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Download RNA Viruses: Orthomyxo (influenza)
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RNA VIRUSES Orthomyxoviruses Epidemic influenza A , B , C Due to Antigenic drift ( minor changes of HA ) Pandermic Antigenic shift ( major changes of HA ) influenza Sings : fever , sorethroat , headache , cough , nasal congestion & Resp. infection Transmission : aerosol Treatment & prevention :; Antiviral (Amantidine) Vaccination : Difficult due to Ag changes RNA Viruses: Orthomyxo (influenza) Paramyxoviruses Parainfluenza human Resp. disease affect young adult & infant ( laryngeotrachitis )“ croup “ ; brocheolitis & pneumonia Transmission : droplet Mumps : common childhood parotitis one or both side are affected . MMR vaccine solid immunity Measles : infectious disease of childhood ; rash , virus enters Resp. tract regional LN viraemia “ prodromal stage “ conjuctivitis , nasal discharge & fever .Sorethroat “ Koplik’s Spots “ Bluish white spots on buccal mucosa opposite molar teeth then Rash ( reactivation of virus & immuno system ) Koplik spots disappear Complications of measeles Resp. complication ; broncho pneumonia Otitis media Neurological - encephalomyelitis - SSPE progressive degenerative disease of brain 1 Gangrenous stomatitis & noma (Cancrum oris) African child suffer from bad nutrition with ANVG Destruction of orofacial tissue Transmission of measles : Resp. secretion & urine ( prodromal stage ) Prevention : MMR Respiratory Syncytial virus ( RSV ) Lower resp. infection of infants & young adults Picronaviruses A: Entero viruses Polioviruses : poliomyelitis Ingestion of contaminated food ( primary replication in oropharyngeal & intestinal mucosa ) mesenteric LN viraemia CNS Coxsackieviruses : ( genra A , B ) cause mild disease Herpangina : common in children Sorethroat , ulceration an tonsil , soft palate grayish white vesicles on posterior hard palate , self limiting disease Hand , Foot & mouth disease : Coxa A , common in children Oral bright red macules vesides pale center on hand & foot Transmission : oral – fecal , nasal route . B: Rhino viruses : Common cold upper resp. ; more than 100 group transmitted by inhalation ( Winter & Autumn ) Togaviruses Rubella : German measles , childhood disease similar to measles but milder . Untreated during pregnancy lead to congenital abnormality spread by nasal secretion prevention : MMR 2 Other RNA viruses Arena Bunya Rota Corona s a ri s Rhabdo Rabies Viruses & Cancers Papova HPV , SV40 cervical carcinoma Adeno animals Herpes HSV-2 , EBV , HHV-8 –Kaposi Hepatitis HBV & HCV hepatocellular carcinoma Retro HTLVs ( AIDS ) 3