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Evolution of prokaryotic genomes
Evolution of prokaryotic genomes

... dent of whether such change results in an alteration of involved in conjuration. These belong to the small autonphenotypic traits or not. omously replicating DNA molecules called plasmids. It It is a long experience of geneticists that mutations is interesting to note that these three basic processe ...
Short Questions
Short Questions

... 4. segregation and independent assortment. 106. Explain the terms transcription and translation. 1. In which structures in the cell does translation occur? 2. How many bases in sequence make up a codon in mRNA? 3. Each mRNA codon specifies one of three possible outcomes during protein synthesis. Nam ...
Notes - Dr. Bruce Owen
Notes - Dr. Bruce Owen

... − so we can think of DNA coding for this functional RNA in much the same way that it codes for proteins − finally, some of the remainder is regulatory genes − stretches of DNA that specific other molecules can bind to − when they do so, they either inhibit or encourage the transcription of some othe ...
INBREEDING Definition
INBREEDING Definition

...  Liver cells fail to remove cholesterol from blood 3. Cancer diseases B. In-Vivo  In Parkinson disease (shaking problem of body), Dopamine-producing cells could be grafted directly to the brain. Examples Vivo 1. Cystic Fibrosis  Liposome tubes consists of lipoprotein  Lipoprotein used for chlori ...
11_Lecture_Presen - Bishop Conaty
11_Lecture_Presen - Bishop Conaty

... 11.3 DNA packing in eukaryotic chromosomes helps regulate gene expression  Eukaryotic chromosomes undergo multiple levels of folding and coiling, called DNA packing – Nucleosomes are formed when DNA is wrapped ...
Presentation
Presentation

... short DNA sequences (upstream promoter elements (UPEs) or proximal control elements) ...
Genetics Unit Organization
Genetics Unit Organization

... In eukaryotes, gene expression is complex and control involves regulatory genes, regulatory elements and transcription factors that act in concert. Examples: o Transcription factors bind to specific DNA sequences and/or other regulatory proteins. 
 o Some of these transcription factors are activator ...
oncogenes-and-tumour-suppressor
oncogenes-and-tumour-suppressor

10.2 Genetics 2 - Mendel, etc Higher level only
10.2 Genetics 2 - Mendel, etc Higher level only

... A male can only pass this gene on to his daughters. There is no male to male transmission of sex-linked traits. Males with a sex-linked condition got the recessive gene from their mother. Females with one recessive gene for the trait are carriers of the condition and are ...
tumour Suppressor Genes
tumour Suppressor Genes

... induces cell suicide (many cancers) p16 inhibits cyclin D-dependent kinase activity WT1 (Wilms tumour of the kidney) BRCA1 functions in repair of damage to DNA (breast and ovarian cancers) BRCA2 functions in repair of damage to DNA (breast cancer) ...
PALB2 and Family History
PALB2 and Family History

... gene is directly involved with the BRCA2 pathway of DNA damage repair. DNA damage from cellular metabolism, environmental exposures, and lifestyle factors accumulates over time if not repaired. DNA damage can lead to genomic instability, unregulated cell growth and proliferation, and ultimately tumo ...
Microbial Genetics
Microbial Genetics

Document
Document

... “proofreading” role This proofreading reduces errors in DNA replication to about one error per 1 billion nucleotides ...
Notes
Notes

... (5) During termination, the completed RNA molecule, or primary transcript is released from the RNA polymerase and the polymerase dissociates from the template DNA. Once released, an RNA polymerase is free to transcribe a new gene. Regulation of transcription Environmental changes induce changes in ...
Fact Sheet 31 | CANCER GENETICS OVERVIEW This fact sheet
Fact Sheet 31 | CANCER GENETICS OVERVIEW This fact sheet

Word Work File L_2.tmp
Word Work File L_2.tmp

... Cells that produce telomerase continue to divide indefinitely beyond the point at which cell division would normally cease. Active telomerase is found in germ cells that give rise to sperm and eggs in animals, but it is absent in somatic cells. The absence of telomerase activity in animal cells may ...
Ch - TeacherWeb
Ch - TeacherWeb

Studying Genomes
Studying Genomes

... the secretory glands. Its main effect is to increase mucus production in the lungs. This mucus builds up, causing inflammation, narrowing the airways and leading to shortness of breath and an increased risk of infection. ...
•How? . . . _____ - Model High School
•How? . . . _____ - Model High School

... • The rungs of the ladder can occur in any order (as long as base-pair rule is followed). the ______________ • If the order of base pairs in a DNA molecule is changed ...
DNA in culture media Conflict of interest?
DNA in culture media Conflict of interest?

... ”of the 10 miRNAs identified, only two (miR-372 and miR-191) was confirmed ….. to be solely in spent media The rest was detected in unexposed media samples ..we assayed both protein-free media and media with added protein substitute* and only detected RNA in the latter” ...
Biology 207 Workshop 9
Biology 207 Workshop 9

... the true-breeding brown strain are crossed with albinos of genotype ccBB; when the F1’s were crossed with albinos of genotype ccbb, three phenotypes were produced: black 102; brown 198; albino 300 a. Explain why one can conclude that the two genes are linked. b. Calculate the percentage recombinatio ...
F plasmid
F plasmid

... Antibiotic-resistance genes ...
Genetic Engineering
Genetic Engineering

... performed experiments showing that DNA is the genetic material of a phage known as T2 To determine the source of genetic material in the phage, they designed an experiment showing that only one of the two components of T2 (DNA or protein) enters an E. coli cell ...
Genetic and epigenetic dissection of cis regulatory
Genetic and epigenetic dissection of cis regulatory

... patterns vary across genotypes and environments, and the role that these modifications play in controlling phenotypic variation. Cytosine methylation is the best-understood eukaryotic epigenetic modification, relatively easy to assay, and an accurate proxy for other epigenetic marks, such as histone ...
Lecture6-Chap4 Sept19 - Department Of Biological Sciences
Lecture6-Chap4 Sept19 - Department Of Biological Sciences

... • interrupted gene – A gene in which the coding sequence is not continuous due to the presence of introns. • primary (RNA) transcript – The original unmodified RNA product corresponding to a transcription unit. • RNA splicing – The process of excising introns from RNA and connecting the exons into a ...
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Cancer epigenetics



Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.
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