Genetic adaptation counters phenotypic plasticity in experimental
... plasticity was initially maladaptive, or the selective pressure changed during the evolutionary process (see below). This somewhat unexpected result strikingly mirrors that from a study published last year in Nature [2], where the same pattern was found for responses of guppies to the presence of pr ...
... plasticity was initially maladaptive, or the selective pressure changed during the evolutionary process (see below). This somewhat unexpected result strikingly mirrors that from a study published last year in Nature [2], where the same pattern was found for responses of guppies to the presence of pr ...
Expert meeting: David Clayton
... 2/ Gene expression part (presented by Koen Herten and Sofie Derycke): - We have performed RNAseq analysis (Quantseq 3’ from Lexogen) on 60 samples from control females of O. nasuta and O. ventralis. - reads: 50-55% of the reads map to the tilapia genome, only 12-17% maps in gene regions => for each ...
... 2/ Gene expression part (presented by Koen Herten and Sofie Derycke): - We have performed RNAseq analysis (Quantseq 3’ from Lexogen) on 60 samples from control females of O. nasuta and O. ventralis. - reads: 50-55% of the reads map to the tilapia genome, only 12-17% maps in gene regions => for each ...
Leukaemia Section inv(3)(q23q26) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Transcription factor; EVI1 targets include: GATA2, ZBTB16 /PLZF, ZFPM2/FOG2, JNK and the PI3K/AKT pathway. Role in cell cycle progression, likely to be cell-type dependant; antiapoptotic factor; involved in neuronal development organogenesis; role in hematopoietic differentiation. ...
... Transcription factor; EVI1 targets include: GATA2, ZBTB16 /PLZF, ZFPM2/FOG2, JNK and the PI3K/AKT pathway. Role in cell cycle progression, likely to be cell-type dependant; antiapoptotic factor; involved in neuronal development organogenesis; role in hematopoietic differentiation. ...
Tutorial - GeneSifter
... Tutorial Transcriptome analysis of apoE mouse aortas 3. Pairwise analysis is used to identify differentially expressed genes in two groups. There are three replicates for each of the two groups in this study. Select the three replicates for the wild type mice (WT Aorta) for group 1. Select the thre ...
... Tutorial Transcriptome analysis of apoE mouse aortas 3. Pairwise analysis is used to identify differentially expressed genes in two groups. There are three replicates for each of the two groups in this study. Select the three replicates for the wild type mice (WT Aorta) for group 1. Select the thre ...
PDF - BioDiscovery
... In summary, our list of differentially regulated genes is enriched with pathways associated with nervous system development and function, and immune system and most of them seem to be around core networks such as those involved in kinase and/or signaling networks. Therefore, our results support the ...
... In summary, our list of differentially regulated genes is enriched with pathways associated with nervous system development and function, and immune system and most of them seem to be around core networks such as those involved in kinase and/or signaling networks. Therefore, our results support the ...
Exam II Answer Key
... of copies of polycistronic mRNAs are generated, as is shown in the image. Further, each mRNA is translated multiple times to produce an explosive increase in the concentration of each encoded protein inside the cell. How is the bacterium able to rapidly produce so many copies of each mRNA? Similarly ...
... of copies of polycistronic mRNAs are generated, as is shown in the image. Further, each mRNA is translated multiple times to produce an explosive increase in the concentration of each encoded protein inside the cell. How is the bacterium able to rapidly produce so many copies of each mRNA? Similarly ...
A Histone Chaperone and a Specific Transcription
... through an N-terminal a-helix. Mutations that disrupt the ability of NRP1 to form dimers and mutants that disrupt its acidic C terminus decrease NPR1’s interaction with histones and with WER1. Moreover, these mutants do not rescue the nrp1-1 nrp2-1 phenotype. ...
... through an N-terminal a-helix. Mutations that disrupt the ability of NRP1 to form dimers and mutants that disrupt its acidic C terminus decrease NPR1’s interaction with histones and with WER1. Moreover, these mutants do not rescue the nrp1-1 nrp2-1 phenotype. ...
The hSEP1 gene is a novel candidate tumor suppressor gene in
... The prevalence of osteogenic sarcoma (OGS) among the children and young adults presents a remarkable distinction from highincidence cancers (such as cancers of the breast, prostate, lung, or skin) that typically affect people of advanced age (1). An age-restricted prevalence of OGS presents a persua ...
... The prevalence of osteogenic sarcoma (OGS) among the children and young adults presents a remarkable distinction from highincidence cancers (such as cancers of the breast, prostate, lung, or skin) that typically affect people of advanced age (1). An age-restricted prevalence of OGS presents a persua ...
