Supplementary Material and Methods
... Pearson correlation to a subtype centroid. A correlation cut-off of 0.2 was used as threshold and samples with the highest correlation <0.2 were set as unclassified. The Jönsson et al. (Jönsson et al., submitted 2009) data set (n=359) was processed similarly as the 200 HER2+ tumors, using the same B ...
... Pearson correlation to a subtype centroid. A correlation cut-off of 0.2 was used as threshold and samples with the highest correlation <0.2 were set as unclassified. The Jönsson et al. (Jönsson et al., submitted 2009) data set (n=359) was processed similarly as the 200 HER2+ tumors, using the same B ...
GeneticsPt1.ppt
... Who is Gregor Mendel and what did he have to do with alleles, chromosomes, traits, or this topic called genetics? ...
... Who is Gregor Mendel and what did he have to do with alleles, chromosomes, traits, or this topic called genetics? ...
The Human Genome Project
... Genome Project • The human genome is nearly the same (99.9%) in all people • Only about 2% of the human genome contains genes, which are the instructions for making proteins • Humans have an estimated 30,000 genes; the functions of more than half of them are unknown • Almost half of all human protei ...
... Genome Project • The human genome is nearly the same (99.9%) in all people • Only about 2% of the human genome contains genes, which are the instructions for making proteins • Humans have an estimated 30,000 genes; the functions of more than half of them are unknown • Almost half of all human protei ...
Inquiry into Life Twelfth Edition
... • 5’-end of the first gRNA hybridizes to an unedited region at the 3’-border of editing I the pre-mRNA • The 5’-ends of the rest of the gRNAs hybridize to edited regions progressively closer to the 5’-end of the region to be edited in the pre-mRNA • All of these gRNAs provide A’s and G’s as template ...
... • 5’-end of the first gRNA hybridizes to an unedited region at the 3’-border of editing I the pre-mRNA • The 5’-ends of the rest of the gRNAs hybridize to edited regions progressively closer to the 5’-end of the region to be edited in the pre-mRNA • All of these gRNAs provide A’s and G’s as template ...
Solid Tumour Section Lung: non-small cell carcinoma with inv(2)(p21p23)
... and EML4ALK(E2;add117A20): Intron 2 of EML4 is ligated to intron 19 of ALK, generating an EML4-ALK mRNA where exon 2 of the former is fused to exon 20 of the latter (also referred to as variant 5a). From the same gene rearrangement, alternative splicing of messages further generates an mRNA where ex ...
... and EML4ALK(E2;add117A20): Intron 2 of EML4 is ligated to intron 19 of ALK, generating an EML4-ALK mRNA where exon 2 of the former is fused to exon 20 of the latter (also referred to as variant 5a). From the same gene rearrangement, alternative splicing of messages further generates an mRNA where ex ...
Text S2
... Supplementary Information Text S2: Functional analysis of the parent genes To explore if any functional preference exists among the parent genes, they were classified into various functional categories under the four major functional classes as defined in the clusters of orthologous groups for eukar ...
... Supplementary Information Text S2: Functional analysis of the parent genes To explore if any functional preference exists among the parent genes, they were classified into various functional categories under the four major functional classes as defined in the clusters of orthologous groups for eukar ...
SoftGenetics releases latest version of NextGENe® software for
... its NextGENe software which provides a no‐scripting, point and click analysis of Next Generation Sequencing from all Illumina and Ion sequencing platforms. The latest version of the software includes a wide‐ranging number of both application additions as well as program enhancements. ...
... its NextGENe software which provides a no‐scripting, point and click analysis of Next Generation Sequencing from all Illumina and Ion sequencing platforms. The latest version of the software includes a wide‐ranging number of both application additions as well as program enhancements. ...
What have we learned from Unicellular Genomes?
... • Variation in the Gs is used to produce transcriptional variation. • Initiation of transcription depends on the number of consecutive guanines on a particular strand at a critical location upstream of the coding region. • Regions of replicating bases are difficult to accurately replicate which will ...
