Chapter 1 Introduction
... kidneys. About 10% of the circulating cortisol is biologically active free cortisol, the major part is bound by corticosteroid binding globulin (CBG). This transporter molecule acts as a buffer system. Cortisol binds to its receptor in the cell cytoplasm, and is then transported to the nucleus where ...
... kidneys. About 10% of the circulating cortisol is biologically active free cortisol, the major part is bound by corticosteroid binding globulin (CBG). This transporter molecule acts as a buffer system. Cortisol binds to its receptor in the cell cytoplasm, and is then transported to the nucleus where ...
What is p53
... the term "p53" appears in the title! This massive interest in a single protein is almost unprecedented and reflects the central place of p53 in the regulation of cell number and the frequency with which abnormalities of p53 occur in human tumours. p53 has been named Molecule of the Year by the edito ...
... the term "p53" appears in the title! This massive interest in a single protein is almost unprecedented and reflects the central place of p53 in the regulation of cell number and the frequency with which abnormalities of p53 occur in human tumours. p53 has been named Molecule of the Year by the edito ...
Resolving Individuals Contributing Trace Amounts of DNA to Highly
... components of the mixture [8]. Nevertheless, these methods based on STRs expectedly suffer from limited power when using severely degraded DNA [8,9]. Mitochondrial DNA (mtDNA) based on hypervariable region sequencing is useful when analyzing degraded DNA due to its high copy number and improved stab ...
... components of the mixture [8]. Nevertheless, these methods based on STRs expectedly suffer from limited power when using severely degraded DNA [8,9]. Mitochondrial DNA (mtDNA) based on hypervariable region sequencing is useful when analyzing degraded DNA due to its high copy number and improved stab ...
Plasmodium Strain Determines Dendritic Cell
... development of protective Th1-dependent immune responses [33,34]. These responses are generated by CD8 DCs during the acute phase of infection [30]. However, DCs from infected mice are unable to prime CD8þ T cells to proliferate and secrete cytokines [34,35], which impairs cross-presentation of vir ...
... development of protective Th1-dependent immune responses [33,34]. These responses are generated by CD8 DCs during the acute phase of infection [30]. However, DCs from infected mice are unable to prime CD8þ T cells to proliferate and secrete cytokines [34,35], which impairs cross-presentation of vir ...
- IRep - Nottingham Trent University
... Genomic expression analysis .................................................................... 66 ...
... Genomic expression analysis .................................................................... 66 ...
Short utrophin isoform Up71 is specifically accumulated in
... been suggested that upregulation of utrophin into extrasynaptic regions of DMD muscle fibers could serve as an adequate therapeutic strategy for this disease [10, 14, 15]. There has been considerable interest in understanding the mechanisms regulating the expression of utrophin in skeletal muscle. S ...
... been suggested that upregulation of utrophin into extrasynaptic regions of DMD muscle fibers could serve as an adequate therapeutic strategy for this disease [10, 14, 15]. There has been considerable interest in understanding the mechanisms regulating the expression of utrophin in skeletal muscle. S ...
The Role of Interleukin-6 in the Febrile Response Namik Hamzic
... situated in the brain vessels. This will subsequently trigger the production of the prostaglandin E2 (PGE2) that enters the brain and exerts its effect by binding to the receptors located on the thermoregulatory neurons. Interleukin-6 (IL-6) is another cytokine essential for fever signaling; however ...
... situated in the brain vessels. This will subsequently trigger the production of the prostaglandin E2 (PGE2) that enters the brain and exerts its effect by binding to the receptors located on the thermoregulatory neurons. Interleukin-6 (IL-6) is another cytokine essential for fever signaling; however ...
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"
... Chlamydia, glucocorticoids and the host9s immune response will be discussed in the Chlamydia pneumoniae and the control and severity of asthma section. Immunopathological mechanisms: the role of heat shock protein 60 Immunopathological mechanisms of chlamydial infections have been widely studied usi ...
... Chlamydia, glucocorticoids and the host9s immune response will be discussed in the Chlamydia pneumoniae and the control and severity of asthma section. Immunopathological mechanisms: the role of heat shock protein 60 Immunopathological mechanisms of chlamydial infections have been widely studied usi ...
