Huntingtin function during zebrafish (Danio rerio) development
... Huntington’s disease shares a common molecular basis with eight other neurodegenerative diseases: expansion of an existing polyglutamine tract. In each case, this repeat tract occurs within otherwise unrelated proteins. These proteins show widespread and overlapping patterns of expression in the bra ...
... Huntington’s disease shares a common molecular basis with eight other neurodegenerative diseases: expansion of an existing polyglutamine tract. In each case, this repeat tract occurs within otherwise unrelated proteins. These proteins show widespread and overlapping patterns of expression in the bra ...
Coffee B, Ikeda M, Budimirovic DB, Hjelm LN, Kaufmann WE and Warren ST: Mosaic FMR1 Deletion Causes Fragile X Syndrome and Can Lead to Molecular Misdiagnosis: A Case Report and Review of the Literature. American J of Medical Genetics Part A 146A:1358-1367 (2008).
... Female with mental retardation with a 10 Mb deletion at Xq27.1q27.3 Female with Hunter syndrome with a 3–5 cM deletion encompassing FMR1 and IDS genes (as well as FMR2) Male with typical features of fragile X syndrome carrying a deletion removing FMR1 and 2.5 Mb of flanking sequences. Deletion proba ...
... Female with mental retardation with a 10 Mb deletion at Xq27.1q27.3 Female with Hunter syndrome with a 3–5 cM deletion encompassing FMR1 and IDS genes (as well as FMR2) Male with typical features of fragile X syndrome carrying a deletion removing FMR1 and 2.5 Mb of flanking sequences. Deletion proba ...
The disease characteristics of different strains of scrapie in Sinc
... models, but is remarkably predictable. Its length depends on both the strain of scrapie agent and genetic factors in the host. The major gene controlling incubation period in mice is the Sinc gene (scrapie incubation), two alleles of which have been identified (s7 and p7) (Dickinson et al., 1968; Di ...
... models, but is remarkably predictable. Its length depends on both the strain of scrapie agent and genetic factors in the host. The major gene controlling incubation period in mice is the Sinc gene (scrapie incubation), two alleles of which have been identified (s7 and p7) (Dickinson et al., 1968; Di ...
Analysis of the Molecular Basis of Flowering Time Variation in
... Cvi, Shakhdara, Kz-9, Kondara, and Wil-2, the flowering time of F1 seedlings from crosses of the accessions to different backgrounds was determined. This provides a preliminary indication of the activity of the different alleles; however, a definitive conclusion on allele functionality requires more ...
... Cvi, Shakhdara, Kz-9, Kondara, and Wil-2, the flowering time of F1 seedlings from crosses of the accessions to different backgrounds was determined. This provides a preliminary indication of the activity of the different alleles; however, a definitive conclusion on allele functionality requires more ...
Retrotransposon-Mediated Fgf5go-Utr Mutant Mice
... the Fgf6- and Fgf7-deficient genetic backgrounds [9]. Fgf5m1Btlr was produced through random germline mutagenesis with N-ethyl-N-nitrosourea (ENU) (http:// mutagenetix.scripps.edu/home.cfm). This mutation is a G-to-T transversion at position 562 of the Fgf5 transcript, which results in replacement o ...
... the Fgf6- and Fgf7-deficient genetic backgrounds [9]. Fgf5m1Btlr was produced through random germline mutagenesis with N-ethyl-N-nitrosourea (ENU) (http:// mutagenetix.scripps.edu/home.cfm). This mutation is a G-to-T transversion at position 562 of the Fgf5 transcript, which results in replacement o ...
Alternatively Spliced Genes
... 3 orientation of U4 and U4atac is from right to left, and that of U1, U11, U2, U12, and U5snRNAs is from left to right. The RNA helices are indicated by Roman numerals, and nucleotide positions by Arabic numerals. The shaded nucleotides are binding sites for Sm proteins, and regions marked with bla ...
... 3 orientation of U4 and U4atac is from right to left, and that of U1, U11, U2, U12, and U5snRNAs is from left to right. The RNA helices are indicated by Roman numerals, and nucleotide positions by Arabic numerals. The shaded nucleotides are binding sites for Sm proteins, and regions marked with bla ...
Full-Text PDF
... copies of the ubiquitin gene. The coexistence of nearly identical redundant ubiquitin coding sequences within eukaryotic species fits in a model of strong concerted evolution [4,5]. Concerted evolution prevents, by homologous recombination, the incorporation of mutations in highly conserved genes, w ...
... copies of the ubiquitin gene. The coexistence of nearly identical redundant ubiquitin coding sequences within eukaryotic species fits in a model of strong concerted evolution [4,5]. Concerted evolution prevents, by homologous recombination, the incorporation of mutations in highly conserved genes, w ...
