ppt - Chair of Computational Biology
... ‘open’ chromatin structure and enable CLOCK-BMAL1 to bind to the E-boxes in cognate promoters and turn on transcription. CLOCK also acetylates BMAL1, making it a target for binding of the CRY repressor, concomitant with deacetylation of histones by histone deacetylases (HDAC). These dual effects of ...
... ‘open’ chromatin structure and enable CLOCK-BMAL1 to bind to the E-boxes in cognate promoters and turn on transcription. CLOCK also acetylates BMAL1, making it a target for binding of the CRY repressor, concomitant with deacetylation of histones by histone deacetylases (HDAC). These dual effects of ...
Gene Section ZBTB7A (zinc finger and BTB domain containing 7A)
... be low in almost all nonmalignant adult tissues, but is highly expressed in many carcinomas, where it is responsible for fatty acid synthesis. Furthermore, knockdown of FBI-1 expression leads to decreased FASN expression. FBI-1 enhances FASN transcriptional activation through SREBP-1a (sterol-respon ...
... be low in almost all nonmalignant adult tissues, but is highly expressed in many carcinomas, where it is responsible for fatty acid synthesis. Furthermore, knockdown of FBI-1 expression leads to decreased FASN expression. FBI-1 enhances FASN transcriptional activation through SREBP-1a (sterol-respon ...
PowerPoint Presentation - Foundations of Biology
... The transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein, may be possible, but transfer from protein to protein, or from protein to nucleic acid, is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or ...
... The transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein, may be possible, but transfer from protein to protein, or from protein to nucleic acid, is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or ...
pattern matching
... HMMs are good for profile searches… but optimising the many parameters when using HMMs to do alignments from scratch is a ...
... HMMs are good for profile searches… but optimising the many parameters when using HMMs to do alignments from scratch is a ...
Control of Gene Expression
... act as simple gene switches that respond to a single signal. Such simple switches predominate in bacteria. Other regulatory DNA sequences, especially those in eucaryotes, are very long (sometimes more than 10,000 nucleotide pairs) and act as molecular microprocessors, integrating information from a ...
... act as simple gene switches that respond to a single signal. Such simple switches predominate in bacteria. Other regulatory DNA sequences, especially those in eucaryotes, are very long (sometimes more than 10,000 nucleotide pairs) and act as molecular microprocessors, integrating information from a ...
The Cell Nucleus…
... amino acid residues in the histone tails – The histone code hypothesis – 1. The state & activity of a particular region of chromatin depends upon the specific modifications, or combination of modifications, to the histone tails in that region – 2. The pattern of modifications on the tails of the cor ...
... amino acid residues in the histone tails – The histone code hypothesis – 1. The state & activity of a particular region of chromatin depends upon the specific modifications, or combination of modifications, to the histone tails in that region – 2. The pattern of modifications on the tails of the cor ...
Ricinus communis - Scientific Research Publishing
... reported that WRI1 specifically binds to a conserved ciselement motif (AW-box) which are identified in upstream promoter regions of seed specific FAS related gene KAS1, BCCP2 and SUS2 in Arabidopsis [9]. Over expression of the WRI1 homologs in Arabidopsis, Brassica and maize resulted in significant ...
... reported that WRI1 specifically binds to a conserved ciselement motif (AW-box) which are identified in upstream promoter regions of seed specific FAS related gene KAS1, BCCP2 and SUS2 in Arabidopsis [9]. Over expression of the WRI1 homologs in Arabidopsis, Brassica and maize resulted in significant ...
Chromatin Structure Is a Focus for Regulation 30.2
... for the dark staining regions seen in interphase chromatin. Heterochromatin is further classified as: • Constitutive: always inactive and condensed: e.g. repetitive DNA, centromeric DNA • Facultative: can exist in both forms. E.g.: Female X chromosome in mammals. ...
... for the dark staining regions seen in interphase chromatin. Heterochromatin is further classified as: • Constitutive: always inactive and condensed: e.g. repetitive DNA, centromeric DNA • Facultative: can exist in both forms. E.g.: Female X chromosome in mammals. ...
