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frame-shift mutation
frame-shift mutation

... • You should be able to evaluate the effects of errors in the replication or transcription processes. • You should be able to identify sections of the DNA molecule based on whether or not they are transcribed. ...
Document
Document

Today is Wednesday, February 3rd, 2010
Today is Wednesday, February 3rd, 2010

... • You should be able to evaluate the effects of errors in the replication or transcription processes. • You should be able to identify sections of the DNA molecule based on whether or not they are transcribed. ...
DNA Base Pairing Activity
DNA Base Pairing Activity

... 2. Inform the students that they should put out their right or left hand based on what letter they  have.  a. A and T = right hand  b. G and C = left hand  3. Inform the students that they can only pair with someone that has the same hand out and a  different color. They will need to hold their card ...
Conservation scores
Conservation scores

... substitutions in each aligned genome • Original score (Cooper, 2005) is “rejected substitutions”: number of substitutions expected under ‘neutrality’ minus number of substitutions observed at each aligned position • New scores based on ML fit of substitution rate at base • Positive scores (fewer tha ...
Elucidating the essentiality of essential genes in E. coli K-12
Elucidating the essentiality of essential genes in E. coli K-12

... coli K-12 by Wanner’s method [1] and simultaneously 303 genes have been predicted as essential genes in LB medium [2]. Elucidating the essentiality of these essential genes is a key to understand the system level organization of living cells. Here we present our analysis to address this issue from t ...
Work Day 2
Work Day 2

... billion/year ...
Protein Synthesis Worksheet
Protein Synthesis Worksheet

... 13. tRNA uses (anticodons/codons) to match to the mRNA. 14. Proteins are made at the (nucleus/ribosome). 15. (tRNA/mRNA) attaches the amino acids into a chain. 16. tRNA is found in the (nucleus/cytoplasm). 17. (Translation/Transcription) converts mRNA into a protein. 18. Translation takes place in t ...
divergent transcription
divergent transcription

... These are a very powerful set if insights and observations. They have significant conclusions as has been articulated by those in Sharp’s Lab. The metaphor of a train station with wandering fragments of often “useless” RNA has certain merit. However all too often those fragments are not useless but ...
Ch. 17 DNA mutations and Repair
Ch. 17 DNA mutations and Repair

... Terms associated with PHENOTYPIC effects of mutations on protein structure ...
video slide - Wesleyan College Faculty
video slide - Wesleyan College Faculty

... This method synthesizes a nested set of DNA strands complementary to the original DNA fragment. Each strand starts with the same primer and ends with a dideoxyribonucleotide (ddNTP), a modified nucleotide. Incorporation of a ddNTP terminates a growing DNA strand because it lacks a 3—OH group, the s ...
RNA
RNA

... as is the base sequence of the amino acid attachment site at the 3 end. The anticodon triplet is unique to each tRNA type. (The asterisks mark bases that have been chemically modified, a characteristic of tRNA.) ...
HumanGeneticDisorders
HumanGeneticDisorders

... Frank eventually ran away from home because he didn't want to bring shame to the family. Nancy Narly settled down with Bill Quiff. After the wedding, the Narly's discovered that Bill could not roll his tongue. Sarah Dorhoff married a man named Ted Goof. Ted was accepted into the family due to the fa ...
Lateral gene transfer and the nature of bacterial innovation
Lateral gene transfer and the nature of bacterial innovation

... transfer events are only rarely observed, and unambiguous evidence of their occurrence must be derived from other sources. Lateral gene transfer creates an unusually high degree of similarity between the donor and the recipient strains for the character in question. Furthermore, because each transfe ...
The Childhood-Onset Epilepsy 40 Genes (3)
The Childhood-Onset Epilepsy 40 Genes (3)

... • Mutations in over 2,000 genes have now been identified in patients with more than 3,000 different disease phenotypes. For the clinicians and their patients, it is becoming increasingly important to obtain a genetic diagnosis • Identifying the genetic aetiology of a disease may influence clinical m ...
19 extranuclear inheritance
19 extranuclear inheritance

... Autosomal dominance is possible, but not an attractive explanation. Let A = disease allele and a = normal allele. All unaffected individuals are homozygous recessive (aa), while all affected individuals, with the possible exception of I-1, are heterozygous (Aa). The mating between individuals II-1 a ...
Reading GuideGeneTransfer
Reading GuideGeneTransfer

... This plasmid consists of genes to build or synthesize a sex pilus and to facilitate transfer of the plasmid. The process of conjugation begins when a F (+) cell binds( using the sex pilus) to a F(-) cell. The F plasmid is cut by an endonuclease at a site on the plasmid called of the origin of trans ...
Searching for Genes
Searching for Genes

... sequences. So, when the Roberts lab began studying the evolution of cellulose synthesis, one place they looked was at the available DNA sequence information. Even now, as they expand their studies to include additional species of plants and algae, this is where they start. Cellulose is an important ...
Case Study: Visualization of annotated DNA sequences
Case Study: Visualization of annotated DNA sequences

... the screen is taken by a canvas. The canvas contains one or more views. In each view one or more data sets are visualized. Figure 1 shows four views: three bar views and one matrix view. The nucleotide and annotation visualization is described in section 4.1. The bar view is described in section 4.2 ...
Structure of DNA and History
Structure of DNA and History

... Harbor Laboratory New York, the famous experiment demonstrated the genetic properties of DNA over proteins. By marking bacteriophages with radioactive isotopes, Hershey and Chase were able to trace protein and DNA to determine which is the molecule of heredity ...
DNA RNA Protein
DNA RNA Protein

6 Possible Alleles
6 Possible Alleles

... 4. Crime Scene Investigators search in areas of the genome that are unique from individual to individual and are “anonymous” (control no known trait or function) The areas examined are Short Tandem Repeats or STR’s ...
Gene Section RAD51L3 (RAD51 like 3 (S. cerevisiae)) -
Gene Section RAD51L3 (RAD51 like 3 (S. cerevisiae)) -

... insertion of proline at the 36th protein position rather than a serine. A third mutation observed is noted to occur at mRNA positions 810 (SNP ID: rs4796033). A mutation at this location results in a sequence of CAG (from the natural CGG). The effect of this substitution is the insertion of a glutam ...
1 How DNA Makes Stuff
1 How DNA Makes Stuff

... Transcription - Copying the DNA It can be misleading to think of DNA as a blueprint, but it works sometimes, like now. (But only just for now—see the box on the next page.) You don't bring the master plans for a building to the job site, where things are messy and windy. You make a copy of the plans ...
Co-amplification of cytochrome b and D-loop mtDNA
Co-amplification of cytochrome b and D-loop mtDNA

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Non-coding DNA

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