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Epigenetics-2015
Epigenetics-2015

... Stress reduces maternal care. Pups are more sensitive to stress and display reduced maternal care, even in the absence of stress The altered gene expression of target genes (GR in the hippocampus) is mediated by DNA methylation and histone modifications Expression patterns are inherited in future ge ...
Lecture 9
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... – Mutation rate is the probability that a gene will mutate when a cell divides; the rate is expressed as 10 to a negative power. • Spontaneous mutation rate = 1 in 109 replicated base pairs (frequency – 10-9 ) or 1 in 106 replicated genes (10-6 ) • Mutations usually occur randomly along a chromosome ...
Identification of genes altered in a mos1 mutagenesis I
Identification of genes altered in a mos1 mutagenesis I

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A Novel Interacting Protein With The DNA Mismatch Repair Gene
A Novel Interacting Protein With The DNA Mismatch Repair Gene

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... (a) The D4Z4 repeat (triangles) is located in the subtelomere of chromosome 4q and can vary between 11 and 100 copies in the unaffected population. This repeat structure has a closed chromatin structure characterized by heterochromatic histone modifications (dense springs), high DNA methylation leve ...
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LS DNA, Heredity and Genetics Booklet PP

... DNA, Genetics and Heredity  PAGE 1- WHAT KIND OF CHARACTERISTICS CAN BE INHERITED FROM PARENTS?  PAGE 2- WHAT ARE CHROMOSOMES, GENES, AND DNA?  PAGE 3- WHAT DOES DNA DO?  PAGE 4- WHAT IS THE SHAPE OF DNA?  PAGE 5- WHAT IS DNA MADE OF?  PAGE 6- MATCH DNA CODE ...
Grade 9 Science - hrsbstaff.ednet.ns.ca
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Dna rEPLICATION - Manning`s Science

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The rhesus macaque is the third primate genome to be completed

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2054, Chap. 13, page 1 I. Microbial Recombination and Plasmids

... 2. contain few genes (usually < 30) 3. not essential to host 4. curing = elimination of plasmid from host cell 5. plasmids with the fertility or F factor contain the information to allow cell attachment and plasmid transfer between specific bacterial strains (conjugation) a. F factor is about 100 kb ...
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DNA and the Genetic Code

... messenger RNA (mRNA) from DNA. The two DNA strands separate from one another. One strand is used for replication, the other for transcription. mRNA is the complement strand of the original DNA except with T replaced by U (uracil). mRNA carries the genetic information out of the nucleus, into the cyt ...
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Chapter 11 Quiz
Chapter 11 Quiz

... No, because parents with type A blood can have a child with type O blood. No, because parents with any blood type (A, B, AB, or O) can produce children with type O blood. Yes, because all of this couple’s children will have type A blood. Yes, because people with type A blood can pass on only A allel ...
What Would You Do? - Honors 210G (Section 01): Ebola
What Would You Do? - Honors 210G (Section 01): Ebola

... alone has more than 500,000 of them. If a scientist using a biobank sample chances upon a disease mutation and wants to get back to the donor, where does she turn? DNA and tissue deposited in such banks are usually stripped of identifying information, and the researcher who first collected them may h ...
Chapter 8: Microbial Genetics
Chapter 8: Microbial Genetics

... • Cell wall becomes permeable to large DNA molecules • Use surface proteins and type 4 pili to extend and take it in • Works best when donor and recipient cells are closely related ...
procedure - DNA Interactive
procedure - DNA Interactive

... In the mid 1940's most geneticists assumed the genome was a static entity with stable genes, replicating faithfully as cells divided and organisms developed. Observations made by Barbara McClintock at Cold Spring Harbor Laboratory told a radically different story. McClintock observed that regions of ...
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Cell-free fetal DNA

Cell-free fetal DNA (cffDNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of cffDNA provides a method of non-invasive prenatal diagnosis.cffDNA originates from the trophoblasts making up the placenta. It is estimated that 2-6% of the DNA in the maternal blood is fetal in origin. The fetal DNA is fragmented and makes its way into the maternal bloodstream via shedding of the placental microparticles into the maternal bloodstream (figure 1). Studies have shown that cffDNA can first be observed as early as 7 weeks gestation, and the amount of cffDNA increases as the pregnancy progresses. cffDNA diminishes quickly after the birth of the baby, so that it is no longer detectable in the maternal blood approximately 2 hours after birth. cffDNA is significantly smaller than the maternal DNA in the bloodstream, with fragments approximately 200bp in size. Many protocols to extract the fetal DNA from the maternal plasma use its size to distinguish it from the maternal DNA.Studies have looked at, and some even optimized, protocols for testing non-compatible RhD factors, sex determination for X-linked genetic disorders and testing for single gene disorders. Current studies are now looking at determining aneuploidies in the developing fetus. These protocols can be done earlier than the current prenatal testing methods, and have no risk of spontaneous abortion, unlike current prenatal testing methods. Non-invasive prenatal diagnosis (NIPD) has been implemented in the UK and parts of the US; it has clear benefits above the standard tests of chorionic villi sample (CVS) and amniocentesis which have procedure-related miscarriage risks of about 1 in 100 pregnancies and 1 in 200 pregnancies, respectively.As a method of prenatal diagnosis, cell-free fetal DNA techniques share the same ethical and practical issues, such as the possibility of prenatal sex discernment and sex selection.
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