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Cephalosporins
Cephalosporins

... spread of antimicrobial resistance. 4. Fourth generation: Cefepime [SEF-eh-peem] is classified as a fourth generation cephalosporin and must be administered parenterally. Cefepime has a wide antibacterial spectrum, being active against streptococci and staphylococci (but only those that are methicil ...
Prescribing Information
Prescribing Information

... glomerular counts in newborn rats when administered systemically to pregnant rats in daily doses approximately 500 times the maximum recommended ophthalmic human dose. There are no adequate and well-controlled studies in pregnant women. Gentamicin should be used during pregnancy only if the potentia ...
Metronidazole - American Academy of Veterinary Pharmacology
Metronidazole - American Academy of Veterinary Pharmacology

... causing a loss of helical structure and strand breakage in the DNA; these effects inhibit nucleic acid synthesis and cause death of the cell. ...
Ocuflox - Allergan
Ocuflox - Allergan

... There are, however, no adequate and well-controlled studies in pregnant women. OCUFLOX® solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing Mothers In nursing women a single 200 mg oral dose resulted in concentrations of ofloxacin ...
pi_azactam_injection - Products - Bristol
pi_azactam_injection - Products - Bristol

... AZACTAM (aztreonam for injection, USP) and other antibacterial drugs, AZACTAM should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecti ...
Pharmacology of Systemic Antibacterial Agents
Pharmacology of Systemic Antibacterial Agents

... The P-site initially is occupied by the fMet-tRNA complex. As the next charged tRNA binds to the 70S ribosomal unit, but before it is allowed to enter the unoccupied A-site, the rRNA must confirm that the charged tRNA carries the specific amino acid called for by the mRNA codon.54 If access is allow ...
Ranzith®
Ranzith®

... Avoid concomitant administration with terfenadine or astemazole. Precaution should be taken in patients with severe renal impairment. Overdosage There is no data on over dosage with Azithromycin. Typical symptoms of over dosage with macrolide antibiotics include hearing loss, severe nausea, vomiting ...
A Quick Reference to Drugs commonly used in the
A Quick Reference to Drugs commonly used in the

... GI side effects, Headaches, dizziness, drowsiness, insomnia, arthralgia. ...
Gentamicin
Gentamicin

... • Polymyxins are active mainly against gramnegative bacilli, particulary pseudomonas and coliform organisms. Mechanism of action of polymyxins Polymyxins act by attaching to the cell membranes of bacteria and other membranes rich in phosphatidylethanolamin (磷脂酰乙醇胺) and disrupting the osmotic propert ...
Gentamicin
Gentamicin

... • Polymyxins are active mainly against gramnegative bacilli, particulary pseudomonas and coliform organisms. Mechanism of action of polymyxins Polymyxins act by attaching to the cell membranes of bacteria and other membranes rich in phosphatidylethanolamin (磷脂酰乙醇胺) and disrupting the osmotic propert ...
DOXYCYCLINE CAPSULES, USP
DOXYCYCLINE CAPSULES, USP

... growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic ...
Cefuroxime Basics
Cefuroxime Basics

... Surgical prophylaxis: I.V.: 1.5 g 30 minutes to 1 hour prior to procedure (if procedure is prolonged can give 750 mg every 8 hours I.M.) Cholecystectomy: I.V.: 1.5 g every 8 hours, discontinue within 24 hours unless infection outside gallbladder suspected Open heart: I.V.: 1.5 g every 12 hours to a ...
Cefazolin Injection, USP in GALAXY Container (PL 2040
Cefazolin Injection, USP in GALAXY Container (PL 2040

... A false positive reaction for glucose in the urine may occur with Benedict’s solution, Fehling’s solution or with CLINITEST ® tablets, but not with enzyme-based tests such as CLINISTIX ® . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose ...
DENS 521 4th SF
DENS 521 4th SF

... skin and skin structure infections and community-acquired bacterial pneumonia  This antimicrobial agent binds to penicillin binding proteins (PBP) inhibiting cell wall synthesis and has a high affinity for PBP2a, which is associated with methicillin resistance  Ceftaroline is consistently active a ...
Serum Creatinine Measuring serum creatinine is a useful and
Serum Creatinine Measuring serum creatinine is a useful and

