Protein Creation Pathway
... The nucleus (flashing circle) is nicknamed the “control center” of a cell. But why? The nucleus contains DNA in its active form and this DNA will ultimately be used as a blueprint to create proteins for use throughout the body. The process of creating a protein begins in the nucleus. Click the arrow ...
... The nucleus (flashing circle) is nicknamed the “control center” of a cell. But why? The nucleus contains DNA in its active form and this DNA will ultimately be used as a blueprint to create proteins for use throughout the body. The process of creating a protein begins in the nucleus. Click the arrow ...
Etude Annotation
... This is a step-‐by-‐step guide as to how I would annotate the practice genome Etude. This is not meant to replace any of the more detailed annotation guides, but is instead supplemental material to ...
... This is a step-‐by-‐step guide as to how I would annotate the practice genome Etude. This is not meant to replace any of the more detailed annotation guides, but is instead supplemental material to ...
Identification of genes involved in the same
... networks. Several promising approaches have also been undertaken in combining both protein–protein interaction data and gene microarray expression data to derive functional modules at both levels (Tornow and Mewes, 2003). Other approaches integrate yet more data, such as growth phenotype data, trans ...
... networks. Several promising approaches have also been undertaken in combining both protein–protein interaction data and gene microarray expression data to derive functional modules at both levels (Tornow and Mewes, 2003). Other approaches integrate yet more data, such as growth phenotype data, trans ...
The Wnt code: cnidarians signal the way
... have been identified in Nematostella and Hydra. These include orthologs of b-catenin (Hobmayer et al., 1996), GSK-3b, Tcf/Lef, Dsh, APC and Axin from the Wnt/ b-catenin pathway (Technau et al., 2005), Flamingo, Van Gogh, and JNK from the Wnt/PCP (planar cell polarity) pathway; and CamKII and PKC from ...
... have been identified in Nematostella and Hydra. These include orthologs of b-catenin (Hobmayer et al., 1996), GSK-3b, Tcf/Lef, Dsh, APC and Axin from the Wnt/ b-catenin pathway (Technau et al., 2005), Flamingo, Van Gogh, and JNK from the Wnt/PCP (planar cell polarity) pathway; and CamKII and PKC from ...
mRNA Export - e
... 5′ end of these transcripts. Recruitment of the TREX1 complex and UAP56 (also known as DDX39B) to the 5′ end of intronless mRNAs (e.g. heat-shock protein 70) occurs through interaction with the cap-binding complex (CBC). This alternative mRNA export pathway, which is termed alternative RNA export (A ...
... 5′ end of these transcripts. Recruitment of the TREX1 complex and UAP56 (also known as DDX39B) to the 5′ end of intronless mRNAs (e.g. heat-shock protein 70) occurs through interaction with the cap-binding complex (CBC). This alternative mRNA export pathway, which is termed alternative RNA export (A ...
Studying Environmental Influences and Breast Cancer
... The traditional view is that hormones cause breast cancer, except in rare cases where women in high-risk families inherit mutations in genes such as BRCA1 or BRCA2. Recent evidence shows that this view is too narrow. A broader view of breast cancer causation is needed that takes environmental factor ...
... The traditional view is that hormones cause breast cancer, except in rare cases where women in high-risk families inherit mutations in genes such as BRCA1 or BRCA2. Recent evidence shows that this view is too narrow. A broader view of breast cancer causation is needed that takes environmental factor ...
Ampicillin versus Tetracycline in the Selection
... collected by centrifugation at 10,000 rpm (in IEC 819 rotor), and suspended in lysozyme breakage buffer. The cell suspension was then treated with sodium dodecyl sulphate (2% SDS) and sodium hydroxide (0.4 M NaOH). Acidified salt buffer was used to precipitate chromosomal DNA. After centrifugation a ...
... collected by centrifugation at 10,000 rpm (in IEC 819 rotor), and suspended in lysozyme breakage buffer. The cell suspension was then treated with sodium dodecyl sulphate (2% SDS) and sodium hydroxide (0.4 M NaOH). Acidified salt buffer was used to precipitate chromosomal DNA. After centrifugation a ...
The cytogenetics of homologous chromosome pairing in meiosis in plants Meiosis
... Numerous plant mutants in early recombination genes show defects in chromosome pairing in addition to their recombination defects, indicating that pairing requires initiation of meiotic recombination and progression through early steps of the recombination pathway (Pawlowski and Cande, 2005; Hamant ...
