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The 2013 Thomas Hunt Morgan Medal Thomas Douglas
The 2013 Thomas Hunt Morgan Medal Thomas Douglas

... equally impressive and included John Pringle, housemates Mike Liskay and Jeff Hall, Bruce Baker, Adelaide Carpenter, Jim and Anita Hopper, Joe Culotti, Carol Newlon, Hannah Klein, and the late Lynna Hereford (who co-occupied with Tom what other students referred to as the “Bay of Pigs”). It was also ...
Pro-Apoptotic Role of the Human YPEL5 Gene Identified by
Pro-Apoptotic Role of the Human YPEL5 Gene Identified by

... human YPEL3, which was described as a small unstable apoptotic protein in murine myeloid cells [4], has been reported to be involved in growth suppression, causing cellular senescence in human cell lines, and its expression is regulated by the tumor suppressor protein p53, with lower expression in s ...
regional mapping of the gene coding
regional mapping of the gene coding

... the following 8 regions: pter -1- - TPI -2- - GAPD -3- - LDHB -4- - ENO2 -8- centromere -6- - SHMT -7- - PEPB -8- - qter. Thus a set of a minimum of 5 clones exhibiting unique combinations of these markers can be selected from Table 1 and used for rapid regional mapping of other genes assigned to ch ...
26
26

... gene was not a major cause of NSARD in Oman. To study the genetic causes of deafness in Oman, one could either study the mutations in each reported gene or carry out genetic linkage mapping. The main objective of this study was to determine the loci for the non-syndromic autosomal recessive deafness ...
Biology and Society: Marathoners versus Sprinters
Biology and Society: Marathoners versus Sprinters

... 4. Describe the basic structure of a chromosome. Explain how DNA is packaged into an elaborate, multilevel system of coiling and folding. 5. Explain how and when chromosomes are duplicated. 6. Describe the key events of each phase of the cell cycle. 7. Describe the key events of each phase of mitosi ...
An alternative model for (breast) cancer predisposition
An alternative model for (breast) cancer predisposition

... More recently, genome-wide association studies (GWAS) have revealed a set of single-nucleotide polymorphisms (SNPs) associated with BC risk in non- selected BC patients20 (BC susceptibility factors), but also in sub-cohorts such as BRCA1 mutation carriers21 (and therefore called genetic modifiers of ...
Patchy distribution of flexible genetic elements in bacterial
Patchy distribution of flexible genetic elements in bacterial

... frequency of a particular plasmid type, as defined by its backbone, and to what extent it confers phenotypic diversity by varying accessory elements in an environmental population of bacteria are scarce. A glimpse into the natural heterogeneity of soil populations due to conjugative plasmids was giv ...
MACS GMP CD3 pure package insert
MACS GMP CD3 pure package insert

... protocols can be found under www.miltenyibiotec.com/170-076-124 or www.miltenyibiotec.com/170-076-116. Warranty The products sold hereunder are warranted only to be free from defects in workmanship and material at the time of delivery to the customer. Miltenyi Biotec GmbH makes no warranty or repres ...
Transcription. (Ms. Shivani Bhagwat)
Transcription. (Ms. Shivani Bhagwat)

... RNA polymerase II All genes that are transcribed and expressed via mRNA are transcribed by RNA polymerase II. Transcription copies the DNA code of a gene and converts it to high mol mass nuclear RNA (hnRNA), which is precessed to mRNA. The mRNA will be used at the ribosome to make polypeptides (prot ...
this PDF file
this PDF file

... Cucumber mosaic virus strain soybean (CMV-S) is one of economically important virus infecting soybean in Indonesia. However, it is very few information related with the CMV-S Indonesia isolates. Thus, the aim of present work is to detect and identify CMV-S isolates from different origin. Leaf sample ...
Milestone7
Milestone7

... phylogenies, and has greatly improved our phylogenetic knowledge. However care must be taken when constructing phylogenetic trees based on molecular data. Phylogenetic trees based on gene sequences do not always correspond exactly to the phylogenetic trees showing the evolutionary relationships betw ...
Genetic analysis and tagging of gene for brown planthopper
Genetic analysis and tagging of gene for brown planthopper

... Table 1 summarizes the data for resistance of the F1, F2, or F3 progeny to BPH biotype 1 in three crosses involving Sanguizhan. In the cross with TN1, all the F1 plants were resistant, and the F2 population segregated in the ratio of 3 resistant: 1 susceptible in the primary study (Liu et al 1992), ...
Biotechnology in Livestock Improvement
Biotechnology in Livestock Improvement

... structure (i.e., shaped like a corkscrew). Their double-helix model had two strands of DNA with the nucleotides pointing inward, each matching a complementary nucleotide on the other strand to form what looks like rungs on a twisted ladder. This structure showed that genetic information exists in th ...
What Do You Mean, “Epigenetic”?
What Do You Mean, “Epigenetic”?