... The kidney's properties of high blood flow, filtration, reabsorption and concentration allow nephrotoxins to accumulate. A patient's BUN and creatinine should always be checked before giving nephrotoxic drugs. If either level is above the normal range, the drug should be held and the patient's physi ...
Erythormycin Ointment Sell Sheet - Akorn
Erythormycin Ointment Sell Sheet - Akorn

... B. Reproduction studies have been performed in Streptococcus pyogenes (group A β-hemolytic) rats, mice, and rabbits using erythromycin and its Alpha-hemolytic streptococci (viridans group) Staphylococcus aureus, including penicillinase- various salts and esters, at doses that were several producing ...
Macrolids
Macrolids

... duration of treatment in many cases. For example, a single 1-g dose of azithromycin is as effective as a 7-day course of doxycycline for chlamydial cervicitis and urethritis. Community-acquired pneumonia can be treated with azithromycin given as a 500-mg loading dose, followed by a 250-mg single dai ...
Penicillin VK - The Main Line Center for the Family
Penicillin VK - The Main Line Center for the Family

... staphylococci. The drug exerts high in vitro activity against staphylococci (except penicillinaseproducing strains), streptococci (groups A, C, G, H, L and M), and pneumococci. Other organisms sensitive in vitro to penicillin V are Corynebacterium diphtheriae, Bacillus anthracis, Clostridia, Actinom ...
DENS 521 4th S
DENS 521 4th S

... skin and skin structure infections and community-acquired bacterial pneumonia  This antimicrobial agent binds to penicillin binding proteins (PBP) inhibiting cell wall synthesis and has a high affinity for PBP2a, which is associated with methicillin resistance  Ceftaroline is consistently active a ...
Levofloxacin 0.5% Eye Drops
Levofloxacin 0.5% Eye Drops

... No teratogenic effect was observed when rabbits were dosed orally as high as 50 mg/kg/day, which corresponds to approximately 400 times the highest recommended maximum human ophthalmic dose, or when dosed intravenously as high as 25 mg/kg/day, corresponding to approximately 200 times the highest rec ...
Dynacin Prescribing Information
Dynacin Prescribing Information

... growth rate has been observed in premature human infants given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and ca ...
Zimax
Zimax

... it should not be used in patients with hepatic disease. Avoid concomitant administration with terfenadine or astemizole. Precaution should be taken in patients with more severe renal impairment. SIDE EFFECT Zimax® (Azithromycin) is well tolerated with a low incidence of side-effects. The side-effect ...
new zealand data sheet
new zealand data sheet

... Upper respiratory tract infections, Genito-urinary tract infections, skin and soft tissue infections For upper respiratory tract infections due to streptococci, pneumococci, non-penicillinaseproducing staphylococci and H. influenzae) or Genito-Urinary Tract Infections (due to Escherichia coli, Prote ...
Systemic Antibiotics
Systemic Antibiotics

... Mechanism of action. The mechanism of action of cephalosporins is the inhibition of the bacterial cell-wall synthesis similar to that of penicillin. It is important to realise that cephalosporins are not active against the following microorganisms: MRSA, methicillin-resistant CNS, Enterococcus spp., ...
Acute Bacterial Conjunctivitis
Acute Bacterial Conjunctivitis

... Both ciprofloxacin and ofloxacin exhibits a similar bactericidal potency and spectrum. Both have been compared with tobramycin when it comes to the management of bacterial conjunctivitis. Gwon et al compared the efficacy and safety of 0.3% ofloxacin with 0.3% tobramycin when treating patients with e ...
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Ciprofloxacin



Ciprofloxacin is an antibiotic used to treat a number of bacterial infections. This includes bone and joint infections, intra abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. For some infections it is used in addition to other antibiotics. It can be taken by mouth or used intravenously.Common side effects include nausea, vomiting, diarrhea, and rash. Ciprofloxacin increases the risk of tendon rupture and worsening muscle weakness in people with the neurological disorder myasthenia gravis. Rates of side effects appear to be higher than some groups of antibiotics such as cephalosporins but lower than others such as clindamycin. Studies in other animals raise concerns regarding use in pregnancy. No problems were identified; however, in the children of a small number of women who took the medication. It appears to be safe during breastfeeding. It is a second-generation fluoroquinolone with a broad spectrum of activity.Ciprofloxacin was introduced in 1987. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication and not very expensive. Wholesale it costs between 0.03 and 0.13 USD a dose. In the United States it is sold for about 0.40 USD per dose.
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