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Download 3/1 Spirochetes and Mycoplasma
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BSC 361 3/4/13 Spirochetes and Mycoplasma Treponema T. pallidum most significant-syphilis Only found in humans Cannot use light microscope Syphilis Primary-lesions at site of inoculation and some lymph node involvement Secondary-flu-like symptoms, more wide spread lymp node involvement and lesions over the body Tertiary or late stage-any body system may be involved-Neurosyphilis is worst Hyaluronidase is important for virulence Also can become coated with fibronectin No vaccine available and can be reinfected Borrelia Causes Relapsing fever and Lyme disease Relapsing fever-two kinds Epidemic-louse borne-body to body contact-single relapse Endemic-soft ticks-multiple relapses Lyme disease B. burgdorferi-stretched out spirochete Typical symptoms- Erythema migrans-wandering rash-bullseye Low grade fever, malaise, myalgia flu-like symptoms Can develop long-term neuritis if left untreated. Onset from 1 month to 2 years after infection Social factors involved in Lyme Vaccine-OspA once available but recalled Mycoplasma and ureaplasma No cell wall, but have sterols in cell membrane Smallest free living bacteria M. pnuemoniae is most significant pathogen Causes walking pneumonia and tracheobronchitis 18 million cases in US in 1998 Expresses P1 protein that binds to the base of cilia on epithelial cells. Eventually the cilia stop moving and the cells are sloughed off This allows secondary infections with bacteria that are often treated rather than the primary infection U. urealyticum (some strains)causes nongonococcal urethritis. Commonly found in sexually active individuals May cause sterility in females, PID, salpyngitis etc. similar to GC