Characterization of transcription factor binding sites by
... Motivation: Accurate and reliable computational tools to predict transcription factor binding sites are still not available. Potential reasons: 1. Lack of adequate experimental data 2. Lack of adequate computational models 3. Lack of an adequate method to estimate the parameters of a computational m ...
... Motivation: Accurate and reliable computational tools to predict transcription factor binding sites are still not available. Potential reasons: 1. Lack of adequate experimental data 2. Lack of adequate computational models 3. Lack of an adequate method to estimate the parameters of a computational m ...
AthaMap web tools for database-assisted identification of
... the identification of binding sites as described previously (6). The following command line was used to run Patser: ‘patserv3d -A a:t 0.320 c:g 0.180 -m matrixfile -f sequencefile -c -li -d2’. For all screens, the default threshold calculated by Patser from the adjusted information content of the ma ...
... the identification of binding sites as described previously (6). The following command line was used to run Patser: ‘patserv3d -A a:t 0.320 c:g 0.180 -m matrixfile -f sequencefile -c -li -d2’. For all screens, the default threshold calculated by Patser from the adjusted information content of the ma ...
Effects of high magnetic fields on in vitro transcription
... form an RNA-DNA hybrid. The RNA separates from the DNA and leaves the polymerase via the RNA exit pore as more amino acids are added to the RNA. This process is called elongation. As transcription progresses, the DNA leaves the polymerase through the DNA exit pore. This process continues until the ...
... form an RNA-DNA hybrid. The RNA separates from the DNA and leaves the polymerase via the RNA exit pore as more amino acids are added to the RNA. This process is called elongation. As transcription progresses, the DNA leaves the polymerase through the DNA exit pore. This process continues until the ...
mRNA
... length that can code for all the amino acids • Example: AGT at a particular position on a DNA strand results in the placement of the amino acid serine at the corresponding position of the polypeptide to be produced ...
... length that can code for all the amino acids • Example: AGT at a particular position on a DNA strand results in the placement of the amino acid serine at the corresponding position of the polypeptide to be produced ...
Basic Principles of Transcription and Translation
... Two dimensional structure. The four base paired regions and three loops are characteristic of all tRNAs as is the base sequence of the amino acid attachment site at the 3’ end. The anticodon triplet is unique to each tRNA type as are some sequences in the other two loops. (the asterisks mark bases t ...
... Two dimensional structure. The four base paired regions and three loops are characteristic of all tRNAs as is the base sequence of the amino acid attachment site at the 3’ end. The anticodon triplet is unique to each tRNA type as are some sequences in the other two loops. (the asterisks mark bases t ...
SURVEY AND SUMMARY Nucleolar responses to DNA double
... Maintenance of cellular homeostasis is key to prevent transformation and disease. The cellular response to DNA double-strand breaks, primarily orchestrated by the ATM/ATR kinases is one of many mechanisms that serve to uphold genome stability and homeostasis. Upon detection of double-strand breaks ( ...
... Maintenance of cellular homeostasis is key to prevent transformation and disease. The cellular response to DNA double-strand breaks, primarily orchestrated by the ATM/ATR kinases is one of many mechanisms that serve to uphold genome stability and homeostasis. Upon detection of double-strand breaks ( ...
Chapter 06 Lecture PowerPoint - McGraw Hill Higher Education
... experiments to distinguish between the hypotheses • Using E.coli polymerase the authors concluded that approximately 100% of all transcription cycles involved scrunching, which suggested that scrunching is required for promoter clearance • The E.coli polymerase achieves abortive transcription by scr ...
... experiments to distinguish between the hypotheses • Using E.coli polymerase the authors concluded that approximately 100% of all transcription cycles involved scrunching, which suggested that scrunching is required for promoter clearance • The E.coli polymerase achieves abortive transcription by scr ...
Supplementary Information (doc 7548K)
... allele-specific expression of GATA2 in each sample. Samples were considered to have allelespecific expression of GATA2 (“1” in the ASE column) if a known SNP (present in dbSNP135) that was heterozygous by exome sequencing (minimum coverage of 10 reads with >3 reads for each allele) showed 80% usage ...
... allele-specific expression of GATA2 in each sample. Samples were considered to have allelespecific expression of GATA2 (“1” in the ASE column) if a known SNP (present in dbSNP135) that was heterozygous by exome sequencing (minimum coverage of 10 reads with >3 reads for each allele) showed 80% usage ...
