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Featured Review: Strategies for monitoring and combating
resistance to combination kinase inhibitors for cancer therapy
Ahronian and Corcoran review recent advances in understanding tumor heterogeneity and resistance
to targeted therapies, focusing on combination kinase inhibitors, and discuss approaches to address
these issues in the clinic.
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Featured Video: Bridging the gap between discovery and
application to diagnose genetic disease
A study by Lupski and colleagues highlights that complementary relationships between research and
clinical laboratories can be mutually beneficial, ensure patients receive the best treatment and
accelerate the pace of disease-gene discovery – see the video abstract for a graphic summary of the
paper.
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Featured Video: De novo and rare mutations in the HSPA1L
heat shock gene associated with inflammatory bowel disease
A study by Ennis, Snyder and colleagues indicates de novo and rare mutations in HSPA1L are
associated with inflammatory bowel disease and also expands our understanding of the roles of
HSP70s in human disease – see the video abstract for a graphic summary of the paper.
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1. Research
DNA methylation-based chromatin compartments and ChIP-seq profiles
reveal transcriptional drivers of prostate carcinogenesis
Poppy Simmonds, Erick Loomis and Edward Curry
Published on: 7 June 2017
2. Research
The genomic road to invasion—examining the similarities and differences in
the genomes of associated oral pre-cancer and cancer samples
Henry M. Wood, Catherine Daly, Rebecca Chalkley, Burcu Senguven, Lisa Ross, Philip
Egan, Preetha Chengot, Jennifer Graham, Neeraj Sethi, Thian K. Ong, Kenneth MacLennan,
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Seed-effect modeling improves the consistency of genome-wide loss-offunction screens and identifies synthetic lethal vulnerabilities in cancer cells
Alok Jaiswal, Gopal Peddinti, Yevhen Akimov, Krister Wennerberg, Sergey Kuznetsov, Jing
Tang and Tero Aittokallio
Published on: 1 June 2017
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A pharmacogenetic signature of high response to Copaxone in late-phase
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Colin J. Ross, Fadi Towfic, Jyoti Shankar, Daphna Laifenfeld, Mathis Thoma, Matthew
Davis, Brian Weiner, Rebecca Kusko, Ben Zeskind, Volker Knappertz, Iris Grossman and
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Published on: 31 May 2017
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Genomic diagnosis for children with intellectual disability and/or
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Kevin M. Bowling, Michelle L. Thompson, Michelle D. Amaral, Candice R. Finnila, Susan
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Gray, Whitley V. Kelley, Neil E. Lamb, Edward J. Lose, Carla A. Rich, Shirley Simmons,
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Published on: 30 May 2017
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1. Comment
The virome: a missing component of biological interaction networks in health
and disease
Scott A. Handley
Published on: 1 April 2016
2. Research
Alterations in fecal microbiota composition by probiotic supplementation in
healthy adults: a systematic review of randomized controlled trials
Nadja B. Kristensen, Thomas Bryrup, Kristine H. Allin, Trine Nielsen, Tue H. Hansen and
Oluf Pedersen
Published on: 10 May 2016
3. Open debate
Constructing narratives of heroism and villainy: case study of Myriad's
BRACAnalysis® compared to Genentech's Herceptin®
A Lane Baldwin and Robert Cook-Deegan
Published on: 31 January 2013
4. Research
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome
editing
Francis Robert, Mathilde Barbeau, Sylvain Éthier, Josée Dostie and Jerry Pelletier
Published on: 27 August 2015
5. Research
Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness
and targeted cancer immunotherapy strategies
Ryan J. Hartmaier, Jehad Charo, David Fabrizio, Michael E. Goldberg, Lee A. Albacker,
William Pao and Juliann Chmielecki
Published on: 24 February 2017
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Aims and scope
Genome Medicine publishes research and reviews that describe important advances in the
application of genetics, genomics and multi-omics to understand, diagnose and treat disease. Areas
covered include, but are not limited to: precision medicine, novel methods and software, cancer
genomics, disease genomics and epigenomics, immunogenomics, infectious disease, microbiome
and systems medicine.
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Precision cancer medicine
Guest editors: Michael Berger and Eliezer Van Allen
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Translating the microbiome: health and disease
Guest editor: Curtis Huttenhower
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Immunogenomics in health and disease
Guest editor: Robert Holt
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The many inflammatory faces of chronic obstructive pulmonary disease
(COPD) cannot be diagnosed by simple testing.
Published on: 06 June 2017
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Comprehensive DNA methylation study identifies novel progression-related
and prognostic markers for cutaneous melanoma
Published on: 05 June 2017
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Can genetic variations predict response to Copaxone in multiple sclerosis
patients?
Published on: 02 June 2017
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