Chromatin-Remodeling and Memory Factors
... Technology, ETH Center, 8092 Zurich, Switzerland (L.H., W.G.) The establishment and heritable maintenance of specific epigenetic states that lead to differential gene expression are crucial for cell differentiation and development. Over the past few years, it has become apparent that epigenetic cont ...
... Technology, ETH Center, 8092 Zurich, Switzerland (L.H., W.G.) The establishment and heritable maintenance of specific epigenetic states that lead to differential gene expression are crucial for cell differentiation and development. Over the past few years, it has become apparent that epigenetic cont ...
Glucocorticoid-remediable aldosteronism
... of ACTH is associatedwith an exuberant and prolonged increase in aldosterone secretion and blood pressure in such subjects. In contrast, in normal individuals ACTH administration is associated with a rise and subsequent decline in aldosteronelevels to basal over several days. As in other etiologies ...
... of ACTH is associatedwith an exuberant and prolonged increase in aldosterone secretion and blood pressure in such subjects. In contrast, in normal individuals ACTH administration is associated with a rise and subsequent decline in aldosteronelevels to basal over several days. As in other etiologies ...
Gene Mapping and Disease Gene Identification
... - Ratio form genetic distance to basepairs range from 0.01cM/Mb to 60 cM/Mb ...
... - Ratio form genetic distance to basepairs range from 0.01cM/Mb to 60 cM/Mb ...
Use of Virus-Like-Particles in Biotechnology
... As new nanomaterials, viruses and VLPs possess several advantages over the products that are produced by chemical synthesis, •Size, which ranges from 10 to 2000 nm. •Availability of high-resolution 3D models of their structure. •Construction flexibility through chemical and ...
... As new nanomaterials, viruses and VLPs possess several advantages over the products that are produced by chemical synthesis, •Size, which ranges from 10 to 2000 nm. •Availability of high-resolution 3D models of their structure. •Construction flexibility through chemical and ...
17 Cell Differentiation and Gene Expression
... stored in DNA is used to produce a functional gene product. Gene products are either proteins or noncoding RNAs, such as tRNA and rRNA, which play essential roles in protein syn thesis, but do not code for proteins. Gene expression is regu lated throughout the lifespan of an individual cell to con ...
... stored in DNA is used to produce a functional gene product. Gene products are either proteins or noncoding RNAs, such as tRNA and rRNA, which play essential roles in protein syn thesis, but do not code for proteins. Gene expression is regu lated throughout the lifespan of an individual cell to con ...
Genetic Algorithms and Artificial Neural Networks in Microarray Data
... enables the measurement of the levels of mRNA molecules inside a cell and, consequently, the proteins being produced. Hence, the role of the genes in a cell at a given moment can be better understood by analyzing their expression levels. In this context, the comparison between gene expression patter ...
... enables the measurement of the levels of mRNA molecules inside a cell and, consequently, the proteins being produced. Hence, the role of the genes in a cell at a given moment can be better understood by analyzing their expression levels. In this context, the comparison between gene expression patter ...
Three Dimensional Organization of Genome Might Have Guided the
... In eukaryotes, genes are nonrandomly organized into short gene-dense regions or “gene-clusters” interspersed by long gene-poor regions. How these gene-clusters have evolved is not entirely clear. Gene duplication may not account for all the gene-clusters since the genes in most of the clusters do no ...
... In eukaryotes, genes are nonrandomly organized into short gene-dense regions or “gene-clusters” interspersed by long gene-poor regions. How these gene-clusters have evolved is not entirely clear. Gene duplication may not account for all the gene-clusters since the genes in most of the clusters do no ...
A Novel Deletion Mutation of Exon 2 of the C19orf12 Gene in an
... This indicates that the detection of this radiological sign does not support the approach of screening for mutations in the PANK2 gene exclusively, and mutations in the C19orf12 gene might be sought based on the clinical presentation. A Polish cohort study identified frameshift and missense mutation ...
... This indicates that the detection of this radiological sign does not support the approach of screening for mutations in the PANK2 gene exclusively, and mutations in the C19orf12 gene might be sought based on the clinical presentation. A Polish cohort study identified frameshift and missense mutation ...
