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Roles of a Community Pharmacy in Management of Type 2 Diabetes Mellitus (T2DM) Point Of View of Practicing Community Pharmacists Tan Kean Chong, Ooi Show Yuen Good Health Pharmacy, Puchong, Selangor 26th August 2012 Introduction Type 2 Diabetes Mellitus (T2DM) is a major disease that poses huge- challenge to public, medical profession & government. In 2006 about 15% of the population above 30 years of age was reportedly diagnosed with T2DM. Prevalence of the above population was estimated to be 20% or more if we were to refer to recent studies. Base on the prevalence mentioned, 1 in every 5 adults above 30 years of age was a diabetic in Malaysia. The latest figures reported in parliament revealed that there are 2.6 million diabetic patients among all the population in Malaysia. It is an epidemic with huge impact to government & society as a whole and undeniably its economic impact sets to be the most challenging for the government. The 2008 Diabcare Study Malaysia further shows to have more shocking findings, it was documented that 70 - 80% of diabetic patients was not well controlled based on the American or international standard. Thus, Community pharmacy (CP) as part of healthcare profession plays crucial roles in cushioning the impact. Accessibility is the key factor that drives diabetic patients to CP for services such as medication refills, getting food supplement , testing for blood glucose and getting advice on diabetic related matters. However, being accessible is not sufficient in providing the services mentioned . A complete understanding of the roles of CP help to alleviate the impact of T2DM and at the same time contribute positively to the profession . Why Does a CP Has Major Roles? The main reason is accessibility. Most CPs are located near residential area with convenient & accommodating business hours. Apart from convenient location & accommodating business hours , the CP retail environment encourages a hassle free interaction with the pharmacist , be it over the counter or in a counseling room . In contrast, an encounter with a doctor is more formal & usually not as casual as in CP. In a candor environment, trust &loyalty will flourish between CP & diabetic patient .All these factors enhance CP role in T2DM management. The other reason is the vast medical needs of diabetic patients. Diabetic patient has many medical needs that can be adequately & readily fulfilled by CP. Diabetic medication refills, blood glucose & pressure measuring, blood glucose meter accessories refills & nutrition product supply are the needs that drive diabetic patient to CP. Besides, if there is a diabetic complication, the needs will be even more profound. For example, a diabetic foot wound need dressing product in large quantity due to the slow healing process. Hence, a patient with this complication will visit CP more frequently. Based on these two reasons, CP is in a good position to play major roles in T2DM management. What Are The Roles Of CP? 1) As motivator i. T2DM is a progressive disease that requires long term medication with medical supervision from a doctor. Quite often the patient will feel taking long term medication is a burden & non-compliance will set in as the disease progresses. Uncontrolled blood sugar makes thing even more daunting to stay motivated & making visits to a clinic becomes an unpleasant one. Eventually, the patient will become de-motivated & stop visiting clinic altogether. CP will have to keep reminding the patient that long term medication & medical supervision are needed as T2DM is a progressive disease. The regular clinic visit is a routine for better control of blood glucose. Though, there is no cure for it, but leading a normal life & avoiding/delaying all the complications is very much achievable. Motivation is the key factor in adhering to medication & leading a healthy lifestyle. ii. How to recognize signs of low motivation? When patient compliance is low e.g. taking longer duration to refill medication than the duration of supply . Or if a patient expresses frustration such as “…tired of taking medication.”, “…..hate taking medication .” , “ …better die than taking medication .”, “…no matter how hard I control my diet & keep on taking medication , my blood sugar is still high .”, “ every time I see doctors ,it is still the same .” ,“ I just can’t afford the new medication” .Any signs of the above mentioned warrants action to be taken to boost motivation. iii. How to re-motivate? CP must regularly remind patients that DM is a progressive disease & taking medication continuously will ensure delaying or even avoiding diabetic complications. Quoting example of severe complication such as diabetic wound might help for certain patient but not all is receptive towards this scare tactic. Pictures of wound healing because of better blood glucose control & proper dressing will be more acceptable than the above. This method is mostly employed by multi- level marketing company which proves to be effective .Currently, all clinical guidelines recommend treating diabetic patient to achieve blood glucose target and aggressive target is set for younger patients . By following these guidelines , drastic change in diabetic medication will be seen