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Soft clustering
Soft clustering

... • Most cluster algorithms always detect clusters, even in random data. • Cluster validation approaches address the number of existing clusters. • Approaches are based on objective functions, figures of merits, resampling, adding noise .... ...
Changing of Gene Frequencies in Beetles
Changing of Gene Frequencies in Beetles

... What is the process called in which the phenotypes in a population are “selected” for based on the surrounding environment? Hint: Think of last unit  _______________________________________________________________________________________ Would the beetle population be able to evolve without mutatio ...
module 3: transcription part ii
module 3: transcription part ii

... "position/search" textbox and then click on the "jump" button. In Module 2, we identified the transcription start site (TSS) of the A isoform of tra at position 9,851. To show the TSS's that have been annotated by the modENCODE project, scroll down to the "Genes and Gene Prediction Tracks" and chang ...
Smiley Face Genetics
Smiley Face Genetics

... Genetics with a Smile Purpose: To distinguish between dominant and recessive traits ...
Naming `junk`: Human non-protein coding RNA (ncRNA) gene
Naming `junk`: Human non-protein coding RNA (ncRNA) gene

... the past decade, the field of RNA research has rapidly expanded, with a concomitant increase in the number of non-protein coding RNA (ncRNA) genes identified in this ‘junk’. Many of the encoded ncRNAs have already been shown to be essential for a variety of vital functions, and this wealth of annota ...
A Genetical Genomics Project
A Genetical Genomics Project

... organellar small ribosomal subunit ...
ISEcp1 pneumoniae  Research Article
ISEcp1 pneumoniae Research Article

... method [21]. The primers for detecting TEM, SHV, CTX-M, CTX-M-3 and ISEcp1 genes are listed in Table 1. Detection of the blaTEM gene Detection of the blaTEM gene was done as reported earlier [17]. Briefly pair of primers matching the conserved sequences specific for TEM gene was used to amplify a sp ...
Figure 2 - GEP Community Server
Figure 2 - GEP Community Server

... "position/search" textbox and then click on the "jump" button. In Module 2, we identified the transcription start site (TSS) of the A isoform of tra at position 9,851. To show the TSS's that have been annotated by the modENCODE project, scroll down to the "Genes and Gene Prediction Tracks" and chang ...
Using metaMA for differential gene expression analysis from
Using metaMA for differential gene expression analysis from

... biological replicates available. Meta-analyses have increased sensitivity by combining different studies but it is expected that even more sensitivity can be obtained using shrinkage approaches when the number of samples is small in each individual study. metaMA proposes a method to calculate modera ...
Annotation Instruction Sheet A. Information for Beginning Annotators
Annotation Instruction Sheet A. Information for Beginning Annotators

... As an annotator your job will be to create a gene model that uses as much evidence as you can gather and synthesize that evidence in a thoughtful and biologically consistent way. Your goal is to create a gene model that is consistent with what is known about the basic biology and is best supported b ...
Computational Biology
Computational Biology

... (e.g. level of conservation of amino acids) of individual genes/proteins. Genetic distance is defined as # mismatches / # matches. Sequence conservation depends on physico-chemical properties of amino acids (and genome context such as G+C content). ...
TEL Gene Is Involved in Myelodysplastic Syndromes
TEL Gene Is Involved in Myelodysplastic Syndromes

... A 1,241-bp TEL cDNA was obtained containing the complete coding sequence. The sequence of this cDNA was identical to the published one.I3 The cDNA was used to screen a chromosome 12 cosmid library. Ten cosmids were obtained and characterized by Southern hybridization with restriction fragments of th ...
What is the Gene Trying to Do?
What is the Gene Trying to Do?

... of secondary importance, or because inclusion of these features would preclude a useful mathematical treatment. It is therefore appropriate, in considering the validity of the FTNS as a theorem, to consider the assumptions upon which it is based. These are either explicit or implicit in the developm ...
the regulation of the differential expression of the human globin
the regulation of the differential expression of the human globin

A global view of pleiotropy and phenotypically
A global view of pleiotropy and phenotypically

... identified by this analysis include enrichment for galactose metabolism in the ‘galactose only’ cluster (P¼3.8 1018), response to DNA damage in the ‘UV only’ cluster (P¼1.8 1017), and cellular respiration in the glycerol and lactate cluster (P¼2.1 1018). For less well-characterized combination ...
A global view of pleiotropy and phenotypically derived gene function
A global view of pleiotropy and phenotypically derived gene function

... identified by this analysis include enrichment for galactose metabolism in the ‘galactose only’ cluster (P¼3.8 1018), response to DNA damage in the ‘UV only’ cluster (P¼1.8 1017), and cellular respiration in the glycerol and lactate cluster (P¼2.1 1018). For less well-characterized combinations ...
pdf file - Department of Statistics
pdf file - Department of Statistics

... portion of the genome. Since a separate statistical test is performed at each locus, traditional pvalue cut-offs of 0.01 or 0.05 had to be made stricter to avoid an abundance of false positive results. The criterion for statistical significance controls the probability that any single false positive ...
Slide 1
Slide 1

... choice. Which would you choose and why? physical genetic material be What methods would you use? disadvantageous for fern evolution? Could it be related to slow speciation 2. Why is the fate of most duplicate genes to rates, compared to angiosperms? Or, on eventually become silenced? Could the other ...
Basic Genetics - The Institute of Canine Biology
Basic Genetics - The Institute of Canine Biology

... DNA has a shape rather like a corkscrewed ladder. The "rungs" of the ladder are of four different types. The information in DNA comes in how those types are ordered along the molecule, just as the information in Morse code comes in how the dashes and dots are ordered. The information in three adjace ...
Ensembl Introduction
Ensembl Introduction

... the UCSC and NCBI Browsers? • The gene set. Automatic annotation based on mRNA and protein information. ...
Genes for Cognitive Function: Developments on the X
Genes for Cognitive Function: Developments on the X

... nonspecific MR from populations in which consanguinity is practiced, because only in such families will it be possible to map by linkage the autosomal recessive gene responsible for MR in single sibships. Autosomal dominant pedigrees with MR do not appear to exist, because except for milder forms, t ...
Mendel’s Laws and Genetics Douglas Wilkin, Ph.D. Jean Brainard, Ph.D.
Mendel’s Laws and Genetics Douglas Wilkin, Ph.D. Jean Brainard, Ph.D.

... of his first set of experiments, Mendel realized that there must be two factors controlling each of the characteristics he studied, with one of the factors being dominant to the other. He also realized that the two factors separate and go to different gametes and later recombine in the offspring. Th ...
Reassignment of the Human CSFl Gene to Chromosome lp13-p21
Reassignment of the Human CSFl Gene to Chromosome lp13-p21

... tory explanation for the hybridization pattern of the CSFI cDNA probe with DNAs from the somatic cell hybrid cell lines led us to reexamine the chromosomal location of the CSFl gene. We used chromosomal fluorescence in situ hybridization techniques, because they allow unambiguous, high-resolution ch ...
Lophotrochozoan relationships and parasites. A snap-shot
Lophotrochozoan relationships and parasites. A snap-shot

... 2001). These analyses place myzostomids within Platyzoa & Zrzavy et al. (2001) erected a new taxon called Promastigozoa uniting myzostomids with Syndermata (rotifers and acanthocephalans) – a clade that was mainly supported by spermatozoan ultrastructural characters and 18S data. This hypothesis was ...
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Gene desert

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