detection and pathogenetic role of mmr missense mutations
... To address a pathogenic significance to these mutations, functional studies dealing with expression level, interaction and localization analysis were developed and performed. The expression levels of the MLH1 and MSH2 mutated proteins were investigated by transfecting an human MMR(-) expression syst ...
... To address a pathogenic significance to these mutations, functional studies dealing with expression level, interaction and localization analysis were developed and performed. The expression levels of the MLH1 and MSH2 mutated proteins were investigated by transfecting an human MMR(-) expression syst ...
The Stromal Processing Peptidase of Chloroplasts is Essential in
... vary greatly in length and amino acid sequence, and while secondary structural features have been reported in some cases the general significance of such observations remains uncertain [10,11]. Thus, it is not fully understood how different preproteins are all targeted quite specifically to the same ...
... vary greatly in length and amino acid sequence, and while secondary structural features have been reported in some cases the general significance of such observations remains uncertain [10,11]. Thus, it is not fully understood how different preproteins are all targeted quite specifically to the same ...
... The differences in clinical outcome of H. pylori infection have been studied intensively and variously attributed to host genetics, virulence of the infecting strain and/or environmental factors such as a high salt diet. Genetic association studies have found a link between gastric cancer and single ...
Mutations in an AP2 Transcription Factor
... expressed genes in leaves and stalks between dil1 mutant and wild type plants were identified in a microarray experiment (data not shown). Although many of the differentially expressed genes are involved in hormone metabolism or are hormone-responsive, it is virtually impossible to identify the gene ...
... expressed genes in leaves and stalks between dil1 mutant and wild type plants were identified in a microarray experiment (data not shown). Although many of the differentially expressed genes are involved in hormone metabolism or are hormone-responsive, it is virtually impossible to identify the gene ...
ACAULIS5 controls Arabidopsis xylem specification
... has also been proposed that they participate in the control of vascular development based on their effect on cell division, interaction with other hormones and H2O2 produced during PA catabolism that could potentially affect processes such as vascular cambial activity, cell differentiation and cell ...
... has also been proposed that they participate in the control of vascular development based on their effect on cell division, interaction with other hormones and H2O2 produced during PA catabolism that could potentially affect processes such as vascular cambial activity, cell differentiation and cell ...
Test Info Sheet
... the lifetime risk to develop ovarian cancer is between 24‐54% for carriers of pathogenic variants in BRCA1 and 11‐ 27% for BRCA2 pathogenic variant carriers (Antoniou 2003, Chen 2007, Ford 1998, King 2003, Risch 2006). Other cancers associated with pathogenic variants in BRCA1 and BRCA2 in women i ...
... the lifetime risk to develop ovarian cancer is between 24‐54% for carriers of pathogenic variants in BRCA1 and 11‐ 27% for BRCA2 pathogenic variant carriers (Antoniou 2003, Chen 2007, Ford 1998, King 2003, Risch 2006). Other cancers associated with pathogenic variants in BRCA1 and BRCA2 in women i ...
... gene and clinical findings was also considered. Interestingly, in a patient who had a point mutation (the same as reported for lung cancer (codon 248 CGG to CAG transition)) lung cancer developed several years after the open lung biopsy (the lung cancer specimen could not be examined for p53 mutatio ...
Prokaryote Gene Expression Section 1 Overview of RNA
... RNA and protein synthesis are coupled processes in prokaryotes As soon as the 5’ end of the mRNA is biosynthesised it is available for translation Ribosomes bind, and start protein synthesis Degradation of the mRNA starts from the 5’ end through exoRNAase action The 5’ end can be degraded before the ...
... RNA and protein synthesis are coupled processes in prokaryotes As soon as the 5’ end of the mRNA is biosynthesised it is available for translation Ribosomes bind, and start protein synthesis Degradation of the mRNA starts from the 5’ end through exoRNAase action The 5’ end can be degraded before the ...
Yr 10 inheritance notes
... An easy way to predict the kinds of offsprings resulting from two parents mating is to use the punnet square. Rules for predicting outcomes of dominant gene inheritance. 1. When a pure dominant parent mates with a pure dominant parent: 1 genotype is produced; 1 phenotype is produced. B B ...
... An easy way to predict the kinds of offsprings resulting from two parents mating is to use the punnet square. Rules for predicting outcomes of dominant gene inheritance. 1. When a pure dominant parent mates with a pure dominant parent: 1 genotype is produced; 1 phenotype is produced. B B ...
1 Supplemental Table 1. FACS-isolated, SSEA-4
... -encodes a membrane protein that mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium, -implicated in the initial attachment during the process of embryo implantation. -acts as a transcriptional activator, -may play a role during embryogenesis. -m ...
... -encodes a membrane protein that mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium, -implicated in the initial attachment during the process of embryo implantation. -acts as a transcriptional activator, -may play a role during embryogenesis. -m ...
fliD operon of Salmonella typhimurium
... h n gene cassette was inserted into pKKD2H at the NaeI site to obtain pKKD2HDS. pKKD2 was digested with NaeI and MluI or Bsu36I and Mld, blunt-ended with T4 DNA polymerase, and ligated with the kan gene cassettes which had been excised from pUC4K with PstI and blunt-ended with T4 DNA polymerase. The ...
... h n gene cassette was inserted into pKKD2H at the NaeI site to obtain pKKD2HDS. pKKD2 was digested with NaeI and MluI or Bsu36I and Mld, blunt-ended with T4 DNA polymerase, and ligated with the kan gene cassettes which had been excised from pUC4K with PstI and blunt-ended with T4 DNA polymerase. The ...