Attachment 2.2 Sequencing results
... only depend on cruciferous vegetables, but further investigation will tell. [9] How does AHR operate? Normally, AHR is located in the cytoplasm where it forms a complex with several proteins, like Hsp90, XAP2 and p23 proteins. [10] The binding of toxic components, for example polycyclic aromatic hyd ...
... only depend on cruciferous vegetables, but further investigation will tell. [9] How does AHR operate? Normally, AHR is located in the cytoplasm where it forms a complex with several proteins, like Hsp90, XAP2 and p23 proteins. [10] The binding of toxic components, for example polycyclic aromatic hyd ...
Parallel Evolution of Copy-Number Variation across Continents in
... selection, confidence in the biological relevance of such differentiation can be increased by asking whether differentiation occurs in parallel across different geographic regions exhibiting similar ecological gradients (e.g., Jones et al. 2012). Therefore, for each differentiated CNV detected on on ...
... selection, confidence in the biological relevance of such differentiation can be increased by asking whether differentiation occurs in parallel across different geographic regions exhibiting similar ecological gradients (e.g., Jones et al. 2012). Therefore, for each differentiated CNV detected on on ...
p53 in Hematologic Malignancies
... have activation of the c-myc gene. Although T-cell leukemia Cases of AML and MDS have been reported that have cell lines have about a 50% frequency of p53 mutations,"" high levels of p53 protein, as determined by either immunoprecipitation or immunochemistry, buthaveno detectable p53 mutations are r ...
... have activation of the c-myc gene. Although T-cell leukemia Cases of AML and MDS have been reported that have cell lines have about a 50% frequency of p53 mutations,"" high levels of p53 protein, as determined by either immunoprecipitation or immunochemistry, buthaveno detectable p53 mutations are r ...
Expression and function of decapentaplegic and thick veins during
... involves the coordinate activities of several signal transduction pathways, including those mediated by the transmembrane receptors Torpedo and Notch. In this report, the role of the signalling molecule Decapentaplegic during vein differentiation has been analysed. It is shown that decapentaplegic i ...
... involves the coordinate activities of several signal transduction pathways, including those mediated by the transmembrane receptors Torpedo and Notch. In this report, the role of the signalling molecule Decapentaplegic during vein differentiation has been analysed. It is shown that decapentaplegic i ...
Mothers against dpp participates in a DPP/TGF
... enhancer driving MAD in the endoderm. This result is also seen in a comparable embryo expressing ubiquitous DPP instead of tkvQ199D (Newfeld et al., 1996). Thus, we infer that Mad functions in the DPP signal transduction cascade downstream of the serine-threonine kinase activity of tkv but upstream ...
... enhancer driving MAD in the endoderm. This result is also seen in a comparable embryo expressing ubiquitous DPP instead of tkvQ199D (Newfeld et al., 1996). Thus, we infer that Mad functions in the DPP signal transduction cascade downstream of the serine-threonine kinase activity of tkv but upstream ...
hhmi resource for new ap bio curriculum
... applicable for the animations, video clips, etc… so it is easy to see how long a video resource will run if used in the classroom. AP® Biology Correlations: This column correlates with the new AP® Biology Curriculum Framework. Each Big Idea (1-4) is at the heading of a sub-column. As a teacher scans ...
... applicable for the animations, video clips, etc… so it is easy to see how long a video resource will run if used in the classroom. AP® Biology Correlations: This column correlates with the new AP® Biology Curriculum Framework. Each Big Idea (1-4) is at the heading of a sub-column. As a teacher scans ...
GENETIC AND MOLECULAR ANALYSIS OF THE garnet EYE
... The garnet eye colour gene of Drosophila melanogaster is one the group of genes called the transport group of eye colour genes. The garnet gene resembles other members of the transport group of eye colour genes in its phenotype and shows extensive genetic interactions with them. The most significant ...
... The garnet eye colour gene of Drosophila melanogaster is one the group of genes called the transport group of eye colour genes. The garnet gene resembles other members of the transport group of eye colour genes in its phenotype and shows extensive genetic interactions with them. The most significant ...
Persistence and dispersion of Acinetobacter spp. in the urban water
... strains, the Subcommittee on the Taxonomy of Moraxella and Allied Bacteria suggested that the genus Acinetobacter should comprise only oxidase-negative strains. This division was supported by the use of several phenotypic tests, which have now been used for over three decades as the basis for inclus ...
