive benefits (Harvey and Keefe 2001; Keefe et al. 1999). This issue is still
controversial as many of the studies are methodologically limited. For instance, many
comparisons of the cognitive benefit of second generation and first generation antipsychotics
include excessive doses of first generation antipsychotic medication, which may unfairly inflate
the benefits attributable to second generation antipsychotics by confusing them with dose effects.
Further, there is evidence that unlike first generation antipsychotics, second generation
medications may allow patients to benefit from practice-related improvements (Harvey et al.
2000). However, recent studies of first episode patients on lower doses of first generation
antipsychotics suggest that second generation antipsychotics have a greater cognitive enhancing
effect (Keefe et al, in press; Harvey et al, submitted).
Summary
In conclusion, the literature on neurocognitive impairment consistently demonstrates that
cognitive impairment is not caused by the symptoms of schizophrenia. Most impressive is the
zero-to-mild cross-sectional correlations between neurocognitive impairment and the positive
symptoms of the illness. While other aspects of schizophrenia, such as negative symptoms,
appear to correlate with neurocognitive impairment, there is as much or more evidence
supporting the idea that neurocognitive impairment causes negative symptoms as there is
evidence that negative symptoms cause neurocognitive impairment. While there is limited
evidence of a relationship between changes in neurocognitive impairment and changes in
symptoms over time, there is certainly no clear evidence that improvements in neurocognitive
23
impairment are caused by improvements in symptoms. In fact, most data point to the relative
independence of these two targets of treatment in schizophrenia.
IV. Clinical Importance of Neurocognitive Impairment.
Cross-sectional Correlations with Function
Although the literature on neurocognitive impairment suggests that it is not strongly
correlated with symptoms, it has proven to be consistently related to a variety of other important
aspects of the illness, such as social functioning (Liberman, Mueser, and Wallace 1986;
Spaulding et al. 1986), functional impairments, unemployment (Brekke et al. 1997; Lysaker and
Bell 1995; McGurk and Meltzer 2000; Velligan et al. 2000), quality of life (Fujii and Wylie
2003), relapse prevention (Fenton, Blyler, and Heinssen 1997; Jarboe and Schwartz 1999),
medical status and economic cost (Knapp 1997; Sevy and Davidson 1995). Neurocognitive
impairment also has considerable power to predict functional status years later.
Relationship of Neurocognitive Impairment to Functioning
Functional outcome in schizophrenia is difficult to define and measure. The three types of
functional outcome that most studies of neurocognitive deficits have examined are: community
(social and occupational) outcome, the ability to solve simulations of interpersonal interactions,
and success in psychosocial rehabilitation programs. Strong support for associations between key
areas of neurocognition and functional outcome are offered by two reviews of the literature
(Green 1996; Green et al. 2000).
The connection between actual community functioning and cognition has been weaker
than the strong link between laboratory measures of community functioning or skills acquisition
and cognition (Green 1996). In a one-year follow-up study of patients with first episode
24
psychosis, the size of the correlations between the number and quality of actual social relations
and various cognitive measures were found to be in the .25 to .35 range (Malla et al. 2002).
Across the studies reviewed by Green (2000), all of the key neurocognitive constructs
(secondary memory, immediate memory, vigilance, and executive functioning / card sorting) had
significant relationships to functional outcome and effect sizes in the medium range. Cognitive
impairments are also correlated with deficits in the performance of specific skills critical for
independent living (Evans et al. 2003; Patterson et al. 2001).
Neurocognitive Impairment and Unemployment
Several studies of cognitive performance and vocational functioning have been conducted
in rehabilitation settings (Bell and Bryson 2001; Lysaker and Bell 1995). Ratings of work
behavior/performance are related to baseline scores on verbal memory tests and the Wisconsin
Card Sorting Test. Additionally, improvement in patient work performance in a 6 month work
rehabilitation program was predicted by baseline performance on various cognitive tests.
A number of positive findings have been reported in studies examining correlates of
competitive employment (Beiser et al. 1994; Brekke et al. 1997; Velligan et al. 2000). Patients
enrolled in school full-time or holding competitive employment show superior performance
across measures of working memory, sustained attention, problem solving, and episodic memory
when compared to unemployed patients (McGurk and Meltzer 2000), with scores of part-time
workers falling between the other two groups. In addition, vocational functioning is significantly
associated with performance on speed of processing tasks such as Trailmaking A and B (McGurk
et al. 2003).
McGurk and Meltzer (2000) evaluated the relationship of cognitive functioning and work
status and concluded that neurocognitive performance plays a more important role than clinical
25
symptoms in the ability of patients with schizophrenia to work. The implication is that patients
with schizophrenia who have higher levels of cognitive impairment may require greater amounts
of vocational support than those with lower levels of impairment (McGurk et al. 2003).
