Results
... Helden used the Poisson distribution to compute the probability of a common transcription factor that binds to the sequence between two genes [16]. Second, Garten et al. used the cumulative hyper-geometric test to estimate the significance of the overlap of two TF sets [17]. Third, Veerla and Höglun ...
... Helden used the Poisson distribution to compute the probability of a common transcription factor that binds to the sequence between two genes [16]. Second, Garten et al. used the cumulative hyper-geometric test to estimate the significance of the overlap of two TF sets [17]. Third, Veerla and Höglun ...
Gregor Mendel - BEHS Science
... that only breed to produce one phenotype Hybrid (heterozygous) = results of crosses between two plants that breed true for different phenotypes for the same trait ...
... that only breed to produce one phenotype Hybrid (heterozygous) = results of crosses between two plants that breed true for different phenotypes for the same trait ...
Bookmarking Target Genes in Mitosis: A Shared
... Recent advances in high-resolution microscopy as well as genome-wide biochemical approaches (e.g., chromatin immunoprecipitation followed by high-throughput sequencing) have provided an unbiased and comprehensive assessment of transcriptional dynamics in mitotic cells. Accruing evidence from studies ...
... Recent advances in high-resolution microscopy as well as genome-wide biochemical approaches (e.g., chromatin immunoprecipitation followed by high-throughput sequencing) have provided an unbiased and comprehensive assessment of transcriptional dynamics in mitotic cells. Accruing evidence from studies ...
Causes, Risk Factors, and Prevention
... Scientists have found few risk factors that make a person more likely to develop adrenal gland tumors. Even if a patient does have one or more risk factors for adrenal gland tumors, it is impossible to know for sure how much that risk factor contributed to causing the cancer. But having a risk facto ...
... Scientists have found few risk factors that make a person more likely to develop adrenal gland tumors. Even if a patient does have one or more risk factors for adrenal gland tumors, it is impossible to know for sure how much that risk factor contributed to causing the cancer. But having a risk facto ...
Transcriptome profiling identifies candidate genes associated with
... the Poly(A) Purist MAG Kit, 480 µg of DNaseI treated total RNA was used, and this was followed by treatment with the RiboMinus Plant Kit for RNA-Seq (Life Technologies). For cDNA Rapid Library Prep, 400 ng of the purified samples was used. Three copies per bead were used for emulsion-based clonal am ...
... the Poly(A) Purist MAG Kit, 480 µg of DNaseI treated total RNA was used, and this was followed by treatment with the RiboMinus Plant Kit for RNA-Seq (Life Technologies). For cDNA Rapid Library Prep, 400 ng of the purified samples was used. Three copies per bead were used for emulsion-based clonal am ...
When bad things happen to good genes: mutation vs. selection
... Several methods have been developed to identify “deleterious mutations” by: (1) their polymorphism at sites that are highly conserved in other mammals; and (2) their predicted disruptive effects on protein structure. Chun & Fay (2009) applied three of these methods to three individual human genome s ...
... Several methods have been developed to identify “deleterious mutations” by: (1) their polymorphism at sites that are highly conserved in other mammals; and (2) their predicted disruptive effects on protein structure. Chun & Fay (2009) applied three of these methods to three individual human genome s ...
Supplement Figures
... increase in the correlation. For this graph we find it hard to deduce what should be the optimal sU:U value, but the result indeed suggests a desired correction for the tAI. Finally we look at the two main correlations we find in the GFP library: the correlation with between the bottleneck relative ...
... increase in the correlation. For this graph we find it hard to deduce what should be the optimal sU:U value, but the result indeed suggests a desired correction for the tAI. Finally we look at the two main correlations we find in the GFP library: the correlation with between the bottleneck relative ...
Molecular evolution and substitution patterns.
... The natural selection has an insidious effect on the data available for bioinformatics analyses With rare exceptions, in fact, in the populations of organisms found in Nature, the only available alleles (variants of a gene) are those which have not had a detrimental effect on the health of the organ ...
... The natural selection has an insidious effect on the data available for bioinformatics analyses With rare exceptions, in fact, in the populations of organisms found in Nature, the only available alleles (variants of a gene) are those which have not had a detrimental effect on the health of the organ ...
Gene overexpression reveals alternative
... increase in GCN4 mRNA translation, coupled with an extensive protein synthesis shut down. However, both phenomena are independent of Gcn2 function (Tzamarias et al., 1989). In addition, the assimilation of GCN4 mRNA translational derepression in vitro, does not require the Gcn2 kinase (Krupitza and ...
... increase in GCN4 mRNA translation, coupled with an extensive protein synthesis shut down. However, both phenomena are independent of Gcn2 function (Tzamarias et al., 1989). In addition, the assimilation of GCN4 mRNA translational derepression in vitro, does not require the Gcn2 kinase (Krupitza and ...
Fundamentals of Genetics
... • F1 plants resembled only one of the parents • F1 hybrids contained two factors for each trait • one dominant; (stronger, masks recessive); • one recessive; (seems to disappear) ...
... • F1 plants resembled only one of the parents • F1 hybrids contained two factors for each trait • one dominant; (stronger, masks recessive); • one recessive; (seems to disappear) ...
