Supplementary information
... from the Gene Expression Omnibus (GEO) and the ArrayExpress databases (Supplementary Table 1). The 14 data sets consisted of gene expression data from 1420 colorectal tumor tissue samples. For each normalized data set, we calculated the Pearson’s correlation coefficient for each pair of genes. Suppl ...
... from the Gene Expression Omnibus (GEO) and the ArrayExpress databases (Supplementary Table 1). The 14 data sets consisted of gene expression data from 1420 colorectal tumor tissue samples. For each normalized data set, we calculated the Pearson’s correlation coefficient for each pair of genes. Suppl ...
Part B - Modeling Transcription: How is RNA modified? Name:
... The most remarkable stage of RNA processing in the eukaryotic nucleus is the removal of a large portion of the RNA molecule that is initially synthesized‐‐a cut‐and‐paste job called RNA splicing. The average length of a transcription unit along a eukaryotic DN ...
... The most remarkable stage of RNA processing in the eukaryotic nucleus is the removal of a large portion of the RNA molecule that is initially synthesized‐‐a cut‐and‐paste job called RNA splicing. The average length of a transcription unit along a eukaryotic DN ...
challenge questions
... (c) Propose an explanation for why the father’s case of retinoblastoma was unilateral, while his sons and brother’s cases were bilateral. The father may have unilateral retinoblastoma because of incomplete penetrance of the mutation in the RB gene. Alleles at another locus or multiple other loci may ...
... (c) Propose an explanation for why the father’s case of retinoblastoma was unilateral, while his sons and brother’s cases were bilateral. The father may have unilateral retinoblastoma because of incomplete penetrance of the mutation in the RB gene. Alleles at another locus or multiple other loci may ...
AIMS Review Packet
... ligase, DNA polymerase, and 3’and 5’ on both old and new strands. 9. Why is DNA replication important? 10. What are 3 differences between DNA and RNA? 11. What is the Central Dogma of biology? (Fill in the blanks) ______________ _______________ _________________ 12. Diagram the process of transc ...
... ligase, DNA polymerase, and 3’and 5’ on both old and new strands. 9. Why is DNA replication important? 10. What are 3 differences between DNA and RNA? 11. What is the Central Dogma of biology? (Fill in the blanks) ______________ _______________ _________________ 12. Diagram the process of transc ...
MEDICAL EMBRYOLOGY
... Because of various levels of regulation, however, the number of proteins derived from these genes is closer to the original predicted number of genes. What has been disproved is the one-gene-one-protein hypothesis. Thus, through a variety of mechanisms, a single gene may give rise to many protei ...
... Because of various levels of regulation, however, the number of proteins derived from these genes is closer to the original predicted number of genes. What has been disproved is the one-gene-one-protein hypothesis. Thus, through a variety of mechanisms, a single gene may give rise to many protei ...
Bioinformatics Drug Design
... agonists/antagonists (for receptors) •Ligands for receptors normally bind via a non-covalent reversible binding. •Enzyme inhibitors have a wide range of modes:non-covalent reversible,covalent reversible/irreversible or suicide inhibition. •Enzymes prefer to bind transition states (reaction intermedi ...
... agonists/antagonists (for receptors) •Ligands for receptors normally bind via a non-covalent reversible binding. •Enzyme inhibitors have a wide range of modes:non-covalent reversible,covalent reversible/irreversible or suicide inhibition. •Enzymes prefer to bind transition states (reaction intermedi ...
Case Study #1 Use of bioinformatics in drug development
... agonists/antagonists (for receptors) •Ligands for receptors normally bind via a non-covalent reversible binding. •Enzyme inhibitors have a wide range of modes:non-covalent reversible,covalent reversible/irreversible or suicide inhibition. •Enzymes prefer to bind transition states (reaction intermedi ...
... agonists/antagonists (for receptors) •Ligands for receptors normally bind via a non-covalent reversible binding. •Enzyme inhibitors have a wide range of modes:non-covalent reversible,covalent reversible/irreversible or suicide inhibition. •Enzymes prefer to bind transition states (reaction intermedi ...
