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Lecture 1. The subject and the main tasks of Medical Genetics
Lecture 1. The subject and the main tasks of Medical Genetics

... Genes exist in pairs and alleles segregate from each other during gamete formation, into equal numbers of gametes. Progeny obtain one determinant from each parent. ...
The role of mechanical load on the chondrogenesis of
The role of mechanical load on the chondrogenesis of

... value compared to samples cultured in medium without into chondrocytes is highly dependant on the signals the TGF-β1. In all the 3 groups where samples were cultured cells receive. TGFβ is used to induce chondrogenesis and in medium with different concentrations of TGF-β1, the yet this would not be ...
Genetics and Genomics in Medicine Chapter 5 Questions Multiple
Genetics and Genomics in Medicine Chapter 5 Questions Multiple

... b) One of the two X chromosomes in each diploid cell of a normal woman is randomly selected to undergo X-inactivation and becomes highly condensed. c) The process involves epigenetic silencing of each gene on one of the two X chromosomes, either the maternal X chromosome or the paternal X chromosome ...
cystic fibrosis
cystic fibrosis

... However, let me emphasize that if you feel uncomfortable about participating in this study in any way, just say 'No.' My feelings won't be hurt. There is no pressure to participate." "If it's inherited and I don't have it, why would they want to test me?" The situation still didn't make sense to Nan ...
Chapter 25
Chapter 25

... - The constitutive genes have GC box (GGGCGG consensus sequence) in their promoters - The structural genes have TATA box (TATATAATA sequence) in their promoters. - are located-25 to -30 on the DNA template strand. • RNAPII promoters: - are located at downstream, +40 to +80 on the DNA template strand ...
Human Genome Project
Human Genome Project

... • identify crime and catastrophe victims • establish paternity and other family relationships • identify endangered and protected species as an aid to wildlife officials (could be used for prosecuting poachers) • detect bacteria and other organisms that may pollute air, water, soil, and food • match ...
What is RNA splicing?
What is RNA splicing?

... We are studying how mRNAs and proteins interact in order to understand how these machines work in general and, in particular, how RNA splicing is regulated as it affects which proteins are produced in each cell and tissue in the body. ...
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Slide 1

... feature that all parasitic plants share is the use of penetrating organs, called haustoria, to connect to the host in order to draw upon its water and nutrient supply. Beyond the occurrence of haustoria, however, parasitic plants can vary widely in their degree of modification, and in the degree to ...
Section 4
Section 4

... – During translation, amino acids are assembled from information encoded in mRNA. – As the mRNA codons move through the ribosome, tRNAs add specific amino acids to the growing polypeptide chain. – The process continues until a stop codon is reached and the newly made protein is released. ...
PPT
PPT

...  cff DNA can be detected in plasma of pregnant woman  cff DNA only makes up about 5% of total cell free DNA extracted most common from the mother  cff DNA derived from the placenta  Can be detected as early as 5 weeks of gestation  Rapidly cleared after delivery Cell free fetal RNA (cff RNA)  ...
PS 4 answers
PS 4 answers

... Mother #1 are a couple, as are Father and Mother #2, and Father and Mother #3.) This problem will show you how to figure out which baby goes with each set of parents. As we have spoken about in class, most of the human genome (>95%) is not genes. Most of the DNA sequence differences between humans a ...
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... Show pathway maps and find Enzyme ID (EC) using KEGG Identify functional domains and Gene Ontology Annotation of the protein sequence using Uniprot, Prosite, Pfam Find orthologs and perform multiple sequence alignment 2.2 Find ortholog protein sequences in Mus musculus, Rattus norvegicus, Saccharomy ...
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... • identify crime and catastrophe victims • establish paternity and other family relationships • identify endangered and protected species as an aid to wildlife officials (could be used for prosecuting poachers) • detect bacteria and other organisms that may pollute air, water, soil, and food • match ...
Lectures by Erin Barley Kathleen Fitzpatrick From Gene to Protein
Lectures by Erin Barley Kathleen Fitzpatrick From Gene to Protein

... RNA polymerase and the initiation of transcription • The completed assembly of transcription factors and RNA polymerase II bound to a promoter is called a transcription initiation complex • A promoter called a TATA box is crucial in forming the initiation complex in eukaryotes © 2011 Pearson Educati ...
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... Genomic DNA is organized in chromosomes. Genome browsers display ideograms (pictures) of chromosomes, with user-selected “annotation tracks” that display many kinds of information. The two most essential human genome browsers are at Ensembl and UCSC. We will focus on UCSC (but the two are equally im ...
PCR-based Detection of Silkworm Diseases
PCR-based Detection of Silkworm Diseases

... activities in India. It is a prerequisite to ensure the silkworms free of pathogens before being supplied to farmers. Lack of accurate disease detection techniques in sericulture causes severe spread of diseases leading to crop loss of 30-40%. The silkworm, B. mori and other related species are susc ...
IS IT GENETIC? How do genes, environment and chance interact to
IS IT GENETIC? How do genes, environment and chance interact to

... of genetic and environmental factors polygenic: a character determined by the combined action of a number of different genetic loci; mathematical polygenic theory assumes there are very many loci, each with a small, additive effect quantitative character: a character that shows continuous distributi ...
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genetic recombination-unit-2-study material- 2012

... extraneous DNA (alien DNA). Such mutations can occur in structural and regulatory genes anywhere on the chromosome. The extraneous DNA consists of so- called insertion sequences (IS elements), which occur in bacterial chromosomes and in plasmids. They have 800—1400 base pairs but do not code for any ...
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2006 7.012 Problem Set 6 KEY

... When an activated helper T cell (TH cell) binds to a B cell presenting the appropriate antigen on the B cell's Class II MHC molecules, the TH activates the B cell. This stimulates the B cell to proliferate and make more antibodies to fight the invasion. (a) Why must the TH and B cells contact each o ...
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The Structure and Genetic Map of Lambda phage

... analogous structures for adsorption. Specific receptors on the bacterial cell like proteins, lipopolysaccharides, pili apart from lipoproteins are exploited by phages for attachment. This is reversible condition. Base plate components mediate permanent binding. Second stage in infection process is p ...
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Gene Section MTA3 (metastasis associated 1 family, member 3 )

... Animal experiments revealed involvement of MTA3 expression in mammary gland morphogenesis mediated by the suppression of the Wnt4 signalling pathway and upregulation of epithelial cell adhesion proteins such as E-cadherin. Normal mammary gland development, as confirmed and studied by several knock o ...
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Unit 4. Week 2. Meiosis and Reproduction

... divide rapidly to heal the wound. When you’re almost healed, the cell division will slow down and then stop. ...
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... host cells (lytic infection) (e.g. T-phages of E.coli). Temperate phages may integrate into the host DNA, causing LYSOGENY. The infection cycle of T-even bacteriophage lasts about 20 minutes, culminating in lysis (bursting-open) of the host cell, E. coli. The whole process can be classified into, (i ...
What Do Studies of Insect Polyphenisms Tell Us about
What Do Studies of Insect Polyphenisms Tell Us about

... has multiple functions; in mammals, DNA methylation in the promoter region of genes has been associated with imprinting and gene silencing [5], but in the majority of animals, including mammals, DNA methylation also occurs on gene bodies (transcription units) [6], as it does in honeybees [7]. Gene b ...
Non Nuclear Inheritance
Non Nuclear Inheritance

... Mitochondria may not only be inherited through the maternal line, according to new research, published August 2002, that promises to overturn accepted biological wisdom. Schwartz and Vissing from Copenhagen have discovered that one of their patients inherited the majority of his mitochondria from hi ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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