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DNA Unit
DNA Unit

... • Enzymes are special proteins that catalyze (speed up) chemical reactions • The beginning substances they work on are called substrates • The substrates are changed into different molecules ...
Mutation
Mutation

... DNA can give rise to one of nine other codons. Two of the possible changes (CUA , UUG) are completely silent, as the resulting codons still code for leucine. These are known as synonymous codons. Two further changes (AUA and GUA) may well have little effect on the protein since the substituted amino ...
Biotechnology and Genetic Engineering
Biotechnology and Genetic Engineering

... Production of antibiotics • Antibiotics, novel antibiotics and polyketide antibiotics • Antibiotics are small metabolites with antimicrobial activity that are produced by Gram-positive and Gramnegative bacteria as well as by fungi • Antibiotics act by 1) disrupting the plasma membranes of microbes, ...
EXERCISE 1: Fred Griffith and Transformation
EXERCISE 1: Fred Griffith and Transformation

... 23. Rosalind Franklin died of ovarian cancer before the Nobel prize was awarded for her work—subsequently she is not recognized as a Nobel laureate (you cannot win the Nobel prize if you are not alive). Do you think there is a relationship between her work and her death? Explain your answer. You hav ...
Nucleic acids
Nucleic acids

... A polynucleotide has a free phosphate group at one end, called the 5' end because the phosphate is attached to carbon 5' of the sugar, and a free OH group at the other end, called the 3' end because it's on carbon 3' of the sugar. The terms 3' and 5' are often used to denote the different ends of a ...
There has been a lot of excitement lately over the new gene
There has been a lot of excitement lately over the new gene

... readily because the technology is improving all the time and the costs are reducing. Now, it could be that people won’t want to reverse the changes, but that’s telling you that the change is valuable in some way. If humanity doesn’t take the opportunity to advance genetic engineering in people, are ...
Lesson 3 * Gene Expression
Lesson 3 * Gene Expression

... RNA has a different base (Uracil rather than Thymine) and a different sugar (Ribose rather than Deoxyribose). It is more stable as a single stranded molecule. ...
ch 12 notes
ch 12 notes

... the ribosome, binding to additional mRNA codons as the mRNA moves through the ribosome like a ribbon. ...
Export to PDF
Export to PDF

... Course Student Learning Outcomes: 1. Discuss the structural and functional characteristics of both prokaryotic and eukaryotic cells. 2. Define biotechnology and discuss its applications in agriculture, medicine, and forensics. 3. Discuss laboratory safety techniques. 4. Demonstrate the use of proper ...
2016 Final Exam Answer Key
2016 Final Exam Answer Key

Phylogenetic DNA profiling : a tool for the investigation of poaching
Phylogenetic DNA profiling : a tool for the investigation of poaching

... individuals to kingdoms. The analysis relies on the comparison of heritable traits. Pre-“DNA,” morphological, biochemical and immunological markers were used to determine relationships, however with the development of sophisticated molecular genetic technology emphasis has shifted towards the utilis ...
Document
Document

... match of a predicted protein sequence to one or more database sequences not only serves to identify the gene function, but also validates the gene prediction. Pseudogenes, gene copies that have lost function, may also be found in this analysis. Only matches with highly significant alignment scores a ...
Document
Document

... piece of DNA per gene. These are (usually) 2color arrays, i.e. two samples are labeled with different dyes and hybridized • Short oligo arrays (Affymetrix): immobilize several short oligonucleotides per gene. These are 1-color arrays, i.e. one sample is hybridized at a time • Tiling arrays: spots do ...
X Chromosome
X Chromosome

... • The expression of genes on the sex chromosomes differs from the expression of autosomal genes. • Genes located on the sex chromosomes are called sex- linked genes or X-linked genes. • Males express all of the alleles on both sex chromosomes. • In females one of the two X chromosomes is randomly tu ...
candy dna model - Center for Precollegiate Education and Training
candy dna model - Center for Precollegiate Education and Training

... identical DNA double helices, each containing one original and one new strand. DNA replication is an important part of the cell division process. Before a cell divides, it first duplicates its DNA so that the new cell will have the same genetic information. The specific base pair matching during rep ...
RUNX1-RUNX1T1 pre
RUNX1-RUNX1T1 pre

... OF THE RUNX1–RUNX1T1 MRNA SPLICING (A) Skipping of exons that were listed in the descending order of their ECI values: experimentally verified transcripts (on the top), predicted transcripts (on the bottom). (B) This picture is similar to (A), but exons were excluded from splicing process in the asc ...
Key
Key

... 1. Use a DNA strand to DRAW and EXPLAIN how a strand of DNA would replicate. Why is it important for DNA to be able to make an exact copy (how does that ability help an organism live?)? DNA must be able to make an exact copy of itself to pass on the stored/coded information to the next generation. F ...
DNA Barcoding - Columbia University
DNA Barcoding - Columbia University

... • Focus on one or a small number of genes provides greater efficiency of effort. • Cost of DNA sequencing is dropping rapidly due to technical advances. • Potential capacity for high throughput and processing large numbers of samples. • Once reference database is established, can be applied by non-s ...
Looking Beyond Our DNA - Federation of American Societies for
Looking Beyond Our DNA - Federation of American Societies for

... of the cells in the body have the same DNA sequence, but differences in the “punctuation” in certain genes determine when and how they are turned on (gene activation). It is these differences in the activation of genes that result in a broad array of cell types with various functions (i.e., muscle, ...
Lecture: How do neurons work
Lecture: How do neurons work

... in the skin, and if an inhibitor could be developed, it might lead to a therapy for acne. You want to find out more about this enzyme. You plan to 1. clone the gene 2. express it in E. coli 3. make lots of the protein and study it's properties How would you clone this gene into E. coli? -- assume yo ...
Gene Regulation - public.iastate.edu
Gene Regulation - public.iastate.edu

... lac operon: effect of an inducer (derepressor) ‹If lactose is present, lac is transcribed » a lactose isomer binds to the repressor protein » the bound repressor protein changes shape » in this shape, it can not bind to the operator » RNA polymerase can now bind & transcribe ...
DNA: The Carrier of Genetic Information
DNA: The Carrier of Genetic Information

... 2. Coding region - has the information on how to construct the protein 3. Termination sequence - signals the end of the gene RNA Polymerase is responsible for reading the gene, and building the mRNA strand. ...
The basic aevol model
The basic aevol model

... The fuzzy subsets of several proteins – or, in graphical terms, their triangles – can overlap partially or completely. This means that several proteins can contribute to a same “biological function”, meaning that they have a functional interaction2. Thus, to know the degree of possibility with which ...
Recall that the nucleus is a small spherical, dense body in a cell
Recall that the nucleus is a small spherical, dense body in a cell

... but how? It is the sequence of bases that determine which protein is to be made. The sequence is like a code that we can now interpret. The sequence determines which proteins are made and the proteins determine which activities will be performed. And that is how the nucleus is the control center of ...
Gene Isolation and Manipulation
Gene Isolation and Manipulation

... As you will see in Chapter 15, most of the genomes of higher eukaryotes (plants and animals) are filled with DNA sequences that are present in hundreds, even thousands, of copies throughout the chromosomes. In the chromosome-walking procedure shown in Figure 10-20, how would the experimenter know wh ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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