Nucleic Acids - Structure and Replication
... lips. Like many other viruses, HSV can remain inactive inside the body for years. When HSV becomes active, it causes cold sores around the mouth. Human cells infected with a virus may undergo programmed cell death. While HSV is inactive inside the body, only one of its genes is transcribed. This gen ...
... lips. Like many other viruses, HSV can remain inactive inside the body for years. When HSV becomes active, it causes cold sores around the mouth. Human cells infected with a virus may undergo programmed cell death. While HSV is inactive inside the body, only one of its genes is transcribed. This gen ...
oncogenes
... proteins that stimulate cell division • mutated forms, called oncogenes, cause stimulatory proteins to be overactive, with the result that cells proliferate excessively • gain of function mutations ...
... proteins that stimulate cell division • mutated forms, called oncogenes, cause stimulatory proteins to be overactive, with the result that cells proliferate excessively • gain of function mutations ...
Cell Division and Mitosis Sexual Reproduction and Meiosis DNA
... 10. In the human body, which cells are constantly dividing? Why is this important? How can this be potentially harmful? 11. Arrange the following terms in the correct order: fertilization, sex cells, meiosis, zygote, mitosis. 12. What are the three types of RNA used during protein synthesis? What is ...
... 10. In the human body, which cells are constantly dividing? Why is this important? How can this be potentially harmful? 11. Arrange the following terms in the correct order: fertilization, sex cells, meiosis, zygote, mitosis. 12. What are the three types of RNA used during protein synthesis? What is ...
Senescence
... • Introduce substances that halt the activity of certain genes (AZT) • Introduce substances that (over) promote activity of certain genes (gamma globin) • Introduce new, functional genes true Gene Therapy – Experimental, currently tested primarily on critically ill patients ...
... • Introduce substances that halt the activity of certain genes (AZT) • Introduce substances that (over) promote activity of certain genes (gamma globin) • Introduce new, functional genes true Gene Therapy – Experimental, currently tested primarily on critically ill patients ...
(PowerPoint) Southeast 2012 - Yale Center for Teaching and Learning
... • Option 1: Given that we still can’t distinguish between the models, design an experiment to help answer the question of what causes color variation in Bulldog lizards. Be ready to share your experimental design in the next class period. • Option 2: We learned that a mutation in B-52 leads to lower ...
... • Option 1: Given that we still can’t distinguish between the models, design an experiment to help answer the question of what causes color variation in Bulldog lizards. Be ready to share your experimental design in the next class period. • Option 2: We learned that a mutation in B-52 leads to lower ...
DNA Fingerprinting and Forensic Analysis - ASAB-NUST
... • They are multigenic • This create huge genetic diversity underlying this phenotype • One could expect fingerprints of twins identical, but they are not • Minor variation happens because of environmental factors • This science is being used for identification by late 1800 ...
... • They are multigenic • This create huge genetic diversity underlying this phenotype • One could expect fingerprints of twins identical, but they are not • Minor variation happens because of environmental factors • This science is being used for identification by late 1800 ...
Cell Evolution in Fast Motion - Max-Planck
... understanding of genetic homogeneity within a species and within an organism. When one considers, for example, that a tobacco leaf comprises significantly more than five million cells, it becomes clear that the cells in one and the same leaf on a plant are not necessarily geneti- ...
... understanding of genetic homogeneity within a species and within an organism. When one considers, for example, that a tobacco leaf comprises significantly more than five million cells, it becomes clear that the cells in one and the same leaf on a plant are not necessarily geneti- ...
Cloning of the TCR b-chain gene by subtractive hybridization
... common to B and T cells. TCR should be in the 2% genes expressed specifically in T cells. (DNA subtractive hybridyzation eliminates 98%) • TCR genes should undergo DNA rearrangements like those observed in the Ig genes of B cells. ...