Neurocognitive Impairment and Quality of Life
Quality of life is often defined by the quality of social, occupational, and interpersonal
aspects of life and is related to cognitive function. Some evidence suggests that reductions in
quality of life are more strongly associated with cognitive deficits than other symptomatic
features of the illness. Specifically, the relationship between subjective experience and social
functioning has been shown to be mediated by executive functioning (Brekke, Kohrt, and Green
2001). Patients have less realistic impressions of their social functioning if they also have more
severe executive deficits.
The need for anticholinergic treatments is also associated with reductions in quality of
life. Reductions in quality of life and anticholinergic medications may be related to the EPS that
triggers anticholinergic medication prescriptions, nonetheless anticholinergic medications
reliably reduce cognitive functioning as well. In patients with schizophrenia, anticholinergic
medications impair attention and memory functions (Spohn and Strauss 1989). These
impairments can induce reductions in subjective quality of life. One study of patients with
schizophrenia that examined the relationship between coping abilities and cognitive dysfunction
suggested that more severe executive and memory deficits are related to decreased use of coping
mechanisms (Wilder-Willis 2002).
Fujii and Wylie (2003) studied the long-term effects of neurocognition on quality of life
in patients with severe schizophrenia. They found that neurocognition does, in fact, have long-
26
term predictive validity for quality of life and that therapeutics targeting neurocognition could
improve quality of life in this population.
Neurocognitive Impairment and Relapse Prevention
Cognitive functions have been shown to be the strongest predictors of patients' ability to
manage medications (Jeste et al. 2003). Cognitive deficits contribute to patterns of medication
mismanagement that are associated with poor adherence and risk of relapse (Fenton, Blyler, and
Heinssen 1997; Jarboe and Schwartz 1999). In one study, memory impairment was the best
predictor of partial compliance (Donohoe et al. 2001). Patients performing poorly in medication
management tests also had poor global scores on a dementia inventory (Patterson et al. 2002).
Decreased medication compliance in schizophrenic patients has been shown to be related to poor
performance on tests of attention and visual memory (Jarboe and Schwartz 1999).
Neurocognitive Impairment and Medical co-morbidity
Neurocognitive Impairment is also related to medical co-morbidities in schizophrenia.
Deficits in organization (executive skills) directly affects patients’ ability to seek treatment for
medical problems. In elderly patients with schizophrenia, cognitive and functional impairments
predicted the later incidence of new-onset medical problems, while medical problems did not
predict the subsequent worsening of cognitive and self-care deficits (Friedman et al. 2002).
Inability of patients with schizophrenia to reduce damaging habits such as smoking has been
correlated with deficits in memory and attention (Buchanan, Holstein, and Breier 1994; George
et al. 2000). Thus, cognitive impairments were shown to directly effect new-onset medical
problems in older patients.
The Costs of Neurocognitive Impairment
27
A major factor in the costs (direct and indirect) associated with schizophrenia is cognitive
impairment (Sevy and Davidson 1995). Factors leading to the increased cost include loss of
ability for self-care, level of inpatient and outpatient care needed, and loss of productivity (for
both patient and caretaker). Although cognitive impairment by itself is rarely a reason for acute
hospitalization of a patient with schizophrenia, it may contribute to the overall length of
hospitalization. It may lead to early admission to nursing homes or long-term care facilities in the
case of elderly patients.
V. Conclusion
A consensus has developed amongst experts in cognition and schizophrenia that
cognitive impairment is a core feature of the illness. The course of neurocognitive impairment
follows a characteristic pattern and following the early phase, is consistent even when positive
and negative symptoms change. Consistent with the demonstration that cognitive impairments
are not a result of symptoms of schizophrenia, on the whole studies show the independence of
these two targets for treatment. Long term functional and cognitive outcome as well as the
longitudinal course of the illness could potentially improve with early treatment using second
generation antipsychotics. Functional status years later can be predicted with considerable
accuracy with the extent of neurocognitive impairments. The relationship has been established
between cognition and many other facets of schizophrenia from social functioning to
unemployment to relapse prevention. Indeed, improved understanding and treatment of
neurocognitive impairments in schizophrenia holds considerable promise for the field and for the
lives of patients with schizophrenia.
