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Genetics - Max Appeal!
Genetics - Max Appeal!

... deletion, or it could be as few as 1:6,000. It is the most frequently occurring chromosome deletion and the second most common cause of congenital heart defects. The frequency of diagnosis has increased enormously over the past decade or so and many individuals who are now found to have the deletion ...
Inheritance Patterns - Santa Susana High School
Inheritance Patterns - Santa Susana High School

... – monosomic - Turner Syndrome (XO) • only viable monosomic disorder in humans • 1/500 births • sterile, less developed secondary sex characteristics (better with estrogen therapy) ...
Genetic Diseases Research Project
Genetic Diseases Research Project

... Triple-X Syndrome (Trisomy X) Turner’s syndrome XYY Syndrome ...
Long QT Syndrome
Long QT Syndrome

... syncope, family h/o SCD, deafness  7 genetic defects  Important for identifying arrhythmia triggers  LQT1 = exercise-related  LQT2 = auditory stimuli  LQT3 = at rest or sleep; no benefit from BB  Most cases discovered after syncope or arrest ...
No Slide Title
No Slide Title

... Test individuals with “odd” sex: – XY females (lack SRY and define portion of Y not required for sex determination) – XX males (have acquired SRY and define portion of Y essential for sex determination) ...
Zoo/Bot 3333
Zoo/Bot 3333

... a) a chromosomal translocation in B cells leads to uncontrolled growth; b) the myc gene is turned on inappropriately; c) the normal maturation process leading to antibody diversity has functioned inappropriately; d) all of the above; e) none of the above. Questions 6-8 pertain to the following. Mr. ...
Karyotype - Ms. Fuller's Biology Class
Karyotype - Ms. Fuller's Biology Class

... chromosome 5p deletion syndrome or Lejeune’s syndrome.  Caused by a deletion of part of chromosome 5  1:50,000 live births, slightly more common in girls.  Symptoms:  Cognitive delays, unique facial features, unique cry ...
Chromosomal Disorders
Chromosomal Disorders

... infantile Tay-Sachs= • Ashkenazi Jewish groups, French Canadian & Cajun: 1 in 30 are carriers • other groups: 1 in 300 are carriers ...
Chromosomal Disorders
Chromosomal Disorders

... infantile Tay-Sachs= • Ashkenazi Jewish groups, French Canadian & Cajun: 1 in 30 are carriers • other groups: 1 in 300 are carriers ...
Karotype Chromosomal Abnormalities
Karotype Chromosomal Abnormalities

... In your groups, brainstorm 3 reasons why genetic diversity can be beneficial ...
Ch. 7 (part 2)
Ch. 7 (part 2)

... Nail-Patella Syndrome – Autosomal dominant: abnormal fingernails and absent (underdeveloped kneecaps) ...
The Genetics of Williams syndrome: An Update
The Genetics of Williams syndrome: An Update

... to have hypertension. Deletions longer than 28 genes (up to considered a normal variant as it is more than 4% of the 40 or even 50 genes) are associated with more severe intelgeneral population. However, there is absolutely no way lectual disability, and seizures (infantile spasms) which are that a ...
Mutations and Disorders worksheet-ANS
Mutations and Disorders worksheet-ANS

... occurs during meiosis I, all of the cells will be affected and if one of the cells is fertilized it will result in a zygote with too many or too few chromosomes. If nondisjunction occurs during meiosis II, half of the cells will be affected and half will be normal. ...
Cytogenetics and multifactorial inheritance
Cytogenetics and multifactorial inheritance

... (a)Translocation – (t) : reciprocal exchange of chromosome segment (b) Deletion – (del) : loss of genetic material (c) Duplication – (dup) : extra copy of chromosome region (d) Isochromosome – (i) : duplication of one arm and lack of others (e) Ring chromosome – (r) : abnormal repair at distal segme ...
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... change in phenotype, the individual is called a mutant ...
Clinical Genetics
Clinical Genetics

... DiGeorge syndrome, velocardiofacial syndrome, or conotruncal anomaly face syndrome. All three clinical syndromes are autosomal dominant conditions with variable expressivity, caused by a deletion within 22q11.2, spanning about 3 Mb. This microdeletion, also mediated by homologous recombination betwe ...
Ectrodactyly-Ectodermal Dysplasia Clefting (EEC) Syndrome
Ectrodactyly-Ectodermal Dysplasia Clefting (EEC) Syndrome

... some individuals, and there may be defects of the reproductive organs or kidneys. Choanal atresia, recurrent infections and growth hormone deficiency have also been reported. In contrast to some other ectodermal dysplasia syndromes, the inheritance pattern in the EEC syndrome is difficult to determi ...
EVOLUTIONARY PERSPECTIVE
EVOLUTIONARY PERSPECTIVE

... FRAGILE X SYNDROME • More common in boys than girls • Boys 1 in 4,000 and girls 1 in 8,000 • Similar physical features across different ethnicities • Cognitive features like hyperventilation and hypersensitivity ...
Cat Eye Syndrome
Cat Eye Syndrome

... recurrence risk for siblings of a CES patient. However, because mosaicism may produce a normal phenotype, chromosomal examination of both parents is indicated after the birth of an affected child. Even if a chromosome study indicates a non-mosaic diploid karyotype, a hidden, including germline mosai ...
AP Biology
AP Biology

... 1. Define linkage and explain why linkage interferes with independent assortment. 2. Show how cross over frequencies are used to make chromosome maps. 3. Describe the inheritance of sex-linked gene such as color-blindness. 4. Explain how sex is genetically determined in humans and the significance o ...
Karyotypes
Karyotypes

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Notes on Chromosomal Mutations
Notes on Chromosomal Mutations

... CHAPTER 10Chromosome Mutations ...
Jazmin Youngblood - Charcot Marie Tooth Syndrome
Jazmin Youngblood - Charcot Marie Tooth Syndrome

...  Does not shorten lifespan  Symptoms appear from age 5 to 25  Causes muscle atrophy in hands and feet ...
7. Oswaldo Hasb n - Cri-du-Chat
7. Oswaldo Hasb n - Cri-du-Chat

... Cri-du-chat syndrome, also known as 5p- (5p minus) syndrome, is a hereditary, congenital condition of partial aneusomy resulting from deletion of the short arm of chromosome 5. Cri-du-chat (cat’s cry) Syndrome acquires its name from the characteristic high-pitched cry of affected infants that sounds ...
GENETIC ABNORMALITIES
GENETIC ABNORMALITIES

... GENETIC ABNORMALITIES Introduction to Biology ...
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DiGeorge syndrome



DiGeorge syndrome is also known as 22q11.2 deletion syndrome,DiGeorge anomaly, velocardiofacial syndrome (VCFS), Shprintzen syndrome, conotruncal anomaly face syndrome (CTAF) or Takao syndrome, Sedlackova syndrome, Cayler cardiofacial syndrome,Strong syndrome, congenital thymic aplasia, and thymic hypoplasia. This syndrome is caused by the deletion of a small piece of chromosome 22. As such, it is recommended that the name ""22q11.2 deletion syndrome (22q11.2DS)"" be used.22q11.2DS is the most common microdeletion syndrome characterized by low copy repeats and the deletion occurs near the middle of the chromosome at a location designated 22q11.2—signifying its location on the long arm of one of the pair of chromosomes 22, on region 1, band 1, sub-band 2. The inheritance pattern is autosomal dominant and it has a prevalence estimated at 1:4000. The syndrome was described in 1968 by the pediatric endocrinologist Angelo DiGeorge. 22q11 deletion is also associated with truncus arteriosus and tetralogy of Fallot.
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