... Numerous plant mutants in early recombination genes show defects in chromosome pairing in addition to their recombination defects, indicating that pairing requires initiation of meiotic recombination and progression through early steps of the recombination pathway (Pawlowski and Cande, 2005; Hamant ...
Biotechnology Explorer™ Ligation and Transformation - Bio-Rad
... vectors frequently contain reporter genes, which distinguish them from cells that do not have inserts. Two common reporter genes are beta-galactosidase (b-gal) and green fluorescent protein (GFP) Some newer plasmid vectors use positive selection, in which the inserted DNA interrupts a gene that woul ...
... vectors frequently contain reporter genes, which distinguish them from cells that do not have inserts. Two common reporter genes are beta-galactosidase (b-gal) and green fluorescent protein (GFP) Some newer plasmid vectors use positive selection, in which the inserted DNA interrupts a gene that woul ...
The cytogenetics of homologous chromosome pairing in meiosis in
... Meiotic DSBs in plants, as in all species examined thus far, are created by SPO11, a member of the type II topoisomerase protein family (Keeney et al., 1997). Unique from other taxa, plants possess multiple copies of SPO11: Arabidopsis and maize have three, while the rice genome contains four (Grelo ...
... Meiotic DSBs in plants, as in all species examined thus far, are created by SPO11, a member of the type II topoisomerase protein family (Keeney et al., 1997). Unique from other taxa, plants possess multiple copies of SPO11: Arabidopsis and maize have three, while the rice genome contains four (Grelo ...
mei-38 Is Required for Chromosome Segregation During Meiosis in
... Meiotic chromosome segregation occurs in Drosophila oocytes on an acentrosomal spindle, which raises interesting questions regarding spindle assembly and function. One is how to organize a bipolar spindle without microtubule organizing centers at the poles. Another question is how to orient the chro ...
... Meiotic chromosome segregation occurs in Drosophila oocytes on an acentrosomal spindle, which raises interesting questions regarding spindle assembly and function. One is how to organize a bipolar spindle without microtubule organizing centers at the poles. Another question is how to orient the chro ...
Detection and analysis of disease-associated single nucleotide
... disease-associated variants and found that phosphorylation binding site disrupting variants are correlated with somatic cancer mutations [8]. Recently, several previous studies [9-11] detected PTM-related nsSNPs or protein sequence variations. Yang et al. [9] collected 15,738 experimental phosphoryl ...
... disease-associated variants and found that phosphorylation binding site disrupting variants are correlated with somatic cancer mutations [8]. Recently, several previous studies [9-11] detected PTM-related nsSNPs or protein sequence variations. Yang et al. [9] collected 15,738 experimental phosphoryl ...
Glioma heterogeneity and the LAT-1
... To date, glioblastoma subject to the most extensive genomic profiling of any cancer (Dunn, et al Genes Dev. 2012 26: 756-784) The Cancer Genome Atlas Research Network (Parsons et al. 2008) and other studies have enabled us to systematically and comprehensively define the genomic landscape of gliobla ...
... To date, glioblastoma subject to the most extensive genomic profiling of any cancer (Dunn, et al Genes Dev. 2012 26: 756-784) The Cancer Genome Atlas Research Network (Parsons et al. 2008) and other studies have enabled us to systematically and comprehensively define the genomic landscape of gliobla ...
Can blue-eyed parents produce brown
... the complexity of real life. We now know that eye colour is inherited due to the action of multiple genes (Table 1) and not the result of a single gene. Thus eye colouration is referred to as a polygenic trait. Moreover, in a condition know as heterochromia an individual can have eyes of different c ...
... the complexity of real life. We now know that eye colour is inherited due to the action of multiple genes (Table 1) and not the result of a single gene. Thus eye colouration is referred to as a polygenic trait. Moreover, in a condition know as heterochromia an individual can have eyes of different c ...
H4K20me1 Contributes to Downregulation of X
... primarily confined to transcribed regions, while on the X, H4K20me1 is elevated across the chromosome, including regions that are more than 5 kb from any annotated gene feature (Figure 1D). This widespread distribution of H4K20me1 on the X chromosome suggests a role in chromosome-wide regulation of ...
... primarily confined to transcribed regions, while on the X, H4K20me1 is elevated across the chromosome, including regions that are more than 5 kb from any annotated gene feature (Figure 1D). This widespread distribution of H4K20me1 on the X chromosome suggests a role in chromosome-wide regulation of ...