... strains, the Subcommittee on the Taxonomy of Moraxella and Allied Bacteria suggested that the genus Acinetobacter should comprise only oxidase-negative strains. This division was supported by the use of several phenotypic tests, which have now been used for over three decades as the basis for inclus ...
Pax1, Pax9, Vertebral column, Chondrogenesis, Proliferation
... Since the original description of dco (Jursnich et al., 1990) many new alleles of the gene have been produced by various mutagenic procedures. We therefore analyzed the phenotypes of these new alleles as well as of some new deficiencies and of the few alleles described earlier (Jursnich et al., 1990 ...
... Since the original description of dco (Jursnich et al., 1990) many new alleles of the gene have been produced by various mutagenic procedures. We therefore analyzed the phenotypes of these new alleles as well as of some new deficiencies and of the few alleles described earlier (Jursnich et al., 1990 ...
Specificity of Insertion by the Translocatable Tetracycline Resistance Element Tn10.
... 1975; BOTSTEINand KLECKNER1977). TnlO is 9300 basepairs in length, with 1400-basepair inverted repetitions at its ends. These repetitions may be intact IS-like sequences (CHAN 1974; SHARP,COHENand DAVIDSON 1973; ROSS, SWAN and KLECKNERin preparation). The specificity of TnlO insertion for sites on a ...
... 1975; BOTSTEINand KLECKNER1977). TnlO is 9300 basepairs in length, with 1400-basepair inverted repetitions at its ends. These repetitions may be intact IS-like sequences (CHAN 1974; SHARP,COHENand DAVIDSON 1973; ROSS, SWAN and KLECKNERin preparation). The specificity of TnlO insertion for sites on a ...
Rhizobium Nodulation Protein NodC Is an Important Determinant of
... these NodC proteins and that it is not influenced by the UDP-GlcNAc concentration. Analysis of oligosaccharide chain lengths in LCOs produced by a R. leguminosarum bv. viciae nodC mutant, expressing the three cloned nodC genes mentioned above, shows that the difference in oligosaccharide chain lengt ...
... these NodC proteins and that it is not influenced by the UDP-GlcNAc concentration. Analysis of oligosaccharide chain lengths in LCOs produced by a R. leguminosarum bv. viciae nodC mutant, expressing the three cloned nodC genes mentioned above, shows that the difference in oligosaccharide chain lengt ...
Ethylene Signal Transduction. Moving beyond
... immature versus mature fruits. Immature fruits produce low levels of ethylene and exogenous ethylene treatment does not stimulate further synthesis (System 1). In contrast, the ethylene produced by ripening fruits is autocatalytic, stimulating its own synthesis (System 2) (Yang, 1987). The differenc ...
... immature versus mature fruits. Immature fruits produce low levels of ethylene and exogenous ethylene treatment does not stimulate further synthesis (System 1). In contrast, the ethylene produced by ripening fruits is autocatalytic, stimulating its own synthesis (System 2) (Yang, 1987). The differenc ...
Forche et al. 2008 PLoS Biology
... system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinica ...
... system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinica ...
The Parasexual Cycle in Candida albicans Provides an
... system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinica ...
... system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinica ...
The-NOS-problem
... o They isolated 32 lethal mutations falling into 5 complementation groups. They further supported that one of these mutants, which they called NOSC (actually dNOSC), had a homozygous lethal allele of NOS (and thus that NOS is essential) by doing the following: o They backcrossed 5 times and found th ...
... o They isolated 32 lethal mutations falling into 5 complementation groups. They further supported that one of these mutants, which they called NOSC (actually dNOSC), had a homozygous lethal allele of NOS (and thus that NOS is essential) by doing the following: o They backcrossed 5 times and found th ...
univERsity oF copEnhAGEn
... Phenotypic variation between individuals of a species is often under quantitative genetic control. Genomic analysis of gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes of variation between individuals. However, there ...
... Phenotypic variation between individuals of a species is often under quantitative genetic control. Genomic analysis of gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes of variation between individuals. However, there ...
Effete, a Drosophila chromatin-associated ubiquitin
... However, TPE and PEV respond differently to genetic modifiers; PEV modifiers do not generally affect TPE of transgenes inserted into the second or the third chromosome subtelomeric regions, but do affect TPE at the telomeres of the fourth chromosome, which shares properties with centric heterochroma ...
... However, TPE and PEV respond differently to genetic modifiers; PEV modifiers do not generally affect TPE of transgenes inserted into the second or the third chromosome subtelomeric regions, but do affect TPE at the telomeres of the fourth chromosome, which shares properties with centric heterochroma ...
6. risk management plan
... Research on biosafety risks ........................................................................................... 75 ...
... Research on biosafety risks ........................................................................................... 75 ...