and some patient will become skeptical of the doctor aggressive approach. The role of CP here is to reassure patients that aggressive treatment is necessary especially for younger patient to avoid complications appearing at an early age . With the reassurance , patient will be motivated to continue with diabetic medication prescribed by his/her doctor . Diet & lifestyle changes are crucial in controlling blood glucose. Any drastic changes in diet & lifestyle will backfire. Therefore , CP must always encourage patient to make small changes in diet or lifestyle to achieve targeted blood glucose & pressure. For example, the patient is advised to reduce consumption of rice by 2-3 tablespoonful in each meal. On top of that , patient is encourage to walk more by parking their car further or using stairs instead of the elevator or escalator on a daily basis . Blood sugar monitoring should be done regularly when making the small changes to show improvement in blood glucose control. Encouragement should be given whenever there is an improvement no matter how small it is. Eventually, the patient will be able to achieve blood glucose targets by taking small but doable changes. Whenever a patient complains about the affordability of diabetic medication, CP should always suggest patient go to the nearest government hospital or clinic to get proper treatment . In Malaysia , no patient should be deprived of proper diabetic care due to financial constraint because the patient can always seek treatment from government clinic or hospital that charge only a nominal fee for good diabetic care . As for compliance on diabetic medication, the best ways is to suggest once a day medication to the patient and getting doctor approval is a prerequisite for any changes. There are many medications that can be administered once a day & readily available in Malaysia. All the methods or ways mentioned are not exhaustive , the CP accumulative experience can become handy in time to come. 2) As screener & reminder in blood glucose monitoring i) Recurring complaints from normal people Recurring complaints such as fatigue, poor sex performance or fungal infection on private part could be the reason for normal people to seek nutrition or herbal supplement or even some over the counter product at CP. For these people, blood glucose screening is really advisable even if it is random blood glucose. If the blood glucose level is high, CP must advise them to seek treatment from medical doctor. The other common complaint is slow wound healing on the foot which always needs extra attention. If a person has been buying dressing items for a while, CP should advise him/her to have the blood glucose test done to make sure this person is free from DM. ii) Blood Glucose Monitoring for diabetic patient i. Blood glucose testing should be done on patient with diabetic as often as required. Each time a patient refills his/her diabetic medication, remind him/her to do blood glucose test to keep tab on blood glucose control. ii. If it is necessary advise patient to have a glucometer at home for selfblood glucose monitoring. This will be helpful in controlling blood glucose level. Besides, for elderly patient who is more prone to hypoglycemic events due to improper use of sulphonylurea (SU), measuring blood sugar during hypoglycemic symptoms will help in managing these avoidable side effects. When a diabetic patient is on insulin, glucometer will be very useful to guide doctor in dosage adjustment as well as for patient to detect hypoglycemic events. Another benefits of doing self- blood glucose monitoring is measuring blood glucose after a meal will find which type of food that contribute towards high sugar level .Subsequently ,patient can avoid taking this high glycemic index food & has better control of blood glucose themselves . iii. Patient must be reminded to fast & avoid taking any diabetic medication before testing for fasting blood glucose (FBG). One common mistake is patient will fast but without knowingly or even purposely taking diabetic medication before going for the test. It will definitely alter the blood glucose & interpreting result will be inaccurate. Doing FBG is to find out whether the diabetic medication taken day before works or otherwise. Some patients who fast overnight but take oral diabetic medication intentionally before going for blood glucose testing to avoid being reprimanded by the doctor for not controlling blood glucose. However, this self-deceiving act will pose danger to patient if severe hypoglycemia occurs. This is seen mostly in patient who has been followed up in government hospital or clinic. 