Compressed q-gram Indexing for Highly Repetitive Biological
... string S appears twice. Let s1 , s2 , . . . , sa be the occurrences of a given q-gram t in S, and x1 , x2 , . . . , xb its occurrences in X. Then, a repetition of the sequence of numbers (s2 − s1 ), (s3 − s2 ), . . . , (sa − sa−1 ) appears in Dt thanks to the differential encoding. Because we wish t ...
... string S appears twice. Let s1 , s2 , . . . , sa be the occurrences of a given q-gram t in S, and x1 , x2 , . . . , xb its occurrences in X. Then, a repetition of the sequence of numbers (s2 − s1 ), (s3 − s2 ), . . . , (sa − sa−1 ) appears in Dt thanks to the differential encoding. Because we wish t ...
Aus dem Max-Planck-Institut für Psychiatrie
... chromosomes in a syntenic manner, i.e. in regions with the identical chromosomal arrangement of genes as in humans. This high level of genetic homology underlines the theory that humans differ from other mammals rather by the complexity of gene regulation than by the number or composition of their g ...
... chromosomes in a syntenic manner, i.e. in regions with the identical chromosomal arrangement of genes as in humans. This high level of genetic homology underlines the theory that humans differ from other mammals rather by the complexity of gene regulation than by the number or composition of their g ...
A crucial role for B cells in neuroinvasive scrapie
... immune-deficient mice developed clinical symptoms of scrapie. This was confirmed by histopathological analysis (not shown) and by transmission of disease to indicator tga20 mice, which overexpress the normal prion protein (PrPC) and are hypersensitive to scrapie14 (Table 1). Transmission to Prnp0/0 ...
... immune-deficient mice developed clinical symptoms of scrapie. This was confirmed by histopathological analysis (not shown) and by transmission of disease to indicator tga20 mice, which overexpress the normal prion protein (PrPC) and are hypersensitive to scrapie14 (Table 1). Transmission to Prnp0/0 ...
13-1
... RNA Editing Like a writer’s first draft, RNA molecules sometimes require a bit of editing before they are ready to be read. These pre-mRNA molecules have bits and pieces cut out of them before they can go into action. The portions that are cut out and discarded are called introns. In eukaryotes, intr ...
... RNA Editing Like a writer’s first draft, RNA molecules sometimes require a bit of editing before they are ready to be read. These pre-mRNA molecules have bits and pieces cut out of them before they can go into action. The portions that are cut out and discarded are called introns. In eukaryotes, intr ...
Indian Patent Law, Office Procedures and Examination
... section 2(1)(j) of the Act as it contained living organisms and not resulting to substance Controller decision was challenged in the high court The grounds taken by the applicant – Act does not bar such invention from patenting. Patents already granted on such matters. Process is a manner of ma ...
... section 2(1)(j) of the Act as it contained living organisms and not resulting to substance Controller decision was challenged in the high court The grounds taken by the applicant – Act does not bar such invention from patenting. Patents already granted on such matters. Process is a manner of ma ...
Isolation of AOXI promoter
... the blood alcohol concentration of an individual. It is constructed using DNA from Pichia pastoris, a strain of yeast with a diauxic metabolic pathway for ethanol and methanol. The alcohol sensor will utilize this metabolic activity, along with a fluorescent protein indicator fused with the alcohol ...
... the blood alcohol concentration of an individual. It is constructed using DNA from Pichia pastoris, a strain of yeast with a diauxic metabolic pathway for ethanol and methanol. The alcohol sensor will utilize this metabolic activity, along with a fluorescent protein indicator fused with the alcohol ...
A Model to Predict Cell-Mediated Immune
... cellular level. Several of the immune theories focus on the central role of Th1/Th2 cross-regulation. In particular, it has been hypothesized that there is a switch from a Th1- to a Th2-dominant cellmediated immune response leading to active disease as is seen in other infections such as Leishmania, ...
... cellular level. Several of the immune theories focus on the central role of Th1/Th2 cross-regulation. In particular, it has been hypothesized that there is a switch from a Th1- to a Th2-dominant cellmediated immune response leading to active disease as is seen in other infections such as Leishmania, ...
