The role of drugs in the pathogenesis of gingival overgrowth
... The pathogenic mechanisms responsible for phenytoin-associated gingival overgrowth remain undisclosed. In vitro studies have investigated the effect of phenytoin on human gingival fibroblasts in tissue culture (155, 178, 179). Shafer (155) reported that the optimal rate of cell growth (2x1occurred a ...
... The pathogenic mechanisms responsible for phenytoin-associated gingival overgrowth remain undisclosed. In vitro studies have investigated the effect of phenytoin on human gingival fibroblasts in tissue culture (155, 178, 179). Shafer (155) reported that the optimal rate of cell growth (2x1occurred a ...
Local Coverage Determination for Ophthalmic Angiography
... Fluorescein angiography must be performed under the direct supervision (physician present in the office and immediately available) of a physician when done by a non-physician practitioner. If excluded by State law, optometrists may not be reimbursed for fluorescein angiography. Fluorescein angiograp ...
... Fluorescein angiography must be performed under the direct supervision (physician present in the office and immediately available) of a physician when done by a non-physician practitioner. If excluded by State law, optometrists may not be reimbursed for fluorescein angiography. Fluorescein angiograp ...
Topical tacrolimus in anterior segment inflammatory disorders
... Box 55307, Riyadh 11534, Saudi Arabia ...
... Box 55307, Riyadh 11534, Saudi Arabia ...
Natural Treatment Alternative for Psoriasis
... are self-administering a form of psoralen– UVA (PUVA) therapy by consuming dong quay and then receiving ultraviolet light therapy or natural sunlight. Koo & Arain, 1998 studied patients with psoriasis, two-thirds patients got complete relief from their disease after oral treatment with this plant ex ...
... are self-administering a form of psoralen– UVA (PUVA) therapy by consuming dong quay and then receiving ultraviolet light therapy or natural sunlight. Koo & Arain, 1998 studied patients with psoriasis, two-thirds patients got complete relief from their disease after oral treatment with this plant ex ...
Characterization of paracellular and aqueous penetration
... experiments were obtained from the superior temporal quadrant. The samples were without any muscle attachments or blood vessels. Six to seven tissues were used for each permeability determination. The tissues were positioned between two plastic rings and placed within 25 minutes from the death in th ...
... experiments were obtained from the superior temporal quadrant. The samples were without any muscle attachments or blood vessels. Six to seven tissues were used for each permeability determination. The tissues were positioned between two plastic rings and placed within 25 minutes from the death in th ...
REVIEW ARTICLE Vernal keratoconjunctivitis
... due to changes in corneal sensitivity and epithelial alterations. Corneal confocal microscopy demonstrates that not only the superficial epithelium, but also the anterior stroma and the corneal nerves are involved in the inflammation (22). Corneal nerve abnormalities, including reduction in density ...
... due to changes in corneal sensitivity and epithelial alterations. Corneal confocal microscopy demonstrates that not only the superficial epithelium, but also the anterior stroma and the corneal nerves are involved in the inflammation (22). Corneal nerve abnormalities, including reduction in density ...
view poster
... Granulocyte-colony-stimulating factor (G-CSF) is a powerful and specific growth factor for neutrophilic granulocytes. G-CSF is currently used clinically for the treatment of neutropenia. GCSF promotes the proliferation, survival, and maturation of cells committed to the neutrophilic granulocyte (NG) ...
... Granulocyte-colony-stimulating factor (G-CSF) is a powerful and specific growth factor for neutrophilic granulocytes. G-CSF is currently used clinically for the treatment of neutropenia. GCSF promotes the proliferation, survival, and maturation of cells committed to the neutrophilic granulocyte (NG) ...
150-514-1-SP - Baqiyatallah University of Medical Sciences
... tissue [1]. Following ischemia reperfusion injury is more severe than the initial injury that is called the ischemiareperfusion injury (IR) [2-3]. The damage could be looking at a stroke, sickle cell anemia, heart attack, blood pressure lowering, shock and bypass surgery which leads to dysfunction o ...
... tissue [1]. Following ischemia reperfusion injury is more severe than the initial injury that is called the ischemiareperfusion injury (IR) [2-3]. The damage could be looking at a stroke, sickle cell anemia, heart attack, blood pressure lowering, shock and bypass surgery which leads to dysfunction o ...
Interactions with Antineoplastic Agents Used in Veterinary Medicine
... Decreases glutathione pool and sensitizes liver to free radical damage4,7 Combination increases risk of acute recall pneumonitis in radiation patients2 Reduces cardiotoxicity of doxorubicin by enhancing coronary blood flow8 Decreases doxorubicin cardiotoxicity; may reduce anti-tumor effectiveness10 ...