3) As advisor on medication , diet & supplement i. Medication a) Side effects of a diabetic medication are always the culprit of non- compliance. Feeling hungry & hand shivering are signs & symptoms of hypoglycemia caused by sulphonylurea (SU), a commonly used diabetic medication. It is always recommended to take SU before or immediately after food. Weight gain is another major side effect of SU which will lead to non-compliance. Preempting patient on the side effects will definitely improve compliance & blood glucose control. Metformin, another commonly used diabetic medication, causes diarrhea or stomach discomfort which sometimes can be very troublesome. As a result,the patient might sometimes ask for a change of metformin due to side effects. Besides , long-term metformin use could cause Vitamin B12 deficiency which can be corrected by taking a Vitamin B12 supplement. b) CP has a major role to play in insulin administration. Currently ,there are many patients on insulin , be it from the private hospital or even from the government hospital. CP must advise patients on proper storage & administration technique which will ensure efficacy & reduce wastage. Showing a diagram on the correct injection site will help to prevent scarring due to multiple injections on a same spot. Although the patient will be given counseling on method of administration the first time he/she is prescribed with insulin, CP will definitely find some patients not fully following the correct way of administration if CP care to ask or enquire about how patient handle insulin injection. Another important message that needs to be conveyed is recognizing hypoglycemic symptoms such as giddiness, tremor, loss of consciousness, delirium, thirsty, hunger etc. . . .Any of the above signs & symptoms warrant immediate action from the patient himself/herself or caretaker to ensure blood glucose rise back to normal level. Therefore, CP has to remind the patient about keeping sweet or sugary drink readily available in case of any emergency. c) Diabetic patient could be on antihypertensive medication that contributes negatively to blood glucose control. The common combination that has this effect is beta blocker & thiazide diuretic which were commonly used back in the 90’s or early 2000. Though, they are less seen now, but CP will definitely come across a diabetic patient who is still on this combination. A CP is duty bound to inform patients about other available antihypertensive options that are neutral towards blood glucose &cholesterol control or even has renoprotective properties. Of course changing the antihypertensive is the prerogative of doctor who clinical judgment is utmost important. Another most commonly seen medication given inappropriately to diabetic patient is cough mixture with a syrup simplex base. A tablespoon of it will cause blood sugar to rise substantially for those who have long been diagnosed with diabetes. Therefore, CP must remind patient to be extra cautious & inform doctors that he/she is a diabetic. Due to lack of medication option in a government hospital or clinic , most of the time patient with cough /cold will be prescribed with cough syrup that is of sugar based .Consequently , the patient’s blood glucose level will be high & bringing this level down will take some time. Ii . Diet a) One of the most common misconception on a diet is substituting rice with noodle, rice vermicelli ( beehoon) or chappati or bread to reduce blood glucose . The common response will be “ I don’t take rice . I take noodles or bread” or “ I only take rice once at night , the rest will be bread or beehoon or noodle” without realizing the carbohydrate content might be higher in noodle or even bread .Thus , the blood glucose will remain high . In order to rectify the misconception, a CP must highlight that rice,noodles , white bread , tosai or chappati are all carbohydrate , replacing one with the other does not give much of a change in blood glucose . Instead, replacing a portion of the above with vegetable, fruit or even protein such as chicken or egg will help in reducing blood glucose. Generally, our Malaysian diet contains excessive carbohydrate. One good example is Chicken rice which contains high portion of rice with very small portions of vegetable & a moderate portion of chicken. Replacing a small portion of rice with vegetable or chicken will definitely reduce the carbohydrate portion and still able to maintain total calorie intake. By doing so, we can address the common complaint “ I take less rice , I will feel hungry faster” and simultaneously reduce blood glucose . Changing diet is a gradual process that needs a lot of patience & motivation from patient & CP as well. It is always good to understand the normal daily diet of a patient before any changes are made. For typical Malaysian breakfast such as nasi lemak , noodle or even roti canai that contains high carbohydrate, blood glucose will be quite difficult to control . Replacing a small portion of carbohydrate of the above with vegetable or fish or even chicken will be the first step of seeing changes in diet & subsequently good blood glucose control will follow. Perseverance is a must for any success to be observed in dietary changes. Once patient experience success with changes in breakfast , replacing a small portion of high carbohydrate food with fruit/vegetable or egg /chicken during lunch & dinner will be more achievable .Following this method , calorie intake for a diabetic patient will be contributed more adequately from fruit/vegetable or even protein instead of depending too much on starchy food . If the situation permits suggest to the patient to have small portion of the meal but taking more frequently to avoid fluctuating blood glucose. As for drink, CP should encourage a diabetic patient to switch to sugar free drink or use artificial sweeteners such as aspartame to have better control of blood glucose .A typical