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Molecular indexing for improved RNA-Seq analysis
Molecular indexing for improved RNA-Seq analysis

... Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. For example, in microarray experiments for gene expression, the RNA samples must first be converted to cDNA and amplified to a suffici ...
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pdf format - Faculty members Homepages

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Chapter 06 Lecture PowerPoint - McGraw Hill Higher Education
Chapter 06 Lecture PowerPoint - McGraw Hill Higher Education

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... There are four different kinds of nucleotides because four different kinds of N-containing bases are involved: adenine (A), thymine (T), cytosine (C) and guanine (G). Examine figure 2.3. The nucleotide sub-units (a) are assembled together to form a chain (b) in which the sugar of one nucleotide is l ...
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... binding site for the drug is located on ribosomal RNA. RNA target sites have now been confirmed for a large number of antibiotics (see, for example, Moazed & Noller, 1987) and there is no reason to believe that cycloheximide is exceptional in this respect. It is reasonable to predict that the drug b ...
Get PDF - Wiley Online Library
Get PDF - Wiley Online Library

... The relative mRNA levels of differentially expressed (DE) and housekeeping (HK) genes of six aneuploid cancer lines with large-scale genomic changes identified by SNP/SKY analysis were compared with similar genes in diploid cells. The aneuploid cancer lines had heterogeneous genomic landscapes with ...
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Messenger RNA



Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression. Following transcription of primary transcript mRNA (known as pre-mRNA) by RNA polymerase, processed, mature mRNA is translated into a polymer of amino acids: a protein, as summarized in the central dogma of molecular biology.As in DNA, mRNA genetic information is in the sequence of nucleotides, which are arranged into codons consisting of three bases each. Each codon encodes for a specific amino acid, except the stop codons, which terminate protein synthesis. This process of translation of codons into amino acids requires two other types of RNA: Transfer RNA (tRNA), that mediates recognition of the codon and provides the corresponding amino acid, and ribosomal RNA (rRNA), that is the central component of the ribosome's protein-manufacturing machinery.The existence of mRNA was first suggested by Jacques Monod and François Jacob, and subsequently discovered by Jacob, Sydney Brenner and Matthew Meselson at the California Institute of Technology in 1961.
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