Upregulation of the cardiac homeobox gene Nkx2–5 (CSX) in feline
... been shown to evoke certain changes in cardiac transcription. Several gene products are reexpressed that are only otherwise expressed during cardiac development. Examples include b-myosin heavy chain (17, 23, 25), ANF (28), a-skeletal actin (26), and atrial myosin light chain-1 (16). This suggests t ...
... been shown to evoke certain changes in cardiac transcription. Several gene products are reexpressed that are only otherwise expressed during cardiac development. Examples include b-myosin heavy chain (17, 23, 25), ANF (28), a-skeletal actin (26), and atrial myosin light chain-1 (16). This suggests t ...
Ventriculoarterial Coupling in Normal and Failing Heart in Humans
... however, that the physiological control mechanisms indeed adopt this criterion for optimal coupling between the heart and artery under physiological circumstances in vivo. Another criterion for optimal coupling between an energy source and its load is the principle of economical fuel consumption, or ...
... however, that the physiological control mechanisms indeed adopt this criterion for optimal coupling between the heart and artery under physiological circumstances in vivo. Another criterion for optimal coupling between an energy source and its load is the principle of economical fuel consumption, or ...
Innovating In A Conventional Market
... some patients where lead placement proves too difficult to implant a device. For those patients who cannot be treated with CRT, there are often no other treatment options to stem the progressive cascade of heart failure with its cycle of repeated hospitalizations until their condition deteriorates t ...
... some patients where lead placement proves too difficult to implant a device. For those patients who cannot be treated with CRT, there are often no other treatment options to stem the progressive cascade of heart failure with its cycle of repeated hospitalizations until their condition deteriorates t ...
Congenital pericardial defects
... Four cases of congenital defect of the pericardium are described; three had complete absence of the left pericardium and one had a partial defect. One of the patients developed acute pulmonary oedema in the immediate post-operative period following repair of a sinus venosus defect. This complication ...
... Four cases of congenital defect of the pericardium are described; three had complete absence of the left pericardium and one had a partial defect. One of the patients developed acute pulmonary oedema in the immediate post-operative period following repair of a sinus venosus defect. This complication ...
opinions and hypotheses
... combined biventricular pacemaker and defibrillator because sudden cardiac death accounts for 30 to 50% of the deaths in class IV patients.3,4,19,28 –31 Longer follow-up and other controlled studies will be required to determine the role and safety of biventricular pacing in the treatment of CHF and ...
... combined biventricular pacemaker and defibrillator because sudden cardiac death accounts for 30 to 50% of the deaths in class IV patients.3,4,19,28 –31 Longer follow-up and other controlled studies will be required to determine the role and safety of biventricular pacing in the treatment of CHF and ...
AHA/ASA Guideline - Professional Heart Daily
... mechanisms • Conventional clinical definitions focal neurological symptoms or signs lasting less than 24 hours has been defined as a TIA • One-third of those are found to have an infarct on brain imaging ...
... mechanisms • Conventional clinical definitions focal neurological symptoms or signs lasting less than 24 hours has been defined as a TIA • One-third of those are found to have an infarct on brain imaging ...
Acute Ischemic Stroke Management
... The purpose of the “Acute Ischemic Stroke Management” course is to provide evidence-based literature to help prepare nurses for the challenges the acute ischemic stroke patient may present during their emergency department and hospital stays. This course will assist nurses in the early recognition o ...
... The purpose of the “Acute Ischemic Stroke Management” course is to provide evidence-based literature to help prepare nurses for the challenges the acute ischemic stroke patient may present during their emergency department and hospital stays. This course will assist nurses in the early recognition o ...
Atorvastatin Slows the Progression of Cardiac Remodeling
... Ventricular myocytes were isolated from neonatal rats at 2 to 3 days of life and cultured as described previously (8). In brief, the cardiomyocytes were incubated for 72 h in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal calf serum and then grown for 48 h under serum-free conditions ...
