Immunosuppressants_team2011-09
... binds to mTOR (Mammalian Target of Rapamycin) which is essential for many cellular functions (See Figure 40.6) 2) Sirolimus does not affect IL-2 production, unlike CsA & Tac, rather inhibits T-cells response to IL-2 (Blocks cytokine-stimulated cell proliferation) 3) Potent inhibitor of B-cell pr ...
... binds to mTOR (Mammalian Target of Rapamycin) which is essential for many cellular functions (See Figure 40.6) 2) Sirolimus does not affect IL-2 production, unlike CsA & Tac, rather inhibits T-cells response to IL-2 (Blocks cytokine-stimulated cell proliferation) 3) Potent inhibitor of B-cell pr ...
Calcineurin inhibitors - British Association of Dermatologists
... or, if used on and around the eyelids, glaucoma (increased pressure within the eye). As a result, they can be particularly useful on the face and neck and in the flexures, particularly if the atopic eczema is very persistent at these sites. What is known about the long-term effects of calcineurin in ...
... or, if used on and around the eyelids, glaucoma (increased pressure within the eye). As a result, they can be particularly useful on the face and neck and in the flexures, particularly if the atopic eczema is very persistent at these sites. What is known about the long-term effects of calcineurin in ...
Solid lipid nanoparticles
... avoidance of organic solvents and no problem with respect to large scale production and sterilization were the proposed advantages of SLNs [5]. ...
... avoidance of organic solvents and no problem with respect to large scale production and sterilization were the proposed advantages of SLNs [5]. ...
Rheumatoid Arthritis
... Rheumatoid Arthritis (RA) Fast facts • PREVALENCE : An estimated 1.5 million adults in the United States have rheumatoid arthritis. Affects 0.5-1.0% of population • Women are two to three times as likely to be affected as men. • Rheumatoid arthritis (RA) is an inflammatory systemic disease, with th ...
... Rheumatoid Arthritis (RA) Fast facts • PREVALENCE : An estimated 1.5 million adults in the United States have rheumatoid arthritis. Affects 0.5-1.0% of population • Women are two to three times as likely to be affected as men. • Rheumatoid arthritis (RA) is an inflammatory systemic disease, with th ...
Induction and Maintenance Therapy
... and DNA synthesis. In this way, activated lymphocytes are selectively inhibited since they are not allowed to proliferate once activated [14–16]. Sirolimus [16, 17] is a macrocyclic lactone produced by S. hygroscopicus and resembles tacrolimus and binds to the same intracellular binding protein or i ...
... and DNA synthesis. In this way, activated lymphocytes are selectively inhibited since they are not allowed to proliferate once activated [14–16]. Sirolimus [16, 17] is a macrocyclic lactone produced by S. hygroscopicus and resembles tacrolimus and binds to the same intracellular binding protein or i ...
投影片 1 - 國防醫學院數位學習系統
... Protective role: trafficking of ICs from kidney by binding to CR1 on RBC Detrimental role: complement activation without cell reflux (membranous), with cell reflux ...
... Protective role: trafficking of ICs from kidney by binding to CR1 on RBC Detrimental role: complement activation without cell reflux (membranous), with cell reflux ...
A short history of anti-rheumatic therapy VIII. The
... folic acid, was synthesized. The observation that therapy with folic acid can favour tumor growth, in that it is essential for the synthesis of purines, which are basic constituents of nucleic acids, suggests that its antagonists could exert a cytostatic action. The first folic acid antagonist, amin ...
... folic acid, was synthesized. The observation that therapy with folic acid can favour tumor growth, in that it is essential for the synthesis of purines, which are basic constituents of nucleic acids, suggests that its antagonists could exert a cytostatic action. The first folic acid antagonist, amin ...
Do mitochondria play a role in ME/CFS?
... Changes in cellular chemicals (i.e. ATP) in a disease or with treatment. > 17,000 metabolities ...
... Changes in cellular chemicals (i.e. ATP) in a disease or with treatment. > 17,000 metabolities ...
chronic superficial keratoconjunctivitis (pannus)
... On-going treatment of pannus over the life of the animal is usually required as a cure does not exist. When started early in the course of disease, medical therapy is usually successful at controlling the condition. Much of the redness and some of the pigment may be resolved. When severe scarring is ...