The geranylgeranyl pyrophosphate synthase gene from Ginkgo
... Geranylgeranyl pyrophosphate synthase (GGDPS, EC: 2.5.1.29) catalyzes the biosynthesis of 20carbon geranylgeranyl pyrophosphate (GGDP), which is a key precursor for ginkgolides biosynthesis. In order to investigate the role of GGDP synthase in ginkgolides biosynthesis, we cloned, characterized and f ...
... Geranylgeranyl pyrophosphate synthase (GGDPS, EC: 2.5.1.29) catalyzes the biosynthesis of 20carbon geranylgeranyl pyrophosphate (GGDP), which is a key precursor for ginkgolides biosynthesis. In order to investigate the role of GGDP synthase in ginkgolides biosynthesis, we cloned, characterized and f ...
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... similar genetic structure separation. Several diseases were found to be associated with HLA-DQB1 alleles. Type IA diabetes is an autoimmune disease with genetic and environmental factors contributing to its etiology. Twin studies, family studies, and animal models have helped to elucidate the geneti ...
... similar genetic structure separation. Several diseases were found to be associated with HLA-DQB1 alleles. Type IA diabetes is an autoimmune disease with genetic and environmental factors contributing to its etiology. Twin studies, family studies, and animal models have helped to elucidate the geneti ...
Identification, characterization, and expression profiling of salt
... 1997). Three protein/protein complexes exist for this purpose: the plasma membrane (H+)-ATPase (P-ATPase) and two vacuolar transport systems, an (H+)-ATPase (V-ATPase), and a pyrophosphatase (PPiase). The plant P-ATPase is represented by a gene family with more than 10 members, encoding proteins of ...
... 1997). Three protein/protein complexes exist for this purpose: the plasma membrane (H+)-ATPase (P-ATPase) and two vacuolar transport systems, an (H+)-ATPase (V-ATPase), and a pyrophosphatase (PPiase). The plant P-ATPase is represented by a gene family with more than 10 members, encoding proteins of ...
A multistep epigenetic switch enables the stable
... that partial expression is not due to the fact that the deletions shift the a mutant in which these sequences were deleted (cHNL332; Fig. 4c). sequences of upstream genes closer to agn43 (cHNL330; Fig. 2d). The above experiments identified two different partial states. One Together, these data sugge ...
... that partial expression is not due to the fact that the deletions shift the a mutant in which these sequences were deleted (cHNL332; Fig. 4c). sequences of upstream genes closer to agn43 (cHNL330; Fig. 2d). The above experiments identified two different partial states. One Together, these data sugge ...
How Common is It? - Canadian Hemochromatosis Society
... disease. The complexity of iron metabolism and the interrelation of several genes, some known, some yet to be discovered, may account for the fact that some carriers develop hemochromatosis, and some people with two defective genes do not. It also may explain why such a wide range of severity and ex ...
... disease. The complexity of iron metabolism and the interrelation of several genes, some known, some yet to be discovered, may account for the fact that some carriers develop hemochromatosis, and some people with two defective genes do not. It also may explain why such a wide range of severity and ex ...
1 Chapter 2 41. Chapter 6 14
... FALSE A mutation in the gene coding for L-aromatic amino acid decarboxylase is likely to be epistatic to the Tph2 gene. One sentence defense/explanation: In a biochemical pathway, mutations in a gene catalyzing an upstream reaction will be epistatic to downstream genes but not necessarily vice versa ...
... FALSE A mutation in the gene coding for L-aromatic amino acid decarboxylase is likely to be epistatic to the Tph2 gene. One sentence defense/explanation: In a biochemical pathway, mutations in a gene catalyzing an upstream reaction will be epistatic to downstream genes but not necessarily vice versa ...
ProdoNet: identification and visualization of prokaryotic gene
... delimited lists. The use of gene or protein symbols within the input list is highly flexible, which means that ProdoNet accepts short names, locus tags and accession numbers from UniProtKB, GenBank, RefSeq and other databases. The explicit usage of locus tags, short names or UniProtKB accession numbe ...
... delimited lists. The use of gene or protein symbols within the input list is highly flexible, which means that ProdoNet accepts short names, locus tags and accession numbers from UniProtKB, GenBank, RefSeq and other databases. The explicit usage of locus tags, short names or UniProtKB accession numbe ...