28
References
Addington J, Addington D: Neurocognitive and social functioning in schizophrenia: a 2.5 year
follow-up study. Schizophr Res 44(1):47-56, 2000
Addington J, Addington D: Facial affect recognition and information processing in schizophrenia
and bipolar disorder. Schizophr Res 32:171-181, 1998
Addington J, McCleary L, Munroe-Blum H: Relationship between cognitive and social
dysfunction in schizophrenia. Schizophr Res 34(1-2):59-66, 1998
Addington, J, Addington, D, Maticka-Tyndale, E: Cognitive functioning and positive and
negative symptoms in schizophrenia. Schizophr Res 5(2):123-134, 1991
Alpert M: The signs and symptoms of schizophrenia. Compr Psychiatry 26(2):103-112, 1985
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th
Edition, Text Revision. Washington, DC, American Psychiatric Publishing, Incorporated,
2000
Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS). Br J Psychiatry
155(Suppl 7):53-58, 1989
Arnold SE, Gur RE, Shapiro RM, et al: Prospective clinicopathologic studies of schizophrenia:
accrual and assessment of patients. Am J Psychiatry 152(5):731-7, 1995
Baddeley A: Working memory. Science 255(5044):556-9, 1992
29
Bell M, Bryson G, Lysaker P: Positive and negative affect recognition in schizophrenia: a
comparison with substance abuse and normal control subjects. Psychiatry Res 73:73-82,
1997
Bell MD, Bryson G: Work rehabilitation in schizophrenia: does cognitive impairment limit
improvement? Schizophr Bull 27:269-279, 2001
Beiser M, Bean G, Erickson D, et al: Biological and psychosocial predictors of job performance
following a first episode of psychosis. Am J Psychiatry 151:857-863, 1994
Bilder RM, Goldman RS, Volavka J, et al: Neurocognitive effects of clozapine, olanzapine,
risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective
disorder. Am J Psychiatry 159(6):1018-28, 2002
Bilder RM, Goldman RS, Robinson D, et al: Neuropsychology of first-episode schizophrenia:
initial characterization and clinical correlates. Am J Psychiatry 157(4):549-59, 2000
Bilder RM, Lipschutz-Broch L, Reiter G, et al. Intellectual deficits in first-episode
schizophrenia: evidence for progressive deterioration. Schizophr Bull 18(3):437-48, 1992
Bilder RM, Mukherjee S, Rieder RO, Pandurangi AK: Symptomatic and neuropsychological
components of defect states. Schizophr Bull 11(3):409-19, 1985
Blyer CR, Gold JM: Cognitive effects of conventional antipsychotics: another look, in Cognitive
Functioning in Schizophrenia: Characteristics, Correlates, and Treatment. Edited by
Sharma T, Harvey P. Oxford University Press, 2000, pp 241–265
Brebion G, Gorman JM, Malaspina D, et al: Clinical and cognitive factors associated with verbal
memory task performance in patients with schizophrenia. Am J Psychiatry 158(5):75864, 2001
30
Brekke JS, Kohrt B, Green MF: Neuropsychological functioning as a moderator of the
relationship between psychosocial functioning and the subjective experience of self and
life in schizophrenia. Schizophr Bull 27:697-708, 2001
Brekke JS, Raine A, Ansel M, Lencz T: Neuropsychological and psychophysiological correlates
of psychosocial functioning in schizophrenia. Schizophr Bull 23:19-28, 1997
Bressi S, Miele L, Bressi C; Astori S; et al: Deficit of central executive component of working
memory in schizophrenia. New Trends in Experimental & Clinical Psychiatry 12(4):243252, 1996
Brewer WJ, Wood SJ, McGorry PD, et al: Impairment of olfactory identification ability in
individuals at ultra-high risk for psychosis who later develop schizophrenia. Am J
Psychiatry 160(10):1790-4, 2003
Brickman A, Buchsbaum M, Bloom R, et al: Neuropsychological Functioning in First-Break,
Never-Medicated Adolescents with Psychosis. J Nerv Ment Dis (in press)
Buchanan RW, Strauss ME, Breier A, et al: Attentional impairments in deficit and nondeficit
forms of schizophrenia. Am J Psychiatry 154(3):363-70, 1997
Buchanan RW, Holstein C, Breier A: The comparative efficacy and long-term effect of clozapine
treatment on neuropsychological test performance. Biol Psychiatry 36:717-725, 1994
Calev A: Recall and recognition in chronic nondemented schizophrenics: Use of matched tasks. J
Abnorm Psychol 93(2):172-177, 1984
Callicott JH, Mattay VS, Bertolino A, et al: Physiological characteristics of capacity constraints
in working memory as revealed by functional MRI. Cereb Cortex 9(1):20-6, 1999
31
Caspi A, Reichenberg A, Weiser M, et al: Cognitive performance in schizophrenia patients
assessed before and following the first psychotic episode. Schizophr Res 65(2-3):87-94,
2003
Carter C, Robertson L, Nordahl T, et al. Spatial working memory deficits and their relationship
to negative symptoms in unmedicated schizophrenia patients. Biol Psychiatry 40(9):9302, 1996
Ciompi L: The natural history of schizophrenia in the long term. Br J Psychiatry 136:413-20,
1980
Corcoran R, Mercer G, Frith CD: Schizophrenia, symptomatology and social influence:
investigating "theory of mind" in people with schizophrenia. Schizophr Res 17:5-13,
1995
Cornblatt B, Obuchowski M, Roberts S, et al: Cognitive and behavioral precursors of
schizophrenia. Dev Psychopathol 11(3):487-508, 1999
Cornblatt BA, Keilp JG: Impaired attention, genetics, and the pathophysiology of schizophrenia.
