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Microbial Genetics
Microbial Genetics

... DNA molecule serves as a template to copy itself, so two identical copies of the DNA helix are formed. Transcription: The sequence of nucleotides in a DNA molecule serves as a template for the synthesis of an RNA molecule; typically, only a small segment of the DNA is copied. This is the first step ...
Introduction to molecular biology
Introduction to molecular biology

... start site, located on the RNA copy of a gene, and proceeds until the first stop codon is encountered The start codon is the triplet AUG (which also encodes for methionine), both in eukaryotes and in prokaryotes The translation is accurate only when the ribosomes examine the codons contained inside ...
The Source of Heredity “Chapter 21”
The Source of Heredity “Chapter 21”

... Today these factors are known as genes. ...
Sickle-cell anemia - Thalassemias
Sickle-cell anemia - Thalassemias

...  The genes Gγ and Aγ are coding for the γ chain; 1 amino acid is different in position 136. Existence of a pseudogene ψβ akin to normal genes but mutated in a way that it is not coding for any protein. ...
1993 HUMAN PROXIMAL TUBULAR CELL MODELS OF
1993 HUMAN PROXIMAL TUBULAR CELL MODELS OF

... aim to solubilise cystine in urine by urine dilution, optimising pH or chelating cystine. However the medications are poorly tolerated, have severe side effects and even compliant patients can continue to form and pass painful kidney stones. Our aim is to develop novel therapies for cystinuria that ...
Lysosomes 2010 Part 1B
Lysosomes 2010 Part 1B

... rafts that float in the liquid phase • These lipid rafts are important in signal transduction processes. • Certain key components of signal transduction, including glycosphingolipids, tend to be concentrated on rafts ...
Chapters 18, 19, 20, 27) Virus, bacteria, gene expression
Chapters 18, 19, 20, 27) Virus, bacteria, gene expression

... Genes within highly packed heterochromatin are not usually expressed Heterochromatin is tightly wound up while euchromatin is long and skinny Chemical modifications to histones and DNA of chromatin influence both chromatin structure and gene expression These modifications can either allow or stop tr ...
Degradation of Mutant Proteins, Underlying “Loss of Function
Degradation of Mutant Proteins, Underlying “Loss of Function

... question of how such mutations cause loss of protein function: if they do not substantially affect the specific activity of the protein molecule, could they instead exert their disease-causing effects by reducing the cellular levels of the active protein? The steady-state concentration of a protein ...
An End to Ageing
An End to Ageing

Rich Probabilistic Models for Genomic Data
Rich Probabilistic Models for Genomic Data

... Find parameter estimates which make observed data most likely General approach, as long as tractable likelihood function exists Can use all available information ...
CSM 101 Fall 2010 Timeline
CSM 101 Fall 2010 Timeline

... e. Nucleosome- The “beads on a string”; a segment of DNA wound around 8 histones. f. Histone –The small protein that binds to the DNA, contributing to the chromatin structure g. Centromere- The central region that joins two sister chromatids h. Centrosome- The microtubule organizing center present i ...
Research Fast Facts: BRCA
Research Fast Facts: BRCA

... Komen-funded research has helped us to understand that: ...
the genetics of viruses and bacteria
the genetics of viruses and bacteria

... releases its viral products.  During a lysogenic cycle, the viral DNA molecule is incorporated by genetic recombination into a specific site on the host cell’s chromosome.  In this prophage stage, one of the viral genes codes for a protein that represses most other prophage genes.  As a result, t ...
Data Mining in Ensembl with BioMart
Data Mining in Ensembl with BioMart

... • A data export tool • A quick table generator • A web interface to mine Ensembl data ...
CSM 101 Fall 2010 Timeline
CSM 101 Fall 2010 Timeline

... e. Nucleosome- The “beads on a string”; a segment of DNA wound around 8 histones. f. Histone –The small protein that binds to the DNA, contributing to the chromatin structure g. Centromere- The central region that joins two sister chromatids h. Centrosome- The microtubule organizing center present i ...
The Genetics of Viruses and Bacteria
The Genetics of Viruses and Bacteria

... releases its viral products.  During a lysogenic cycle, the viral DNA molecule is incorporated by genetic recombination into a specific site on the host cell’s chromosome.  In this prophage stage, one of the viral genes codes for a protein that represses most other prophage genes.  As a result, t ...
Laboratory of RNA – ebook
Laboratory of RNA – ebook

... supported the notion that the technique could one day become commonplace. The group is carrying out studies to develop a cure for a rare neurodegenerative disease: FrontoTemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17). FTDP-17 patients have single nucleotide mutations in the ge ...
Name: : - Ms. Poole`s Biology
Name: : - Ms. Poole`s Biology

... position of disulfide bonds can be resolved using protein sequencing techniques. Also, protein modifications, such as the excision of residues or the covalent attachment of other groups, can be detected. These changes in protein sequence and structure would evade detection by nucleic acid sequencing ...
MEIOSIS Notes
MEIOSIS Notes

... Since the combination of maternal and parental chromosomes received by a gamete is random. And we have 23 pairs of chromosomes The possible combinations in an egg or a sperm are 223 = 8,388,608 combinations in an offspring 223 X 223 = 70,368,744,177,664 Result: Generates new combinations of genes (a ...
슬라이드 1
슬라이드 1

... •SLG (S-Locus Glycoprotein) which encodes part of a receptor present in the cell wall of the stigma; •SRK (S-Receptor Kinase), which encodes the other part of the receptor. Kinases attach phosphate groups to other proteins. SRK is transmembrane protein embedded in the plasma membrane of the stigma c ...
Foundations of Biology - Geoscience Research Institute
Foundations of Biology - Geoscience Research Institute

... for the about 100,000 proteins; 50,000 in older estimates, 150,000 in more recent estimates  Non-coding DNA was once called “junk” DNA as it was thought to be the molecular debris left over from the process of evolution  We now know that much non-coding DNA plays important roles like regulating ex ...
Heterochromatin-2015
Heterochromatin-2015

... Pol IV is recruited to chromatin and transcribes ssRNA which is converted to dsRNA by RDR2 siRNA is produced by DCL3 and loaded onto AGO4 Pol V transcribes a scaffold RNA that base pairs with AGP4-bound siRNA DNA is unwound and DRM2 is recruited and methylates DNA Histones are modified to reinforce ...
TURNING PAGES
TURNING PAGES

... of my scientific gestalt. And, not surprisingly, having worked with globin genes, I kept thinking that it ought to be possible to use DNA coding for the normal human B globin gene, which was now readily available, to correct the mutant human B globin gene that leads to sickle cell anemia, the most f ...
MCB 104: Genetics, Cell Biology, Genomics
MCB 104: Genetics, Cell Biology, Genomics

... among these are Life, Liberty and the Pursuit of Happiness -- That to secure these Rights, Governments are instituted among Men, deriving their just Powers from the Consent of the Governed, that whenever any Form of Government becomes destructive of these Ends, it is the Right of the People to alter ...
Genetics - David Bogler Home
Genetics - David Bogler Home

... John and Julian Lennon ...
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NEDD9

Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.
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