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WJG-23-1787
WJG-23-1787

... It is generally believed that the network-based identification of hub miRNA patterns possesses higher accuracy compared with non-network-based methods. Thus, we employed the strategy illustrated in Figure 4A to identify the miRNA-mRNA regulatory network in L02 cells transfected with HBx. Through ana ...
A B
A B

... B is for Bio —computational kind. We’re into B big, with B we’re aligned. But it’s not like those DNA seqs are aligned. Instead, B and CS are now intertwined. In the 1990s, recognizing the influence CS could have in comp bio, we began looking for faculty. Dexter Kozen, a complexity person, and other ...
Pairwise sequence alignment - uni
Pairwise sequence alignment - uni

... • Positions at which a letter is paired with a null are called gaps.  • Gap scores are typically negative.  • Since a single mutational event may cause the insertion or  deletion of more than one residue, the presence of a gap is  ascribed more significance than the length of the gap. Thus  there ar ...
rna metabolism: how different bacteria reached the same
rna metabolism: how different bacteria reached the same

... future aim of his laboratory is to study how interacting proteins of RNase Y, such as those involved in biofilm formation, modify the activity of the enzyme. His lab will also take advantage of recent advancements made in the field of super-resolution microscopy, which offers resolution beyond the t ...
Chapter 8.qxp
Chapter 8.qxp

... and UAA as the amino acid glycine. To Candida fungi, the RNA codon CUG, which normally means leucine, instead specifies serine. The existence of such variations demonstrates that the code can evolve and may provide clues about how it did. In all three domains of life, a nonstandard 21st amino acid, ...
Leukaemia Section dic(9;20)(p11 13;q11) -
Leukaemia Section dic(9;20)(p11 13;q11) -

... replaced by that of the partner gene, which does not change the affinity for the protein to bind to recognition sites, but does effect the expression of certain downstream PAX5 target genes. Furthermore, transfected vectors encoding the PAX5-C20ORF112 are able to suppress the transcriptional activit ...
Example-Abstract
Example-Abstract

... biochemical analysis and find it to be the same as described before by genetic studies. Human and Saccharomyces cerevisiae RNASEH2A/Rnh201p subunits contain the catalytic center and are similar to each other and to prokaryotic RNase HII, which is functionally active as a single polypeptide. Although ...
Genetic Evolution Note Review
Genetic Evolution Note Review

... 26. If one of the animals is homozygous for a lighter color and another is heterozygous (a carrier), does either of them have an advantage for survival? Explain your answer. For the following statements, determine if it is true or false? If false, change the underlined word to make it true. _______ ...
`Candidatus Midichloria mitochondrii`, an endosymbiont of the tick
`Candidatus Midichloria mitochondrii`, an endosymbiont of the tick

... This symbiont of I. ricinus has provisionally been designated IricES1 (Beninati et al., 2004). IricES1 has been observed in the ovaries of females of I. ricinus with 100 % prevalence, while lower prevalence is reported in male ticks (Lo et al., 2006). In females, the bacterium inhabits the cytoplasm ...
Molecular markers closely linked to fusarium resistance genes in
Molecular markers closely linked to fusarium resistance genes in

... from a wide cross between chickpea (Cicer arietinum L., resistant parent) and Cicer reticulatum (susceptible parent) segregating for the closely linked resistances against Fusarium oxysporum f.sp. ciceri races 4 and 5 was used to develop DNA amplification fingerprinting markers linked to both resist ...
Catastrophic Epilepsy of Infancy
Catastrophic Epilepsy of Infancy

... be deleterious, and therefore should be subtracted from the total) • If the clinical symptoms are compatible, such a result is accepted as sufficient evidence of causality • (compare with p values of 0.05; we rarely get this definite in clinical medicine) ...
Issues
Issues

... Question 5: What strategies are included in public health initiatives aimed at reducing the incidence of smoking-related diseases? What impact have these initiatives had on smoking rates and associated medical costs? Question 6: Gene therapy is a way of treating/preventing genetic disorders at the g ...
Chapter 10 - Everglades High School
Chapter 10 - Everglades High School

... 2. RNA nucleotides contain the five-carbon sugar ribose rather than the sugar deoxyribose, which is found in DNA nucleotides. 3. In addition to the A, G, and C nitrogen bases found in DNA, RNA nucleotides can have a nitrogen base called uracil (U). Chapter menu ...
Anopheles gambiae APL1 Is a Family of Variable LRR Proteins
Anopheles gambiae APL1 Is a Family of Variable LRR Proteins