Schizophr Bull 20(1):31-46, 1994
Corrigan PW, Davies-Farmer RM, Stolley MR: Social cue recognition in schizophrenia under
variable levels of arousal. Cognit Ther Res 14:353-361, 1990
Cuesta MJ, Peralta V, Caro F, de Leon J: Schizophrenic syndrome and Wisconsin Card Sorting
Test dimensions. Psychiatry Res 58(1):45-51, 1995
David AS, Malmberg A, Brandt L, et al: IQ and risk for schizophrenia: a population-based
cohort study. Psychol Med 27(6):1311-23, 1997
32
Davidson M, Reichenberg A, Rabinowitz J, et al: Behavioral and intellectual markers for
schizophrenia in apparently healthy male adolescents. Am J Psychiatry 156(9):1328-35,
1999
Davidson M, Harvey PD, Powchik P, et al: Severity of symptoms in chronically institutionalized
geriatric schizophrenic patients. Am J Psychiatry 152(2):197-207, 1995
Deci EL, Flaste R: Why We Do What We Do: Understanding Self-Motivation. New York, NY,
Penguin Books, 1996
DeLisi LE, Tew W, Xie S, et al: A prospective follow-up study of brain morphology and
cognition in first-episode schizophrenic patients: preliminary findings. Biol Psychiatry
38(6):349-60, 1995
Dickerson F, Boronow JJ, Ringel N, Parente F: Social functioning and neurocognitive deficits in
outpatients with schizophrenia: a 2-year follow-up. Schizophr Res 4;37(1):13-20, 1999
Donohoe G, Owens N, O'Donnell C, et al: Predictors of compliance with neuroleptic medication
among inpatients with schizophrenia: a discriminant function analysis. Eur Psychiatry
16(5):293-8, 2001
Doody GA, Gotz M, Johnstone EC, et al: Theory of mind and psychoses. Psychol Med
28(2):397-405, 1998
Drury VM, Robinson EJ, Birchwood M: "Theory of mind" skills during an acute episode of
psychosis and following recovery. Psychol Med 28:1101-1112, 1998
Edwards J, Pattison PE, Jackson HJ, Wales RJ: Facial affect and affective prosody recognition in
first-episode schizophrenia. Schizophr Res 48:235-253, 2001
Elvevag B, Weickert T, Wechsler M, et al: An investigation of the integrity of semantic
boundaries in schizophrenia. Schizophr Res 53(3):187-98, 2002
33
Ertugrul A, Ulug B: The influence of neurocognitive deficits and symptoms on disability in
schizophrenia. Acta Psychiatr Scand 105(3):196-201, 2002
Evans JD, Heaton RK, Paulsen JS, et al: The relationship of neuropsychological abilities to
specific domains of functional capacity in older schizophrenic patients. Biol Psychiatry
53: 422-430, 2003
Fenton WS, Blyler CR, Heinssen RK: Determinants of medication compliance in schizophrenia:
empirical and clinical findings. Schizophr Bull 23:637-651, 1997
Friedman JI, Harvey PD, McGurk SR, et al: Correlates of change in functional status of
institutionalized geriatric schizophrenic patients: focus on medical co-morbidity. Am J
Psychiatry 159:1388-1394, 2002
Fujii DE, Wylie AM: Neurocognition and community outcome in schizophrenia: long-term
predictive validity. Schizophr Res 59(2-3):219-23, 2003
Fuller R, Nopoulos P, Arndt S, et al: Longitudinal assessment of premorbid cognitive
functioning in patients with schizophrenia through examination of standardized scholastic
test performance. Am J Psychiatry 159(7):1183-9, 2002
Gaebel W, Wolwer W: Facial expression and emotional face recognition in schizophrenia and
depression. Eur Arch Psychiatry Clin Neurosci 242:46-52, 1992
Galletly CA, Clark CR, McFarlane AC, Weber DL: The effect of clozapine on the speed and
accuracy of information processing in schizophrenia. Prog Neuropsychopharmacol 24:8
1329-1338, 2000
George TP, Ziedonis, DM, Feingold A et al.. Nicotine transdermal patch and atypical
antipsychotic medications for smoking cessation in schizophrenia. Am J Psychiatry
157:1835-1842, 2000
34
Gold JM, Wilk CM, McMahon RP, et al: Working memory for visual features and conjunctions
in schizophrenia. J Abnorm Psychol 112(1):61-71, 2003
Gold JM, Goldberg RW, McNary SW, et al: Cognitive Correlates of Job Tenure Among Patients
With Severe Mental Illness. Am J Psychiatry 159:1395-1402, 2002
Gold S: Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia.
