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MBBS II (Second) Professional Examination 2012-13 Course Code: MBS201 Paper ID: 0322402 Pathology-I Time: 2 Hours 40 Minutes Max Marks: 30 Note: Attempt all questions. Draw proper diagrams to support your answer. Part ‘B’ 1. Discuss Apoptosis in detail. 2. c) d) A 42 year old man was referred with 2 weeks history of fever, gum hypertrophy and bleeding gums. The total leukocyte count was>1 lakh/cumm. (1+2+2+2) What is your diagnosis? Draw and describe peripheral smear and bone marrow findings. Write the WHO classification of the disease. Describe use of cytochemistry to subtype the disease. (2x4=8) a) b) c) d) Write short notes on: I.T.P. Type I Hypersensitivity reaction Genetic basis of Thalassemia Metastasis Describe briefly: Mechanism of Irreversible injury Calcification Embolism Healing by Primary intention (2x4=8) a) b) c) d) a) b) 3. 4. (7) MBBS II (Second) Professional Examination 2012-13 Roll No. Student’s Name Student’s Signature Invigilator’s Signature Course Code: MBS201 Paper ID: 0322402 Pathology-I Part ‘A’ Time: 20 Minutes Max Marks: 10 Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes. 2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed. 3. For answering please use Ball- pen only. Q.1 Hypertrophy is a type of: a) Cell injury b) Cellular adaptation c) Carcinoma d) Cell aging b) c) d) Q.7 Q.2 Basement membrane mediated by: a. Metalloproteases b. Oxidases c. Elastasis d. Hydrocyclases Q.3 The commonest mode of inheritance of von Willebrand’s disease: a) Codominant b) Autosomal recessive c) Autosomal dominant d) X-linked recessive Q.4. degeneration is Most common translocation in follicular lymphomas: a) t 14;18 b) t 17;19 c) t 11;14 d) t 9;22 Q.5 Deficiency of the intrinsic factor causes: a) Megaloblastic anemia b) Pernicious anemia c) Aplastic anemia d) Iron deficiency anemia Q.6 In - thalassemia there is: in chain, in alpha chain a) in -chain, in alpha chain in -chain, in alpha chain in -chain, in alpha chain The primary defect which leads to sickle cell anemia is: a) An abnormality in porphyrin part of hemoglobin b) Replacement of glutamate by valine in chain of Hb A c) A nonsense mutation in the chain of Hb A d) Substitution of valine by glutamate in the alpha chain of Hb A Q.8 Osmotic fragility is increased in: a) Sickle cell anemia b) Thalassemia c) Hereditary spherocytosis d) Chronic lead poisoning Q.9 An example of cancer suppressor gene is: a) Bcl b) P 53 c) Ras d) C -myc Q.10 When a functional gene is inherited from one parent only, the condition is know as: a) Genomic imprinting b) Alleles c) Mosacism d Chimerism P.T.O Q.11 Q.12 All of the enzymes are involved in free radical scavenger reactions except: a) Catalase b) Superoxide dismutase c) Creatine phosphokinase d) Glutathione peroxidase Which of the following is not a component of Virchow’s triad: a) Activation of coagulation cascade b) Endothelial injury c) Stasis of blood d) Blood hypercoagulability Q.13 Which of the following is not an oncogenic DNA virus: a) HPV b) EBV c) HTLV - I d) HBV Q.14 During inflammation, VCAM-1 molecules on endothelium binds with: 1 - integrin a) b) Sialyl-Lewis X c) L - selectin 2 - integrin d) Q.15 Which of the following vitamins are involved in formation of collagen: a) Vitamin A b) Vitamin B c) Vitamin C d) Vitamin D Q.16 Which of the following is not a type of hemolytic anemia? a) Hereditary spherocytosis b) G6PD deficiency anemia c) Thalassemia d) Megaloblastic anemia Q.17 All of the following subtypes of Hodgkin’s lymphoma are associated with Ebstein Barr virus infection except: a) Mixed cellularity b) Lymphocyte rich c) Nodular sclerosis d) Lymphocyte depletion Q.18 Genes encoding MHC complex of proteins are located on: a) Chromosome 3 b) Chromosome 6 c) Chromosome 9 d) Chromosome 16 Q.19 All of the following are features of congenital syphilis except: a) Hepar lobatum b) Interstitial keratitis c) Hutchinson teeth d) 8th nerve deafness Q.20 Genetic defect seen in Burkitt lymphoma is: a) t(9;22) b) t(8;14) c) t(15;17) d) inv. of chromosome 16