Carbohydrate profiling reveals a distinctive role for
... and function within the immune system. It has been postulated that C-type lectins function in cell–cell adhesion, antigen recognition and serve as signaling molecules influencing the balance between tolerance and immunity (6). C-type lectin stimulation can either enhance or inhibit TLR signaling, th ...
... and function within the immune system. It has been postulated that C-type lectins function in cell–cell adhesion, antigen recognition and serve as signaling molecules influencing the balance between tolerance and immunity (6). C-type lectin stimulation can either enhance or inhibit TLR signaling, th ...
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite
... Figure 2. Proportions of Peripheral-Blood Leukocytes and Cell-Surface–Marker Phenotypes in Amish and Hutterite Children. The percentages of total peripheral-blood leukocytes (Panel A) were determined with flow cytometry for neutrophils (defined as CD66b+Siglec-8+), eosinophils (defined as CCR3+Sigle ...
... Figure 2. Proportions of Peripheral-Blood Leukocytes and Cell-Surface–Marker Phenotypes in Amish and Hutterite Children. The percentages of total peripheral-blood leukocytes (Panel A) were determined with flow cytometry for neutrophils (defined as CD66b+Siglec-8+), eosinophils (defined as CCR3+Sigle ...
Athymic Nude Mice
... of CD4+ and CD8+ T-cell(s) associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T-cell maturation. In addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T-cell subpopulation in ...
... of CD4+ and CD8+ T-cell(s) associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T-cell maturation. In addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T-cell subpopulation in ...
Directionality in FLP Protein-promoted Site
... recombining sites. This further implies that critical DNA-DNA interactions between the spacer region of the two sites involved in the reaction occur at some stage duringsite-specific recombination in this system. The specific spacer sequence itself appears to be unimportant as long as homology is ma ...
... recombining sites. This further implies that critical DNA-DNA interactions between the spacer region of the two sites involved in the reaction occur at some stage duringsite-specific recombination in this system. The specific spacer sequence itself appears to be unimportant as long as homology is ma ...
The immune response to resistive breathing REVIEW
... difference (pv0.05) from F; z: statistically significant difference (pv0.01) from the moderate-load run. Modified from [5] with permission. ...
... difference (pv0.05) from F; z: statistically significant difference (pv0.01) from the moderate-load run. Modified from [5] with permission. ...
Immune Responses In Vitro and In Vivo Oligodeoxynucleotide for
... a phosphodiester ODN with a single copy of the optimal human CpG motif triggers ⬃60% of human peripheral blood B cells to proliferate and express high levels of CD86. We also demonstrated that this ODN, of sequence 2080, promotes growth, activation, and maturation of human peripheral blood dendritic ...
... a phosphodiester ODN with a single copy of the optimal human CpG motif triggers ⬃60% of human peripheral blood B cells to proliferate and express high levels of CD86. We also demonstrated that this ODN, of sequence 2080, promotes growth, activation, and maturation of human peripheral blood dendritic ...
Foundations of Biology
... Pharming is the use of recombinant domestic animals to produce proteins and other bioactive compounds One of the most common strategies in pharming involves engineering mammals to produce desired proteins in their milk This strategy was first used to produce t-PA in the milk of goats It is not coinc ...
... Pharming is the use of recombinant domestic animals to produce proteins and other bioactive compounds One of the most common strategies in pharming involves engineering mammals to produce desired proteins in their milk This strategy was first used to produce t-PA in the milk of goats It is not coinc ...
Seminar Winter Semester 2002/2003
... • Important to study what parts of a protein that binds to MHC molecules. • MHC I binds peptides with 8-10 aa • MHC II bind peptides with 12-25 aa • Potentials of peptide vaccines • Prediction of peptides is important!!!! ...
... • Important to study what parts of a protein that binds to MHC molecules. • MHC I binds peptides with 8-10 aa • MHC II bind peptides with 12-25 aa • Potentials of peptide vaccines • Prediction of peptides is important!!!! ...
Study of PepT1 and SPAK on Intestinal Homeostasis and Intestinal
... Figure 5.2 Flow diagram of the low-temperature method used to obtain villi and crypts from intestinal epithelial cells at 4˚C. ............................................................................................... 93 Figure 5.3 Isolation of villi and crypt epithelial cells of the jejunum fr ...