... Ventricular myocytes were isolated from neonatal rats at 2 to 3 days of life and cultured as described previously (8). In brief, the cardiomyocytes were incubated for 72 h in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal calf serum and then grown for 48 h under serum-free conditions ...
A cardiovascular-respiratory control system
... are global control mechanisms that act on the entire system to maintain appropriate blood flow and these mechanisms are supplemented by local mechanisms in each vascular region which act to shunt blood to those regions where demand is high and away from areas where demand is low. The overall control ...
... are global control mechanisms that act on the entire system to maintain appropriate blood flow and these mechanisms are supplemented by local mechanisms in each vascular region which act to shunt blood to those regions where demand is high and away from areas where demand is low. The overall control ...
Delaying shock for cardiopulmonary resuscitation
... drop precipitously. During this initial period, the intravascular volume redistributes into the venous and right-sided heart system. As the right side of the heart distends and the left side empties, a low-pressure gradient continues in providing some small amount of coronary and carotid flow. After ...
... drop precipitously. During this initial period, the intravascular volume redistributes into the venous and right-sided heart system. As the right side of the heart distends and the left side empties, a low-pressure gradient continues in providing some small amount of coronary and carotid flow. After ...
From cardiac electrical activity to the ECG
... clinical measurements when comparing local deformation patterns. Furthermore, simulations were performed to study whether the model is able to simulate cardiac wall strain for normal activation and in case of a left bundle branch block (LBBB)[29]. The activation sequence was adjusted to what was fou ...
... clinical measurements when comparing local deformation patterns. Furthermore, simulations were performed to study whether the model is able to simulate cardiac wall strain for normal activation and in case of a left bundle branch block (LBBB)[29]. The activation sequence was adjusted to what was fou ...
Human Identification Using the Main Loop of the Vectorcardiogram
... After filtering, individual complete ECG signals are extracted from each record. As the QRS wave shows great stability with the change of the Heart Rate on the contrary to both the T and P waves, the end of the T wave point and the boundaries of the QRS complex are delineated by using minimum radius ...
... After filtering, individual complete ECG signals are extracted from each record. As the QRS wave shows great stability with the change of the Heart Rate on the contrary to both the T and P waves, the end of the T wave point and the boundaries of the QRS complex are delineated by using minimum radius ...
Accident Medical Expense Pays for out-of
... atrial fibrillation and flutter, and ventricular fibrillation and flutter. Heart attack: a myocardial infarction resulting in the death of an area of the heart muscle due to insufficient blood supply to that area. The basis of the diagnosis must include: • Serial measurements of cardiac biomarkers s ...
... atrial fibrillation and flutter, and ventricular fibrillation and flutter. Heart attack: a myocardial infarction resulting in the death of an area of the heart muscle due to insufficient blood supply to that area. The basis of the diagnosis must include: • Serial measurements of cardiac biomarkers s ...
The heart requires glycerol as an energy substrate through
... and substrates that may serve as possible candidates for a cardiac energy source have not been fully studied. Several reports showed that a moderate expression of aquaporin 7 (AQP7), a member of the aquaglyceroporin family that is permeated by glycerol and water, is observed in heart tissue. However ...
... and substrates that may serve as possible candidates for a cardiac energy source have not been fully studied. Several reports showed that a moderate expression of aquaporin 7 (AQP7), a member of the aquaglyceroporin family that is permeated by glycerol and water, is observed in heart tissue. However ...
a patient`s guide to heart valve surgery
... Valve repair or replacement surgeries have been performed safely and effectively for many years. Advances in surgical techniques and new products have led to the development of minimally invasive cardiac surgery. Minimally invasive valve surgery involves a smaller incision than the one the surgeon m ...
... Valve repair or replacement surgeries have been performed safely and effectively for many years. Advances in surgical techniques and new products have led to the development of minimally invasive cardiac surgery. Minimally invasive valve surgery involves a smaller incision than the one the surgeon m ...