Malaysian diet contains excessive starchy food and real improvement in blood glucose can be observed if positive diet changes can be implemented by the patient with the help of CP. b) Read the nutrition label 1. Calories 2. Carbohydrate 3. Sugar 4. Fiber The educated diabetic patient should be informed of the importance of reading nutrition label & making a comparison on food product available. This act of reading & comparing will directly lead to better blood glucose control. Food that contains low in calories, carbohydrate & sugar content but high in fiber content should be the choice of every diabetic patient. The key thing is to compare & then choose the best option. Continual education is a main factor in changing the habit of choosing food that is best for diabetic patients. iii. Supplement a) The desire of trying an alternative medicine for reducing blood glucose is always strong among diabetic patients. It could be due to our cultural background which makes us think natural or herbal medicine is better. Sometimes the desire is so strong, CP just has to let the diabetic patient try alternative medicine with close monitoring of blood glucose. Any intention to change or substitute diabetic medication must be discouraged unless with prior consent from a doctor. The most commonly used supplements are product derived from bitter gourd, chromium or vanadium. Any recommendation of these products must be done as a supplement to diet, exercise & medication. Patient must not take the recommendation as a replacement without doctor consent. b) Though not much been documented but it has been accepted that vitamin B 1, B6 & B12 should be used by diabetic patient with neuropathy symptoms. CP should recommend this supplement whenever it is indicated. As for patient on long term metformin, Vitamin B12 is advisable to replenish depleted storage due to long term use of metformin. 4) As a collaborator with medical doctors in managing & preventing complications i. Diabetic Wound a. It is the most common diabetic complication that drives patients to CP. Initially, patients will visit the clinic for daily dressing. Once the condition improves, the patient might opt to do the dressing himself or herself & getting the dressing supplies from CP. The role of CP is to remind patients of the importance of monitoring wound progress. If the wound healing is slow, patient must be advised to visit a clinic & debridement must be done if necessary. ii. Prevention a. Any adult customer with in- grown nail on the toes that buys antibiotic ointment or antiseptic lotion should be informed that if he/she is a diabetic, doctor’s consultation is a must. No self-treatment is allowed for diabetic patients with ingrown nail on the toes. b. The first question for an adult with Corn/Callus/Warts on his/her feet who needs salicylic solution is “Are you a diabetic?” If the answer is yes, please inform the patient that doctor’s consultation is really important before treating herself/himself. 5) As myth buster i) Alternative or traditional medicine is able to cure DM. Every diabetic patient has to be informed that DM is a progressive disease with no cure at the moment. However, leading a normal life without complications is achievable. This is the key message that CP must find ways to drum it into patient mind & if possible rooted deeply in the mind. Otherwise there will be a lot opportunist who will convince a diabetic patient that alternative medication or treatment can cure DM. ii) Insulin administration equals severe stage of DM Most patients are afraid of insulin injection and even the educated one has the same fear. With new development in DM treatment, insulin is given much earlier than patient’s expectation. The main thing of giving insulin at an early stage is to preserve whatever pancreatic function left in diabetic patient & provide good blood glucose control. Some patient might need insulin at very early stage base on clinical judgments of doctors eg. when a patient is critically ill. From a patient point of view , insulin is the most dreaded treatment for diabetic patient .CP must change this stigma .Actually , CP must inform patient that insulin is the only treatment that is able to lower blood sugar unlimitedly & control blood sugar effectively with proper usage .Ask any of diabetic patient about starting on insulin & most likely the answer will be “ I am not that bad or serious , let me really control my diet & exercise regularly first before starting on insulin ” or “ I don’t want , I would rather take more medicine than injecting myself with insulin” or “ I feel shy using insulin in public place .” CP must always encourage patients to use insulin if it has been advised by doctor. iii) Diabetic medication will cause damage to the kidney. The fact is kidney damage is caused by long term uncontrolled blood glucose. High blood glucose will cause nephropathy. Even educated patient sometimes has the idea that taking long term diabetic medications will have detrimental effect on kidney. It is so unfortunate for these patients .CP must inform patients that if diabetic medication is truly harmful, no government or doctor with a sane mind will prescribe diabetic medication so freely. The true culprit that damages the kidney is uncontrolled high blood