... Figure 2. Among the APL1 family, only APL1C specifically protects against P. berghei infection. The three APL1 family genes were individually assayed to determine their relative contributions to host defense against P. berghei infection. Horizontal axis indicates the gene target of RNAi knockdown, w ...
Protein A gene expression is regulated by DNA supercoiling which
Protein A gene expression is regulated by DNA supercoiling which

... (Dorman, 1991; Hsieh et al., 1991). In Escherichia coli, it has been estimated that roughly 50 % of the supercoiling is constrained by proteins bound to DNA. The remaining supercoils are maintained actively at the cost of ATP hydrolysis, via topoisomerase activities (Hatfield & Benham, 2002). Thus, ...
Human pigmentation genetics: the difference is only skin deep
Human pigmentation genetics: the difference is only skin deep

... The TRP-2 protein is associated with dopachrome tautomerase activity and is encoded by 8 exons at the TYRP2 locus on chromosome 13q31–32.(44,50) Amino acid substitutions are present in the mouse Tyrp2 gene, which maps genetically to the slaty coat color mutant.(1) It is to be expected that some form ...
the Highest Connected Isoforms
the Highest Connected Isoforms

... • What does that mean for proteogenomics analyses? • Most (but not all!) detected novel coding genes/isoforms are likely to have little evolutionary history and few protein features. • We find that standard proteomics experiments are less likely to detect peptides for these regions. • If many novel ...
DNA Tribes Digest for October 28, 2010
DNA Tribes Digest for October 28, 2010

... Hello, and welcome to the October 2010 issue of DNA Tribes® Digest. This month’s issue will explore genetic relationships near the Caucasus Mountains, in particular looking at the nation of Georgia. These mountains have traditionally divided the more urban civilizations of the south from the wilder ...
Pseudogenes as regulators of biological function
Pseudogenes as regulators of biological function

... families, such as those found in the Hox gene clusters, but if part of the gene is not faithfully copied then these can lead to frameshift mutations or the loss of a promoter or enhancer, thus resulting in a non-functional duplicated pseudogene. The final class, known as the processed pseudogene (Fi ...
The role of variable DNA tandem repeats in bacterial adaptation
The role of variable DNA tandem repeats in bacterial adaptation

... regions (Gur-Arie et al., 2000), whereas in the genome of the Japanese pufferfish (Fugu rubripes), only 11.6% of SSRs are intragenic (Edwards et al., 1998). Generally, long mono- and dinucleotide SSRs are excluded from coding regions, probably because they have a higher probability to rearrange and ...
Interview Notes on Donor 2422 - The Sperm Bank of California
Interview Notes on Donor 2422 - The Sperm Bank of California

... Donor 2602 was a delight to interview as he is a very open, intelligent young man. I got the sense that he was raised with discipline and high standards for achievement, as well as a lot of love. He mentioned that he focused on his studies throughout high school, and that it wasn’t until he took a y ...
I. The Effect of Puromycin on the Duplication of DNA*
I. The Effect of Puromycin on the Duplication of DNA*

... The influence of puromycin on the accelera2ion of DNA synthesis.—A number of investigators have demonstrated that puromycin is a highly effective inhibitor of protein synthesis in both intact ani mals and cell-free systems (@, 9, 10, 15, 16). This inhibition results from the blocking of the trans ...
Impact of Tandem Repeats on the Scaling of Nucleotide Sequences
Impact of Tandem Repeats on the Scaling of Nucleotide Sequences

... 1. Introduction Understanding patterns in eukaryotic DNA sequences is an area of active research. This is more so with the rapid completion of eukaryotic genomes. DNA sequences are composed of four nucleotides (A, G, C and T), with (A, G) representing the purines and (C, T) the pyrimidines. Repetiti ...
PART II Introducció 53
PART II Introducció 53

... segon reordenament més comú que afecta el cromosoma 15 i dóna lloc a un cromosoma 15 extranumerari (Blennow et al., 1995; Huang et al., 1997). S’han identificat duplicacions proximals de 15q en casos d’autisme i individus amb graus variables de retard mental (Cook et al., 1997). A la regió més prox ...
HCLSIG$$Meetings$$2009-02
HCLSIG$$Meetings$$2009-02

... Originally from AAAI 1999- Ontologies Panel by Gruninger, Lehmann, McGuinness, Uschold, Welty; – updated by McGuinness. Description in: www.ksl.stanford.edu/people/dlm/papers/ontologies-come-of-age-abstract.html ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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