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NAME: NWAIWU ROSEMARY DEPT: BIOCHEMISTRY COURSE
NAME: NWAIWU ROSEMARY DEPT: BIOCHEMISTRY COURSE

... an entire gene or several neighboring genes. The deleted DNA may alter the function of the resulting protein(s) DUPLICATION- A duplication consists of a piece of DNA that is abnormally copied one or more times. This type of mutation may alter the function of the resulting protein. FRAMESHIFT MUTATI ...
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Learner outcomes File

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1 Unit 9: Modern Genetics Advance Organizer Topic: DNA, RNA

... e. Distinguish between the three types of RNA. f. Differentiate between types of mutations. g. Identify mutations in a string of DNA or RNA and describe the consequences of that mutation when forming proteins. 2. Key Vocabulary (20) nucleotide ...
A4.3.1HowDoChromosomesCarryInformation
A4.3.1HowDoChromosomesCarryInformation

... 6. Where are centromeres located on chromosomes? Make a sketch of a chromosome and indicate where its centromere is located. 7. Where are telomeres located on chromosomes? Make a sketch of a chromosome and indicate where its telomeres are located. 8. From the variation window, select one of the chro ...
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Basic principles of DT40

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... division. The proteins that these genes code, help to prevent uncontrolled cell growth. Any mutation that results in the decrease of the activity of the tumor-suppressor genes can cause cancer. According to today’s theory of cancer development, more than one somatic mutation is needed to produce all ...
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... Over the last 28 years many defects in genes have been linked to cancer, each promising to be the magic in understanding and curing cancer. The understanding now indicates cancer as a multistep process, each of these steps generally due to a genetic aberration. Accumulation of these mutations in gen ...
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... • Two species that appear to be closelyrelated based on fossil and molecular evidence should also be more similar in DNA and protein sequences than are more distantly related species. – In fact, the sequence of amino acids in hemoglobin molecules differ by only one amino acid between humans and gor ...
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... A.) Introns are the parts of mRNA that are translated. B.) Introns are removed during translation C.) In general, human genes have fewer introns than genes of other organisms. ____35.) Which mode of information transfer usually does not occur? A.) DNA to DNA B.) DNA to RNA C.) DNA to protein D.) All ...
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... DNA duplexes that are organized into several chromosomes within the nucleus. • Consist of long continuous DNA molecule associated with small basic proteins called histones. • In eukarotic cells, there are normally two copies of each chromosome (homologous pairs) in every somatic cell. ...
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... used to convert the nicked DNA to closed circular duplex DNA. DNA in this form is most efficiently transformed into E. coli. The methods to make mutants differ in their approach to remove the wt or non-mutated strand from the strand that is mutated in the duplex DNA. Once the non-mutated stand is re ...
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Foundations in Microbiology

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Cancer epigenetics



Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.
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