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Overview of Articles for the literature talks Nr PMID Titel Date
Overview of Articles for the literature talks Nr PMID Titel Date

... roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes with aberrant copy number, sequence, or expression in various cancer types, providing a survey of the genes that may have a causal role in cancer. A complementary approach is to perform syst ...
Overview of Articles for the literature talks Nr PMID Titel Date
Overview of Articles for the literature talks Nr PMID Titel Date

... that underlie the function of signaling networks. 3. The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network Schulz et al. 2014 During early development of female mouse embryos, both X chromosomes are transiently active. X gene dosage ...
Shotgun DNA sequencing using cloned DNase I
Shotgun DNA sequencing using cloned DNase I

... A large DNA fragment can be completely sequenced by cloning smaller subfragments in a single-stranded phage vector to produce a representative library, then sequencing randomly-chosen clones using the dideoxynucleotide chain termination method and a flanking universal primer [1-6]. This method, in w ...
Conference Report - IGB-CNR
Conference Report - IGB-CNR

... better genetic markers and maps, and finally the full human genomic sequence and the technologies to analyze it at an acceptable cost. The speaker focused the attention on the latest developments that have led to the unraveling of the underlying genetic components of most high penetrance cancer synd ...
Diapositiva 1
Diapositiva 1

... sequence snippets). A typical symptom is that a gene appears to map to multiple loci on the same chromosome, with very high sequence similarity. – But there are also sequences that are nearly indentical, but duplicated. This has happened not long ago in evolution by means of transposable elements. ...
lytic cycle - Cloudfront.net
lytic cycle - Cloudfront.net

... • SOME VIRUSES CAN COEXIST WITH THEIR HOSTS BY INCORPORATING THEIR GENOME INTO THE HOST’S GENOME • TEMPERATE VIRUSES - VIRUSES THAT CAN INTEGRATE THEIR GENOME INTO A HOST CHROMOSOME AND REMAIN LATENT UNTIL THEY INITIATE A LYTIC CYCLE – THEY HAVE TWO POSSIBLE MODES OF REPRODUCTION, THE LYTIC CYCLE AN ...
Pharmacogenomics
Pharmacogenomics

... data of host and pathogens to identify potential drug targets • Involves a variety of techniques/disciplines such as sequence analysis, protein structure, genomics, micorarray analysis and others • These fields rely heavily on bioinformatics • Usually focuses on medical or agricultural applications ...
Lecture 20  DNA Repair and Genetic Recombination
Lecture 20 DNA Repair and Genetic Recombination

... Modulators of the L1 lifecycle. The L1 amplification cycle can be divided into several steps. (a) Transcription. L1 amplification initiates with transcription, and regulation of L1 at this step can be modified by epigenetic modifications, DNA methylation, and recruitment of transcription factors. (b ...
Transcription and Translation - Microbiology and Molecular Genetics
Transcription and Translation - Microbiology and Molecular Genetics

... discovery of new biological insights as well as to create a global perspective from which unifying principles in biology can be discerned ...
SBI4U- Molecular Genetics
SBI4U- Molecular Genetics

... resulting in death for the bacterium b) Not every antibiotic that can affect ribosome operation can be given to humans for treatment. Give a reason as to why. (2 marks) Humans have their own ribosomes and need to make key proteins for life too so a potential antibiotic might not just affect the bact ...
Genetics Lecture V
Genetics Lecture V

... Making Copies of Genes Copies of genes need to be made so that scientists can study them further  The process of “copying DNA” is known as the polymerase chain reaction ...
Nutritional genomics - Academe Research Journals
Nutritional genomics - Academe Research Journals

... There is an association between food intake and the incidence and severity of chronic disease, but the concept that food contains bioactive chemicals is not apparent from the design of many molecular and genetic association studies or laboratory animal or cell culture experiments. The variety and co ...
tutorial9_12
tutorial9_12

... Domain A structural unit which can be found in multiple protein contexts. ...
gal
gal

