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Iron, Anemia, and Dialysis Iron makes red blood cells, which carry oxygen throughout the body. This oxygen is necessary for energy. The kidneys signal the body to make red blood cells, but when you have chronic kidney disease, the kidneys may not secrete enough erythropoietin to send this signal. If enough red blood cells are not made, a person develops anemia. Iron is important for the health of red blood cells. Your doctor may prescribe an erythropoietin-stimulating agent, and you will need extra iron to increase the medication’s effectiveness. This is because your iron will become depleted as it is used in new hemoglobin molecules created after administration of the erythropoietin. Iron and oxygen make hemoglobin, which is the part of the red blood cell that carries oxygen. Testing You will receive iron testing each month until your hemoglobin reaches normal levels, after which you will have testing every 3 months. If you have kidney disease, you should have your hemoglobin measured at least annually. Cardiac problems Anemia is even more likely to occur in people who have diabetes, are African American, or are female. Anemia can cause serious, life-threatening cardiac problems. When a person is anemic, the heart has to work harder to pump blood throughout the body in order to meet oxygen demands. This leads to thickened muscle on the left side of the heart, which results in a condition called left ventricular hypertrophy. It is estimated that 80% of patients have left ventricular hypertrophy when they start dialysis. Having high blood pressure also increases the risk for developing left ventricular hypertrophy. Iron-deficiency anemia People on dialysis are at an even greater risk for developing iron-deficiency anemia, because their diet is more limited and blood is lost during dialysis. Symptoms of iron-deficiency anemia include: Lethargy Weakness Pallor Depression Irritability Poor appetite Trouble breathing Chest pain Dizziness or light-headedness Headaches Confusion Insomnia Cravings for strange things, such as dirt or ice Numbness or coldness of the extremities Tachycardia Brittle fingernails Restless legs syndrome Tips to help you feel better These suggestions might help you feel better: See a dietitian, who can help you work iron-rich foods, such as the following, into your diet: – Beef liver – Beef, pork, venison, and lamb – Cream of Wheat® – Dried fruits (raisins, dates, prunes, and apricots) – Fish and shellfish – Greens (spinach, kale, mustard greens, collard greens, and turnip greens) – Iron-fortified whole grains – Legumes and beans – Poultry (turkey, chicken, etc) – Raisin bran – Some vegetables (broccoli, asparagus, Brussels sprouts, potatoes, and peas) – Tofu and soy-based meat alternatives (veggie burgers) Take an iron supplement as prescribed by your physician Follow your doctor’s advice about taking a multivitamin and mineral supplement that contains iron, vitamin B12, and folic acid Receive intravenous iron at your doctor’s office, if suggested References and recommended readings American Association of Kidney Patients. Anemia and kidney disease: what you should know. Available at: http://www.aakp.org/aakp-library/anemia-kidney-disease/. Accessed September 4, 2012. National Kidney Foundation™. Anemia and Chronic Kidney Disease: Stages 1–4. Available at: http://www.kidney.org/atoz/pdf/anemia.pdf. Accessed November 10, 2012. National Kidney Foundation. Iron and Chronic Kidney Disease: What You Need to Know. Available at: http://www.kidney.org/atoz/pdf/11-100284_PatBro_IronDeficiency.pdf. Accessed November 10, 2012. National Kidney Foundation. Iron needs in dialysis. Available at: http://www.kidney.org/atoz/content/ironDialysis.cfm. Accessed November 10, 2012. Contributed by Elaine M. Koontz, RD, LD/N Review Date 11/12 R-0594