Inotropic, chronotropic, and dromotropic effects - AJP
... activation of pacemaker cells and cardiac muscle cells when a quite narrow stimulation pulse duration (0.01–0.06 ms) for parasympathetic nerve stimulation was used (8). To stimulate extracardiac parasympathetic efferent nerves to the heart, two fine copper needle electrodes were inserted into each c ...
... activation of pacemaker cells and cardiac muscle cells when a quite narrow stimulation pulse duration (0.01–0.06 ms) for parasympathetic nerve stimulation was used (8). To stimulate extracardiac parasympathetic efferent nerves to the heart, two fine copper needle electrodes were inserted into each c ...
Contractility and ischemic response of hearts from transgenic mice
... Left ventricular developed pressure was higher in TG hearts as compared to hearts from paired non-TG animals. This increase was not due to hypertrophy. In addition, there was no decrease in LVDP of transgenic hearts when extracellular Ca2+ was decreased from 1.75 to 1.25 mM, and β−adrenergic respons ...
... Left ventricular developed pressure was higher in TG hearts as compared to hearts from paired non-TG animals. This increase was not due to hypertrophy. In addition, there was no decrease in LVDP of transgenic hearts when extracellular Ca2+ was decreased from 1.75 to 1.25 mM, and β−adrenergic respons ...
120102EZ Manual
... • Filtration (sterile filter 0.45µm) in the course of preparation and inclusion of 1µm filters in recirculating perfusion circuits to remove precipitants and denatured proteins. • Making up fresh (not storing) glucose- or substrate-containing buffers which are good bacterial growth media. If buffe ...
... • Filtration (sterile filter 0.45µm) in the course of preparation and inclusion of 1µm filters in recirculating perfusion circuits to remove precipitants and denatured proteins. • Making up fresh (not storing) glucose- or substrate-containing buffers which are good bacterial growth media. If buffe ...
Decreased Expression of the Cardiac LIM Domain
... To address this question, we investigated MLP expression in the failing left ventricular myocardium from patients with dilated and ischemic cardiomyopathy. MLP protein concentrations were significantly decreased in failing hearts, whereas MLP mRNA concentrations were unchanged compared with non-fail ...
... To address this question, we investigated MLP expression in the failing left ventricular myocardium from patients with dilated and ischemic cardiomyopathy. MLP protein concentrations were significantly decreased in failing hearts, whereas MLP mRNA concentrations were unchanged compared with non-fail ...
Electrophysiology Circulation: Arrhythmia &
... Disclaimer: The manuscript and its contents are confidential, intended for journal review purposes only, and not to be further disclosed. ...
... Disclaimer: The manuscript and its contents are confidential, intended for journal review purposes only, and not to be further disclosed. ...
ABC of clinical electrocardiography Broad complex tachycardia—Part I
... It is important to scrutinise the tracings from all 12 leads of the electrocardiogram, as P waves may be evident in some leads but not in others ...
... It is important to scrutinise the tracings from all 12 leads of the electrocardiogram, as P waves may be evident in some leads but not in others ...
Venous Thromboembolism Increases the Risk of Atrial Fibrillation
... adjusted for potential confounders including sex, BMI, smoking status, diastolic blood pressure, cholesterol levels, selfreported CVD, and diabetes. In addition, subgroup analyses of PE and DVT as exposure variables for atrial fibrillation were performed. Since the incidence of both VTE and atrial fib ...
... adjusted for potential confounders including sex, BMI, smoking status, diastolic blood pressure, cholesterol levels, selfreported CVD, and diabetes. In addition, subgroup analyses of PE and DVT as exposure variables for atrial fibrillation were performed. Since the incidence of both VTE and atrial fib ...
What Is A Patent Foramen Ovale?
... complications associated with the long-term use of these drugs, many cardiologists have recommended that PFOs be closed. Closure may eliminate the need to continue the use of anticoagulants and/or platelet inhibitors and reduce the risk of recurrent stroke or transient ischemic attack (TIA). ...