... – …bacteria also have plasmids (T Plasmids) that they transfer to other organisms, – …upon infection, the T plasmid enters the host cell, becomes incorporated in the host genome, and the T plasmid genes become expressed, – …Agrobacterium tumefaceins transfers genes that force plants to make strange ...
14_lecture_ppt - Tracy Jubenville Nearing
14_lecture_ppt - Tracy Jubenville Nearing

...  Took 13 years to sequence three billion base pairs along the length of chromosomes. ...
BICH/GENE 431 KNOWLEDGE OBJECTIVES Chapter 9 – Mutations
BICH/GENE 431 KNOWLEDGE OBJECTIVES Chapter 9 – Mutations

... Intercalating agents – know examples; insert between bases in DNA to cause insertions or deletions during replication Direct reversal of damage - DNA photolyase to remove thymine dimers (plants, bacteria, not humans) - Methyltransferase enzyme to repair O6-methylguanine (single turnover) Base excisi ...
TRASK Zool 3200: Cell Biology Exam 2
TRASK Zool 3200: Cell Biology Exam 2

... You are interested in understanding the gene regulation of Lkp1, a protein that is normally produced in liver  and kidney cells in mice. Interestingly, you find that the LKP1 gene is not expressed in heart cells. You isolate  the DNA upstream of the LKP1 gene, and clone it upstream of the gene for  ...
F. Mutation and Repair 1. Background on DNA Mutations
F. Mutation and Repair 1. Background on DNA Mutations

... 2. Common Types and Mechanisms of DNA Damage, Mutation and Repair a. The alteration of a single base pair (point mutation) can result from chemical damage followed by copying error b. The insertion or deletion of a single base pair (point mutation) during DNA replication c. Single-stranded and doubl ...
Chapter 5
Chapter 5

... advancing complexity of living organisms. 1. The idea is that during meiosis in sexually reproducing organisms, crossover mutations can form multiple copies of a gene, a chromosome or the entire genome. 2. The organism survived just fine with one copy so it only repairs damages (mutations) to one co ...
What is DNA? - ScienceWithMrShrout
What is DNA? - ScienceWithMrShrout

... Replication of DNA • Before a cell can divide by mitosis or meiosis, it must first make a copy of its chromosomes. • The DNA in the chromosomes is copied in a process called DNA replication. • Without DNA replication, new cells would have only half the DNA of their parents. • DNA is copied during i ...
LOTUS-DB: an integrative and interactive database for
LOTUS-DB: an integrative and interactive database for

... The sequencing data was assembled into nine megascaffolds based on 3 605 scaffolds, from which 26 685 protein coding genes consisting of 132 653 exons, 108 887 introns and 628 200 repetitive sequences were predicted using de novo and homologous methods with MAKER (version 2.22) (27). Approximately 8 ...
24. DNA testing
24. DNA testing

... Recombination hotspot (12% between markers at either end of gene) a. DNA sequencing can be used to identify a mutation anywhere in gene due to completion of human genome project, it's becoming cheaper and easier for some mutations other methods might be preferred due to speed, cost, or need to have ...
Bioinformatics and Supercomputing
Bioinformatics and Supercomputing

... This visualizes results of Alu repeats from Chimpanzee and Human Genomes. Young families (green, yellow) are seen as tight clusters. This is projection of MDS dimension reduction to 3D of 35399 repeats – each with about 400 base pairs ...
Summary of sixth lesson - UC Berkeley College of Natural
Summary of sixth lesson - UC Berkeley College of Natural

... • If a species has arisen, it must have some adaptive advantages that should not be watered down by mixing with other species • Will allow mating to happen only if individuals recognized as belonging to the same species • Plus alleles at one of 5 loci (S P V1 V2 V3) ...
2012
2012

... Circle the correct answer 23. [3 points] Describe briefly the relationship between chromatin structure and transcription in eukaryotes. In eukaryotic chromosomes promoter access is restricted. Condensed chromatin is inaccessible and must be remodeled. Remodeling can occur through covalent modificati ...
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Genomics

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism). Advances in genomics have triggered a revolution in discovery-based research to understand even the most complex biological systems such as the brain. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.
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