Benzodiazepines
... • Encourage dependent pts to withdraw, offer them a detoxification programme at regular intervals (at least annually) and document • A significant number of requests for repeat benzodiazepine prescribing are associated with addiction problems, primarily alcohol, or in urban areas, opiate misuse. A d ...
... • Encourage dependent pts to withdraw, offer them a detoxification programme at regular intervals (at least annually) and document • A significant number of requests for repeat benzodiazepine prescribing are associated with addiction problems, primarily alcohol, or in urban areas, opiate misuse. A d ...
ANTI-ANXIETY DRUGS
... • Withdrawal symptoms may occur between doses during continuous use (inter-dose withdrawal). Patients may think these symptoms are due to the original problem. • Withdrawal symptoms: increased anxiety, ...
... • Withdrawal symptoms may occur between doses during continuous use (inter-dose withdrawal). Patients may think these symptoms are due to the original problem. • Withdrawal symptoms: increased anxiety, ...
Benzodiazepines
... U.S. and are mainly used to treat anxiety and insomnia • Second most frequently abused prescription • Combination with other CNS depressants can cause dangerous drug interactions, and contribute to death via overdose ...
... U.S. and are mainly used to treat anxiety and insomnia • Second most frequently abused prescription • Combination with other CNS depressants can cause dangerous drug interactions, and contribute to death via overdose ...
ANXIOLYTICS AND HYPNOTICS
... therapeutic index (severe CNS depressant doses/antianxiety doses) than older agents ...
... therapeutic index (severe CNS depressant doses/antianxiety doses) than older agents ...
Inhalation Anesthetic Agents
... anesthesia such as Halothane, and Neostigmine. It also helps prevent bradycardia from excessive vagal stimulation. There is usually an increase in heart rate and sometimes a tachycardia as well as inhibition of secretions. Since atropine crosses the blood brain barrier, CNS effects in the elderly ma ...
... anesthesia such as Halothane, and Neostigmine. It also helps prevent bradycardia from excessive vagal stimulation. There is usually an increase in heart rate and sometimes a tachycardia as well as inhibition of secretions. Since atropine crosses the blood brain barrier, CNS effects in the elderly ma ...
Converting oral to intravenous or subcutaneous infusions
... Dornase alpha, 2.5mg, neb, BD Midazolam 2mg, IV/SC, PRN max hourly = 0.4(oral bioavailability) x 5mg Midazolam infusion 6mg/24 hours IV = 0.4 x 15mg (total dose in last 24h) Morphine infusion 15mg/24 hours IV = 0.5 (oral bioavailability) x 30mg (total dose in last 24h) Morphine bolus 2.5mg IV/SC PRN ...
... Dornase alpha, 2.5mg, neb, BD Midazolam 2mg, IV/SC, PRN max hourly = 0.4(oral bioavailability) x 5mg Midazolam infusion 6mg/24 hours IV = 0.4 x 15mg (total dose in last 24h) Morphine infusion 15mg/24 hours IV = 0.5 (oral bioavailability) x 30mg (total dose in last 24h) Morphine bolus 2.5mg IV/SC PRN ...
Eye of the Storm: Induction Techniques in Children
... fear of needles fear of hunger and thirst fear of separation fear of being awake in OR loss of autonomy ...
... fear of needles fear of hunger and thirst fear of separation fear of being awake in OR loss of autonomy ...
Benzodiazepines
... implications.1 To be characterized as such, each benzodiazepine displays one or more of the following drug actions: anxiety relief, hypnotic, muscle relaxant, anti-convulsant, or an amnesiatic (mild memory-loss inducer). Due to their sedative properties, benzodiazepines have a high potential for abu ...
... implications.1 To be characterized as such, each benzodiazepine displays one or more of the following drug actions: anxiety relief, hypnotic, muscle relaxant, anti-convulsant, or an amnesiatic (mild memory-loss inducer). Due to their sedative properties, benzodiazepines have a high potential for abu ...
No Slide Title - Open.Michigan
... Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical i ...
... Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical i ...
