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Skip to main content Advertisement Login to your account Search Search BioMed Central articles Search Genome Medicine Main menu Home About Articles Submission Guidelines Search Submit a manuscript Genomic Technologies: New special issue Read more Disease Neurogenomics: Call for papers Read more Featured Review: Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy Ahronian and Corcoran review recent advances in understanding tumor heterogeneity and resistance to targeted therapies, focusing on combination kinase inhibitors, and discuss approaches to address these issues in the clinic. Read more Featured Video: Bridging the gap between discovery and application to diagnose genetic disease A study by Lupski and colleagues highlights that complementary relationships between research and clinical laboratories can be mutually beneficial, ensure patients receive the best treatment and accelerate the pace of disease-gene discovery – see the video abstract for a graphic summary of the paper. Read more Featured Video: De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease A study by Ennis, Snyder and colleagues indicates de novo and rare mutations in HSPA1L are associated with inflammatory bowel disease and also expands our understanding of the roles of HSP70s in human disease – see the video abstract for a graphic summary of the paper. Read more Articles Recent Most accessed Recent articles RSS 1. Research DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis Poppy Simmonds, Erick Loomis and Edward Curry Published on: 7 June 2017 2. Research The genomic road to invasion—examining the similarities and differences in the genomes of associated oral pre-cancer and cancer samples Henry M. Wood, Catherine Daly, Rebecca Chalkley, Burcu Senguven, Lisa Ross, Philip Egan, Preetha Chengot, Jennifer Graham, Neeraj Sethi, Thian K. Ong, Kenneth MacLennan, Pamela Rabbitts and Caroline Conway Published on: 7 June 2017 3. Research Seed-effect modeling improves the consistency of genome-wide loss-offunction screens and identifies synthetic lethal vulnerabilities in cancer cells Alok Jaiswal, Gopal Peddinti, Yevhen Akimov, Krister Wennerberg, Sergey Kuznetsov, Jing Tang and Tero Aittokallio Published on: 1 June 2017 4. Research A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis Colin J. Ross, Fadi Towfic, Jyoti Shankar, Daphna Laifenfeld, Mathis Thoma, Matthew Davis, Brian Weiner, Rebecca Kusko, Ben Zeskind, Volker Knappertz, Iris Grossman and Michael R. Hayden Published on: 31 May 2017 5. Research Genomic diagnosis for children with intellectual disability and/or developmental delay Kevin M. Bowling, Michelle L. Thompson, Michelle D. Amaral, Candice R. Finnila, Susan M. Hiatt, Krysta L. Engel, J. Nicholas Cochran, Kyle B. Brothers, Kelly M. East, David E. Gray, Whitley V. Kelley, Neil E. Lamb, Edward J. Lose, Carla A. Rich, Shirley Simmons, Jana S. Whittle… Published on: 30 May 2017 View all articles Most accessed articles RSS 1. Comment The virome: a missing component of biological interaction networks in health and disease Scott A. Handley Published on: 1 April 2016 2. Research Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials Nadja B. Kristensen, Thomas Bryrup, Kristine H. Allin, Trine Nielsen, Tue H. Hansen and Oluf Pedersen Published on: 10 May 2016 3. Open debate Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis® compared to Genentech's Herceptin® A Lane Baldwin and Robert Cook-Deegan Published on: 31 January 2013 4. Research Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing Francis Robert, Mathilde Barbeau, Sylvain Éthier, Josée Dostie and Jerry Pelletier Published on: 27 August 2015 5. Research Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies Ryan J. Hartmaier, Jehad Charo, David Fabrizio, Michael E. Goldberg, Lee A. Albacker, William Pao and Juliann Chmielecki Published on: 24 February 2017 View all articles Aims and scope Genome Medicine publishes research and reviews that describe important advances in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas covered include, but are not limited to: precision medicine, novel methods and software, cancer genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome and systems medicine. Article collections Special issue Precision cancer medicine Guest editors: Michael Berger and Eliezer Van Allen Special issue Translating the microbiome: health and disease Guest editor: Curtis Huttenhower Special issue Immunogenomics in health and disease Guest editor: Robert Holt See all article collections Tweets From the blog View feed The many inflammatory faces of chronic obstructive pulmonary disease (COPD) cannot be diagnosed by simple testing. Published on: 06 June 2017 Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma Published on: 05 June 2017 Can genetic variations predict response to Copaxone in multiple sclerosis patients? Published on: 02 June 2017 Advertisement Submit a manuscript Editorial Board Editorial Team Sign up to article alerts Contact us Impact factor: 5.85 Follow Follow us on Twitter Advertisement Genome Medicine ISSN: 1756-994X Contact us Editorial email: [email protected] Support email: [email protected] Publisher Main Menu Explore journals Get published About BioMed Central By continuing to use this website, you agree to our Terms and Conditions, Privacy statement and Cookies policy. 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