... On-going treatment of pannus over the life of the animal is usually required as a cure does not exist. When started early in the course of disease, medical therapy is usually successful at controlling the condition. Much of the redness and some of the pigment may be resolved. When severe scarring is ...
Use of Steroids and Immunosuppressive Drugs in the
... disease resulting in reduced vision, steroids are still the best drug but cyclosporin is becoming widely used in combination with steroid theraphy, in patients who do not respond to steroids alone or in whom the dose of steroids required to control the disease process is unacceptably high. Cyclospor ...
... disease resulting in reduced vision, steroids are still the best drug but cyclosporin is becoming widely used in combination with steroid theraphy, in patients who do not respond to steroids alone or in whom the dose of steroids required to control the disease process is unacceptably high. Cyclospor ...
Calcium-independent calcineurin regulation
... calcineurin B for binding to calcineurin A11. Cabin 1 (also call Cain) is a mainly nuclear, noncompetitive inhibitor that interacts with activated calcineurin12. Of particular interest to immunologists is the A238L protein encoded by the African swine fever virus. This protein shares sequence simila ...
... calcineurin B for binding to calcineurin A11. Cabin 1 (also call Cain) is a mainly nuclear, noncompetitive inhibitor that interacts with activated calcineurin12. Of particular interest to immunologists is the A238L protein encoded by the African swine fever virus. This protein shares sequence simila ...
Atopic Keratoconjunctivitis (AKC)
... of the eye. It is present in a high percentage of patients suffering from the skin condition, atopic dermatitis. Atopic keratoconjunctivitis requires long-term treatment to prevent sight-threatening complications such as scarring of the cornea (the clear window at the front of the eye). In the early ...
... of the eye. It is present in a high percentage of patients suffering from the skin condition, atopic dermatitis. Atopic keratoconjunctivitis requires long-term treatment to prevent sight-threatening complications such as scarring of the cornea (the clear window at the front of the eye). In the early ...
Chemotherapy Review 2002
... • Given the well documented increased cardiovascular risks of people post-HCT the next steps in the evolution of care is to identify those at risk early and to implement interventions to modify those risks or ...
... • Given the well documented increased cardiovascular risks of people post-HCT the next steps in the evolution of care is to identify those at risk early and to implement interventions to modify those risks or ...
optimmune - MSD Animal Health New Zealand
... Remove debris from affected eye(s) with suitable non-irritating solution. For KCS apply a 6 mm strip of ointment to the affected eye(s) every 12 hours. For CSK apply a 6-10 mm strip of ointment to the affected eye(s) every 12 hours. Place the ointment directly on the cornea or into the conjuctival s ...
... Remove debris from affected eye(s) with suitable non-irritating solution. For KCS apply a 6 mm strip of ointment to the affected eye(s) every 12 hours. For CSK apply a 6-10 mm strip of ointment to the affected eye(s) every 12 hours. Place the ointment directly on the cornea or into the conjuctival s ...
A Novel Tissue Protective Peptide: Cyclic Helix B Peptide
... of toll-like receptor (TLR). As a result, the CHPB-induced immature DC ameliorated acute rejection in a rat kidney transplantation model [8]. ...
... of toll-like receptor (TLR). As a result, the CHPB-induced immature DC ameliorated acute rejection in a rat kidney transplantation model [8]. ...
Mechanism of action, Pharmacokinetics, Indications and
... inflammation and immune responses when administered at pharmacological doses. At a molecular level, unbound glucocorticoids readily cross cell membranes and bind with high affinity to specific cytoplasmic receptors. This binding induces a response by modifying transcription and, ultimately protein s ...
... inflammation and immune responses when administered at pharmacological doses. At a molecular level, unbound glucocorticoids readily cross cell membranes and bind with high affinity to specific cytoplasmic receptors. This binding induces a response by modifying transcription and, ultimately protein s ...
Characterization and protein engineering of L
... Characterization and protein engineering of Lasparaginase 1 from Saccharomyces cerevisiae to evaluate its use as biopharmaceutical Prof. Dr. Gisele Monteiro Department of Biochemical and Pharmaceutical Technology ...