Riley Hospital for Children - Indiana University Department of
... children with failing hearts. The basic and translational research team is supported by a National Institutes of Health Program Project grant, a major institutional grant looking at the cause and treatment of heart failure in children. Combined with Riley Hospital’s pioneering approach to family-cen ...
... children with failing hearts. The basic and translational research team is supported by a National Institutes of Health Program Project grant, a major institutional grant looking at the cause and treatment of heart failure in children. Combined with Riley Hospital’s pioneering approach to family-cen ...
Device-Based Therapy of Cardiac Rhythm Abnormalities
... whenever possible, evidence based. The schema for classification of recommendations and level of evidence is summarized in Table 1, which also illustrates how the grading system provides an estimate of the size of the treatment effect and an estimate of the certainty of the treatment effect. The fol ...
... whenever possible, evidence based. The schema for classification of recommendations and level of evidence is summarized in Table 1, which also illustrates how the grading system provides an estimate of the size of the treatment effect and an estimate of the certainty of the treatment effect. The fol ...
Percutaneous Mitral Valve Intervention and modelling with multi
... respectively. Death rates were similar (17.4 vs. 17.8%, p=0.91) as was the incidence of MR grade 3 / 4 + (21.7 vs. 24.7%, p= 0.745), respectively. Surgery for mitral valve dysfunction occurred in 24 vs. 5.5 %, respectively, (p<0.001) at four years. The EVEREST II trial confirmed that following Mitra ...
... respectively. Death rates were similar (17.4 vs. 17.8%, p=0.91) as was the incidence of MR grade 3 / 4 + (21.7 vs. 24.7%, p= 0.745), respectively. Surgery for mitral valve dysfunction occurred in 24 vs. 5.5 %, respectively, (p<0.001) at four years. The EVEREST II trial confirmed that following Mitra ...
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... • Etiology: There is a re-entrant pathway looping in a ventricle (most common cause). ...
... • Etiology: There is a re-entrant pathway looping in a ventricle (most common cause). ...
FETAL ARRYTHMIAS FETAL CARDIOLOGY ABSTRACT
... orthodromic reciprocating atrioventricular tachycardia. The reentry circuit in this type of supraventricular tachycardia conducts antegradely through atrioventricular node and retrogradely through an accessory pathway. The rate of this tachycardia is usually 220 to 240 beats per minute with little b ...
... orthodromic reciprocating atrioventricular tachycardia. The reentry circuit in this type of supraventricular tachycardia conducts antegradely through atrioventricular node and retrogradely through an accessory pathway. The rate of this tachycardia is usually 220 to 240 beats per minute with little b ...
CPR Course
... • In SCA, ventricular tachycardia or ventricular fibrillation causes the heart to beat too fast. ● Ventricular tachycardia (VT), a dangerously fast rhythm in the lower two chambers of the heart. ● Ventricular fibrillation (VF), a rapid and chaotic quivering of the ventricles, which can be triggered ...
... • In SCA, ventricular tachycardia or ventricular fibrillation causes the heart to beat too fast. ● Ventricular tachycardia (VT), a dangerously fast rhythm in the lower two chambers of the heart. ● Ventricular fibrillation (VF), a rapid and chaotic quivering of the ventricles, which can be triggered ...
LRRC10 is required to maintain cardiac function in - AJP
... machinery embedded in the Z-disc cytoskeleton, and sarcolemma (25, 38, 49). At the whole organ level, the heart undergoes hypertrophy as an adaptive mechanism to maintain cardiac output and reduce ventricular wall stress (20, 23, 38). While initially beneficial, prolonged cardiac hypertrophy becomes ...
... machinery embedded in the Z-disc cytoskeleton, and sarcolemma (25, 38, 49). At the whole organ level, the heart undergoes hypertrophy as an adaptive mechanism to maintain cardiac output and reduce ventricular wall stress (20, 23, 38). While initially beneficial, prolonged cardiac hypertrophy becomes ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.