Download RNA Viruses: Orthomyxo (influenza)

RNA VIRUSES
Orthomyxoviruses
Epidemic influenza A , B , C
Due to Antigenic drift ( minor changes of HA )
Pandermic
Antigenic shift ( major changes of HA )
 influenza
Sings : fever , sorethroat , headache , cough , nasal
congestion & Resp. infection
Transmission : aerosol
Treatment & prevention :; Antiviral (Amantidine)
Vaccination : Difficult due to Ag changes
RNA Viruses: Orthomyxo (influenza)
Paramyxoviruses
 Parainfluenza
human Resp. disease affect young adult
& infant
( laryngeotrachitis )“ croup “ ; brocheolitis & pneumonia
Transmission : droplet
 Mumps : common childhood
parotitis one or
both side are affected .
MMR vaccine
solid immunity
 Measles : infectious disease of childhood ; rash ,
virus enters Resp. tract
regional LN
viraemia
“ prodromal stage “ conjuctivitis , nasal discharge & fever
.Sorethroat
“ Koplik’s Spots “
Bluish white spots on buccal mucosa opposite molar teeth
then
Rash ( reactivation of virus & immuno system )
Koplik spots disappear
Complications of measeles
Resp. complication ; broncho pneumonia
Otitis media
Neurological
- encephalomyelitis
- SSPE
progressive degenerative disease of brain
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Gangrenous stomatitis & noma (Cancrum oris)
African child suffer from bad nutrition with ANVG
Destruction of orofacial tissue
Transmission of measles :
Resp. secretion & urine ( prodromal stage )
Prevention : MMR
Respiratory Syncytial virus ( RSV )
Lower resp. infection of infants & young adults
Picronaviruses
A: Entero viruses
Polioviruses : poliomyelitis
Ingestion of contaminated food ( primary replication in
oropharyngeal & intestinal mucosa )
mesenteric LN
viraemia
CNS
Coxsackieviruses : ( genra A , B ) cause mild disease
Herpangina : common in children
Sorethroat , ulceration an tonsil , soft palate grayish
white vesicles on posterior hard palate , self limiting
disease
Hand , Foot & mouth disease :
Coxa A , common in children
Oral bright red macules
vesides pale center on
hand & foot
Transmission : oral – fecal , nasal route .
B: Rhino viruses :
Common cold
upper resp. ; more than 100 group
transmitted by inhalation ( Winter & Autumn )
Togaviruses
Rubella : German measles , childhood disease
similar to measles but milder .
Untreated during pregnancy lead to congenital
abnormality
spread by nasal secretion
prevention : MMR
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Other RNA viruses
Arena
Bunya
Rota
Corona
s a ri s
Rhabdo
Rabies
Viruses & Cancers
Papova
HPV , SV40 cervical carcinoma
Adeno
animals
Herpes
HSV-2 , EBV , HHV-8 –Kaposi
Hepatitis HBV & HCV hepatocellular carcinoma
Retro
HTLVs ( AIDS )
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