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PRINCIPLES OF BIOMEDICAL SCIENCE Syllabus Bob Jones High School 650 Hughes Road Madison, AL 35758 Teacher: Email: Phone: Melinda Lawson [email protected] 256-772-2547 Room N210 Course Description: Principles of Biomedical Science This course provides an introduction to the biomedical sciences through exciting handson projects and problems. Students investigate concepts of biology and medicine as they explore health conditions including heart disease, diabetes, sickle-cell disease, hypercholesterolemia, and infectious diseases. They will determine the factors that led to the death of a fictional woman as they sequentially piece together evidence found in her medical history and her autopsy report. Students will investigate lifestyle choices and medical treatments that might have prolonged the woman’s life and demonstrate how the development of disease is related to changes in human body systems. The activities and projects introduce students to human physiology, basic biology, medicine, and research processes and allow students to design experiments to solve problems. Key biological concepts including maintenance of homeostasis in the body, metabolism, inheritance of traits, and defense against disease are embedded in the curriculum. This course is designed to provide an overview of all the courses in the biomedical sciences program and lay the scientific foundation for subsequent courses. Course Objectives: Course objectives are unit specific and numerous. Please see the attached list of the entire list of objectives. Classroom Expectations: Students must comply with the following rules: 1. Bring all needed materials to class 2. Be in your seat and ready to work when the bell rings 3. Be respectful and polite to everyone. 4. Be respectful of others’ property. This includes property belonging to the school 5. Handle lab equipment only when instructed by the teacher. 6. Absolutely no eating food or drinking beverages (includes water) in class! 7. No chewing gum in class! 8. Obey all school rules (see student handbook) Any distractions that interfere with the student learning process will face the following consequences: 1. First offense: Verbal warning 2. Second offense: Detention and parental notification 3. Third offense: Office referral and parental notification BJ Grading Policy: Grading scale: A 90-100 B 80-89 C 70-79 D 65-69 F 0-64 Tests, projects & papers=70% Homework, Class work, Quizzes & Participation=30% BJ Make-up Test Policy: Make-up tests will only be given to a student who has an excused absence. The student Page 1 PRINCIPLES OF BIOMEDICAL SCIENCE Syllabus Bob Jones High School 650 Hughes Road Madison, AL 35758 Teacher: Email: Phone: Melinda Lawson [email protected] 256-772-2547 Room N210 must make arrangements with the teacher. Tests may be taken on Thursday at 7:00 am. Text and Other Required Reading: No textbook is required. Our curriculum is completely online. We will be utilizing online data searches as part of the curriculum. Materials and Supplies Needed: White long sleeve lab coat with length to mid-thigh( more information to come) Blue or black pens Notebook paper 2 inch 3 ring binder 2 packs of notebook dividers with tabs 1 roll of paper towel 1 Box of Kleenex Concerning laptop utilization: 1. Under no circumstances are student laptops to be wired to the network or have print capabilities. 2. No discs, flash drives, jump drives, or other USB devices will be allowed. 3. Neither the teacher, nor the school is responsible for broken, stolen, or lost laptops. 4. Laptops will be used at the individual discretion of the teacher. Note: 1. The academic misconduct policy of the school will be followed in this course. 2. The attendance policy of the school will be followed for this course. 