Benzodiazepine Pharmacology and Central Nervous System
... proved as effective for treating panic disorders as alprazolam, and termination did not cause rebound anxiety symptoms13 because of clonazepam’s long elimination half-life. Because clonazepam displays low lipid solubility, it is less likely to cause anterograde amnesia compared to the other high-pot ...
... proved as effective for treating panic disorders as alprazolam, and termination did not cause rebound anxiety symptoms13 because of clonazepam’s long elimination half-life. Because clonazepam displays low lipid solubility, it is less likely to cause anterograde amnesia compared to the other high-pot ...
Sedatives
... Withdrawal from chronic drug use can lead to rebound increase in REM sleep Anesthesia: o Loss of consciousness may occur at high doses (with amnesia and suppression of reflexes) ...
... Withdrawal from chronic drug use can lead to rebound increase in REM sleep Anesthesia: o Loss of consciousness may occur at high doses (with amnesia and suppression of reflexes) ...
Patient Monitoring and Documentation
... 1) Measure QT and RR interval from rhythm strip before first dose of haloperidol 2) Use Table 1 to determine QTc. 3) Measure QT and RR interval from rhythm strip before each dose successive of haloperidol. 4) Discontinue haloperidol if QTc increases by 25% from baseline. 5) Observe and assess patien ...
... 1) Measure QT and RR interval from rhythm strip before first dose of haloperidol 2) Use Table 1 to determine QTc. 3) Measure QT and RR interval from rhythm strip before each dose successive of haloperidol. 4) Discontinue haloperidol if QTc increases by 25% from baseline. 5) Observe and assess patien ...
Shared care available. Brand prescribing
... Midazolam should be used with caution in patients with chronic renal failure, impaired hepatic or cardiac function. Midazolam may accumulate in patients with chronic renal failure or impaired hepatic function whilst in patients with impaired cardiac function it may cause decreased clearance of midaz ...
... Midazolam should be used with caution in patients with chronic renal failure, impaired hepatic or cardiac function. Midazolam may accumulate in patients with chronic renal failure or impaired hepatic function whilst in patients with impaired cardiac function it may cause decreased clearance of midaz ...
General Anesthetics
... – sodium thiopental Propofol (Diprivan) – similar to thiopental except that it can be used for longer periods of anesthesia Dissociative – ketamine Benzodiazepines – diazepam, midazolam Etomidate (Amidate) Dexmedetomidine (Precedex) Barbiturates ...
... – sodium thiopental Propofol (Diprivan) – similar to thiopental except that it can be used for longer periods of anesthesia Dissociative – ketamine Benzodiazepines – diazepam, midazolam Etomidate (Amidate) Dexmedetomidine (Precedex) Barbiturates ...
Midazolam (Versed) - Paramedic Protocol Provider
... ♦ Reactions such as agitation, involuntary movements (including tonic/clonic movements and muscle tremors), hyperactivity, and combativeness have been reported Contraindications: ♦ Hypersensitivity to benzodiazepines ♦ Narrow angle glaucoma (relative contraindication) ♦ Shock ...
... ♦ Reactions such as agitation, involuntary movements (including tonic/clonic movements and muscle tremors), hyperactivity, and combativeness have been reported Contraindications: ♦ Hypersensitivity to benzodiazepines ♦ Narrow angle glaucoma (relative contraindication) ♦ Shock ...
LOCAL ANESTHETICS,IV SEDATION AND PAIN MANAGEMENT
... katamine • Cataleptic, analgesic, and dissociative anesthetic agent. • Onset of action 30 sec. For IV ,12-25 min for IM dosing. • Dosage:induction 2.0 mg/kg IV over 60 sec or 10 mg/kg IM (adults and children). • Maintenance of anesthesia: 50% of induction dose IV or IM, as anesthesia is lost. ...
... katamine • Cataleptic, analgesic, and dissociative anesthetic agent. • Onset of action 30 sec. For IV ,12-25 min for IM dosing. • Dosage:induction 2.0 mg/kg IV over 60 sec or 10 mg/kg IM (adults and children). • Maintenance of anesthesia: 50% of induction dose IV or IM, as anesthesia is lost. ...
