SVPaper050711
... SVs and the SV’s ancestral state, was used to infer the likely mechanism of formation for simple SVs. To obtain breakpoint sequence, we performed de novo local assembly at 80.3% of deletions23. Comparison of 1,314 predicted deletion breakpoints to the breakpoint delineated by PCR and sequencing (Sup ...
... SVs and the SV’s ancestral state, was used to infer the likely mechanism of formation for simple SVs. To obtain breakpoint sequence, we performed de novo local assembly at 80.3% of deletions23. Comparison of 1,314 predicted deletion breakpoints to the breakpoint delineated by PCR and sequencing (Sup ...
Scoliosis Ethiopathonenesis: Changing Paradigms Through The
... Scoliosis prevalence was detected as 27% in the sisters of patients with scoliosis of more than 15 degrees. The said ratio rises to 36% in dizygotic twins, and as high as 73% in monozygotic twins. The studies conducted indicate an “X-linked” genetic disorder with a complex structure (12, 13). Variou ...
... Scoliosis prevalence was detected as 27% in the sisters of patients with scoliosis of more than 15 degrees. The said ratio rises to 36% in dizygotic twins, and as high as 73% in monozygotic twins. The studies conducted indicate an “X-linked” genetic disorder with a complex structure (12, 13). Variou ...
gsea user guide
... dataset. For example, before running hierarchical clustering, you might remove genes that have low variance across the dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not f ...
... dataset. For example, before running hierarchical clustering, you might remove genes that have low variance across the dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not f ...
Gene List for Cucurbita species
... Symbols of genes that have been published in previous lists but have been modified for this list are Pm (to be used solely for powdery mildew resistance in C. lundelliana, with the separate designation Pm-0 for resistance in and derived from C. okeechobeensis), and Zym (with separate designations f ...
... Symbols of genes that have been published in previous lists but have been modified for this list are Pm (to be used solely for powdery mildew resistance in C. lundelliana, with the separate designation Pm-0 for resistance in and derived from C. okeechobeensis), and Zym (with separate designations f ...
SALSA MLPA probemix P222-A2 LCA mix-2 - MRC
... polymorphism in the sequence detected by a probe can also cause a reduction in relative peak area, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplicatio ...
... polymorphism in the sequence detected by a probe can also cause a reduction in relative peak area, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplicatio ...
Product description P003-D1 MLH1-MSH2-v01 - MRC
... Not all abnormalities detected by MLPA are pathogenic. In some genes, intragenic deletions are known that result in very mild or no disease (Schwartz et al. 2007). For many genes, more than one transcript variant exists. Copy number changes of exons that are not present in all transcript variants ma ...
... Not all abnormalities detected by MLPA are pathogenic. In some genes, intragenic deletions are known that result in very mild or no disease (Schwartz et al. 2007). For many genes, more than one transcript variant exists. Copy number changes of exons that are not present in all transcript variants ma ...
Nonsensemediated decay of glutathione peroxidase 1 mRNA in the
... the resulting cytoplasmic mRNA and (ii) an exon±exon junction located >50±55 nucleotides downstream of a translation termination codon functions to elicit cytoplasmic NMD, as is the case for nucleus-associated NMD. We go on to show using a doxycycline-repressible promoter to drive GPx1 gene expressi ...
... the resulting cytoplasmic mRNA and (ii) an exon±exon junction located >50±55 nucleotides downstream of a translation termination codon functions to elicit cytoplasmic NMD, as is the case for nucleus-associated NMD. We go on to show using a doxycycline-repressible promoter to drive GPx1 gene expressi ...
Regulation of limb bud initiation and limbtype
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
::: Gene Set Enrichment Analysis - GSEA
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. The one-sample KS test compares the empirica ...
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. The one-sample KS test compares the empirica ...
1 FRQ-interacting RNA Helicase (FRH) Mediates Negative and
... for the feedback loop, and the model of the core oscillator as a single negative feedback loop (Crosthwaite et al. 1997). Later work established that FRQ actually binds to and inhibits the activity of its own transcription activators, the WCC (Cheng et al. 2001a; Denault et al. 2001; Froehlich et a ...
... for the feedback loop, and the model of the core oscillator as a single negative feedback loop (Crosthwaite et al. 1997). Later work established that FRQ actually binds to and inhibits the activity of its own transcription activators, the WCC (Cheng et al. 2001a; Denault et al. 2001; Froehlich et a ...
