A new FISH protocol with increased sensitivity for
... (de Jong et al., 1999), can be enhanced by increasing the power of detection tools, such as CCD cameras and digital imaging, and/or by increasing the signal intensity. This study worked on enhancing signal intensity, and within this parameter on optimizing target accessibility, labelling and hybridi ...
... (de Jong et al., 1999), can be enhanced by increasing the power of detection tools, such as CCD cameras and digital imaging, and/or by increasing the signal intensity. This study worked on enhancing signal intensity, and within this parameter on optimizing target accessibility, labelling and hybridi ...
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... forensic sciences. It would be interesting to share several murder cases with students that were solved with these techniques or to show how these techniques have cleared many convicted felons of their supposed crimes. ...
... forensic sciences. It would be interesting to share several murder cases with students that were solved with these techniques or to show how these techniques have cleared many convicted felons of their supposed crimes. ...
The bonobo genome compared with the chimpanzee and human
... chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours1–4, and for some of these traits they show more similarity with humans than with each other. Here we report the sequen ...
... chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours1–4, and for some of these traits they show more similarity with humans than with each other. Here we report the sequen ...
Chapter 5
... During the 1850s, Mendel studied genetics by doing controlled breeding experiments with pea plants. Pea plants were ideal for genetic studies because • they reproduce quickly. This enabled Mendel to grow many plants and collect a lot of data. • they have easily observed traits, such as flower color ...
... During the 1850s, Mendel studied genetics by doing controlled breeding experiments with pea plants. Pea plants were ideal for genetic studies because • they reproduce quickly. This enabled Mendel to grow many plants and collect a lot of data. • they have easily observed traits, such as flower color ...
A program for annotating and predicting the effects of single
... An example of a start-gained SNP is found in the 5' UTR of Ecdysone inducible protein 63E (Eip63E) gene, which is predicted to be a cyclin J dependent kinase required for oogenesis and embryonic development (Fig. 2).21 The potential start-gain SNP (A > G) in Eip63E changes 5'-ATA-3' to 5'-ATG-3' in ...
... An example of a start-gained SNP is found in the 5' UTR of Ecdysone inducible protein 63E (Eip63E) gene, which is predicted to be a cyclin J dependent kinase required for oogenesis and embryonic development (Fig. 2).21 The potential start-gain SNP (A > G) in Eip63E changes 5'-ATA-3' to 5'-ATG-3' in ...
B.2 Specific Aims. The term `epigenetics` literally means `above the
... modifications of gene expression potential[1]. DNA methylation is one molecular mechanism mediating epigenetic phenomena, and indicates the covalent transfer of a methyl group to the carbon at position 5 of cytosine residues,[2] usually within regions of DNA in which cytosine occurs next to a guanin ...
... modifications of gene expression potential[1]. DNA methylation is one molecular mechanism mediating epigenetic phenomena, and indicates the covalent transfer of a methyl group to the carbon at position 5 of cytosine residues,[2] usually within regions of DNA in which cytosine occurs next to a guanin ...
Molecular studies of major depressive disorder
... that these conditions may be aetiologically related and perhaps share common inherited risk factors.14 The apparently clear contribution of inherited factors to MDD led to early optimism among the psychiatric genetics research community that loci involved in aetiology would be identified with ease. ...
... that these conditions may be aetiologically related and perhaps share common inherited risk factors.14 The apparently clear contribution of inherited factors to MDD led to early optimism among the psychiatric genetics research community that loci involved in aetiology would be identified with ease. ...
13 The Klenow fragment of DNA polymerase I Pol I actually appears
... also lie at the base of the palm. As we shall see later, it is these acidic residues that bind the Mg 2+ ions that are essential for catalysis. The second substrate, dNTP, is bound by a pocket in the fingers domain. Interestingly, there are no hydrogen bonds formed between the enzyme and the new bas ...
... also lie at the base of the palm. As we shall see later, it is these acidic residues that bind the Mg 2+ ions that are essential for catalysis. The second substrate, dNTP, is bound by a pocket in the fingers domain. Interestingly, there are no hydrogen bonds formed between the enzyme and the new bas ...
DNA Chips: Genes to Disease
... are expressed (transcribed) in different tissues under different conditions. This is what gives different tissues their different phenotypes (appearance and function). *Note: Gametes contain half of the genes that somatic cells do, and enucleated cells (such as mature red blood cells) do not contain ...
... are expressed (transcribed) in different tissues under different conditions. This is what gives different tissues their different phenotypes (appearance and function). *Note: Gametes contain half of the genes that somatic cells do, and enucleated cells (such as mature red blood cells) do not contain ...