Am J Psychiatry 156(9):1342-8, 1999
Goldberg TE, Aloia MS, Gourovitch ML, et al: Cognitive substrates of thought disorder, I: The
semantic system. Am J Psychiatry 155(12):1671-1676, 1998
Goldberg TE, Gold JM, Greenberg R, et al: Contrasts between patients with affective disorders
and patients with schizophrenia on a neuropsychological test battery. Am J Psychiatry
150(9):1355-62. 1993a
Goldberg TE, Hyde TM, Kleinman JE, Weinberger DR: Course of schizophrenia:
neuropsychological evidence for a static encephalopathy. Schizophr Bull 19(4):797-804,
1993b
Goldberg TE, Weinberger DR, Berman KF, et al: Further evidence for dementia of the prefrontal
type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test.
Arch Gen Psychiatry 44(11):1008-14, 1987
Goldberg TE, Ragland JD, Torrey EF, Gold JM, et al: Neuropsychological assessment of
monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 47(11):1066-1072,
1990
Goldman RS, Tandon R, Liberzon I, Greden JF: Measurement of depression and negative
symptoms in schizophrenia. Psychopathology 25(1):49-56, 1992
35
Goldman-Rakic PS: Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin
Neurosci 6(4):348-57, 1994
Goldman-Rakic PS: Circuitry of the frontal association cortex and its relevance to dementia.
Arch Gerontol Geriatr 6(3):299-309, 1987
Goldstein G, Zubin J: Neuropsychological differences between young and old schizophrenics
with and without associated neurological dysfunction. Schizophr Res 3(2):117-26, 1990
Granholm E, Morris SK, Sarkin AJ, et al: Pupillary responses index overload of working
memory resources in schizophrenia. J Abnorm Psychol 106(3):458-67, 1997
Granholm E, Asarnow RF, Sarkin AJ, Dykes KL: Pupillary responses index cognitive resource
limitations. Psychophysiology 33(4):457-61, 1996
Green MF, Kern RS, Braff DL, Mintz J: Neurocognitive deficits and functional outcome in
schizophrenia: are we measuring the "right stuff"? Schizophr Bull 26:119-136, 2000
Green MF: What are the functional consequences of neurocognitive deficits in schizophrenia?
Am J Psychiatry 153:321-330, 1996
Green MF, Ganzell S, Satz P, Vaclav JF: Teaching the Wisconsin Card Sorting Test to
schizophrenic patients. Arch Gen Psychiatry 47(1):91-2, 1990
Gur RE, Maany V, Mozley D, et al: Subcortical MRI volumes in neuroleptic-naive and treated
patients with schizophrenia. Am J Psychiatry 155(12):1711-1717, 1998
Harvey PD, Green MF, Keefe RSE, Velligan DI: Cognitive function in schizophrenia: Its role in
the definition and evaluation of effective treatments for the illness. Journal of Clinical
Psychiatry (in press).
Harvey PD, Keefe RSE: Studies of cognitive change in patients with schizophrenia following
novel antipsychotic treatment. Am J Psychiatry 158(2):176-184, 2001
36
Harvey PD, Moriarty PJ, Serper MR, Schnur E, Lieber D: Practice-related improvement in
information processing with novel antipsychotic treatment. Schizophr Res 46(2-3):13948, 2000
Harvey PD: Treatment of Cognitive Deficits in Elderly Schizophrenic Patients. in Improving
Cognitive Function in the Schizophrenic Patient. Edited by Keefe RSE. Science Press,
1999
Harvey PD, Howanitz E, Parrella M, et al: Symptoms, cognitive functioning, and adaptive skills
in geriatric patients with lifelong schizophrenia: a comparison across treatment sites. Am
J Psychiatry 155:1080-1086, 1998
Harvey PD, Keefe RSE: Cognitive impairment in schizophrenia and implications of atypical
neuroleptic treatment. CNS Spectr 2:1-11, 1997
Harvey PD, Lombardi J, Leibman M, et al: Cognitive impairment and negative symptoms in
geriatric chronic schizophrenic patients: a follow-up study. Schizophr Res 22(3):223-31,
1996
Harvey PD, Keefe RS, Moskowitz J, et al. Attentional markers of vulnerability to schizophrenia:
Performance of medicated and unmedicated patients and normals. Psychiatry Res
33(2):179-188, 1990
Hawkins KA, Addington J, Keefe RS, et al: Neuropsychological status of subjects at high risk
for a first episode of psychosis. Schizophr Res 67(2-3):115-22, 2004
Heaton RK, Gladsjo JA, Palmer BW, et al: Stability and course of neuropsychological deficits in
schizophrenia. Arch Gen Psychiatry 58(1):24-32, 2001
Heaton R, Paulsen JS, McAdams LA, et al: Neuropsychological deficits in schizophrenics.