Transcriptional and epigenetic control of gene expression in embryo
... CBP/p300 is a widely used co-activator and histone acetyltransferase (HAT) involved in transcriptional activation. We discovered that CBP occupies the genome preferentially together with Dorsal, and has a specific role during development in coordinating the dorsal-ventral axis of the Drosophila embr ...
... CBP/p300 is a widely used co-activator and histone acetyltransferase (HAT) involved in transcriptional activation. We discovered that CBP occupies the genome preferentially together with Dorsal, and has a specific role during development in coordinating the dorsal-ventral axis of the Drosophila embr ...
Export To Word
... This is a 3-4 day lesson which focuses on the role of DNA and RNA in protein synthesis. It teaches students about the process Alien Encounters -of transcription and translation which makes the amino acid Transcription and Translation chains. This lesson has a variety of activities to engage students ...
... This is a 3-4 day lesson which focuses on the role of DNA and RNA in protein synthesis. It teaches students about the process Alien Encounters -of transcription and translation which makes the amino acid Transcription and Translation chains. This lesson has a variety of activities to engage students ...
RNA and transcription
... • 80 % of total RNA in the cells are rRNA. • rRNA are found in combination with several proteins ( about 82 proteins) as component of the ribosome Which is the site of protein synthesis. • In Eucaryotic ( mammals). There are 4 size types of rRNA (5S, 5.8S, 18Ss and 28S) representing 2/3 particle mas ...
... • 80 % of total RNA in the cells are rRNA. • rRNA are found in combination with several proteins ( about 82 proteins) as component of the ribosome Which is the site of protein synthesis. • In Eucaryotic ( mammals). There are 4 size types of rRNA (5S, 5.8S, 18Ss and 28S) representing 2/3 particle mas ...
tryptophan operon - Biology Notes Help
... Under severe tryptophan starvation trp genes are expressed maximally and controlled by attenuation. This is accomplished by a mechanism that controls the ...
... Under severe tryptophan starvation trp genes are expressed maximally and controlled by attenuation. This is accomplished by a mechanism that controls the ...
Transcription factories
... Although transcription factories are easily visualized in fixed cells by immunofluorescence either by electron microscopy or confocal light microscopy, they are not easily visualized in live eukaryotic cells by GFP tagging. Rather, in such cells, a diffuse nuclear fluorescence is typically seen. Hieda ...
... Although transcription factories are easily visualized in fixed cells by immunofluorescence either by electron microscopy or confocal light microscopy, they are not easily visualized in live eukaryotic cells by GFP tagging. Rather, in such cells, a diffuse nuclear fluorescence is typically seen. Hieda ...
RNAP IIO
... Other CTD phosphatases specific for Ser5 SCPs - a family of small CTD phosphatases that preferentially catalyze the dephosphorylation of Ser5 within CTD. Expression of SCP1 inhibits activated transcription from a number of promoters. SCP1 may play a role in transition from initiation/capping to proc ...
... Other CTD phosphatases specific for Ser5 SCPs - a family of small CTD phosphatases that preferentially catalyze the dephosphorylation of Ser5 within CTD. Expression of SCP1 inhibits activated transcription from a number of promoters. SCP1 may play a role in transition from initiation/capping to proc ...
Morphology of nuclear transcription | SpringerLink
... The transcribed sequences differ substantially between Pol I and Pol II transcription sites. The sequences that attach to transcription factories are typically the promoters of actively transcribed or poised genes, which are accessible for Pol II molecules. Sequences that can be found in one transcr ...
... The transcribed sequences differ substantially between Pol I and Pol II transcription sites. The sequences that attach to transcription factories are typically the promoters of actively transcribed or poised genes, which are accessible for Pol II molecules. Sequences that can be found in one transcr ...
slides pdf - Auburn University
... genes that use RNA polymerase II commonly have a “TATA box” about 25 nucleotides upstream of the point where transcription begins ...
... genes that use RNA polymerase II commonly have a “TATA box” about 25 nucleotides upstream of the point where transcription begins ...
Transcription factor
In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes.A defining feature of transcription factors is that they contain one or more DNA-binding domains (DBDs), which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA-binding domains, and, therefore, are not classified as transcription factors.