MHF1 plays Fanconi anaemia complementation group M protein
... plants was characterised. It was shown that AtFANCM is involved in the suppression of spontaneous HR events in somatic cells (Knoll et al., 2012). Moreover, AtFANCM is important for HR during meiosis to ensure proper synapsis and MUS81-dependent CO formation (Crismani et al., 2012; Knoll et al., 201 ...
... plants was characterised. It was shown that AtFANCM is involved in the suppression of spontaneous HR events in somatic cells (Knoll et al., 2012). Moreover, AtFANCM is important for HR during meiosis to ensure proper synapsis and MUS81-dependent CO formation (Crismani et al., 2012; Knoll et al., 201 ...
EFFECT OF FSH β-SUB UNIT AND FSHR GENES
... development and steroidogenesis regulation in the ovary. FSH is composed of a common α subunit and a hormone-specific β-sub unit, and although both of subunits contribute to bind the FSH receptor (FSHR), the β-sub unit dictates its binding specificity (Fan and Hendrickson, 2005). Bulls with mutation ...
... development and steroidogenesis regulation in the ovary. FSH is composed of a common α subunit and a hormone-specific β-sub unit, and although both of subunits contribute to bind the FSH receptor (FSHR), the β-sub unit dictates its binding specificity (Fan and Hendrickson, 2005). Bulls with mutation ...
PDF
... Bank and collected all full-length mRNAs and promoter sequences Chromosome 22 web server (http://www.sanger.ac.uk/HGP/ of the genes on chromosomes 21 and 22. Next, we downloaded the Chr22) and Chromosome 21 Sequencing Consortium assembled sequences (both the original and the repeat-masked (http://er ...
... Bank and collected all full-length mRNAs and promoter sequences Chromosome 22 web server (http://www.sanger.ac.uk/HGP/ of the genes on chromosomes 21 and 22. Next, we downloaded the Chr22) and Chromosome 21 Sequencing Consortium assembled sequences (both the original and the repeat-masked (http://er ...
Identification of novel micro RNAs and their targets in Cocos
... MicroRNAs are endogenous, non-translated, small RNAs of ~21 nucleotides that are processed from stem-loop regions of long transcripts. MicroRNA is responsible for regulation of gene expression of diverse aspects of plant development at the post-transcriptional level. Coconut is one of the major pere ...
... MicroRNAs are endogenous, non-translated, small RNAs of ~21 nucleotides that are processed from stem-loop regions of long transcripts. MicroRNA is responsible for regulation of gene expression of diverse aspects of plant development at the post-transcriptional level. Coconut is one of the major pere ...
BROWSING GENES AND GENOMES WITH ENSEMBL
... and which strand of the genome is this gene located? How many transcripts (splice variants) have been annotated for it? (b) What is the longest transcript? How long is the protein it encodes? Has this transcript been annotated automatically (by Ensembl) or manually (by Havana)? How many exons does i ...
... and which strand of the genome is this gene located? How many transcripts (splice variants) have been annotated for it? (b) What is the longest transcript? How long is the protein it encodes? Has this transcript been annotated automatically (by Ensembl) or manually (by Havana)? How many exons does i ...
Adaptation of Sucrose Metabolism in the Escherichia coli Wild
... addition to Salmonella enterica serovar Typhimurium LT2 revealed that the csc genes are located in a hot spot region for chromosomal rearrangements in enteric bacteria. The comparison further indicated that the csc genes might have been transferred relatively recently to the E. coli wild-type EC3132 ...
... addition to Salmonella enterica serovar Typhimurium LT2 revealed that the csc genes are located in a hot spot region for chromosomal rearrangements in enteric bacteria. The comparison further indicated that the csc genes might have been transferred relatively recently to the E. coli wild-type EC3132 ...
BMB 400 PART THREE
... the gene. In general, more highly expressed genes tend to use codons that are frequently used in genes in the rest of the genome. This has been quantitated as a "codon adaptation index". Thus in analyzing complete genomes, a previously unknown gene whose codon usage profile matches the preferred cod ...
... the gene. In general, more highly expressed genes tend to use codons that are frequently used in genes in the rest of the genome. This has been quantitated as a "codon adaptation index". Thus in analyzing complete genomes, a previously unknown gene whose codon usage profile matches the preferred cod ...
me-6 - Genetics
... reversal of polarity depending on propinquity of sites to one or the other end of the paired region. The Fixed Pairing Region model predicts that among prototrophic recombinants selected as random spores, the more frequent class having flanking markers of parental combination represents conversion o ...