Relationship to age, chronicity, and dementia. Arch Gen Psychiatry 51(6):469-76, 1994
37
Heaton RK: Wisconsin Card Sorting Test manual. Odessa, FL, Psychological Assessment
Resources, 1981
Heinrichs RW, Zakzanis KK: Neurocognitive deficit in schizophrenia: a quantitative review of
the evidence. Neuropsychology 12:426-444, 1998
Ho BC, Alicata D, Ward J, et al: Untreated initial psychosis: relation to cognitive deficits and
brain morphology in first-episode schizophrenia. Am J Psychiatry 160(1):142-8, 2003
Hoff AL, Sakuma M, Wieneke M, et al: Longitudinal neuropsychological follow-up study of
patients with first-episode schizophrenia. Am J Psychiatry 156(9):1336-41, 1999
Hoff AL, Riordan H, O'Donnell DW, et al: Neuropsychological functioning of first-episode
schizophreniform patients. Am J Psychiatry 149(7):898-903, 1992
Hughes C, Kumari V, Soni W, et al: Longitudinal study of symptoms and cognitive function in
chronic schizophrenia. Schizophr Res 1;59(2-3):137-46, 2003
Hyde TM, Nawroz S, Goldberg TE, et al: Is there cognitive decline in schizophrenia? A crosssectional study. Br J Psychiatry 164(4):494-500, 1994
Hyman SE, Fenton WS: What Are the Right Targets for Psychopharmacology? Science 299:350351, 2003
Jarboe KS, Schwartz SK: The relationship between medication noncompliance and cognitive
function in patients with schizophrenia. J Am Psychiatr Nurses Assoc 5:S2-S8, 1999
Jeste SD, Patterson TL, Palmer BW, et al: Cognitive predictors of medication adherence among
middle-aged and older outpatients with schizophrenia. Schizophr Res 63(1-2):49-58,
2003
Jeste DV, Harris MJ, Krull A, et al: Clinical and neuropsychological characteristics of patients
with late-onset schizophrenia. Am J Psychiatry 152(5):722-30, 1995
38
Jin H, Zisook S, Palmer BW, et al: Association of depressive symptoms and functioning in
schizophrenia: A study of older outpatients. J Clin Psychiatry 62:797–803, 2001
Jones P, Rodgers B, Murray R, Marmot M: Child development risk factors for adult
schizophrenia in the British 1946 birth cohort. Lancet 344(8934):1398-402, 1994
Keefe RSE, Seidman, LJ, Christensen, BK, et al: Comparative effect of atypical and
conventional antipsychotic drugs on neurocognition in first-episode psychosis: A
Randomized double-blind trial of olanzapine versus haloperidol. Am J Psychiatry (in
press).
Keefe RS, Arnold MC, Bayen UJ, et al: Source-monitoring deficits for self-generated stimuli in
schizophrenia: multinomial modeling of data from three sources. Schizophr Res
57(1):51-67, 2002
Keefe RSE: Neurocognition. in Current Issues in the Psychopharmacology of Schizophrenia.
Edited by Breier A, Tran PV, Herrera J, Bymaster F, Tollefson G. Baltimore: Lippincott
Williams & Wilkins Publishers, 2001, pp 192-208
Keefe, RSE: The assessment of neurocognitive treatment response and its relation to negative
symptoms in schizophrenia. in Negative Symptom and Cognitive Deficit Treatment
Response in Schizophrenia. Edited by Keefe RSE, Mcevoy JP. Washington: APA, 2000,
pp 85-110
Keefe RSE, Silva SG, Perkins DO, Lieberman JA: The effects of atypical antipsychotic drugs on
neurocognitive impairment in schizophrenia: A review and meta-analysis. Schizophr Bull
25:2 201-222, 1999
Keefe RSE: The contribution of neuropsychology to psychiatry. Am J Psychiatry 152(1):6-15,
1995
39
Knapp M: Costs of schizophrenia. Br J Psychiatry 171:509-518, 1997
Kremen WS, Seidman LJ, Faraone SV, et al: The paradox of normal neuropsychological
function in schizophrenia. J Abnorm Psychol 109:743-752, 2000
Lieberman JA, Tollefson G, Tohen M, et al: Comparative efficacy and safety of atypical and
conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind
trial of olanzapine versus haloperidol. Am J Psychiatry 160(8):1396-404, 2003
Lieberman JA: Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological
perspective. Biol Psychiatry 46(6):729-39, 1999
Liberman RP, Mueser KT, Wallace CJ: Social skills training for schizophrenic individuals at risk
for relapse. Am J Psychiatry. 1986 Apr;143(4):523-6, 1986
Lindenmayer JP, Grochowski S, Hyman RB: Five factor model of schizophrenia: replication
across samples. Schizophr Res 14(3):229-34, 1995
Lysaker P, Bell M: Work rehabilitation and improvements in insight in schizophrenia. J Nerv
Ment Dis 183:103-106, 1995
Malla AK, Norman RMG, Manchanda LT: Symptoms, cognition, treatment adherence and
functional outcome in first-episode psychosis. Psychol Med 32(6):1109-1119, 2002
Manschreck TC, Maher BA, Waller NG, et al: Deficient motor synchrony in schizophrenic
disorders: clinical correlates. Biol Psychiatry 20(9):990-1002, 1985
McGurk SR, Mueser KT, Harvey PD, et al: Cognitive and symptom predictors of work outcomes
for clients with schizophrenia in supported employment. Psychiatr Serv 54(8):1129-35,
2003
McGurk SR, Meltzer HY: The role of cognition in vocational functioning in schizophrenia.