Solid Tumour Section Soft tissue tumors: Aggressive angiomyxoma in Oncology and Haematology
... of genomic DNA. It is highly expressed in embryonic tissue. In normal adult tissues, only low gene expression levels have been detected, and only in kidney, lung, and synovia. In all other terminally differentiated cells, no expression of this gene has been detected. Protein The HMGA2 gene encodes a ...
... of genomic DNA. It is highly expressed in embryonic tissue. In normal adult tissues, only low gene expression levels have been detected, and only in kidney, lung, and synovia. In all other terminally differentiated cells, no expression of this gene has been detected. Protein The HMGA2 gene encodes a ...
Folie 1 - Tresch Group
... Application: Osmotic stress in yeast Use the guilt by association trick to construct an interaction matrix for all transcription factors using only a two group microarray comparison! ...
... Application: Osmotic stress in yeast Use the guilt by association trick to construct an interaction matrix for all transcription factors using only a two group microarray comparison! ...
Fact Sheet 8 | AUTOSOMAL DOMINANT INHERITANCE This fact
... In all the cells of our body, our genes are found on chromosomes (long strings of genes). We have many thousands of genes that provide information for our body to grow, develop and remain healthy. The gene sends messages to the cell to make important chemical products such as proteins. There are usu ...
... In all the cells of our body, our genes are found on chromosomes (long strings of genes). We have many thousands of genes that provide information for our body to grow, develop and remain healthy. The gene sends messages to the cell to make important chemical products such as proteins. There are usu ...
Supplementary material
... Close to 1,000 of the clones find multiple potential genes with our method. This often is a result of ESTs for the same clone belonging to different Unigene clusters, and can also be the result of closely related genes being found with the Blast method. In some cases, this automated method may not c ...
... Close to 1,000 of the clones find multiple potential genes with our method. This often is a result of ESTs for the same clone belonging to different Unigene clusters, and can also be the result of closely related genes being found with the Blast method. In some cases, this automated method may not c ...
Gene duplication and divergence in the early evolution of
... DCC model suggests that a multifunctional state, and therefore presumably some degree of complexity, must precede duplication rather than follow it. It should be noted, however, that although subfunctionalisation might be required for initial duplicate maintenance, it is not incompatible with subseq ...
... DCC model suggests that a multifunctional state, and therefore presumably some degree of complexity, must precede duplication rather than follow it. It should be noted, however, that although subfunctionalisation might be required for initial duplicate maintenance, it is not incompatible with subseq ...
Testing for Hereditary Cancers - FAP
... If one member of a family has already been found to have an APC or MYH ...
... If one member of a family has already been found to have an APC or MYH ...
Selective breeding
... destroy the cancer cells. This type of gene therapy is fraught with difficulties such as: It is difficult getting the genes into the cancer cells. Using modified viruses to do this can result in diseases being inserted. In trials there have been some unexplained deaths. ...
... destroy the cancer cells. This type of gene therapy is fraught with difficulties such as: It is difficult getting the genes into the cancer cells. Using modified viruses to do this can result in diseases being inserted. In trials there have been some unexplained deaths. ...
Genome Annotation
... If there are too few observations, the model is compared to each of the next order down model, using a chisquare test. • If the new model isn’t significantly different from the lower order model, it is discarded. • If the new model is significantly different, it is weighted based on the number of ob ...
... If there are too few observations, the model is compared to each of the next order down model, using a chisquare test. • If the new model isn’t significantly different from the lower order model, it is discarded. • If the new model is significantly different, it is weighted based on the number of ob ...
Chapter 13 PATTERNS OF INHERITANCE
... Genes and Mendel’s Findings • An individual with 2 identical alleles is said to be homozygous, while an individual with 2 different alleles is said to be heterozygous. • The genetic make-up of an individual is its genotype. The appearance or expression of the genotype is called its phenotype. ...
... Genes and Mendel’s Findings • An individual with 2 identical alleles is said to be homozygous, while an individual with 2 different alleles is said to be heterozygous. • The genetic make-up of an individual is its genotype. The appearance or expression of the genotype is called its phenotype. ...
Introduction
... [1] Isaac Kohane, Daniel Masys, and Russ Altman. "The Incidentalome: A Threat to Genomic Medicine" ...
... [1] Isaac Kohane, Daniel Masys, and Russ Altman. "The Incidentalome: A Threat to Genomic Medicine" ...