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SENSES ANSWERS 4) Sequences which make sense Rearrange the following 10 concepts relating stimulation of a Pacinian corpuscle into a numbered chronological sequence which shows how one leads to the next (as in a concept map). 1. Vibrator applied to skin 7.Firing of action potentials down axon 5.Generator potential develops at initial segment 10.Rapid adaptation of membrane potential 4.Na influx and K efflux occurs 8.Synaptic transmission occurs in thalamus 2.Deformation of connective tissue layers 6.Threshold for action potential reached in axon 3.Cation channels mechanically opened 9.Awareness of sensation occurs in somatosensory cortex 1. Vibrator applied to skin ↓ 2.Deformation of connective tissue layers ↓ 3.Cation channels mechanically opened ↓ 4.Na influx and K efflux occurs ↓ 5.Generator potential develops at initial segment ↓ 6.Threshold for action potential reached in axon ↓ 7.Firing of action potentials down axon ↓ 8.Synaptic transmission occurs in thalamus ↓ 9.Awareness of sensation occurs in somatosensory cortex ↓ 10.Rapid adaptation of membrane potential Concept maps Touch pressure sensory neurone Temperature perception SENSES ANSWERS from Reflexes Misconception MCQ Answer d) Extra notes Pupillary Reflexes ( From Senses Practical notes) The pupillary reflexes, particularly the light reflexes, are of great clinical importance. ........................................................................................................................................ Knowing these actions you can predict the consequences of applying drugs to the eye, as is done in visual examinations. What will happen to pupil diameter and lens power if (i) atropine (ii) adrenaline is used? (i) Atropine is a muscarinic cholinergic antagonist, so will block transmission from all the motoneurons onto the smooth muscles in the parasympathetic pathways. The circular muscle of the iris of both pupils will relax, resulting in dilation of both pupils. The ciliary muscle of the lens will also relax, resulting in flattening of the lens and less power. (ii) Adrenaline is a sympathetic agonist, so will stimulate the smooth muscles activated by sympathetic pathways. The radial muscle of the iris of both pupils will contract, also resulting in dilation of both pupils. The ciliary muscle of the lens will also relax, producing the same lens flattening and decreased power as with atropine. Concept map 1.Light shone into left eye 2. APs travel along left optic nerve to synapse in left & right Edinger -Westphal nuclei 7. Pupillary constriction occurs 3. APs travel along left & right oculomotor nerves to synapse in ciliary ganglia 6. APs in sympathetic nerves to radial dilator smooth muscle cells of both pupils are inhibited 4. APs travel in parasympathetic nerves to circular smooth muscle cells of irises of both pupils 5. Simultaneously descending inputs from cortex, hypothalamus, midbrain are inhibited