Evolutionary dynamics of nematode operons
... million years (Myr). Of the 1133 C. elegans operons annotated, 12 did not have protein sequences in at least one of the constituent genes, and therefore, were not used in our analysis. For an additional 98 operons, their gains and losses could not be unambiguously determined for various reasons (see ...
... million years (Myr). Of the 1133 C. elegans operons annotated, 12 did not have protein sequences in at least one of the constituent genes, and therefore, were not used in our analysis. For an additional 98 operons, their gains and losses could not be unambiguously determined for various reasons (see ...
GSEA - Bioinformatics Unit
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. ...
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. ...
molecular marker-based characterization of barley powdery mildew
... factors (Weibull et al., 2003), thus, race nonspecific resistance genes are desirable. Naturally occurring and induced recessive mutations at the Mlo locus on the barley chromosome 4H confer race nonspecific resistance against most of the powdery mildew pathotypes (Jørgensen, 1992). The Mlo gene has ...
... factors (Weibull et al., 2003), thus, race nonspecific resistance genes are desirable. Naturally occurring and induced recessive mutations at the Mlo locus on the barley chromosome 4H confer race nonspecific resistance against most of the powdery mildew pathotypes (Jørgensen, 1992). The Mlo gene has ...
Computational Definition of
... Two versions of the test minigene were used. The terminal exons of this construct were from the hamster dihydrofolate reductase (dhfr) gene separated by dhfr intron sequences. Exon 8 of the human CHUK gene was inserted into this minigene, either with or without approximately 55 nt of flank beyond th ...
... Two versions of the test minigene were used. The terminal exons of this construct were from the hamster dihydrofolate reductase (dhfr) gene separated by dhfr intron sequences. Exon 8 of the human CHUK gene was inserted into this minigene, either with or without approximately 55 nt of flank beyond th ...
Time to asthma onset Asthma score Bivariate analysis - Hal-CEA
... characterize chromosomal regions harbouring genes underlying time to asthma onset and to search for pleiotropic QTL influencing both time to asthma onset and the asthma score. We conducted a genome-wide linkage screen for time to asthma onset, modelled by martingale residuals from Cox survival model ...
... characterize chromosomal regions harbouring genes underlying time to asthma onset and to search for pleiotropic QTL influencing both time to asthma onset and the asthma score. We conducted a genome-wide linkage screen for time to asthma onset, modelled by martingale residuals from Cox survival model ...
Running Header: WHAT ARE THE GENETICS BEHIND DYSLEXIA
... Many people have heard about dyslexia and most of those people know that it is a reading disorder, but the complex genetics behind is unknown and is beginning to be uncovered. Dyslexia is defined as “a specific learning disability that is neurobiological in origin” and it’s characterized by difficul ...
... Many people have heard about dyslexia and most of those people know that it is a reading disorder, but the complex genetics behind is unknown and is beginning to be uncovered. Dyslexia is defined as “a specific learning disability that is neurobiological in origin” and it’s characterized by difficul ...
Molecular cloning of a laccase isozyme gene from
... properties of the various copper centres within the protein allow for classification into three different kinds of copper sites : type 1 (T1), type 2 (T2) and type 3 (T3) (Malkin & Malmstrom, 1970). T1 copper is responsible for the intense blue colour, absorbs maximally in the visible range and is r ...
... properties of the various copper centres within the protein allow for classification into three different kinds of copper sites : type 1 (T1), type 2 (T2) and type 3 (T3) (Malkin & Malmstrom, 1970). T1 copper is responsible for the intense blue colour, absorbs maximally in the visible range and is r ...
High grade B-cell lymphomas (HGBL): Altered terminology in the
... BCR/proliferation: Has more abundant expression of cell-cycle regulatory genes (CDK2, MCM family members, etc.); increased expression of DNA repair genes (PMS2, H2AX, PTIP, P53); higher levels of BCR signaling cascade components (CD19, Ig, CD79a, SYK, BLK) and B-cell-related transcription factors (P ...
... BCR/proliferation: Has more abundant expression of cell-cycle regulatory genes (CDK2, MCM family members, etc.); increased expression of DNA repair genes (PMS2, H2AX, PTIP, P53); higher levels of BCR signaling cascade components (CD19, Ig, CD79a, SYK, BLK) and B-cell-related transcription factors (P ...
Endogenous Cerberus activity is required for anterior head
... conclude that reducing Cerberus activity in the ADE was not sufficient to impair head formation in the Xenopus embryo. Gain of BMP, Nodal or Wnt function in the ADE perturbs head formation Cerberus protein can bind to and antagonize BMP4, Xnr1 and Xwnt8 molecules (Piccolo et al., 1999). We reasoned ...
