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Slowing of wound healing by psychological stress
Slowing of wound healing by psychological stress

... interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activation.1 Furthermore, cytokines released by the recruited cells regulate the ability of fibroblasts and epithelial cells to remodel damaged ...
Synthetic Chemical Inducers and Genetic
Synthetic Chemical Inducers and Genetic

... respect to inducer concentration, in contrast to the “all or nothing” response of the Plac and ParaBAD systems.16,23 LRhamnose, a naturally occurring deoxy-hexose, is nontoxic to bacterial cells, unlike the inducers of some other systems such as tetracycline, the lactose analogue isopropyl β-D-1-thi ...
Inflammation Macrophage Activation and Acute TLR-2 and IL
Inflammation Macrophage Activation and Acute TLR-2 and IL

... dose-dependent, being seen with doses of chitin as low as 20 ␮g/ml (Fig. 1B). Chitin-induced increases in intracellular IL-17 protein levels were also readily apparent (Fig. 1C). This effect was not specific for peritoneal cells because chitin also stimulated bone marrow-derived macrophage IL-17 pro ...
Influenza: A case study
Influenza: A case study

... 1 Background to the case study Influenza is a myxovirus belonging to the family of viruses known as Orthomyxoviridae. The virus was originally confined to aquatic birds, but it made the transition to humans 6000–9000 years ago, coinciding with the rise of farming, animal husbandry and urbanisation. ...
the innate immunity in bovine mastitis
the innate immunity in bovine mastitis

... MyD88 (myeloid differentiation primary-response protein 88) dependent pathways are associated with early-phase NF-κB response whereas as MyD88 independent pathways are associated with late-phase NFκB response. These NF-κB factors subsequently enter the nucleus and bind to target promoters. A wealth ...
Gene Section ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)
Gene Section ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)

... angiogenesis. ID4 is expressed in the central nervous system. ID4 is required for G1-S transition and enhance proliferation in early cortical progenitors. On the other hand, ID4 enhances RB1 -mediated inhibition of proliferation of differenciating neurons, either by direct inter-action or through in ...
Role of C-C chemokine receptor type 7 and its ligands during
Role of C-C chemokine receptor type 7 and its ligands during

... systemic nature of this infection and the presence of abundant antigen [43]. This was associated not only with delayed T-cell responses including decreased interferon-γ production, but also a significant defect in the recruitment of inflammatory macrophages [43]. This points to either a direct or in ...
Th1, Th2 and Treg associated factors in relation to allergy Camilla Janefjord
Th1, Th2 and Treg associated factors in relation to allergy Camilla Janefjord

... associated cytokine IFN-γ and enhances the responses of activated T cells to IL-12. This may be due to an up-regulation of the signal-transducing β2-chain of the IL-12 receptor. CD2 function may be impaired in allergic children. As IL-12 is a strong promotor of Th1 like responses, this may be one co ...
R educed atherosclerosis in interleukin
R educed atherosclerosis in interleukin

... R. Elhage et al. / Cardiovascular Research 59 (2003) 234–240 ...
Press release
Press release

... The first step in the selection process consists of purifying the DNA, which needs to be purified for analysis or, in other words, free of contamination. The oKtopure from LGC was developed to speed up breeding programs and many other molecular biological analyses. The robot allows 8 x 96 Deepwell p ...
Isotype-switched immunoglobulin G antibodies to HIV Gag proteins
Isotype-switched immunoglobulin G antibodies to HIV Gag proteins

Characteristics of Peptide
Characteristics of Peptide

... determines whether foreign (e.g., microbial) antigens in that cell will be recognized by T cells. There are several important features of the expression of MHC molecules that contribute to their role in protecting individuals from diverse microbial infections. ...
An Evaluation of the Efficiency of Lymphocytic Choriomeningitis Virus- In Vivo  by
An Evaluation of the Efficiency of Lymphocytic Choriomeningitis Virus- In Vivo by

... The cell-mediated component of the immune system is essential for specific, adaptive immune responses to many foreign pathogens. This system is most important during bacterial and viral infections when neutralizing antibodies from the humoral immune response cannot access these pathogens inside cell ...
MB_47_win
MB_47_win

... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
Monocytes + CD11c + Human CD14 Single
Monocytes + CD11c + Human CD14 Single

... Address correspondence and reprint requests to Dr. Ken J. Ishii, Department of Host ...
Section 2 Specific Defense
Section 2 Specific Defense

... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
Unit 3 Resource
Unit 3 Resource

View/Open - Minerva Access
View/Open - Minerva Access

... We also wish to thank Ms Jenny Davis for the animal welfare and handling. This work was supported by NHMRC grants: APP1029878 and APP1008106. ...
Immunity to Intracellular Salmonella Depends on Surface
Immunity to Intracellular Salmonella Depends on Surface

... be particularly well recognized by CD4 T cells [12,19]. Antigen in vivo expression can be deduced from various complementary approaches including screening of promoter trap libraries [20,21], proteomics [22], serum antibody response [23–26], as well as mutant virulence phenotypes. In addition to ant ...
DNA Evidence: Probability, Population Genetics, and the Courts
DNA Evidence: Probability, Population Genetics, and the Courts

... difficult for the courts, and those that have generated the most disagreement within the scientific community, involve statistics. The disagreements revolve around one central challenge-presenting the degree of similarity between DNA in a crime sample and DNA in a defendant's sample so that a judge ...
Protective influenza-specific CD8 T cell responses require
Protective influenza-specific CD8 T cell responses require

... to antiinfluenza immunity by trafficking from the lungs to the LN to initiate adaptive CD8 T cell responses. Therefore, given that this role is fulfilled by 48 h a.i. and the newly recruited lung DCs do not traffic to the LN (6), it was unclear what role the newly recruited lung DCs may play in infl ...
A Nonpolymorphic Major Histocompatibility Complex Class Ib
A Nonpolymorphic Major Histocompatibility Complex Class Ib

Lymphatic System
Lymphatic System

... located at the back of the throat, the pharyngeal tonsil, is sometimes referred to as the adenoid when swollen. Such swelling is an indication of an active immune response to infection. Histologically, tonsils do not contain a complete capsule, and the epithelial layer invaginates deeply into the in ...
West Nile Virus: Basic Principles, Replication
West Nile Virus: Basic Principles, Replication

... The viral nonstructural proteins are responsible for regulating viral mechanisms of transcription, translation and replication and attenuate host antiviral responses (Table 1). NS1 protein functions as a cofactor for viral RNA replication and is the only nonstructural protein that is secreted in hig ...
Role of complement in health and disease
Role of complement in health and disease

... from one species can react with antibodies of  other species. • Soluble proteins and glycoproteins • Synthesized mainly by liver hepatocytes, also by  blood monocytes, tissue macrophages and  epithelial cells of GIT and GUT. ...
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DNA vaccination



DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.
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