... reversal of polarity depending on propinquity of sites to one or the other end of the paired region. The Fixed Pairing Region model predicts that among prototrophic recombinants selected as random spores, the more frequent class having flanking markers of parental combination represents conversion o ...
A New DNA-Based S-Box
... In the field of cryptography and for any symmetric encryption algorithm, the S-Box (substitution box) is the only nonlinear unit of the symmetric encryption algorithms which performs substitution [1].Usually, Usually, the cipher uses the S-box to build the association of the key and the cryptosystem ...
... In the field of cryptography and for any symmetric encryption algorithm, the S-Box (substitution box) is the only nonlinear unit of the symmetric encryption algorithms which performs substitution [1].Usually, Usually, the cipher uses the S-box to build the association of the key and the cryptosystem ...
Transcriptional analysis of the gene for glutamine synthetase II and
... Sanger Centre, Hinxton, UK) provides further evidence that S. coelicolor GSI is post-translationally modi®ed by Ntr-like proteins. Fisher and Wray (1989) have shown that glnA is monocistronically transcribed from the same promoter during all phases of growth; the sequence of this promoter is compati ...
... Sanger Centre, Hinxton, UK) provides further evidence that S. coelicolor GSI is post-translationally modi®ed by Ntr-like proteins. Fisher and Wray (1989) have shown that glnA is monocistronically transcribed from the same promoter during all phases of growth; the sequence of this promoter is compati ...
Chpt15_PosNegCntrl.doc
... Isolation and purification of the protein was greatly aided by use of mutant strain with up-promoter mutations for lacI, so that many more copies of the protein were present in each cell. This general strategy of over-producing the protein is widely used in purification schemes. Now the gene for the ...
... Isolation and purification of the protein was greatly aided by use of mutant strain with up-promoter mutations for lacI, so that many more copies of the protein were present in each cell. This general strategy of over-producing the protein is widely used in purification schemes. Now the gene for the ...
Genome organization of Magnaporthe grisea
... with MAGGY internal regions as probes (Farman et al. 1997b), and 57 MAGGY-hybridizing clones were identified in approximately 3500 cosmids screened. The cosmid DNAs were purified and used as a template to sequence 5@ and/or 3@ flanking regions of MAGGY (Farman et al. 1997). Based on the sequence of ...
... with MAGGY internal regions as probes (Farman et al. 1997b), and 57 MAGGY-hybridizing clones were identified in approximately 3500 cosmids screened. The cosmid DNAs were purified and used as a template to sequence 5@ and/or 3@ flanking regions of MAGGY (Farman et al. 1997). Based on the sequence of ...
using a DNA test
... Testing in Finland: The testing of the applicant residing in Finland takes place around the same time that their family members are tested abroad. The samples needed for a DNA-test are taken by a public health service professional at the Helsinki University department of Forensic Medicine, or a loca ...
... Testing in Finland: The testing of the applicant residing in Finland takes place around the same time that their family members are tested abroad. The samples needed for a DNA-test are taken by a public health service professional at the Helsinki University department of Forensic Medicine, or a loca ...
Total dissociative electron attachment cross sections for molecular
... damage to the bases alone does not appear to account for the major portion of the strand breaks. The presence of an OH group on the ribose surrogate considerably enhances its cross section. Model compounds in which protonation or OH groups are used to terminate bonds may therefore display larger cro ...
... damage to the bases alone does not appear to account for the major portion of the strand breaks. The presence of an OH group on the ribose surrogate considerably enhances its cross section. Model compounds in which protonation or OH groups are used to terminate bonds may therefore display larger cro ...
Contig annotation tool CAT robustly classifies assembled
... in detail. In the example shown in Figure 2, the DIAMOND homology searches of the protein translations of five ORFs identified on the DNA sequence yielded four, zero, three, four, and four hits, respectively. For the first ORF, the top DIAMOND hit is present in Escherichia coli and the hit had a bit ...
... in detail. In the example shown in Figure 2, the DIAMOND homology searches of the protein translations of five ORFs identified on the DNA sequence yielded four, zero, three, four, and four hits, respectively. For the first ORF, the top DIAMOND hit is present in Escherichia coli and the hit had a bit ...
Mining medical data using multiple corpora
... biomedicine arise because there are many databases in this field (records, news) and most of the time, every database has its own vocabulary, which distorts the query even though the concept behind the term is well known. "The Metathesaurus is a database of information on concepts that appear in one ...
... biomedicine arise because there are many databases in this field (records, news) and most of the time, every database has its own vocabulary, which distorts the query even though the concept behind the term is well known. "The Metathesaurus is a database of information on concepts that appear in one ...