X chromosome gene expression in human tissues
... the 9 genes have previously been reported to escape X inactivation. However, in general, no consistent pattern was seen for the expression of Xlinked genes between in vitro and in vivo systems. This study indicates that factors other than the X-inactivation process may impact on the expression of X- ...
... the 9 genes have previously been reported to escape X inactivation. However, in general, no consistent pattern was seen for the expression of Xlinked genes between in vitro and in vivo systems. This study indicates that factors other than the X-inactivation process may impact on the expression of X- ...
Inquiry into Life Twelfth Edition
... folds – Prevents formation of a hairpin – This is part of the transcription termination signal which causes attenuation ...
... folds – Prevents formation of a hairpin – This is part of the transcription termination signal which causes attenuation ...
Migration and mutation
... [4] Class [3] refers to migration of individual genes rather than pairs of genes, as expected if migration involves diploid individuals. Our first paper [5], which I wrote, with migration from the mainland into a single island population, ignores this complication. I have to admit that I entirely fo ...
... [4] Class [3] refers to migration of individual genes rather than pairs of genes, as expected if migration involves diploid individuals. Our first paper [5], which I wrote, with migration from the mainland into a single island population, ignores this complication. I have to admit that I entirely fo ...
Basic Concepts of Bioinformatics
... One of the goals of bioinformatics is to reduce the time and cost involved with it. The process ...
... One of the goals of bioinformatics is to reduce the time and cost involved with it. The process ...
Chromosomes and Genetics
... severely retarded, as well as having a variety of physical problems. Translocational Down syndrome is caused by most of chromosome 21 becoming joined with chromosome 14. Some children of a person with this translocation will inherit the ...
... severely retarded, as well as having a variety of physical problems. Translocational Down syndrome is caused by most of chromosome 21 becoming joined with chromosome 14. Some children of a person with this translocation will inherit the ...
•MOLECULAR CELL BIOLOGY
... mRNA processing – RNA splicing, 5’ and 3’ retain noncoding regions (untranslated regions; UTRs). In mammalian mRNA, 5’ UTR about >100 nucleotides, 3’ UTR about several kilobases The ribose of the second nucleotide also is methylated ...
... mRNA processing – RNA splicing, 5’ and 3’ retain noncoding regions (untranslated regions; UTRs). In mammalian mRNA, 5’ UTR about >100 nucleotides, 3’ UTR about several kilobases The ribose of the second nucleotide also is methylated ...
Root Hairs - Biological Sciences
... The TTG gene encodes a small protein with WD40 repeats (Walker et al., 1999). Although the protein sequence does not provide a clear mechanistic understanding of TTG’s role, it is known that ttg mutations can be functionally complemented by expression of the maize R cDNA (under the control of the st ...
... The TTG gene encodes a small protein with WD40 repeats (Walker et al., 1999). Although the protein sequence does not provide a clear mechanistic understanding of TTG’s role, it is known that ttg mutations can be functionally complemented by expression of the maize R cDNA (under the control of the st ...
in the Budding Yeast, Saccharomyces cer isiae
... medium and cultured at 23~ for 2 h to allow the cells to enter into mitosis. This same experimental design was performed with wild-type strains and a strain with a temperature-sensitive mutation in the gene CDC3. A spontaneous actl-4 revertant was isolated by growing eight individual isolates of the ...
... medium and cultured at 23~ for 2 h to allow the cells to enter into mitosis. This same experimental design was performed with wild-type strains and a strain with a temperature-sensitive mutation in the gene CDC3. A spontaneous actl-4 revertant was isolated by growing eight individual isolates of the ...
Possible consequences of the overlap between the CaMV 35S
... viral movement and influences viral host range.10,29-31 Thus, the D4 domain appears to be partially dispensable. For short P35S sequences that overlap only with the D4 domain of P6 and for promoters that harbour an additional 35S enhancer that overlaps only with the D4 domain, it is unlikely that ch ...
... viral movement and influences viral host range.10,29-31 Thus, the D4 domain appears to be partially dispensable. For short P35S sequences that overlap only with the D4 domain of P6 and for promoters that harbour an additional 35S enhancer that overlaps only with the D4 domain, it is unlikely that ch ...
Molecular regulators of phosphate homeostasis in plants
... revealed mutants with aberrant Pi accumulation in the shoots. pho1 was isolated as a Pi-deficient mutant with leaf Pi concentration of only 5% of that of the wild type but with normal root Pi concentration (Poirier et al., 1991). The normal Pi uptake and root Pi concentration but lower shoot Pi conc ...
... revealed mutants with aberrant Pi accumulation in the shoots. pho1 was isolated as a Pi-deficient mutant with leaf Pi concentration of only 5% of that of the wild type but with normal root Pi concentration (Poirier et al., 1991). The normal Pi uptake and root Pi concentration but lower shoot Pi conc ...
Transformation of Maize Cells and Regeneration of
... are compatible with regeneration of fertile plants. Recently, we have been able to overcome these obstacles by bombarding embryogenic maize suspension cells with tungsten particles coated with the selectable marker gene bar. The Streptomyces hygroscopicus bar gene encodes phosphinothricin acetyltran ...
... are compatible with regeneration of fertile plants. Recently, we have been able to overcome these obstacles by bombarding embryogenic maize suspension cells with tungsten particles coated with the selectable marker gene bar. The Streptomyces hygroscopicus bar gene encodes phosphinothricin acetyltran ...
... MW 85 kDa, 95 kDa by SDS-PAGE; contains in Nterm a forkhead associated domain (amino acids 24100) and a breast cancer domain (BRCT; amino acids 105-190), both domains being found in the various DNA damage responsive cell cycle checkpoint proteins; 4 possible nuclear localization domains in the C-ter ...