... Decreases glutathione pool and sensitizes liver to free radical damage4,7 Combination increases risk of acute recall pneumonitis in radiation patients2 Reduces cardiotoxicity of doxorubicin by enhancing coronary blood flow8 Decreases doxorubicin cardiotoxicity; may reduce anti-tumor effectiveness10 ...
targeting mitochondrial function in sepsis
... elevated muscle oxygen levels can be observed [9]. When intracellular oxygen levels increase, non-enzymatic production of ROS at complex I and III can occur (Figure 1). The increased ROS can react and thereby directly damage mitochondrial proteins, lipids and DNA [11,27,28]. Mitochondrial abnormalit ...
... elevated muscle oxygen levels can be observed [9]. When intracellular oxygen levels increase, non-enzymatic production of ROS at complex I and III can occur (Figure 1). The increased ROS can react and thereby directly damage mitochondrial proteins, lipids and DNA [11,27,28]. Mitochondrial abnormalit ...
150-505-1-SP - Baqiyatallah University of Medical Sciences
... significantly decreased in animals treated with EPO for three days after the ischemia, Li and his colleagues suggested that regardless of the increased level of endothelial vascular growth factor, EPO maintains the dam of the blood-brain against the blood-brain barrier damage induced by ischemia eve ...
... significantly decreased in animals treated with EPO for three days after the ischemia, Li and his colleagues suggested that regardless of the increased level of endothelial vascular growth factor, EPO maintains the dam of the blood-brain against the blood-brain barrier damage induced by ischemia eve ...
Chapter 13. Hepatic toxicity biomarkers - SciTech Connect
... transporters (Xu et al., 2005). The coordinated metabolism and transport of xenobiotics typically makes the xenobiotic less toxic and more water soluble, thereby aiding its elimination from the body. Classically, the initial metabolic step is referred to as Phase I or the oxidation phase (Guengerich ...
... transporters (Xu et al., 2005). The coordinated metabolism and transport of xenobiotics typically makes the xenobiotic less toxic and more water soluble, thereby aiding its elimination from the body. Classically, the initial metabolic step is referred to as Phase I or the oxidation phase (Guengerich ...
TABLES TABLE 1. Examples of the use of drug
... sodium and a high permeation through the bio-engineered human cornea (produced from immortalized human corneal endothelial cells (HENC), stromal fibroblasts and epithelial cells CEPI 17 CL 4). - Cyclosporine A (CsA) loaded SLN was prepared by the high shear homogenization and the ultrasound method u ...
... sodium and a high permeation through the bio-engineered human cornea (produced from immortalized human corneal endothelial cells (HENC), stromal fibroblasts and epithelial cells CEPI 17 CL 4). - Cyclosporine A (CsA) loaded SLN was prepared by the high shear homogenization and the ultrasound method u ...
IOSR Journal Of Environmental Science, Toxicology And Food Technology (IOSR-JESTFT)
... myeloid leukaemia (CML), and is now recommended as standard treatment for the accelerated and chronicphase disease [1], as well as for the management of advanced gastrointestinal stromal tumors [2]. Authors [3] reported CML have a gene mutation called the Philadelphia chromosome. Every cell in the b ...
... myeloid leukaemia (CML), and is now recommended as standard treatment for the accelerated and chronicphase disease [1], as well as for the management of advanced gastrointestinal stromal tumors [2]. Authors [3] reported CML have a gene mutation called the Philadelphia chromosome. Every cell in the b ...
James Cassidy, Jane Kivlin, Carol Lindsley and James Nocton 2006;117;1843 DOI: 10.1542/peds.2006-0421
... PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication, it has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois, 60007. Co ...
... PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication, it has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois, 60007. Co ...
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... genes.3-8 Myocardin, a recently discovered cardiac restricted gene, has potent effects on the cardiovascular system, and has been proven in prior studies to be upregulated to result in cardiomyocyte hypertrophy after stress signals.4,9-12 Different pharmacological agents are thought to be effective ...
... genes.3-8 Myocardin, a recently discovered cardiac restricted gene, has potent effects on the cardiovascular system, and has been proven in prior studies to be upregulated to result in cardiomyocyte hypertrophy after stress signals.4,9-12 Different pharmacological agents are thought to be effective ...
For effective and well-tolerated treatment
... represents one of the most significant breakthroughs in immunosuppressive therapy. It was first isolated from a soil-dwelling fungus, Tolypocladium inflatum, in 1972 and has since become a standard of care for maintenance immunosuppression in solid organ transplant recipients. The compound has very ...
... represents one of the most significant breakthroughs in immunosuppressive therapy. It was first isolated from a soil-dwelling fungus, Tolypocladium inflatum, in 1972 and has since become a standard of care for maintenance immunosuppression in solid organ transplant recipients. The compound has very ...
OPHTHALMIC DRUG DELIVERY
... The EMA has stopped short of a general p o p u l a t i o n . The EMA has recommendation not to use preservatives stopped short in eye drops, but they recommend that of a general “preservative free formulations whenever recommendation not to use possible should be considered” and that preservatives “ ...