Mechanistic Comparison of High-Fidelity and Error
... 1.1. Scope of This Review Discovered in the early 1970s, DNA polymerase β (Pol β) was the first mammalian DNA repair polymerase to be characterized. Its relatively small size (39 kD) and the fact that it lacks an exonuclease proofreading activity make it a tractable system for studying the mechanism ...
... 1.1. Scope of This Review Discovered in the early 1970s, DNA polymerase β (Pol β) was the first mammalian DNA repair polymerase to be characterized. Its relatively small size (39 kD) and the fact that it lacks an exonuclease proofreading activity make it a tractable system for studying the mechanism ...
INTERPLAY BETWEEN HELICOBACTER PYLORI AND THE
... immune response, whereas MHC class I restricted CD8 T cells are not essential. Further experiments showed the presence of IL-12 (36) and IL-18 (37) in the gastric mucosa. Both of these cytokines are responsible for directing gastric T lymphocytes to Th1 mediated response. Experimental data in animal ...
... immune response, whereas MHC class I restricted CD8 T cells are not essential. Further experiments showed the presence of IL-12 (36) and IL-18 (37) in the gastric mucosa. Both of these cytokines are responsible for directing gastric T lymphocytes to Th1 mediated response. Experimental data in animal ...
Collaborative coupling between polymerase and helicase for
... open a base pair to incorporate a new nucleotide (strand displacement synthesis activity). This phase gives rise to a large change in extension, typically 0.8 nm for a nucleotide incorporated at 10 pN. After reaching the end of the loop region, the enzyme only needs to extend the primer (primer ext ...
... open a base pair to incorporate a new nucleotide (strand displacement synthesis activity). This phase gives rise to a large change in extension, typically 0.8 nm for a nucleotide incorporated at 10 pN. After reaching the end of the loop region, the enzyme only needs to extend the primer (primer ext ...
Horizontal Gene Transfer between Bacteria
... ‘Genetic material’ refers to any fraction of the genome (DNA or RNA), usually a gene or part thereof, which can include coding and/or non-coding sequences. ‘Organism’, as used here, includes cellular organism or replication competent virus. ‘Reproduction’ refers to the generation of offspring sexual ...
... ‘Genetic material’ refers to any fraction of the genome (DNA or RNA), usually a gene or part thereof, which can include coding and/or non-coding sequences. ‘Organism’, as used here, includes cellular organism or replication competent virus. ‘Reproduction’ refers to the generation of offspring sexual ...
University of Bucharest, Faculty of Biology, Molecular Biology Center
... neutrophiles across membranes to destroy invading pathogens [6; 9; 10]. The molecular basis of BLAD is a single point mutation (A-G) at position 383 in the cDNA of the CD18 gene. This mutation results in a substitution of a glycine for an aspartic acid at position 128 in the D128G protein [2; 5; 8; ...
... neutrophiles across membranes to destroy invading pathogens [6; 9; 10]. The molecular basis of BLAD is a single point mutation (A-G) at position 383 in the cDNA of the CD18 gene. This mutation results in a substitution of a glycine for an aspartic acid at position 128 in the D128G protein [2; 5; 8; ...
Evolutionary Origin of Recombination during Meiosis
... Leishmania, which cause widespread and devastating human diseases, were recently shown to have a sexual cycle (Akopyants et al. 2009). Trichomonas vaginalis, a parasitic protist, causes a range of infections in humans and is thought to have diverged from the eukaryotic lineage at an early point. Nei ...
... Leishmania, which cause widespread and devastating human diseases, were recently shown to have a sexual cycle (Akopyants et al. 2009). Trichomonas vaginalis, a parasitic protist, causes a range of infections in humans and is thought to have diverged from the eukaryotic lineage at an early point. Nei ...
Respiratory and Metabolic Impacts of Crustacean Immunity: Are
... hemolymph flow and oxygenation at the gill. Small shifts to anaerobic metabolism only partially compensate for this decrease in oxygen uptake. The resulting metabolic depression is likely to impact other energy-expensive cellular processes and whole-animal performance. For crustaceans that often liv ...