... conclude that reducing Cerberus activity in the ADE was not sufficient to impair head formation in the Xenopus embryo. Gain of BMP, Nodal or Wnt function in the ADE perturbs head formation Cerberus protein can bind to and antagonize BMP4, Xnr1 and Xwnt8 molecules (Piccolo et al., 1999). We reasoned ...
Phylogenetic analysis of three complete gap
... extracellular loop. The remaining 2 of the 39 identified genes may not represent connexins since the predicted polypeptides contain only 2 conserved cysteine residues per extracellular loop (i.e., NCBI gene NM_001013546 or BC091468 identified from BAC zK283F18, position 34438 – 36613; zC159A3. 00872 ...
... extracellular loop. The remaining 2 of the 39 identified genes may not represent connexins since the predicted polypeptides contain only 2 conserved cysteine residues per extracellular loop (i.e., NCBI gene NM_001013546 or BC091468 identified from BAC zK283F18, position 34438 – 36613; zC159A3. 00872 ...
C 2: A A -
... analysis of blaVEB-1-like genes was the isolation of P. aeruginosa strains from an intensive care unit of a Kuwaiti hospital harboring blaVEB–like genes, blaVEB-1a and blaVEB-1b, that differ from the blaVEB-1 gene by nucleotide substitutions in the DNA sequence encoding the leader peptide (50) (Tabl ...
... analysis of blaVEB-1-like genes was the isolation of P. aeruginosa strains from an intensive care unit of a Kuwaiti hospital harboring blaVEB–like genes, blaVEB-1a and blaVEB-1b, that differ from the blaVEB-1 gene by nucleotide substitutions in the DNA sequence encoding the leader peptide (50) (Tabl ...
Effete, a Drosophila chromatin-associated ubiquitin
... DNA replication and shield chromosome ends from inappropriate DNA repair, which might result in end-to-end fusion (Palm and De Lange 2008; Jain and Cooper 2010; Raffa et al. 2011). In most organisms, telomeres terminate with tandemly repeated of G-rich sequences, which are added to chromosome ends b ...
... DNA replication and shield chromosome ends from inappropriate DNA repair, which might result in end-to-end fusion (Palm and De Lange 2008; Jain and Cooper 2010; Raffa et al. 2011). In most organisms, telomeres terminate with tandemly repeated of G-rich sequences, which are added to chromosome ends b ...
The Complex Inheritance of Maize Domestication Traits and Gene
... C.3 Number of genomic paired end reads and coverage obtained for constructing pseudo-transcriptomes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 C.4 Proportion of divergence due to cis regulatory effect grouped by overall parental divergence. . . . . . . . . . . . . . . . . . . . . ...
... C.3 Number of genomic paired end reads and coverage obtained for constructing pseudo-transcriptomes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 C.4 Proportion of divergence due to cis regulatory effect grouped by overall parental divergence. . . . . . . . . . . . . . . . . . . . . ...
Retrotransposon-Mediated Fgf5go-Utr Mutant Mice
... of the genomic DNA containing exon 3 of Fgf5 in Fgf5goUtr mutants may have been caused by ETn insertion, although the exact relation between insertion of LTR and the deletion of the 9.3-kb region is unclear. Therefore, the Fgf5go-Utr allele is a novel mutation of Fgf5 mediated by a retrotransposon. ...
... of the genomic DNA containing exon 3 of Fgf5 in Fgf5goUtr mutants may have been caused by ETn insertion, although the exact relation between insertion of LTR and the deletion of the 9.3-kb region is unclear. Therefore, the Fgf5go-Utr allele is a novel mutation of Fgf5 mediated by a retrotransposon. ...
as Adobe PDF - Edinburgh Research Explorer
... Figure 1. Biniou-bound enhancers drive expression in diverse spatial domains. (A) Schematic diagram showing the experimental design. The green arrow indicates Biniou’s continuous expression from stage 10 (∼6 h after egg laying) to the end of embryogenesis. ChIP-on-chip experiments were conducted at ...
... Figure 1. Biniou-bound enhancers drive expression in diverse spatial domains. (A) Schematic diagram showing the experimental design. The green arrow indicates Biniou’s continuous expression from stage 10 (∼6 h after egg laying) to the end of embryogenesis. ChIP-on-chip experiments were conducted at ...