... The EMA has stopped short of a general p o p u l a t i o n . The EMA has recommendation not to use preservatives stopped short in eye drops, but they recommend that of a general “preservative free formulations whenever recommendation not to use possible should be considered” and that preservatives “ ...
Keratoconjunctivitis sicca (dry eye)
... their rehabilitation and recovery phases capturing the main aspects of the 12-step programs used by Alcoholics Anonymous, Noranon and Narcotics Anonymous etc. Dr. Rapiti’s 4 step program focuses on the importance of spirituality in one’s life; importance of correcting one’s faults; value for family ...
... their rehabilitation and recovery phases capturing the main aspects of the 12-step programs used by Alcoholics Anonymous, Noranon and Narcotics Anonymous etc. Dr. Rapiti’s 4 step program focuses on the importance of spirituality in one’s life; importance of correcting one’s faults; value for family ...
lactic acidosis with chloramphenicol treatment in a child with cystic
... intracellular synthetic activity.6 Thus, mitochondrial toxicity can lead to lactic acidosis in subjects exposed to such antimicrobials. This seems to be the case of linezolid, which has a high affinity for ribosomal 23S subunit of the 50S unit of bacteria.9,16 Binding to this subunit prevents comple ...
... intracellular synthetic activity.6 Thus, mitochondrial toxicity can lead to lactic acidosis in subjects exposed to such antimicrobials. This seems to be the case of linezolid, which has a high affinity for ribosomal 23S subunit of the 50S unit of bacteria.9,16 Binding to this subunit prevents comple ...
Permeability of Ocular Vessels and Transport Across the
... This paper reviews quantitative studies on the permeability of retinal and choroidal vessels and the exchange of nutrients over the blood retinal barrier (BRB). The fen estrated capillaries in the choroid are very permeable to low molecular weight sub stances; sodium permeability in the choroid is ...
... This paper reviews quantitative studies on the permeability of retinal and choroidal vessels and the exchange of nutrients over the blood retinal barrier (BRB). The fen estrated capillaries in the choroid are very permeable to low molecular weight sub stances; sodium permeability in the choroid is ...
Managing Anal Furunculosis in Dogs
... The second goal of therapy should be to reduce the mg/kg PO q48h) was then administered for varying diameter, depth, extent, and recurrence of sinus tracts. durations (8 to 16 weeks). All 27 dogs completed the Medical management comprises immunosuppressive or study, with 33.3% of them showing comple ...
... The second goal of therapy should be to reduce the mg/kg PO q48h) was then administered for varying diameter, depth, extent, and recurrence of sinus tracts. durations (8 to 16 weeks). All 27 dogs completed the Medical management comprises immunosuppressive or study, with 33.3% of them showing comple ...
Newer Immunosuppressive Drugs: A Review
... wisdom has held that the price for reducing the incidence of allograft rejection by improved immunosuppressants is a proportional increase in the incidence of infection and malignancy. When the data from Phase III trials of new immunosuppressants are analyzed, however, the statistically significant ...
... wisdom has held that the price for reducing the incidence of allograft rejection by improved immunosuppressants is a proportional increase in the incidence of infection and malignancy. When the data from Phase III trials of new immunosuppressants are analyzed, however, the statistically significant ...
F1-ATPase`
... translocator in vivo and consists of a group of hydrophobic integral membrane proteins abbreviated FO in both mitochondria and chloroplasts (for reviews, see Nelson [14], and Senior and Wise [23]). The mitochondrial F,-ATPases from animals and the CF,-ATPases from higher plants have been extensively ...
... translocator in vivo and consists of a group of hydrophobic integral membrane proteins abbreviated FO in both mitochondria and chloroplasts (for reviews, see Nelson [14], and Senior and Wise [23]). The mitochondrial F,-ATPases from animals and the CF,-ATPases from higher plants have been extensively ...
Sulodexide - Wiley Online Library
... Clinical trials have demonstrated the beneficial effects of sulodexide in the treatment of deep vein thrombosis. Errichi et al. reported that after 6, 12, and 24 months of oral sulodexide treatment (50 mg daily) the recurrence of deep vein thrombosis was significantly attenuated (p < 0.05) in high-r ...
... Clinical trials have demonstrated the beneficial effects of sulodexide in the treatment of deep vein thrombosis. Errichi et al. reported that after 6, 12, and 24 months of oral sulodexide treatment (50 mg daily) the recurrence of deep vein thrombosis was significantly attenuated (p < 0.05) in high-r ...
Ciclosporin
Ciclosporin (INN/BAN) (pronounced /ˌsaɪkləˈspɔrɪn/); cyclosporine (USAN); cyclosporin (former BAN); or ciclosporin A, cyclosporine A, or cyclosporin A (often shortened to CsA) is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells.It was initially isolated from the fungus Tolypocladium inflatum (Beauveria nivea), found in a soil sample obtained in 1969 from Hardangervidda, Norway, by Hans Peter Frey, a Sandoz biologist. Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.