... complications associated with the long-term use of these drugs, many cardiologists have recommended that PFOs be closed. Closure may eliminate the need to continue the use of anticoagulants and/or platelet inhibitors and reduce the risk of recurrent stroke or transient ischemic attack (TIA). ...
NIH Public Access - Scientific Computing and Imaging Institute
... ICD systems typically utilize transvenous ICD leads in a standard SVC-RV coil orientation. Extracardiac ICDs utilizing subcutaneous defibrillation leads (S-ICD) are currently in development.4–6. This concept has generated interest, as it might provide alternative ICD implant strategies allowing more ...
... ICD systems typically utilize transvenous ICD leads in a standard SVC-RV coil orientation. Extracardiac ICDs utilizing subcutaneous defibrillation leads (S-ICD) are currently in development.4–6. This concept has generated interest, as it might provide alternative ICD implant strategies allowing more ...
abnormal curves in terms of the pathological conditions with which
... in each heart beat during normal complete respiratory cycles, and the results averaged. Mean pressures were determined by planimetric integration. The data from arterial pressure records include average maximum (systolic), average minimum (diastolic), and mean pressures. For the auricle, only mean p ...
... in each heart beat during normal complete respiratory cycles, and the results averaged. Mean pressures were determined by planimetric integration. The data from arterial pressure records include average maximum (systolic), average minimum (diastolic), and mean pressures. For the auricle, only mean p ...
Cardiac Arrhythmias: Diagnosis and Management. The Tachycardias
... Summary of review: Normal cardiac rhythm originates from impulses generated within the sinus node. These impulses are conducted to the atrioventricular node where they are delayed before they are distributed to the ventricular myocardium via the His-Purkinje system. Abnormalities in cardiac rhythm a ...
... Summary of review: Normal cardiac rhythm originates from impulses generated within the sinus node. These impulses are conducted to the atrioventricular node where they are delayed before they are distributed to the ventricular myocardium via the His-Purkinje system. Abnormalities in cardiac rhythm a ...
Acute Respiratory Acidosis Decreases Left Ventricular Contractility
... or alternatively, by enhanced venous return and altered loading conditions in the face of decreased left ventricular contractility. To distinguish between these two possibilities, we measured the left ventricular end-systolic pressure-volume relation (ESPVR) and hemodynamics during respiratory acido ...
... or alternatively, by enhanced venous return and altered loading conditions in the face of decreased left ventricular contractility. To distinguish between these two possibilities, we measured the left ventricular end-systolic pressure-volume relation (ESPVR) and hemodynamics during respiratory acido ...
View Dhiraj Gupta`s Resume / CV
... population of 2.8 million, and is the largest cardiac centre in the United Kingdom. I am a very high volume operator in interventional EP, and have performed over 200 ablation cases annually since 2009. I am the trust lead for Left Atrial Appendage Occluder Service, and our hospital is one of 10 sit ...
... population of 2.8 million, and is the largest cardiac centre in the United Kingdom. I am a very high volume operator in interventional EP, and have performed over 200 ablation cases annually since 2009. I am the trust lead for Left Atrial Appendage Occluder Service, and our hospital is one of 10 sit ...
Ex Vivo Reversal of Heparin-Mediated Cardioprotection by
... Glycosaminoglycans, including heparin, have been demonstrated both in vitro and in vivo to protect the ischemic myocardium against reperfusion injury. In the present study, we sought to determine whether the cardioprotective effects of heparin administration could be reversed by the heparin-degradin ...
... Glycosaminoglycans, including heparin, have been demonstrated both in vitro and in vivo to protect the ischemic myocardium against reperfusion injury. In the present study, we sought to determine whether the cardioprotective effects of heparin administration could be reversed by the heparin-degradin ...
CfE Higher Human Biology Unit 2: Physiology and
... The testes are the male reproductive organs. They have two functions: 1. the production of sperm in the seminiferous tubules; 2. the production of testosterone in the interstitial cells, which are found between the seminiferous tubules. Each testis contains several intensely folded seminiferous tubu ...
