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“This is getting really old . . . ” The Genetics of Aging
“This is getting really old . . . ” The Genetics of Aging

... • Genes involved in aging (longevity) have other functions in cells, especially roles in stress response and control of metabolism. • Increased stress resistance correlates with longevity. • Telomeres shorten with age. Telomere shortening leads to cell growth arrest, and correlates with mitochondria ...
view PDF - Children`s Hospital of Wisconsin
view PDF - Children`s Hospital of Wisconsin

... determine all of our features such as eye color and hair color. Genes work by instructing cells to make proteins; it is the proteins that carry out the functions of the cell. Change in genes cause genetic disorders. For example, changes in one gene give rise to cystic fibrosis (CFTR) while changes ...
DNA power point
DNA power point

... are the purines Adenine and Guanine, and the pyrimidines Thymine and Cytosine. Chargraff”s Rule states purines bond with pyrimidines in the specific pairings of Adenine to Thymine and Guanine to Cytosine. These pairings create the double helix structure DNA is known for and the end result of DNA Rep ...
Enzyme Discovery and
Enzyme Discovery and

... – Site specific (pick up some interesting sites) B) DNA shuffling – In vitro recombination between members in a protein family – Methods have been developed for non-homologous recombination  Recombination effectively exploits information present in the parental sequences to form new functional sequ ...
DNA, Protein Synth, Mutations
DNA, Protein Synth, Mutations

... 2.1 Mutations • sometimes mutations can be a good thing (e.g. the mutated protein works better than the “normal” protein or has a new beneficial function). These are known as POSITIVE MUTATIONS and they INCREASE survival rate. • e.g. mutated gene  proteins that make them RESISTANT TO HIV INFECTION ...
History of DNA WebQuest
History of DNA WebQuest

... His research, with the help from ________________, led to the discovery of the DNA molecule structure. This discovery was made by American biologist, ________________, and British physicist, ________________. ...
**Study all vocabulary terms!!** 1. Explain why people look like their
**Study all vocabulary terms!!** 1. Explain why people look like their

... Explain why people look like their parents. (Use ALL information we have discussed!) Explain why siblings do not look the same, even if they come from the same parents. Explain what DNA is. (Parts, what bonds with what, what is codes for) Describe how the structure of DNA was discovered. (who was in ...
Horak - Blumberg Lab
Horak - Blumberg Lab

... Plasmid: Contains Swi4 and HA tag → transcribe together - How to get in cells? - Overexpress plasmid by transfection - HA-Swi4 incorporate into yeast genome → transcribed → bind to parts of DNA ...
Glencoe Biology
Glencoe Biology

Lesson 12 Mutations
Lesson 12 Mutations

... embryo, one cob produces a large sample of offspring; making it an ideal species for genetic research. ...
Assembling and Annotating the Draft Human Genome
Assembling and Annotating the Draft Human Genome

... aligning ...
DNA Recombination - Home - KSU Faculty Member websites
DNA Recombination - Home - KSU Faculty Member websites

... exchange between molecules with extended sequence homology. For example, transformation and conjugation between related bacterial strains. Site-specific recombination refers to DNA recombination between molecules that shared limited regions of sequence homology. ...
chapter 12 - Fullfrontalanatomy.com
chapter 12 - Fullfrontalanatomy.com

... sentence, without spaces between letters, and then conduct a word-processing edit placing a space between any place where an “e” is followed by the letter “n.” The resulting fragments of this original sentence would look like this, and would be like a type of “genomic library.” Age nomic library of ...
Integration of Average Amino Acid Identity (AAI)
Integration of Average Amino Acid Identity (AAI)

... • Metric is clear and intuitively understood, reflects unit of selection/conservation  (proteins rather than randomly broken DNA seq) • Applicable above species level, but no widely accepted thresholds (yet) • Does not consider non‐orthologous sequences • No easily accessible tools ...
A recombinatorial method useful for cloning dominant alleles in
A recombinatorial method useful for cloning dominant alleles in

You Light Up My Life
You Light Up My Life

... only during translation.  Polypeptide chains are built on ribosomes. ...
Station 1: Draw the nucleotide below and then label the
Station 1: Draw the nucleotide below and then label the

... DNA is copied before the cell divides to ensure that all new cells in the body have the same instructions for building the body. ...
PDF - 1.4 MB
PDF - 1.4 MB

... and Function of DNA Binding Proteins." clear that some other genes are also upScience 290, no. 5500 (Dec. 22, 2000): 2306-9. regulated. (This figure shows just a small snapshot of the response.) These additional genes are Fur4, Gcy1, Mth1, and Pcl10, and their co-regulation along with the Gal genes ...
DNA - Priory Haiku
DNA - Priory Haiku

... When the double helix structure was first discovered, scientists were very excited about the complimentary relationship between the sequence of nucleotides. ...
DNA Practice Test KEY NAME Test Section SCORE Retake
DNA Practice Test KEY NAME Test Section SCORE Retake

... direction of the growing replication fork. Because of its orientation, replication of the lagging strand is more complicated as compared to that of the leading strand. The lagging strand is synthesized in short, separated segments. On the lagging strand template, a primase "reads" the template DNA a ...
slides - Yin Lab @ NIU
slides - Yin Lab @ NIU

... proteins with the same fold often have peripheral elements of secondary structure and turn regions that differ in size and conformation. Proteins placed together in the same fold category may not have a common evolutionary origin: the structural similarities could arise just from the ph ...
Glossary - Berkeley Technology Law Journal
Glossary - Berkeley Technology Law Journal

... Enzyme - A functional protein that catalyzes a chemical reaction but is itself neither consumed nor altered. Enzymes control the rate of metabolic processes in an organism; they are, for instance, the active agents in the fermentation process. Eukaryote - A higher, compartmentalized cell characteriz ...
Slide 1
Slide 1

... • rRNA or Ribosomal RNA molecules along with several dozen proteins form the ribosomes. • tRNA or Transfer RNA molecules transfer amino acids to the ribosomes as it is specified by coded messages in the mRNA ...
Exercise 7: DNA and Protein Synthesis
Exercise 7: DNA and Protein Synthesis

... cytoplasm. Thus, a messenger molecule is needed to carry the DNA code to instruct the ribosomes how to construct each protein. This messenger molecule is called messenger RNA (mRNA). The purpose of this lab activity is to review the molecular structure of DNA, how it divides, and the process of prot ...
Gene-Boosted Assembly of a Novel Bacterial Genome from
Gene-Boosted Assembly of a Novel Bacterial Genome from

...  94% of bases in single scaffold  5602 protein-coding genes identified  Error rate per read = 1.04%  Error with coverage > 20X is zero  Slight bias toward high gene coverage ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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