Using High-Throughput Sequencing to Investigate the Transgenerational
... differential gene expression analysis based on the negative binomial distribution and it includes a variety of exploratory data analysis procedures such as count matrix normalization, principal component analysis (PCA), MA plots, volcano plots, and dispersion estimates. Following initial DESeq2 anal ...
... differential gene expression analysis based on the negative binomial distribution and it includes a variety of exploratory data analysis procedures such as count matrix normalization, principal component analysis (PCA), MA plots, volcano plots, and dispersion estimates. Following initial DESeq2 anal ...
Gene Annotation Naming Guidelines
... built from multiple protein sequence alignments. Each HMM has associated with it a 'noise' cutoff score and a 'trusted' cutoff score. ORFs are considered to be members of the HMM model if they score higher than the trusted cutoff. If an ORF yields a score between the trusted cutoff and the noise cut ...
... built from multiple protein sequence alignments. Each HMM has associated with it a 'noise' cutoff score and a 'trusted' cutoff score. ORFs are considered to be members of the HMM model if they score higher than the trusted cutoff. If an ORF yields a score between the trusted cutoff and the noise cut ...
blood12715insidebloodcombined 1841..1845
... g-carboxylation of blood-clotting enzymes vs MGP. The power of this cell-based assay system is that the GGCX enzyme is functioning within the natural milieu of the endoplasmic reticulum, relying on the remaining enzymes of the native vitamin K cycle to produce vitamin KH2. Tie et al1 studied a baby ...
... g-carboxylation of blood-clotting enzymes vs MGP. The power of this cell-based assay system is that the GGCX enzyme is functioning within the natural milieu of the endoplasmic reticulum, relying on the remaining enzymes of the native vitamin K cycle to produce vitamin KH2. Tie et al1 studied a baby ...
Clustering Time-Series Gene Expression Data Using Smoothing
... We use splines for continuous representations, as ...
... We use splines for continuous representations, as ...
- Wiley Online Library
... thereby indicating that other genes must be involved in testis determination. One such gene is SOX9, which also encodes a protein containing an HMG-related motif of amino acids, and is a transcription factor. Mutations in SOX9 lead to a syndrome of campomelic dysplasia (severe thoracic and limb skel ...
... thereby indicating that other genes must be involved in testis determination. One such gene is SOX9, which also encodes a protein containing an HMG-related motif of amino acids, and is a transcription factor. Mutations in SOX9 lead to a syndrome of campomelic dysplasia (severe thoracic and limb skel ...
Cancer Prone Disease Section Birt-Hogg-Dubé Syndrome (BHD) Atlas of Genetics and Cytogenetics
... Location: 17p11.2 DNA/RNA Description: Total gene size: 24971 bp. Transcription: Alternative splicing results in two transcript variants encoding different isoforms. mRNA is expressed in a variety of tissues, including the skin, the kidney, the lung, the pancreas, parotid gland, and the brain. Tissu ...
... Location: 17p11.2 DNA/RNA Description: Total gene size: 24971 bp. Transcription: Alternative splicing results in two transcript variants encoding different isoforms. mRNA is expressed in a variety of tissues, including the skin, the kidney, the lung, the pancreas, parotid gland, and the brain. Tissu ...
Integrating Genetic and Network Analysis to Characterize
... • The blue module is comprised of genes that relate to physiologically interesting traits, in particular body weight. • Gene ontology: The blue module is enriched for genes in the ‘extra-cellular matrix (ECM) receptor interaction’ (p=2.3x10-9) and ‘complement and coagulant cascades’ (p=1.0x10-6) pat ...
... • The blue module is comprised of genes that relate to physiologically interesting traits, in particular body weight. • Gene ontology: The blue module is enriched for genes in the ‘extra-cellular matrix (ECM) receptor interaction’ (p=2.3x10-9) and ‘complement and coagulant cascades’ (p=1.0x10-6) pat ...
NeuroGeM, a knowledgebase of genetic modifiers
... involved in protein quality control are likely to modify disease progression [3]. For this reason, the disease-modifying effect of heat shock proteins (HSP) has been widely studied in model organisms [4–7]. In addition to HSPs, transcription factors regulating the expression of HSPs have also been i ...