Metabolism - Wayne State University
... Few hours active in CNS Anatagonist – flumazenil (short ½) & no effect on REM ...
... Few hours active in CNS Anatagonist – flumazenil (short ½) & no effect on REM ...
Nasal Drug Delivery in EMS - Intranasal medication delivery
... Elimination of needle eliminates needle stick risk They awaken more gently than with IV naloxone New epidemiology shows prescription drugs (methadone, etc) are causing many deaths that naloxone at home could reverse. Simple enough that lay public can administer Every ambulance system, police agenc ...
... Elimination of needle eliminates needle stick risk They awaken more gently than with IV naloxone New epidemiology shows prescription drugs (methadone, etc) are causing many deaths that naloxone at home could reverse. Simple enough that lay public can administer Every ambulance system, police agenc ...
11/19/2014 Sedative‐Hypnotic and Anxiolytic Medications
... Several generate active metabolites in vivo – Valium®, Librium® and thus have longer activities Half‐lives range from 2 hours to 80 hours Elderly patients metabolize more slowly – half‐lives may reach 7‐10 days for diazepam (Valium®) ...
... Several generate active metabolites in vivo – Valium®, Librium® and thus have longer activities Half‐lives range from 2 hours to 80 hours Elderly patients metabolize more slowly – half‐lives may reach 7‐10 days for diazepam (Valium®) ...
Nasal Drug Delivery in EMS
... kids, 10 mg straight dose in adults) Effective in children and adults (even exited delirium in EMS) Safe – no reports of respiratory depression ...
... kids, 10 mg straight dose in adults) Effective in children and adults (even exited delirium in EMS) Safe – no reports of respiratory depression ...
sedative-hypnotic
... tolerance occurs with prolonged use. Zolpidem is rapidly absorbed from the gastrointestinal tract, and it has a rapid onset of action and short elimination half-life. Zolpidem undergoes hepatic oxidation by the cytochrome P450 system to inactive products. Adverse effects: Agitation, nightmares, head ...
... tolerance occurs with prolonged use. Zolpidem is rapidly absorbed from the gastrointestinal tract, and it has a rapid onset of action and short elimination half-life. Zolpidem undergoes hepatic oxidation by the cytochrome P450 system to inactive products. Adverse effects: Agitation, nightmares, head ...
PREMEDICATION DRUGS
... Midazolam Imidazo – benzodiazepine derivative It is this imidazole ring which imparts water solubility ...
... Midazolam Imidazo – benzodiazepine derivative It is this imidazole ring which imparts water solubility ...
Tranquillizers Benzodiazepines are a group of
... Benzodiazepines can cause dependence (addiction), especially when used regularly for more than a few weeks or at higher doses. Drug users develop a need to continue taking the drug at increasing doses. ...
... Benzodiazepines can cause dependence (addiction), especially when used regularly for more than a few weeks or at higher doses. Drug users develop a need to continue taking the drug at increasing doses. ...
Midazolam
Midazolam, marketed under the trade names Versed among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. It works by making people sleepy, decreasing anxiety, and causing a loss of ability to create new memories. It is also useful for the treatment of seizures. Midazolam can be give by mouth, intravenously, by injection into a muscle, sprayed into the nose, or in the cheek. When given intravenously it begins working typically within five minutes, when injected into a muscle it can take fifteen minutes to begin working. Effects last for between one and six hours.Side effects can include a decrease in efforts to breathe, low blood pressure, and sleepiness. Tolerance to its effects and withdrawal syndrome may occur following long term use. Paradoxical effects, such as increased activity, can occur especially in children and older people. There is evidence of risk when used during pregnancy but no evidence of harm with a single dose during breastfeeding. It is of the benzodiazepine class and works through the GABA neurotransmitter.Midazolam first came into use in 1976. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Midazolam is available as a generic medication and is not very expensive. Wholesale a vial is about 0.35 USD. In many countries it is a controlled substance.