Exome sequencing as a tool for Mendelian disease gene discovery
... protein-coding genes that are present in a sample, although the contribution of exome sequencing to our understanding of complex diseases has been much smaller than its contribution to our understanding of Mendelian traits. Exome sequencing is often used in conjunction with two sampling strategies: ...
... protein-coding genes that are present in a sample, although the contribution of exome sequencing to our understanding of complex diseases has been much smaller than its contribution to our understanding of Mendelian traits. Exome sequencing is often used in conjunction with two sampling strategies: ...
Costimulatory receptors in jawed vertebrates: Conserved
... of medaka (Oryzias latipes), fugu (Takifugu rubripes or Fugu rubripes), green spotted pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the availabl ...
... of medaka (Oryzias latipes), fugu (Takifugu rubripes or Fugu rubripes), green spotted pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the availabl ...
The Mean Between Meme and Gene Comparison
... recognizes that the development of the gene and meme pool differ in the method and rate of mutation. Most genetic mutations occur during the process of reading and transposing DNA and sexual reproduction. Genes are generally quite stable, which is one of the key reasons for the successful formulati ...
... recognizes that the development of the gene and meme pool differ in the method and rate of mutation. Most genetic mutations occur during the process of reading and transposing DNA and sexual reproduction. Genes are generally quite stable, which is one of the key reasons for the successful formulati ...
Chpt12_RNAProcessing.doc
... cleave a particular mRNA, thereby turning off expression of a particular gene. If over-expression or ectopic expression of a defined gene were the cause of some pathology (e.g. some form of cancer), then reducing its expression could have therapeutic value. Other RNAs possibly involved in catalysis, ...
... cleave a particular mRNA, thereby turning off expression of a particular gene. If over-expression or ectopic expression of a defined gene were the cause of some pathology (e.g. some form of cancer), then reducing its expression could have therapeutic value. Other RNAs possibly involved in catalysis, ...
Small aminoacyl transfer centers at GU within a larger RNA
... Separate aminoacyl transfer centers related to the small …GUNNN..: NNNU ribozyme seem possible at the frequent GU sequences dispersed throughout an RNA tertiary structure. In fact, such activity is easily detected and varies more than 2 orders in rate, probably being faster at sites with less struct ...
... Separate aminoacyl transfer centers related to the small …GUNNN..: NNNU ribozyme seem possible at the frequent GU sequences dispersed throughout an RNA tertiary structure. In fact, such activity is easily detected and varies more than 2 orders in rate, probably being faster at sites with less struct ...
Corning® Epoxide Coated Slides Instruction Manual
... methods of preparation, analysis or use may be covered by intellectual property rights held by others in certain countries. Use of this product is recommended only for applications for which the user has a license under proprietary rights of third parties or for technology for which a license is not ...
... methods of preparation, analysis or use may be covered by intellectual property rights held by others in certain countries. Use of this product is recommended only for applications for which the user has a license under proprietary rights of third parties or for technology for which a license is not ...
DNA Methylation Analysis
... have been targeted on the HumanMethylation27 BeadChip with additional markers for higher resolution analysis. The HumanMethylation27 panel targets CpG sites covering over 14,000 genes, including almost 13,000 genes in the NCBI CCDS Database9 (Genome Build 36). Additional markers provide increased re ...
... have been targeted on the HumanMethylation27 BeadChip with additional markers for higher resolution analysis. The HumanMethylation27 panel targets CpG sites covering over 14,000 genes, including almost 13,000 genes in the NCBI CCDS Database9 (Genome Build 36). Additional markers provide increased re ...
Am I a Warrior? - Erasmus University Thesis Repository
... When spoken of an individual’s DNA profile, it refers to the set up of genes which contain genetic instructions. DNA, or deoxyribonucleic acid, is acid consisting of multiple genes. The genes are the segments with information which give shape to the DNA. This genetic information is the blueprint of ...
... When spoken of an individual’s DNA profile, it refers to the set up of genes which contain genetic instructions. DNA, or deoxyribonucleic acid, is acid consisting of multiple genes. The genes are the segments with information which give shape to the DNA. This genetic information is the blueprint of ...
Characterization of microbial activity in the surface layers of a
... this is true in situ, the production rates must b e at least as high. Since the input of organic matter from detritus and photoautotrophs in this system is limited to the interface a n d the chemoautotrophs are probably limited in number, a very active heterotrophic population would be expected to a ...
... this is true in situ, the production rates must b e at least as high. Since the input of organic matter from detritus and photoautotrophs in this system is limited to the interface a n d the chemoautotrophs are probably limited in number, a very active heterotrophic population would be expected to a ...
Molecular Design of Expression Systems
... have been cloned and utilized to regulate transcription of cloned genes!,25 In each of these systems, the transcription activity of the promoter-operator depends upon interaction with a corresponding specific repressor protein. This interaction may be influenced by adjusting the temperature (ts regu ...
... have been cloned and utilized to regulate transcription of cloned genes!,25 In each of these systems, the transcription activity of the promoter-operator depends upon interaction with a corresponding specific repressor protein. This interaction may be influenced by adjusting the temperature (ts regu ...
Lab: Colony PCR amplification of the 16S ribosomal RNA gene I
... Archaea. With the aid of the polymerase chain reaction (PCR), these strategies have greatly enhanced our ability to describe the genetic diversity of microorganisms in the natural environment without the need for cultivation. The cloning and sequencing of PCR-amplified SSU rRNA genes is now a routin ...