... involved in protein quality control are likely to modify disease progression [3]. For this reason, the disease-modifying effect of heat shock proteins (HSP) has been widely studied in model organisms [4–7]. In addition to HSPs, transcription factors regulating the expression of HSPs have also been i ...
Deletions of ultraconserved elements have no obvious phenotype
... of extremely conserved sequences that show 100% identity over 200 bp or greater between the human, mouse, and rat genomes [3]. This category of extreme evolutionary sequence conservation is represented by 481 sequences in the human genome, of which over half show no evidence of transcription. Furthe ...
... of extremely conserved sequences that show 100% identity over 200 bp or greater between the human, mouse, and rat genomes [3]. This category of extreme evolutionary sequence conservation is represented by 481 sequences in the human genome, of which over half show no evidence of transcription. Furthe ...
Leukaemia Section Splenic lymphoma with villous lymphocytes (SLVL)
... Trisomy 3: gene unknown but region 3q13.q32-q29 over-represented. t(6;14)(p21;q32) cyclin D3 is located on 6p21 and, as CDK6, is implicated in the progression through the G1 phase of the cell cycle. t(2;7)(p12;q21). CDK6 is located on 7q21 and dysregulation of CDK6 gene expression could be contribut ...
... Trisomy 3: gene unknown but region 3q13.q32-q29 over-represented. t(6;14)(p21;q32) cyclin D3 is located on 6p21 and, as CDK6, is implicated in the progression through the G1 phase of the cell cycle. t(2;7)(p12;q21). CDK6 is located on 7q21 and dysregulation of CDK6 gene expression could be contribut ...
Mouse mutants and phenotypes - Case Transgenic And Targeting
... the IKMC for selecting and prioritizing genes. For example, it indicates to the IKMC for what genes mutant ES cells or mice have already been generated by other researchers. Because all this external information and links to pertinent resources are also readily available through the web site, the IK ...
... the IKMC for selecting and prioritizing genes. For example, it indicates to the IKMC for what genes mutant ES cells or mice have already been generated by other researchers. Because all this external information and links to pertinent resources are also readily available through the web site, the IK ...
Feb 20 lecture presentation
... particle num ber, a nd morphology of individual colonies/plaques Relatively small genomes Haploid genomes (not yeast) Grow th on defined media possible, thus allowing isolation of mut ants unable to grow -defines metabolic/catabolic pathway s ...
... particle num ber, a nd morphology of individual colonies/plaques Relatively small genomes Haploid genomes (not yeast) Grow th on defined media possible, thus allowing isolation of mut ants unable to grow -defines metabolic/catabolic pathway s ...
PART I
... Therefore they are not considered suitable to be used for the production of agronomically important GM crops. As the technology progressed, the long and cumbersome cointegration method was replaced by the binary system, which is now the standard method for Agrobacterium vector production. This syst ...
... Therefore they are not considered suitable to be used for the production of agronomically important GM crops. As the technology progressed, the long and cumbersome cointegration method was replaced by the binary system, which is now the standard method for Agrobacterium vector production. This syst ...
A-level Human Biology Question paper Unit 2 - Making Use of
... (a) Two different enzymes are required to produce the modified plasmid. Name these two enzymes. Describe the function of each in producing the modified plasmid. ...
... (a) Two different enzymes are required to produce the modified plasmid. Name these two enzymes. Describe the function of each in producing the modified plasmid. ...
Chromatin Modifications
... complexes, one of them has a speciofic targeting and the other has a global targeting. Some HATs have a large but limited region – usually enzymes that are involved in heterochromation formation. No specific HMTs are known to interact with TFs, but some do recruit specifically to coding regions. ...
... complexes, one of them has a speciofic targeting and the other has a global targeting. Some HATs have a large but limited region – usually enzymes that are involved in heterochromation formation. No specific HMTs are known to interact with TFs, but some do recruit specifically to coding regions. ...
VUMC team pinpoints genes that dictate five fingers
... protein that turns other genes on or off, depending on whether it is present as an activator (the “on” form) or a repressor (the “off” form). The investigators demonstrate that Sonic hedgehog blocks the conversion of Gli3 activator forms to Gli3 repressor forms. When there is a lot of Sonic hedgehog ...