glucose. Therefore, CP must reiterate that uncontrolled blood glucose is the true culprit that damages the kidney & no diabetic medication has been proven to cause kidney to fail. 6) As Diet & Exercise (D&E) Advocate i. A CP must realize that medication alone without changes in diet & exercise causes uncontrolled blood glucose. All the clinical guidelines available emphasize on healthy diet & exercise before starting on the medication. This shows the important of D&E . Some desperate patient will enquire about the best or latest diabetic medication, some even request to be given insulin for controlling their blood glucose. However, CP must drive into patient mind that changes in diet & doing exercise are very important in diabetic treatment. In fact diet, exercise & medication are the 3 pillars in treating DM. A treatment plan that is lack of any one of the pillars is deemed to be heading for definite failure. ii. Convenience seeking patient will definitely request for good diabetic medication without compromising on their excessive appetite or sedentary lifestyle. This must be rectified with good communication skill from CP. Driving home the message of proper diet, adequate exercise & strict medication compliance must be achieved if any improvement were to be seen. iii. If a patient intends to take up the sport, he/she has to be informed that proper sporting gear is very important to prevent injury. If an injury happens such as osteoarthritis on the knee, it will affect the exercise program & subsequently patient blood glucose will become difficult to control . Moreover, the proper sporting shoe will avoid injury on foot which might develop into diabetic foot .Swimming & brisk walking are sports that less likely to cause injury which are suitable for diabetic patient. The latest guideline on the duration of exercise is 150 minutes per week. It is quite a task for those who have sedentary lifestyle all the while. In order to overcome the beginning stage inertia, CP should advise patient to start slow like 30 minutes each session for 3 days & gradually improve to 5 days .The patient has to be informed that any exercise is better than no exercise at all. Even muscle strengthening exercise has proven to reduce high blood glucose. THE CHALLENGES i)Profitability Vs Professionalism CP must not diagnose, change medication & dosage of a diabetic patient. A medical doctor is the best profession to carry out the above. Even if the patient complains about the service or attitude of his/her doctor. The only best thing CP can do is recommending a good doctor with a strong interest in treating DM. The true responsibility of CP is medication refills, advice on diet & exercise, alert patient of possible side effects of medication, guide patient in taking of medication. Monitoring of blood sugar is also beneficial to the patient which could fall under the responsibility of CP. CP must have a clear mind on what falls under his or her responsibility & avoid crossing the border of responsibility with doctor due to temptation to increase sales or profitability . CP should focus on professionalism. However, it is a difficult task especially for a new CP .The temptation to increase or even maintain profit is hard to overcome. At the end of the day, balancing between profitability & professionalism will be a difficult but doable. The basis of professionalism is to provide up to date & accurate information without being selective on patient & with patient interest in CP mind. Soon profit will follow. The 1 million Ringgit question will be how soon? If it is too soon, professionalism surely will be jeopardized. If it is too late, there will be no opportunity for professionalism to take place. It is really up to the person who runs the CP . ii)Staff & Training 1)Hiring a pharmacist who has an interest in DM is time-consuming . A pharmacist must show interest in self-educating if he/she wants to play a role in T2DM management. In an everchanging world of medicine, once a pharmacist ceases from gaining new knowledge , that is the time he/she will turn into a professional retailer .Currently , pharmacist with an interest in DM is still very few and far between .But fortunately , if CP tries hard enough to look for pharmacist with an interest in DM , eventually CP will find one to join the journey of uplifting CP profession . Training a pharmacist with an interest in DM is easy & really rewarding. Just allocate a project on DM to a passionate pharmacist, it will be considered done even at the early stage. 2)Training of pharmacy assistant (PA) on basic of DM , simple diet & exercise tips , blood glucose target of a diabetic patient is time- consuming & sometimes challenging . Worst still if the turnover of pharmacy assistant is high. Overcoming these challenges could be done by using a simple chart on DM, target blood glucose, diet & exercise tips & always help PA when he/she is doing blood glucose testing. 