... hemolymph flow and oxygenation at the gill. Small shifts to anaerobic metabolism only partially compensate for this decrease in oxygen uptake. The resulting metabolic depression is likely to impact other energy-expensive cellular processes and whole-animal performance. For crustaceans that often liv ...
Vaccinia Virus G1L Protein Expression and Purification
... ymxG (Hypothetical zinc protease from B. subtilis) ...
... ymxG (Hypothetical zinc protease from B. subtilis) ...
Asthma, inflammation and anti-inflammatory treatments: Controlling
... Appendices 1 and 2 provide the interested reader with a comprehensive listing of the indexed extant medical literature on these subjects. The term MESH in the titles is an abbreviation for ‘MEdical SearcH’. The collected references represent the entirety of the currently available scientific literat ...
... Appendices 1 and 2 provide the interested reader with a comprehensive listing of the indexed extant medical literature on these subjects. The term MESH in the titles is an abbreviation for ‘MEdical SearcH’. The collected references represent the entirety of the currently available scientific literat ...
Survival strategies of Borrelia burgdorferi, the etiologic agent of
... in disease-susceptible animals [19]. These studies suggested that disease susceptibility may be influenced more by lymphocyte hyporesponsiveness to IL-10 than by sheer production of this cytokine (by lymph node cells) in the presence of B. burgdorferi [19,20]. 2.3. Immune complexes B. burgdorferi ma ...
... in disease-susceptible animals [19]. These studies suggested that disease susceptibility may be influenced more by lymphocyte hyporesponsiveness to IL-10 than by sheer production of this cytokine (by lymph node cells) in the presence of B. burgdorferi [19,20]. 2.3. Immune complexes B. burgdorferi ma ...
Doctoral thesis from the Department of Immunology,
... studies have shown that the raw extract of Evanta (Galipea longiflora, Angostura longiflora (Krause) Kallunki) exhibits antileishmanial activity. We hypothesized that the healing observed when using this plant might not only be due to the direct action on the Leishmania parasite, but possibly to a p ...
... studies have shown that the raw extract of Evanta (Galipea longiflora, Angostura longiflora (Krause) Kallunki) exhibits antileishmanial activity. We hypothesized that the healing observed when using this plant might not only be due to the direct action on the Leishmania parasite, but possibly to a p ...
reviews
... of inter-individual variation, the composition of the microbiota within adults appears to be relatively stable over time40,155,156. Environmental and genetic factors have a major influence of the composition of commensal bacterial communities, whereas the influence of factors including mode of infan ...
... of inter-individual variation, the composition of the microbiota within adults appears to be relatively stable over time40,155,156. Environmental and genetic factors have a major influence of the composition of commensal bacterial communities, whereas the influence of factors including mode of infan ...
J Urol - prostata
... prostatectomy, external beam radiation, brachytherapy and androgen deprivation therapy its role as a survival outcome predictor for prostate cancer patients treated with cryoablation has not yet been examined. Anecdotal evidence suggesting that cryoablation may be independent of DNA ploidy type led ...
... prostatectomy, external beam radiation, brachytherapy and androgen deprivation therapy its role as a survival outcome predictor for prostate cancer patients treated with cryoablation has not yet been examined. Anecdotal evidence suggesting that cryoablation may be independent of DNA ploidy type led ...
Homologous Recombination Generates T-Loop
... (TRF2⌬B) does not impede the DNA binding activity of TRF2 (M. van Breughel and T.d.L., unpublished data) or abrogate its ability to promote t-loop formation in vitro (R. Stansel, T.d.L., and J.W. Griffith, unpublished data). TRF2⌬B localizes to telomeres in vivo (van Steensel et al., 1998) and can b ...
... (TRF2⌬B) does not impede the DNA binding activity of TRF2 (M. van Breughel and T.d.L., unpublished data) or abrogate its ability to promote t-loop formation in vitro (R. Stansel, T.d.L., and J.W. Griffith, unpublished data). TRF2⌬B localizes to telomeres in vivo (van Steensel et al., 1998) and can b ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.