... common to B and T cells. TCR should be in the 2% genes expressed specifically in T cells. (DNA subtractive hybridyzation eliminates 98%) • TCR genes should undergo DNA rearrangements like those observed in the Ig genes of B cells. ...
Gene Section RB1 (retinoblastoma) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... nuclear proteins with significant sequence similarity in two discontinuous areas (pockets domains); conditional on the phosphorylation status, these pocket proteins can bind transforming proteins of DNA tumor viruses as well as nuclear proteins. ...
... nuclear proteins with significant sequence similarity in two discontinuous areas (pockets domains); conditional on the phosphorylation status, these pocket proteins can bind transforming proteins of DNA tumor viruses as well as nuclear proteins. ...
Genit 2
... It is the passage of genes from one generation to another. This passage is well controlled, but in some cases (ex. Closed population that doesn’t mix with others) abnormalities or problems might occur like gene drift or shift. For example, Bema Indians is a closed population, they always marry from ...
... It is the passage of genes from one generation to another. This passage is well controlled, but in some cases (ex. Closed population that doesn’t mix with others) abnormalities or problems might occur like gene drift or shift. For example, Bema Indians is a closed population, they always marry from ...
Clock-Controlled Genes
... oscillator components. Therefore, the output genes are not only subject to circadian control of gene expression, but also to tissue-specific control. At the moment, we have much better insight into the circadian control than the tissue-specific control of circadian output genes. However, it appears ...
... oscillator components. Therefore, the output genes are not only subject to circadian control of gene expression, but also to tissue-specific control. At the moment, we have much better insight into the circadian control than the tissue-specific control of circadian output genes. However, it appears ...
Lecture 5
... The rrn16 target site mutations are recessive, and were 100-fold less efficient than the currently used dominant aadA gene. Streptomycin resistance encoded in the rps12 ribosomal protein gene was also included in an early vector. The neo (aph(3')IIa) gene encodes neomycin phosphotransferase II [NPTI ...
... The rrn16 target site mutations are recessive, and were 100-fold less efficient than the currently used dominant aadA gene. Streptomycin resistance encoded in the rps12 ribosomal protein gene was also included in an early vector. The neo (aph(3')IIa) gene encodes neomycin phosphotransferase II [NPTI ...
AIMS Review Packet
... 23. Diagram the process of DNA replication. Include the replication fork, helicase, ligase, DNA polymerase, and 3’and 5’ on both old and new strands. ...
... 23. Diagram the process of DNA replication. Include the replication fork, helicase, ligase, DNA polymerase, and 3’and 5’ on both old and new strands. ...
Prokaryotic Gene Regulation (PowerPoint) Gulf Coast 2012
... of steps in lac operon function FIRST: Post and discuss the model of the lac operon SECOND: Assign students into groups to discuss the sequence of the events that must happen in the model ...
... of steps in lac operon function FIRST: Post and discuss the model of the lac operon SECOND: Assign students into groups to discuss the sequence of the events that must happen in the model ...
DNA and Evolution
... are always limited, which implies that some individuals die without reproducing. Survival is affected by how well an individual is adapted to the environment. Or, how well the individual’s genes match the needs and challenges imposed by the environment it lives in. – adaptations are specific traits ...
... are always limited, which implies that some individuals die without reproducing. Survival is affected by how well an individual is adapted to the environment. Or, how well the individual’s genes match the needs and challenges imposed by the environment it lives in. – adaptations are specific traits ...
File - NCEA Level 3 Biology
... nucleotide triplet codes which code for specific amino acids and the order they are arranged in. This is a universal code, so in theory the same protein can be made by any organism. – The promoter region – controls gene expression. Regulates in which tissue the gene should be expressed, at what time ...
... nucleotide triplet codes which code for specific amino acids and the order they are arranged in. This is a universal code, so in theory the same protein can be made by any organism. – The promoter region – controls gene expression. Regulates in which tissue the gene should be expressed, at what time ...