... protein that turns other genes on or off, depending on whether it is present as an activator (the “on” form) or a repressor (the “off” form). The investigators demonstrate that Sonic hedgehog blocks the conversion of Gli3 activator forms to Gli3 repressor forms. When there is a lot of Sonic hedgehog ...
Gastrulation in Drosophila:the formation of the ventral furrow and
... consequences of the more severe defects in PMG formation (Zusman and Wieschaus, 1985). In this work we show that in both fog and eta the VF defects precede those in the PMG and as such are not secondary consequences of the latter. The PMG is more strongly affected than the VF by both mutations, sugg ...
... consequences of the more severe defects in PMG formation (Zusman and Wieschaus, 1985). In this work we show that in both fog and eta the VF defects precede those in the PMG and as such are not secondary consequences of the latter. The PMG is more strongly affected than the VF by both mutations, sugg ...
Biol 101 Study Guide Exam 5
... 1) Which one of the following statements is false? 1 A) Once a person is infected with the herpesvirus, the virus remains permanently latent in the body. B) Viruses can enter a host cell when the protein molecules on the outside of the virus fit into receptor molecules on the outside of the cell. C) ...
... 1) Which one of the following statements is false? 1 A) Once a person is infected with the herpesvirus, the virus remains permanently latent in the body. B) Viruses can enter a host cell when the protein molecules on the outside of the virus fit into receptor molecules on the outside of the cell. C) ...
The Arabidopsis BET Bromodomain Factor GTE4
... there are 12 BET genes; however, only two of them, IMBIBITION INDUCIBLE1 and GENERAL TRANSCRIPTION FACTOR GROUP E6 (GTE6), were functionally analyzed. We characterized GTE4 and show that gte4 mutant plants have some characteristic features of cell cycle mutants. Their size is reduced, and they have ...
... there are 12 BET genes; however, only two of them, IMBIBITION INDUCIBLE1 and GENERAL TRANSCRIPTION FACTOR GROUP E6 (GTE6), were functionally analyzed. We characterized GTE4 and show that gte4 mutant plants have some characteristic features of cell cycle mutants. Their size is reduced, and they have ...
Slide 1
... TFIIIB is the transcription factor that assembles Pol III at the start site of transcription. Sequence conservation predicts that TFIIIB containing Brf2 also plays a role in promoter opening. [edit] Termination Polymerase III terminates transcription at small polyTs stretch (5-6). In Eukaryotes, a h ...
... TFIIIB is the transcription factor that assembles Pol III at the start site of transcription. Sequence conservation predicts that TFIIIB containing Brf2 also plays a role in promoter opening. [edit] Termination Polymerase III terminates transcription at small polyTs stretch (5-6). In Eukaryotes, a h ...
DnaJ-related protein essential for placentation - Development
... expressed on the basal surface of the chorion (Gurtner et al., 1995; Kwee et al., 1995; Yang et al., 1995). Deficiencies in either VCAM1 or α4 integrin result in failure of chorioallantoic fusion in mice (Gurtner et al., 1995; Kwee et al., 1995; Yang et al., 1995). However, this phenotype occurs in ...
... expressed on the basal surface of the chorion (Gurtner et al., 1995; Kwee et al., 1995; Yang et al., 1995). Deficiencies in either VCAM1 or α4 integrin result in failure of chorioallantoic fusion in mice (Gurtner et al., 1995; Kwee et al., 1995; Yang et al., 1995). However, this phenotype occurs in ...
Model information sheet - EU
... E14 clone of embryonic stem cells was derived from mice of 129P2 substrain. (Hooper et al, 1987; Papaioanou and Johnson, 1993). Substrain 129S2 is widely used in gene targeting experiments because most of the available embryonic stem cell lines have been developed from strain 129S2. The D3 clone of ...
... E14 clone of embryonic stem cells was derived from mice of 129P2 substrain. (Hooper et al, 1987; Papaioanou and Johnson, 1993). Substrain 129S2 is widely used in gene targeting experiments because most of the available embryonic stem cell lines have been developed from strain 129S2. The D3 clone of ...