... Characterization and protein engineering of Lasparaginase 1 from Saccharomyces cerevisiae to evaluate its use as biopharmaceutical Prof. Dr. Gisele Monteiro Department of Biochemical and Pharmaceutical Technology ...
1- Rheumatoid arthritis
... It is a first choice DMARD . It is active in this condition at much lower doses than those needed in cancer chemotherapy. Mechanism of action. ...
... It is a first choice DMARD . It is active in this condition at much lower doses than those needed in cancer chemotherapy. Mechanism of action. ...
Ocular Surface Dry Eye Disease
... diffuse effects on both the adaptive and innate immune system and ciclosporin, which targets adaptive immunity. Ciclosporin treatment is associated with fewer unwanted side effects than those related to corticosteroid use and is considered an important tool for the treatment of ocular surface inflam ...
... diffuse effects on both the adaptive and innate immune system and ciclosporin, which targets adaptive immunity. Ciclosporin treatment is associated with fewer unwanted side effects than those related to corticosteroid use and is considered an important tool for the treatment of ocular surface inflam ...
Mechanism of DI
... leaves & flowers 450 mg bid (1 dose = 84.3 mg of oligomeric procyanides) led to decrease of maximal plasma concentration of digoxine by 14 % and minimal plasma ...
... leaves & flowers 450 mg bid (1 dose = 84.3 mg of oligomeric procyanides) led to decrease of maximal plasma concentration of digoxine by 14 % and minimal plasma ...
Vernal Keratoconjunctivitis (Spring catarrh)
... effect of the condition may cause them to miss school. VKC produces inflammation of the eye surface. On the underside of the upper eyelids, bumps shaped like tiny cobblestones appear. Substances released from this tissue can cause damage to the cornea (the clear window of the eye). Sometimes a whiti ...
... effect of the condition may cause them to miss school. VKC produces inflammation of the eye surface. On the underside of the upper eyelids, bumps shaped like tiny cobblestones appear. Substances released from this tissue can cause damage to the cornea (the clear window of the eye). Sometimes a whiti ...
Cardiovascular Disaster in Hemodialysis patients
... >> cardiac hypertrophy and fibrosis • Decrease heart rate variability (reflecting autonomic dysfunction) >> increased risk for all-cause and SD in HD ...
... >> cardiac hypertrophy and fibrosis • Decrease heart rate variability (reflecting autonomic dysfunction) >> increased risk for all-cause and SD in HD ...
Autoimmune Disorders
... • Chronic, progressive, inflammatory autoimmune disease associated with articular, extra-articular and systemic effects • Affects 0.5-1% of the adult population in developed regions • Characterized by: • Synovial inflammation • Autoantibody production ...
... • Chronic, progressive, inflammatory autoimmune disease associated with articular, extra-articular and systemic effects • Affects 0.5-1% of the adult population in developed regions • Characterized by: • Synovial inflammation • Autoantibody production ...
Document
... Dr. King Immunopharmacological Agents Page 3 of 5 iv. Prevents B and T-cell proliferation b. Pharmacology i. Rapidly removed from blood and distributed to muscles, liver, skin and intestines. ii. Prednisolone is the biologically active preparation, but is converted in the body to other forms. iii. S ...
... Dr. King Immunopharmacological Agents Page 3 of 5 iv. Prevents B and T-cell proliferation b. Pharmacology i. Rapidly removed from blood and distributed to muscles, liver, skin and intestines. ii. Prednisolone is the biologically active preparation, but is converted in the body to other forms. iii. S ...
Ciclosporin
Ciclosporin (INN/BAN) (pronounced /ˌsaɪkləˈspɔrɪn/); cyclosporine (USAN); cyclosporin (former BAN); or ciclosporin A, cyclosporine A, or cyclosporin A (often shortened to CsA) is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells.It was initially isolated from the fungus Tolypocladium inflatum (Beauveria nivea), found in a soil sample obtained in 1969 from Hardangervidda, Norway, by Hans Peter Frey, a Sandoz biologist. Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.