Schizophr Res 45:175-184, 2000
40
McKenna PJ, Lund CE, Mortimer AM: Negative symptoms: relationship to other schizophrenic
symptom classes. Br J Psychiatry 7:104-7, 1989
Meltzer HY, McGurk SR: The effects of clozapine, risperidone, and olanzapine on cognitive
function in schizophrenia. Schizophr Bull 25(2):233-55, 1999
Mohamed S, Paulsen JS, O'Leary D, et al: Generalized cognitive deficits in schizophrenia: a
study of first-episode patients. Arch Gen Psychiatry 56(8):749-54, 1999
Morris RG, Rushe T, Woodruffe PW, Murray RM: Problem solving in schizophrenia: a specific
deficit in planning ability. Schizophr Res 14(3):235-46, 1995
Morrison RL, Bellack AS, Mueser KT: Deficits in facial-affect recognition and schizophrenia.
Schizophr Bull 14:67-83, 1988
Moss M, Albert M: Geriatric Neuropsychology, Edited by Albert M, Moss M. New York,
Guilford Press, 1988
Mueser KT, Bellack AS, Douglas MS, Wade JH: Prediction of social skill acquisition in
schizophrenic and major affective disorder patients from memory and symptomatology.
Psychiatry Res 37(3):281-96, 1991
Nopoulos P, Flashman L, Flaum M, Arndt S, Andreasen N: Stability of cognitive functioning
early in the course of schizophrenia. Schizophr Res 14(1):29-37, 1994
O'Donnell BF, Faux SF, McCarley RW, et al: Increased rate of P300 latency prolongation with
age in schizophrenia. Electrophysiological evidence for a neurodegenerative process.
Arch Gen Psychiatry 52(7):544-9, 1995
Palmer BW, Heaton RK, Paulsen JS, et al: Is it possible to be schizophrenic yet
neuropsychologically normal? Neuropsychology 11:437-446, 1997
41
Patterson TL, Lacro J, McKibbin CL, et al: Medication management ability assessment: results
from a performance-based measure in older outpatients with schizophrenia. J Clin
Psychopharmacol 22:11-19, 2002
Patterson TL, Goldman S, McKibbin CL, et al: UCSD performance-based skills assessment:
development of a new measure of everyday functioning for severely mentally ill adults.
Schizophr Bull 27:235-245, 2001
Paulsen JS, Heaton RK, Sadek JR, et al: The nature of learning and memory impairments in
schizophrenia. J Int Neuropsychol Soc 1(1):88-99, 1995
Penn DL, Corrigan PW, Bentall RP, et al: Social cognition in schizophrenia. Psychol Bull
121:114-132, 1997
Penn DL, Spaulding W, Reed D, Sullivan M: The relationship of social cognition to ward
behavior in chronic schizophrenia. Schizophr Res 20:327-335, 1996
Pinkham AE, Penn DL, Perkins DO, Lieberman J: Implications for the neural basis of social
cognition for the study of schizophrenia. Am J Psychiatry 160(5):815-824, 2003
Rund BR: A review of longitudinal studies of cognitive functions in schizophrenia patients.