... • Variation in the Gs is used to produce transcriptional variation. • Initiation of transcription depends on the number of consecutive guanines on a particular strand at a critical location upstream of the coding region. • Regions of replicating bases are difficult to accurately replicate which will ...
Lecture 17 Protein synthesis pp101-110
... • RNA Polymerase, An enzyme that oversees the synthesis of RNA Unwinds the DNA template (17 base pair at a time) ...
... • RNA Polymerase, An enzyme that oversees the synthesis of RNA Unwinds the DNA template (17 base pair at a time) ...
triplex-forming oligonucleotide (TFO)
... increased HbF with these treatments! – With hydroxyurea treatment, for example, only about 60% of patients were found to ...
... increased HbF with these treatments! – With hydroxyurea treatment, for example, only about 60% of patients were found to ...
Microbial Genetics Chromosomes Genes Related to Obesity in the
... • Occurs when naked DNA fragments of one bacteria are close to another living cell. • Some bacteria have the ability to pick up naked DNA fragments and recombine the DNA into their own DNA • The new recombinant cell now has some new DNA from the disintegrating cell. • The now transformed bacte ...
... • Occurs when naked DNA fragments of one bacteria are close to another living cell. • Some bacteria have the ability to pick up naked DNA fragments and recombine the DNA into their own DNA • The new recombinant cell now has some new DNA from the disintegrating cell. • The now transformed bacte ...
Brain architecture and neuroinformatics: applications for
... High-density microarrays conducted post-mortem Data matrix: ~62k probes x ~1000 brain samples Data from 3 adult brains (Ages 24, 39, and 57) We are also beginning to look at the Human Developing Transcriptome Project (http://brainspan.org) ...
... High-density microarrays conducted post-mortem Data matrix: ~62k probes x ~1000 brain samples Data from 3 adult brains (Ages 24, 39, and 57) We are also beginning to look at the Human Developing Transcriptome Project (http://brainspan.org) ...
Gene tech test
... Answers should be written in continuous prose. Credit will be given for biological accuracy, the organisation and presentation of the information and the way in which the answer is expressed. Cancer may be treated by chemotherapy. This involves using drugs which kill cancer cells but have no effect ...
... Answers should be written in continuous prose. Credit will be given for biological accuracy, the organisation and presentation of the information and the way in which the answer is expressed. Cancer may be treated by chemotherapy. This involves using drugs which kill cancer cells but have no effect ...
How can my child have a condition passed from us if we are healthy?
... represents a faulty gene that does not work, then the diagram below shows how many people may carry a gene fault for a particular condition in the general population. ...
... represents a faulty gene that does not work, then the diagram below shows how many people may carry a gene fault for a particular condition in the general population. ...
Lesson 2- environmental inheritance and dominant recessive alleles
... VARIATION Examples include: - Language spoken - Religion - Hair length - Weight - Piercings - Tattoos ...
... VARIATION Examples include: - Language spoken - Religion - Hair length - Weight - Piercings - Tattoos ...
RNA notes 2015 - OG
... An insertion mutation is when a nitrogen base is added to the existing DNA A deletion mutation is when a nitrogen base is subtracted from the DNA A substitution mutation is when one nitrogen base is put in place of another. If our DNA was AATTGGCC An insertion would be AATTAGGCC A deletion would be ...
... An insertion mutation is when a nitrogen base is added to the existing DNA A deletion mutation is when a nitrogen base is subtracted from the DNA A substitution mutation is when one nitrogen base is put in place of another. If our DNA was AATTGGCC An insertion would be AATTAGGCC A deletion would be ...
Chapt 11
... 11.5 Small RNAs play multiple roles in controlling gene expression Only about 1.5% of the human genome codes for proteins. (This is also true of many other multicellular eukaryotes.) Another small fraction of DNA consists of genes for ribosomal RNA and transfer RNA. A flood of recent data sug ...