3) Remuneration package based on performance will be beneficial for CP & PA. Developing a fair & yet rewarding package must be discussed thoroughly & openly between both parties to address high turnover in CP. Performance based incentive can be incorporated into a basic salary package of pharmacist and even PA . By doing so, a pharmacist or PA will be more loyal and less likely to be lured by other CP or chain pharmacy. iii)Space & Privacy One of the major constraints in CP growth is floor space. Allocating a room for counseling will be very ideal in providing comfort & privacy to the patient but at the expense of optimal use of floor space. In retail, efficient use of floor space will enhance revenue or even profitability. In other words, the more product that can be displayed per square feet, the more sales can be generated per square feet .CP must balance between providing comfort & privacy and efficient use of floor space. As mentioned earlier, casualness will be sacrificed if counseling is done in a room as some experience seen in the doctor’s room. CP must find ways to address this issue in order to gain …. first trust & then loyalty of patient. iv)Time Time constraints will be a major hindrance for CP to play a major role in T2DM management. At an early stage of growth of a CP, time is not an issue. However, as CP grows, time will become difficult to come by. Sufficient time must be made available to have a good & effective counseling. Precise information must flow between CP & diabetic patient. With limited time, precise flow of information will be hard to achieve. As a result, it will hinder a CP in rectifying or improving patient condition. There are many ways a CP can address the time constraints issue & one of it is to employ extra pharmacist who will immediately address this issue but CP must be wary of the extra cost incurred. At the end of the day, an investment of an extra headcount has to have a fair return at the bottom line. Another way of addressing this issue is by informing a diabetic patient who needs extra attention to come in the afternoon when CP is less busy or even during the weekend. Thus, patient will get the attention needed whereas a CP will efficiently use the limited time available for patient counseling. v)Education background Education background of a patient will determine the level of communication involved. Those who are less educated might need more time & creativity in conveying the message across. Whereas for those who are educated needs less time in conveying a message. Using a chart or picture will be helpful in communicating with a patient who is less educated. A patient’s motivation to control blood glucose is influenced by patient awareness of diabetic complications and it is regardless of patient’s education background .The higher the awareness, the higher the motivation. A patient could be holding a degree but leading an unhealthy lifestyle without any remorse or regret. Once complications set in, any remedial action taken will be futile in reversing the condition. vi)Price Competition Currently, price competition is very bloody among CPs. Price undercutting becomes a norm in CP daily practice. Though, many CPs know exactly the consequences of price undercutting but resolving this issue seems to be very remote. CP has sometimes been too engrossed in this bloody war & unknowingly neglecting patient interest. Hence, the role of CP in T2DM management will be jeopardized. A CP will be demotivated to see his/her effort in playing the role in T2DM management goes down the drain when patient hopping around for the lowest priced medication. A CP must stay focus & have a heart of steel together with a continuous flow of creativity to overcome the price competition issue. It will be a tough but rewarding if CP is able to divert patient attention from price oriented to service oriented. vii) Recognition The role of a community pharmacist in playing a role in managing T2DM is not being recognized by other medical professions . Dietician , diabetic counselor and diabetic foot nurse supporting roles has been rightly or deservingly recognized by medical doctors . However , CP may not gain much recognition in playing a role of supporting medical doctor in managing T2DM . Questions have to be asked on how CP can gain recognition or respect from other medical professions . Inward looking into the professionalism of CP is the way to go before any progress can be made .From the current situation , the journey towards gaining recognition from other medical professions is still far away but within reach if CPs & relevant authorities begin to look into ways of rectify any shortcomings in the profession holistically . CONCLUSION If CP involvement could reduce uncontrolled diabetic by 1 %, it will translate into 26000 patients that will likely to be free of diabetic complication. Existing diabetic care system is not sufficient in handling the diabetic epidemic as reported in 2008 Diabcare Study .Hence; there is a room for CP involvement to support the existing diabetic care system. There are many areas a CP can be involved as discussed but personal interest of individual CP will determine the direction to be taken by CP. Though the challenges are daunting but if CP really strives to carry the responsibility, the return will not only be rewarding but also will uplift CP profession. The role of CP in T2DM management will only grow with time as a result of ever growing diabetic population in Malaysia. Therefore, CP must be ready to grab the opportunity arises & turn the profession into a well- respected one in the eye of the community.