... Figure 5.2 Flow diagram of the low-temperature method used to obtain villi and crypts from intestinal epithelial cells at 4˚C. ............................................................................................... 93 Figure 5.3 Isolation of villi and crypt epithelial cells of the jejunum fr ...
RabAvert - GSK Source
... or Equine Rabies Immune Globulin (ERIG), 40 IU per kg body weight, at the time of the first dose. In most studies (8, 9, 13, 17), the addition of either HRIG or ERIG caused a slight decrease in GMTs which was neither clinically relevant nor statistically significant. In one study (16), patients rece ...
... or Equine Rabies Immune Globulin (ERIG), 40 IU per kg body weight, at the time of the first dose. In most studies (8, 9, 13, 17), the addition of either HRIG or ERIG caused a slight decrease in GMTs which was neither clinically relevant nor statistically significant. In one study (16), patients rece ...
Julio`s MCB - Digital Access to Scholarship at Harvard
... importers for heme and Fe/S cluster biogenesis. A genetic deficiency of Mfrn1 results in a profound hypochromic anemia in vertebrate species. To map the cis-regulatory modules (CRMs) that control expression of the Mfrn genes, we utilized genome-wide chromatin immunoprecipitation (ChIP) datasets for ...
... importers for heme and Fe/S cluster biogenesis. A genetic deficiency of Mfrn1 results in a profound hypochromic anemia in vertebrate species. To map the cis-regulatory modules (CRMs) that control expression of the Mfrn genes, we utilized genome-wide chromatin immunoprecipitation (ChIP) datasets for ...
Endometrial dendritic cell populations during the normal menstrual
... directly and indirectly with many other types of leukocytes, including T cells, B cells, natural killer cells and macrophages, thereby shaping the immune response in its entirety (Banchereau and Steinman, 1998). Despite the importance of DCs as antigen-presenting cells, there is a scarcity of resear ...
... directly and indirectly with many other types of leukocytes, including T cells, B cells, natural killer cells and macrophages, thereby shaping the immune response in its entirety (Banchereau and Steinman, 1998). Despite the importance of DCs as antigen-presenting cells, there is a scarcity of resear ...
Hepatitis B vaccination: a completed schedule...enough to control
... Data presented at the meeting confirmed that HepB vaccination has proven to be a safe and effective way of protecting populations from developing clinical acute or chronic HBV infection. Global routine infant immunization programmes have succeeded in the interruption of perinatal transmission of HBV ...
... Data presented at the meeting confirmed that HepB vaccination has proven to be a safe and effective way of protecting populations from developing clinical acute or chronic HBV infection. Global routine infant immunization programmes have succeeded in the interruption of perinatal transmission of HBV ...
Nature of Immunity - Napa Valley College
... A controlled exposure to a diseasedisease-producing pathogen which triggers antibody production and prevents disease Provides protection for months to years ...
... A controlled exposure to a diseasedisease-producing pathogen which triggers antibody production and prevents disease Provides protection for months to years ...
p53, the Cellular Gatekeeper Review for Growth and Division
... but some evidence has suggested that ubiquitin-mediated proteolysis plays a role. In addition to this low protein concentration, in some cells p53 probably also exists in a latent form, inactive for transcription. Under these conditions, the p53 protein must receive a signal or alteration to activat ...
... but some evidence has suggested that ubiquitin-mediated proteolysis plays a role. In addition to this low protein concentration, in some cells p53 probably also exists in a latent form, inactive for transcription. Under these conditions, the p53 protein must receive a signal or alteration to activat ...
Agrobacterium: nature`s genetic engineer
... and that the bacterium was necessary to start the infection but not for continued tumor development. He developed the concept of a tumor inducing principle (TIP), the factor that actually caused the disease. Thirty years later the TIP was shown to be a piece of a tumor inducing (Ti) plasmid excised ...
... and that the bacterium was necessary to start the infection but not for continued tumor development. He developed the concept of a tumor inducing principle (TIP), the factor that actually caused the disease. Thirty years later the TIP was shown to be a piece of a tumor inducing (Ti) plasmid excised ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.