... 11.5 Small RNAs play multiple roles in controlling gene expression Only about 1.5% of the human genome codes for proteins. (This is also true of many other multicellular eukaryotes.) Another small fraction of DNA consists of genes for ribosomal RNA and transfer RNA. A flood of recent data sug ...
Aim: What is positive feedback of bacterial operons?
... Operon summary Repressible enzymes generally function in anabolic pathways, synthesizing end products. (tryptophan synthesis). Inducible enzymes usually function in catabolic pathways, digesting nutrients to simpler molecules. (lactose metabolism). Both repressible and inducible operons demon ...
... Operon summary Repressible enzymes generally function in anabolic pathways, synthesizing end products. (tryptophan synthesis). Inducible enzymes usually function in catabolic pathways, digesting nutrients to simpler molecules. (lactose metabolism). Both repressible and inducible operons demon ...
6 Review of Molecular Biology
... start-to-end and joined by hydrogen bonds along their lengths.[ Each strand is a chain of chemical "building blocks", called nucleotides, of which there are four types: adenine (abbreviated A), cytosine (C), guanine (G) and thymine (T) These bases of nucleic acids can be arranged in the polymer in a ...
... start-to-end and joined by hydrogen bonds along their lengths.[ Each strand is a chain of chemical "building blocks", called nucleotides, of which there are four types: adenine (abbreviated A), cytosine (C), guanine (G) and thymine (T) These bases of nucleic acids can be arranged in the polymer in a ...
RNA polymerase
... • Within the promotor is the starting point for the transcription of a gene. • The promotor also includes a binding site for RNA polymerase several dozen nucleotides upstream of the start point. • In prokaryotes, RNA polymerase can recognize and bind directly to the promotor region. ...
... • Within the promotor is the starting point for the transcription of a gene. • The promotor also includes a binding site for RNA polymerase several dozen nucleotides upstream of the start point. • In prokaryotes, RNA polymerase can recognize and bind directly to the promotor region. ...
Genome-wide RNAi screening in Caenorhabditis elegans
... 1. Genes with close homologs can often be abated in addition to target ...
... 1. Genes with close homologs can often be abated in addition to target ...
ppt - Sol Genomics Network
... 705,000 kb in herterochromatin (slide 2) 705,000 / 200 = 3525 heterochromatin genes 35,000 estimated tomato genes - 1032 - 3525 = 30,500 genes ...
... 705,000 kb in herterochromatin (slide 2) 705,000 / 200 = 3525 heterochromatin genes 35,000 estimated tomato genes - 1032 - 3525 = 30,500 genes ...
Chapter 10.qxp
... Insertion or deletion mutations can have major consequences: Imagine the deletion mutation that turns the sentence “I’ll have the mousse for dessert” into “I’ll have the mouse for dessert,” or the insertion mutation implicit in “She turned me down for a date after I asked her to go boweling with me. ...
... Insertion or deletion mutations can have major consequences: Imagine the deletion mutation that turns the sentence “I’ll have the mousse for dessert” into “I’ll have the mouse for dessert,” or the insertion mutation implicit in “She turned me down for a date after I asked her to go boweling with me. ...
Request Form - Exeter Clinical Laboratory International
... Exome sequencing for a couple who have had one or more pregnancies affected with a lethal, presumed autosomal recessive disorder (Ellard et al 2015 Eur J Hum Genet PMID 24961629). Our strategy identifies genes where both parents have a heterozygous potentially pathogenic variant. Likely disease-caus ...
... Exome sequencing for a couple who have had one or more pregnancies affected with a lethal, presumed autosomal recessive disorder (Ellard et al 2015 Eur J Hum Genet PMID 24961629). Our strategy identifies genes where both parents have a heterozygous potentially pathogenic variant. Likely disease-caus ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.