... effects on gene expression and that these effects persisted through mitosis, corresponded to Nanney’s (1958a,b) writings on the stability of expression states. This prompted Holliday to redefine epigenetics in a way that was more specific and squarely focused on the inheritance of expression states ( ...
An eye on trafficking genes: identification of four eye color mutations
An eye on trafficking genes: identification of four eye color mutations

... Genes that code for proteins involved in organelle biogenesis and intracellular trafficking produce products that are critical in normal cell function. Conserved orthologs of these are present in most or all eukaryotes including Drosophila melanogaster. Some of these genes were originally identified ...
Power Point for Lecture 9
Power Point for Lecture 9

... A. Uninducible mutants: mutants cannot be expressed at all. B. Constitutive mutants: mutants continuously express genes that do not respond to regulation. 3. Operator (lacO): cis-acting element Repressor (lacI): trans-acting element ...
1st Quarter Syllabus
1st Quarter Syllabus

... 4 Discussion: The Endomembrane System and its Associated Organelles. 5 Discussion: Using the Leica BM E Microscope. Lab: Using a Compound Microscope. 6 Lab: Making a Wet Mount. 7 Lab: Examining Plant and Animal Cells. 8 Quiz: Organelles. Activity: Gridiron Glory: A Cell Review Game. 9 TEST: CELL STR ...
The trp Operon
The trp Operon

... answer to this question lies in the fact that genetic information is not simply inherited and automatically used in every cell all the time. Each cell is using or expressing only a small portion of the total genes that it contains. The finger cells are not expressing the gene for insulin production. ...
Xist - TeachLine
Xist - TeachLine

Cell and Gene Therapy Catapult UK clinical trials database 2016
Cell and Gene Therapy Catapult UK clinical trials database 2016

... The purpose of this study is to test the safety of repeated bone marrow stem cell infusion in patients with MS. We want to find out what effects, good and/or bad, it has on you and your disability. The results of a previous safety study of bone marrow Repeat Infusion of Autologous Bone stem cell inf ...
(Rfg, Rbg), (Gfg, Gbg)
(Rfg, Rbg), (Gfg, Gbg)

... Department of Biotechnology ...
Validated preCRMs
Validated preCRMs

... (Benz et al. 1980). The luciferase reporter gene is driven by the promoter from the HBG1 gene, which is expressed in K562 cells. Activity measurements from predicted neutral fragments (preNeutral) rarely exceed log2 of 0.7 (corresponding to a 1.6-fold increase, Fig. 2B), confirming that they have li ...
Roles of BRCA1 and BRCA2 in homologous recombination, DNA
Roles of BRCA1 and BRCA2 in homologous recombination, DNA

... genes suggests that they participate in a common pathway to facilitate orderly homologous recombination and thereby maintain genomic integrity. As a consequence of this defect in homologous recombination, tumors that arise in BRCA carriers are likely to be more sensitive to ionizing radiation. This ...
Alisch RS, Wang T, Chopra P, Visootsak J, Conneely KN, Warren ST . Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. BMC Med Genet. 2013 Jan 29;14:18. doi: 10.1186/1471-2350-14-18.
Alisch RS, Wang T, Chopra P, Visootsak J, Conneely KN, Warren ST . Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. BMC Med Genet. 2013 Jan 29;14:18. doi: 10.1186/1471-2350-14-18.

... methylation denoted as β, calculated as the ratio of methylated to total DNA. This is a highly reproducible and widely used assay ([14-18] that measures β at 485,512 CpG dinucleotides located proximal to the promoters of nearly all RefSeq genes. To determine whether FXS-associated DNA methylation ch ...
Document
Document

... analysis we measured: accuracy, specificity and sensitivity. Accuracy was defined as (TP + TN)/(TP + FP + FN + TN), specificity as TN/(TN + FP) and sensitivity as TP/(TP + FN) where TP is the number of true positives, TN is the number of true negatives, FP is the number of false positives and FN is ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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