Chapter 25
... - The constitutive genes have GC box (GGGCGG consensus sequence) in their promoters - The structural genes have TATA box (TATATAATA sequence) in their promoters. - are located-25 to -30 on the DNA template strand. • RNAPII promoters: - are located at downstream, +40 to +80 on the DNA template strand ...
... - The constitutive genes have GC box (GGGCGG consensus sequence) in their promoters - The structural genes have TATA box (TATATAATA sequence) in their promoters. - are located-25 to -30 on the DNA template strand. • RNAPII promoters: - are located at downstream, +40 to +80 on the DNA template strand ...
Birth of a new gene on the Y chromosome of Drosophila melanogaster
... ancient duplications, with amino acid identities to the putative ancestors ranging from 30% to 74%, and poor (if any) alignment at the nucleotide level. Most of them have introns in conserved positions compared with their autosomal paralogs, ruling out retrotransposition and suggesting DNA-based dup ...
... ancient duplications, with amino acid identities to the putative ancestors ranging from 30% to 74%, and poor (if any) alignment at the nucleotide level. Most of them have introns in conserved positions compared with their autosomal paralogs, ruling out retrotransposition and suggesting DNA-based dup ...
Bioinformatics
... changes are less significant than non-synonymous and conservative changes less significant than non-conservative. Does not account for functions of “orthologs”. In many cases, an analysis will be based on the assumption that orthologs (determined by sequence homology) have the same function. But, ...
... changes are less significant than non-synonymous and conservative changes less significant than non-conservative. Does not account for functions of “orthologs”. In many cases, an analysis will be based on the assumption that orthologs (determined by sequence homology) have the same function. But, ...
Review Slides
... Cancer sequencing studies have primarily identified cancer driver genes by the accumulation of protein-altering mutations. An improved method would be annotation independent, sensitive to unknown distributions of functions within proteins and inclusive of noncoding drivers. We employed densitybased ...
... Cancer sequencing studies have primarily identified cancer driver genes by the accumulation of protein-altering mutations. An improved method would be annotation independent, sensitive to unknown distributions of functions within proteins and inclusive of noncoding drivers. We employed densitybased ...
Probing Lymphocyte Biology by Genomic-Scale Gene Expression Analysis.
... were found to be maximally repressed at 3 and 6 hr following activation and then return to near-resting levels after 24 hr. This suggests that a window of time exists early during T cell activation in which the trafficking of the cell is inhibited. A second repressed gene that may illuminate T cell ...
... were found to be maximally repressed at 3 and 6 hr following activation and then return to near-resting levels after 24 hr. This suggests that a window of time exists early during T cell activation in which the trafficking of the cell is inhibited. A second repressed gene that may illuminate T cell ...
No Slide Title
... Analysis of gene expression in cDNA libraries A fundamental approach to studying gene expression is through cDNA libraries. • Isolate RNA (always from a specific organism, region, and time point) ...
... Analysis of gene expression in cDNA libraries A fundamental approach to studying gene expression is through cDNA libraries. • Isolate RNA (always from a specific organism, region, and time point) ...
Gene Regulation
... inactivated lacIrare dominant lacc mutations... ...all mapped to lacI inactived LacI protein but it could still form tetramers As a Tool in Molecular Biology lac promoter is inducible. Allowing production of toxic genes IPTG, nonclevable derivative of allolactose Several colorimetric substrates exis ...
... inactivated lacIrare dominant lacc mutations... ...all mapped to lacI inactived LacI protein but it could still form tetramers As a Tool in Molecular Biology lac promoter is inducible. Allowing production of toxic genes IPTG, nonclevable derivative of allolactose Several colorimetric substrates exis ...
Gene Regulation
... arac muants are rare because the mutation must make AraC active without binding arabinose Inactivation of araC (unlike lacI) produces an ara- phenotype AraC must also be an antiactivator since... araCc mutations should be dominant (but they are not). IV. The trp operon (Negative regulation and trans ...
... arac muants are rare because the mutation must make AraC active without binding arabinose Inactivation of araC (unlike lacI) produces an ara- phenotype AraC must also be an antiactivator since... araCc mutations should be dominant (but they are not). IV. The trp operon (Negative regulation and trans ...
CAT GENETICS
... color in humans shows that three genes interact to determine the level of pigment in an individual's skin (actually there are > 10 genes involved in the production of melanin). The dominant alleles (A, B, and C) each contribute one "unit" of pigment to the individual, and their effects are cumulativ ...
... color in humans shows that three genes interact to determine the level of pigment in an individual's skin (actually there are > 10 genes involved in the production of melanin). The dominant alleles (A, B, and C) each contribute one "unit" of pigment to the individual, and their effects are cumulativ ...