... The testes are the male reproductive organs. They have two functions: 1. the production of sperm in the seminiferous tubules; 2. the production of testosterone in the interstitial cells, which are found between the seminiferous tubules. Each testis contains several intensely folded seminiferous tubu ...
Higher Human Biology Physiology and Health
... The testes are the male reproductive organs. They have two functions: 1. the production of sperm in the seminiferous tubules; 2. the production of testosterone in the interstitial cells, which are found between the seminiferous tubules. Each testis contains several intensely folded seminiferous tubu ...
... The testes are the male reproductive organs. They have two functions: 1. the production of sperm in the seminiferous tubules; 2. the production of testosterone in the interstitial cells, which are found between the seminiferous tubules. Each testis contains several intensely folded seminiferous tubu ...
ACLS-ECG-Slides - UCSF Department of Anesthesia and
... • Recognize & initiate early management of periarrest conditions that may result in cardiac arrest • Manage cardiac arrest until return of spontaneous circulation, or transfer of care • Understanding of arrhythmia interpretation ...
... • Recognize & initiate early management of periarrest conditions that may result in cardiac arrest • Manage cardiac arrest until return of spontaneous circulation, or transfer of care • Understanding of arrhythmia interpretation ...
Common Pulmonary Vein Atresia
... 1). These strands, however, demonstrate the relationship between CPVA and total anomalous pulmonary venous return. It then becomes only a matter of degree whether the cases of Hastreiter7 and Hauck,8 which showed a confluence of pulmonary veins and a small accessory pulmonary vein draining one of th ...
... 1). These strands, however, demonstrate the relationship between CPVA and total anomalous pulmonary venous return. It then becomes only a matter of degree whether the cases of Hastreiter7 and Hauck,8 which showed a confluence of pulmonary veins and a small accessory pulmonary vein draining one of th ...
Therapeutic effect of MG132 on diabetic cardiomyopathy is
... increased in these mice with a progressive manner from 3 to 6 months (P<0.05, Fig. 1B). However, ...
... increased in these mice with a progressive manner from 3 to 6 months (P<0.05, Fig. 1B). However, ...
Full Text
... levels and troponins (25,28,29,36,40,41) and larger reductions in strain or SR measurements, suggesting that there is biological plausibility for these findings. Prognostic value of myocardial deformation parameters to detect cardiotoxicity. Although the early detection of myocardial changes appears ...
... levels and troponins (25,28,29,36,40,41) and larger reductions in strain or SR measurements, suggesting that there is biological plausibility for these findings. Prognostic value of myocardial deformation parameters to detect cardiotoxicity. Although the early detection of myocardial changes appears ...
Hypertrophic Cardiomyopathy: A Review
... The MV apparatus abnormalities can include anterior displacement of papillary muscles, hypertrophied papillary muscles touching the septum, elongated mitral leaflets, or anomalous insertion of the papillary muscle onto the anterior mitral leaflet.18,21,22 LVOTO can be precipitated or aggravated by d ...
... The MV apparatus abnormalities can include anterior displacement of papillary muscles, hypertrophied papillary muscles touching the septum, elongated mitral leaflets, or anomalous insertion of the papillary muscle onto the anterior mitral leaflet.18,21,22 LVOTO can be precipitated or aggravated by d ...
Progressive muscle metaboreflex activation gradually decreases
... averaging all slopes computed within a given test period, was calculated and taken as a measure of spontaneous baroreflex sensitivity for that period. Sinoaortic baroreflex denervation virtually abolishes baroreflex sensitivity assessed via this method, indicating that these spontaneous reciprocal H ...
... averaging all slopes computed within a given test period, was calculated and taken as a measure of spontaneous baroreflex sensitivity for that period. Sinoaortic baroreflex denervation virtually abolishes baroreflex sensitivity assessed via this method, indicating that these spontaneous reciprocal H ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.