Transcriptional analysis of the gene for glutamine synthetase II and
... Sanger Centre, Hinxton, UK) provides further evidence that S. coelicolor GSI is post-translationally modi®ed by Ntr-like proteins. Fisher and Wray (1989) have shown that glnA is monocistronically transcribed from the same promoter during all phases of growth; the sequence of this promoter is compati ...
... Sanger Centre, Hinxton, UK) provides further evidence that S. coelicolor GSI is post-translationally modi®ed by Ntr-like proteins. Fisher and Wray (1989) have shown that glnA is monocistronically transcribed from the same promoter during all phases of growth; the sequence of this promoter is compati ...
Linköping University Post Print Segment-specific generation of Drosophila
... indicate a specific down-regulation of the respective transcription factors, or is it a result of selective cell death? ...
... indicate a specific down-regulation of the respective transcription factors, or is it a result of selective cell death? ...
Full text - The American Association of Immunologists
... for their pioneering studies on the major histocompatibility complex (MHC). Benacerraf demonstrated that genetic factors regulate an individual’s immune responses. This discovery shed light on the association of certain autoimmune diseases with particular MHC antigens and the variations in individua ...
... for their pioneering studies on the major histocompatibility complex (MHC). Benacerraf demonstrated that genetic factors regulate an individual’s immune responses. This discovery shed light on the association of certain autoimmune diseases with particular MHC antigens and the variations in individua ...
Functions of DNA methylation: islands, start sites, gene bodies and
... there is abundant evidence that methylated CGIs at TSSs are associated with some silent genes, the timing of de novo methylation with respect to gene silencing is now beginning to be elucidated. The function of DNA methylation is intrinsically linked to the mechanisms for establishing, maintaining a ...
... there is abundant evidence that methylated CGIs at TSSs are associated with some silent genes, the timing of de novo methylation with respect to gene silencing is now beginning to be elucidated. The function of DNA methylation is intrinsically linked to the mechanisms for establishing, maintaining a ...
Mathematical Modeling of the Hardy
... Mathematical Modeling of the Hardy-Weinberg Equilibrium Evolution occurs in populations of organisms and involves variation, heredity, and differential survival. One way to study evolution is to study how the frequency of alleles in a population changes from one generation to the next. In other word ...
... Mathematical Modeling of the Hardy-Weinberg Equilibrium Evolution occurs in populations of organisms and involves variation, heredity, and differential survival. One way to study evolution is to study how the frequency of alleles in a population changes from one generation to the next. In other word ...
functional analysis of chromatin assembly genes in tetrahymena
... The basic structural unit of chromatin is the nucleosome composed of ~147 base pairs of DNA wrapped around an octamer of histone proteins. Post-translational modifications such as histone acetylation or the substitution of histone variants in place of core histones have been implicated in various ch ...
... The basic structural unit of chromatin is the nucleosome composed of ~147 base pairs of DNA wrapped around an octamer of histone proteins. Post-translational modifications such as histone acetylation or the substitution of histone variants in place of core histones have been implicated in various ch ...
Inheritance of White Colour in Alpacas
... What the report is about This project has generated essential basic information about the Mendelian inheritance and molecular genetics of fibre colour in alpacas. Such basic science underpins successful animal breeding, and is information that is known about every other commercially produced livesto ...
... What the report is about This project has generated essential basic information about the Mendelian inheritance and molecular genetics of fibre colour in alpacas. Such basic science underpins successful animal breeding, and is information that is known about every other commercially produced livesto ...
Novel p53 mutants selected in BRCA
... These mutants therefore fall into a novel category of p53 mutants which dissociate transformation suppression from other wild-type functions. The rarity of these mutants in human cancer and their multiple occurrence in BRCA-associated breast tumours suggests that these novel p53 mutants are selected ...
... These mutants therefore fall into a novel category of p53 mutants which dissociate transformation suppression from other wild-type functions. The rarity of these mutants in human cancer and their multiple occurrence in BRCA-associated breast tumours suggests that these novel p53 mutants are selected ...
Gene Section DLX6 (distal-less homeobox 6) Atlas of Genetics and Cytogenetics
... proline stretch, 11-20 CAG/CCG repeat long, which has been found to be conserved in mouse (Pfeffer et al., 2001; see further "trinucleotide repeats"). The functional consequences of these expansions upon DLX6 activity remain to be determined. ...
... proline stretch, 11-20 CAG/CCG repeat long, which has been found to be conserved in mouse (Pfeffer et al., 2001; see further "trinucleotide repeats"). The functional consequences of these expansions upon DLX6 activity remain to be determined. ...