Schizophr Bull 24(3):425-35, 1998
Sarfati Y, Hardy-Bayle MC, Nadel J, Chevalier JF, Widloecher D: Attribution of mental states to
others by schizophrenic patients. Cognitive Neuropsychiatry 2:1-17, 1997
Saykin AJ, Shtasel DL, Gur RE, et al: Neuropsychological deficits in neuroleptic naive patients
with first-episode schizophrenia. Arch Gen Psychiatry 51(2):124-31, 1994
Saykin AJ, Gur RC, Gur RE, et al: Neuropsychological function in schizophrenia. Selective
impairment in memory and learning. Arch Gen Psychiatry 48(7):618-24, 1991
42
Seidman LJ, Pepple JR, Faraone SV: Neuropsychological performance in chronic schizophrenia
in response to neuroleptic dose reduction. Biol Psychiatry 33:575-584, 1993
Sevy S, Davidson M: The cost of cognitive impairment in schizophrenia. Schizophr Res 17(1):13, 1995
Silver H, Feldman P, Bilker W, Gur RC: Working Memory Deficit as a Core
Neuropsychological Dysfunction in Schizophrenia Am. J. Psychiatry 160:1809-1816,
2003
Spaulding WD, Storms L, Goodrich V, Sullivan M: Applications of experimental
psychopathology in psychiatric rehabilitation. Schizophr Bull 12(4):560-77, 1986
Spohn HE, Strauss ME: Relation of Neuroleptic and anticholinergic medication to cognitive
functions in schizophrenia. J Abnorm Psychol 98, 478-486, 1989
Stirling J, White C, Lewis S, et al: Neurocognitive function and outcome in first-episode
schizophrenia: a 10-year follow-up of an epidemiological cohort. Schizophr Res 65(23):75-86, 2003
Strauss ME: Relations of symptoms to cognitive deficits in schizophrenia. Schizophr Bull
19(2):215-31, 1993
Summerfelt AT, Alphs LD, Funderburk FR, et al: Impaired Wisconsin Card Sort performance in
schizophrenia may reflect motivational deficits. Arch Gen Psychiatry 48(3):282-3, 1991
Sweeney JA, Haas GL, Keilp JG, Long M: Evaluation of the stability of neuropsychological
functioning after acute episodes of schizophrenia: One-year followup study. Psychiatry
Res 38(1):63-76, 1991
Tamlyn D, McKenna PJ, Mortimer AM, et al: Memory impairment in schizophrenia: its extent,
affiliations and neuropsychological character. Psychol Med 22(1):101-15, 1992
43
Trumbetta, Susan L; Mueser, Kim T: Social functioning and its relationship to cognitive deficits
over the course of schizophrenia. in Negative Symptom and Cognitive Deficit Treatment
Response in Schizophrenia. Keefe RSE, Mcevoy JP, editors. Washington: APA, 2001
Twamley EW, Doshi RR, Nayak GV, et al: Generalized cognitive impairments, ability to
perform everyday tasks, and level of independence in community living situations of
older patients with psychosis. Am J Psychiatry 159(12):2013-20, 2003
Van der Does AJ, Willem, Dingemans PMAJ, Linszen DH, Nugter MA, et al. Dimensions and
subtypes of recent-onset schizophrenia: A longitudinal analysis. J Nerv Ment Dis
183(11):681-687, 1995
Velligan DI, Bow-Thomas C, Mahurin RK, et al: Do specific neurocognitive deficits predict
specific domains of community function in schizophrenia? J Nerv Ment Dis 188:518-524,
2000
Waddington JL, Youssef HA: Cognitive dysfunction in chronic schizophrenia followed
prospectively over 10 years and its longitudinal relationship to the emergence of tardive
dyskinesia. Psychol Med 26(4):681-688, 1996
Walker E, Lewine RJ: The positive/negative symptom distinction in schizophrenia. Validity and
etiological relevance. Schizophr Res 1(5):315-28, 1988
Weinberger DR: Implications of normal brain development for the pathogenesis of
schizophrenia. Arch Gen Psychiatry 44(7):660-9, 1987
Wechsler D: Weschsler Adult Intelligence Scale-III. San Antonio, TX: The
Psychological Corporation, 1997
Wilder-Willis KE, Shear PK, Steffen JJ, Borkin J: The relationship between cognitive
dysfunction and coping abilities in schizophrenia. Schizophr Res 55(3):259-67, 2002
44
Yung AR, McGorry PD: The prodromal phase of first-episode psychosis: Past and current
conceptualizations. Schizophr Bull 22(2):353-370, 1996
Zorrilla LT, Eyler, Heaton RK, et al: Cross-sectional study of older outpatients with
schizophrenia and healthy comparison subjects: No differences in age-related cognitive
decline. Am J Psychiatry 157(8):1324-1326, 2000
45
Table 1. Cognitive Impairments in Schizophrenia and Their Severitya
Severe Impairments (2 to 3 SD below the meanb)
 Serial learning
 Executive functioning
 Vigilance
 Motor speed
 Verbal fluency
Moderate Impairments (1 to 2 SD below the mean)
 Distractibility
 Delayed recall
 Visuo-Motor skills
 Immediate memory span
 Working memory
Mild Impairments (0.5 to 1 SD below the mean)
 Perceptual skills
 Delayed recognition memory
 Confrontation naming
 Verbal and full-scale IQ
No Impairment
 Word recognition reading
 Long-term factual memory
a
The estimated average severity scores are corrected on the basis of age and relative education level.
The “mean” refers to the average level of performance of normal individuals who are similar in age and
educational attainment.
FROM: Harvey and Keefe, CNS Spectrums, 1997
b
46
Course of Cognitive Impairment in
Schizophrenic Patients Using Typical
Neuroleptics
0
Normal
?
–1
Standard
Deviations
Psychosis-Free
Patients
–2
–3
Premorbid
Onset
Initial
Therapy
2 Years
20 Years
After Start After Onset
of Therapy
10
Figure 1. Course of Cognitive Impairment in Schizophrenic Patients Using Typical
Neuroleptics.
From: Keefe RSE: Neurocognition. in Current Issues in the Psychopharmacology of
Schizophrenia. Breier A, Tran PV, Herrera J, Bymaster F, Tollefson G, eds. Lippincott
Williams & Wilkins Publishers. Baltimore, 2001
47