3. Any student who receives failing grades during this course is urged to discuss this with the teacher immediately. Course overview: Principles of the Biomedical Sciences™ Course Overview The Principles of the Biomedical Sciences (PBS) course is divided into six units designed to introduce students to the study of human biology and medicine. The following is a description of each unit in the PBS course. Unit 1 – The Mystery Unit one provides the foundation and develops the theme for the course. Students are engaged by reading about a woman, Anna Garcia, who is found dead in her home. Students investigate the scene, gather evidence, and then move to the lab to analyze their findings. Through their examination of key evidence, students learn notebook organization, observation and documentation skills, and well as the fundamentals of experimental design. Students are introduced to the structure of DNA and investigate how basic molecular biology techniques can be used to connect suspects with a crime scene. In each unit of the course, students obtain additional medical history information for Anna as well as details from her autopsy report as they explore the various illnesses she encountered throughout her life. Students will maintain a medical file for Anna Garcia, compile their ideas and findings over the duration of the course, and ultimately determine her cause of death in the final unit. Unit 2 – Diabetes Students walk through Anna Garcia’s diagnosis of diabetes by completing simulated laboratory tests. Given results of the tests, students can deduce the basic biology of both Type 1 and Type 2 diabetes. Students investigate the connection between insulin and glucose and discuss how feedback systems in the body regulate the function of key hormones. Page 2 PRINCIPLES OF BIOMEDICAL SCIENCE Syllabus Bob Jones High School 650 Hughes Road Madison, AL 35758 Teacher: Email: Phone: Melinda Lawson [email protected] 256-772-2547 Room N210 Students investigate the biochemical makeup of food and complete experiments to demonstrate the relationship between energy and food. As students explore diabetes, they are introduced to basic chemistry, the structure and function of macromolecules, and the relationship of these molecules to metabolic function. The causes, symptoms, treatments and side effects of diabetes are studied as well as the life style implications associated with this disease. Students examine complications related to diabetes and finally brainstorm and develop an innovation to help with the management or treatment of the disease. Unit 3 – Sickle Cell Disease Students learn basic concepts of genetics and inheritance as they explore Anna Garcia’s struggle with sickle cell disease. Students examine sickled red blood cells under a microscope and learn what life is like with the disease by reading and writing patient diary entries. They simulate the process of protein synthesis, examine the assembly of the protein hemoglobin, and demonstrate how sickle cell disease results from a mutation that alters a protein product. Students create chromosome spreads, examine the structure of chromosomes, and show how traits are passed through generations on these chromosomes in our cells. Students also discuss the bioethics of scientific research and explore the bounds of HIPAA legislation. Unit 4 – Heart Disease Students examine the normal function of the human heart and investigate malfunctions in the cardiovascular system that can lead to heart disease. Students complete a dissection to tour heart anatomy and study heart function using probes and data acquisition software. They collect and analyze heart data including heart rate, blood pressure, and EKG readings and analyze cardiac test results of Anna Garcia. Students explore the role cholesterol plays in the body. Students further their knowledge of molecular biology as they run gel electrophoresis and complete RFLP analysis to diagnose familial hypercholesterolemia. Students design models to simulate the function of a pump and design visuals to show interventions for blocked coronary vessels. Unit 5 – Infectious Disease Students follow the spread of a simulated epidemic as engagement to a thorough examination of the agents of disease. Students use clues from their investigation of Anna Garcia’s medical history to deduce that she was suffering from a bacterial infection. Through a series of laboratory investigations, students learn the fundamentals of aseptic technique, complete visual identification