... Archaea. With the aid of the polymerase chain reaction (PCR), these strategies have greatly enhanced our ability to describe the genetic diversity of microorganisms in the natural environment without the need for cultivation. The cloning and sequencing of PCR-amplified SSU rRNA genes is now a routin ...
PDF
... not with genetic divergence [28,29]. These correlations are inferred to be due to an indirect effect of recombination due to the interaction between selection and linkage and their strength can be used to make inferences about the pervasiveness of natural selection. Positive selection on favourable ...
... not with genetic divergence [28,29]. These correlations are inferred to be due to an indirect effect of recombination due to the interaction between selection and linkage and their strength can be used to make inferences about the pervasiveness of natural selection. Positive selection on favourable ...
DNA Base Composition, DNA-DNA Homology and Long
... respectively. These data are in good agreement with the previous reports of about 38 to 42 mol % G + C within these species (Deibel & Seeley, 1974; Kilpper-Balz et al., 1982). The results of DNA-DNA hybridization experiments are shown in Table 2. Streptococcus salivarius and S. therrnophilus strains ...
... respectively. These data are in good agreement with the previous reports of about 38 to 42 mol % G + C within these species (Deibel & Seeley, 1974; Kilpper-Balz et al., 1982). The results of DNA-DNA hybridization experiments are shown in Table 2. Streptococcus salivarius and S. therrnophilus strains ...
Article Purifying Selection Maintains Dosage
... genes, dosage imbalances have been avoided entirely by preserving the Y chromosome allele through strong selection (Bellott et al. 2014; Cortez et al. 2014). These recent findings have raised a number of new questions about the selective forces that shape degeneration and gene loss across the Y chro ...
... genes, dosage imbalances have been avoided entirely by preserving the Y chromosome allele through strong selection (Bellott et al. 2014; Cortez et al. 2014). These recent findings have raised a number of new questions about the selective forces that shape degeneration and gene loss across the Y chro ...
Maintenance of genomic integrity by p53: complementary
... S phase arrest In another checkpoint response pathway which operates in S phase and slows down the rate of DNA replication, p21Waf1 binds to the proliferatingcell nuclear antigen (PCNA) and blocks its activity, interfering with cell-cycle progression by blocking the elongation step in DNA replicatio ...
... S phase arrest In another checkpoint response pathway which operates in S phase and slows down the rate of DNA replication, p21Waf1 binds to the proliferatingcell nuclear antigen (PCNA) and blocks its activity, interfering with cell-cycle progression by blocking the elongation step in DNA replicatio ...
Category 2000
... coactivator 1 (PPARGC1A) is a versatile coactivator with many functions, but is primarily involved in fat and energy metabolism. Therefore, it is a very interesting candidate gene for meat quality, which is one of the most important criteria in pig selection today. PPARGC1A however, does not have th ...
... coactivator 1 (PPARGC1A) is a versatile coactivator with many functions, but is primarily involved in fat and energy metabolism. Therefore, it is a very interesting candidate gene for meat quality, which is one of the most important criteria in pig selection today. PPARGC1A however, does not have th ...
Nucleic acid vaccines against rickettsial diseases and methods of use
... This application is a continuation-in-part of Ser. No. 09/337,827, ?led Jun. 22, 1999 noW abandoned; Which is a divisional of Ser. No. 08/953,326, ?led Oct. 17, 1997, now US. Pat. No. 6,251,872; Which is a continuation-in-part of ...
... This application is a continuation-in-part of Ser. No. 09/337,827, ?led Jun. 22, 1999 noW abandoned; Which is a divisional of Ser. No. 08/953,326, ?led Oct. 17, 1997, now US. Pat. No. 6,251,872; Which is a continuation-in-part of ...
The physics behind the larger scale organization of DNA in eukaryotes
... organization/condensation before the genetic material fits into the nucleus. This larger scale organization will be the main issue we will address in this paper. Our paper is organized as follows. In section 2, we discuss the local fiber structures of in vitro 30 nm fibers and the relation to the fi ...
... organization/condensation before the genetic material fits into the nucleus. This larger scale organization will be the main issue we will address in this paper. Our paper is organized as follows. In section 2, we discuss the local fiber structures of in vitro 30 nm fibers and the relation to the fi ...
In the near future, EU thresholds for adventitious
... the power of any comparison between the real-time quantification and the seed pool quantification be determined. One real-time PCR result exhibited a downward bias. The 0.9% GM seed sample gave 0.66% for MS8 which was expected to be 0.9%. The reason for this is not known, although in general the acc ...
... the power of any comparison between the real-time quantification and the seed pool quantification be determined. One real-time PCR result exhibited a downward bias. The 0.9% GM seed sample gave 0.66% for MS8 which was expected to be 0.9%. The reason for this is not known, although in general the acc ...
Results - BioMed Central
... the isolated strains whether were H. sinensis. After this procedure, it can be basically ...
... the isolated strains whether were H. sinensis. After this procedure, it can be basically ...
Expansion of the Pseudo-autosomal Region and Ongoing
... progress towards a complete genome sequence (International Human Genome Sequencing Consortium 2001). Eutherian PARs now include only a few genes (e.g., Van Laere et al. 2008), making it unlikely that SA polymorphisms will be found among them, so mammal PARs are no longer likely to be informative abo ...
... progress towards a complete genome sequence (International Human Genome Sequencing Consortium 2001). Eutherian PARs now include only a few genes (e.g., Van Laere et al. 2008), making it unlikely that SA polymorphisms will be found among them, so mammal PARs are no longer likely to be informative abo ...