of bacterial morphology, use the Gram stain to examine bacterial cell structure, and run metabolic tests to pinpoint the particular bacterium at the heart of the illness. Students explain the functioning of the human immune system in a visual project and explore how this system is designed to protect against invaders. Unit 6 – Post Mortem In the final unit of the course, students put together all they have learned throughout the course to determine Anna Garcia’s cause of death. Students will investigate the structure and function of key human body systems and relate the illnesses in the course to a breakdown in these systems. Students will begin to recognize the coordination and interconnections of the body systems required to maintain homeostasis, a precursor to the theme of the Human Body Systems course. Page 3 PRINCIPLES OF BIOMEDICAL SCIENCE Syllabus Bob Jones High School 650 Hughes Road Madison, AL 35758 Teacher: Email: Phone: Melinda Lawson [email protected] 256-772-2547 Room N210 18 – WEEK PLAN Week 1 Introduction and Unit 1Unit One: The Mystery Lesson 1.1: Investigating the Scene Activity 1.1.1: A Mysterious Death Activity 1.1.2: The Evidence Project 1.1.3: Blood Spatter Analysis Week 2 Lesson 1.2: DNA Analysis Activity 1.2.1: What is DNA? Activity 1.2.2: Structure of DNA Activity 1.2.3: DNA Analysis Week 3 Lesson 1.3: The Findings Activity 1.3.1: The Autopsy Activity 1.3.2: Was It a Crime? Week 4 Unit Two: Diabetes Lesson 2.1: What Is Diabetes? Activity 2.1.1: Diagnosing Diabetes Project 2.2.2: The Insulin Glucose Connection Activity 2.1.3: Feedback Lesson 2.2: The Science of Food Project 2.2.1: Food Testing Activity 2.2.2: Food Labels Activity 2.2.3: The Biochemistry of Food Activity 2.2.4: Energy in Food Week 5 Week 6 Lesson 2.3: Life With Diabetes (16 days) Activity 2.3.1: A Day in the Life of a Diabetic Project 2.3.2: Diabetic Emergency! Activity 2.3.3: Complications of Diabetes Problem 2.3.4: The Future of Diabetes Management and Treatment Week 7 Unit Three: Sickle Cell Disease Lesson 3.1: The Disease Activity 3.1.1: Blood Detectives Activity 3.1.2: Sickle Cell Diaries Week 8 Lesson 3.2: It’s In the Genes Activity 3.2.1: Protein Synthesis Activity 3.2.2: The Genetic Code Activity 3.2.3: Does Changing One Nucleotide Make a Big Difference? Page 4 PRINCIPLES OF BIOMEDICAL SCIENCE Syllabus Bob Jones High School 650 Hughes Road Madison, AL 35758 Teacher: Email: Phone: Week 9 Lesson 3.3: Chromosomes Week 10 Lesson 3.4: Inheritance Activity 3.4.1: Family Inheritance Activity 3.4.2: What’s the Probability? Activity 3.4.3: World Distribution of Sickle Cell Disease (Optional) Week 11 Unit 4: Heart Disease Lesson 4.1: Heart Structure Activity 4.1.1: Path of Blood in the Heart Activity 4.1.2: Anatomy of the Heart Week 12 Lesson 4.2: The Heart at Work Week 13 Unit 5 Lesson 4.3: Heart Dysfunction Week 14 Lesson 4.4: Heart Intervention Project 4.4.1: Unblocking the Vessels Project 4.4.2: Heart Disease Intervention Week 15 Melinda Lawson [email protected] 256-772-2547 Room N210 Activity 3.3.1: How is DNA Passed Through the Generations Activity 3.3.2: Chromosomes – A Closer Look Activity 3.3.3: The Immortal Cells Activity 3.3.4: Confidentiality Project 4.2.1: Heart Rate Project 4.2.2: Blood Pressure Activity 4.2.3: EKG Project 4.3.1: What is Cholesterol? Activity 4.3.2: Hypercholesterolemia Problem 4.3.3: The Heart as a Pump Unit 6 Unit 5: Infectious Disease Lesson 5.1: Infection Activity 5.1.1: Contagious Activity 5.1.2: Infectious Disease Agents Activity 5.1.3: Isolating Bacteria Activity 5.1.4: Gram Staining Activity 5.1.5: Bacterial Identification Project 5.1.6: Lines of Defense Week 16 Unit 6: Post Mortem Lesson 6.1: Analyzing Anna Project 6.1.1: How Do the Parts Make a Whole? Activity 6.1.2: How Did She Die? Page 5 PRINCIPLES OF BIOMEDICAL SCIENCE Syllabus Bob Jones High School 650 Hughes Road Madison, AL 35758 Week 17 Week 18 Teacher: Email: Phone: Melinda Lawson [email protected] 256-772-2547 Room N210 Catch up and complete all lessons Review and standardized final exam. This is a tentative schedule. We may move faster or slower than planned and will vary schedule to accommodate class. . Page 6