Lecture 13 Transposable elements Transposons are usually
... Let’s say that we are interested in the E. coli genes that are involved in synthesis of histidine. To find insertion mutants that can not synthesize histidine (His–) we could screen amongst our collection of 2x104 random Tn5 insertions to find those that are His–. The easiest way to do this would be ...
... Let’s say that we are interested in the E. coli genes that are involved in synthesis of histidine. To find insertion mutants that can not synthesize histidine (His–) we could screen amongst our collection of 2x104 random Tn5 insertions to find those that are His–. The easiest way to do this would be ...
The Inherited Cancer Connect Mutation Carrier Database
... Centres (FCCs), seeking to improve the outcomes of people with rare inherited cancers. One role of this partnership is to establish a national database of individuals found to have gene faults or mutations causing an increased risk of cancer. ...
... Centres (FCCs), seeking to improve the outcomes of people with rare inherited cancers. One role of this partnership is to establish a national database of individuals found to have gene faults or mutations causing an increased risk of cancer. ...
Assiut university researches Some Molecular Biological Studies on
... indicates the different origin of our isolated strains. - Antigenic index results suggest that our isolates could be antigenically distinctive compared to vvIBDV reference strains so confirmation of the presence of antigenic variation request additional immunologic studies to elucidate the exact nat ...
... indicates the different origin of our isolated strains. - Antigenic index results suggest that our isolates could be antigenically distinctive compared to vvIBDV reference strains so confirmation of the presence of antigenic variation request additional immunologic studies to elucidate the exact nat ...
X Linked Inheritance
... a blood test to see if they are also carriers, if they wish. This information may also be useful in helping diagnose other family members. This might be particularly important to family members who already have children, or are likely to have children in the future. Some people find it difficult to ...
... a blood test to see if they are also carriers, if they wish. This information may also be useful in helping diagnose other family members. This might be particularly important to family members who already have children, or are likely to have children in the future. Some people find it difficult to ...
Using Statistical Design and Analysis to Detect Differentially
... Weindruch, R. (2002). A mixture model approach for the analysis of microarray gene expression data, Computational Statistics and Data Analysis, 39, 1-20. • Model p-value distribution as a mixture of a Uniform(0,1) distribution (corresponding to true nulls) and a Beta(α,β) distribution (corresponding ...
... Weindruch, R. (2002). A mixture model approach for the analysis of microarray gene expression data, Computational Statistics and Data Analysis, 39, 1-20. • Model p-value distribution as a mixture of a Uniform(0,1) distribution (corresponding to true nulls) and a Beta(α,β) distribution (corresponding ...
+ n° 6 - Octubre 2007
... variants influencing height, we examined genome-wide association data from 4921 individuals. Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P=4x10-8). HMGA2 is also a strong biological candidate for height because rare, severe mutations in this gene alt ...
... variants influencing height, we examined genome-wide association data from 4921 individuals. Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P=4x10-8). HMGA2 is also a strong biological candidate for height because rare, severe mutations in this gene alt ...
The Case of the Threespine Stickleback
... Macroevolution: a small change in the regulatory DNA causes a large change in the morphology (no pelvis develops), without affecting other features. This can then be selected for or against, resulting in a new species in a fairly short period of time (the marine and freshwater populations no longer ...
... Macroevolution: a small change in the regulatory DNA causes a large change in the morphology (no pelvis develops), without affecting other features. This can then be selected for or against, resulting in a new species in a fairly short period of time (the marine and freshwater populations no longer ...
Genetic Linkage and Genetic Maps tutorial
... chromosome. But all the genes on the chromosome are incorporated in a single molecule of DNA. Genes are simply portions of the molecule (open reading frames or ORFs) encoding products that create the observed trait (phenotype). The rapid progress in DNA sequencing has produced complete genomes for h ...
... chromosome. But all the genes on the chromosome are incorporated in a single molecule of DNA. Genes are simply portions of the molecule (open reading frames or ORFs) encoding products that create the observed trait (phenotype). The rapid progress in DNA sequencing has produced complete genomes for h ...
Biol. 303 EXAM I 9/22/08 Name
... Could the characteristics followed in the pedigree be caused by an X-linked recessive allele? A. Yes, all individuals fit the X-linked recessive inheritance pattern. B. No, the offspring of I-1 and I-2 contradict an X-linked recessive inheritance. C. No, the offspring of I-3 and I-4 contradict an X- ...
... Could the characteristics followed in the pedigree be caused by an X-linked recessive allele? A. Yes, all individuals fit the X-linked recessive inheritance pattern. B. No, the offspring of I-1 and I-2 contradict an X-linked recessive inheritance. C. No, the offspring of I-3 and I-4 contradict an X- ...
Guidelines for BioLINK Gene List Evaluation
... "In some of these mutants (fat, lgd, c43, dco) the overgrowing tissue is hyperplastic..." "A locus has been found, an allele of which causes a modification of some allozymes of the enzyme esterase 6 in Drosophila melanogaster." 3. Example of a gene mentioned in passing: "Fast and slow electrophoreti ...
... "In some of these mutants (fat, lgd, c43, dco) the overgrowing tissue is hyperplastic..." "A locus has been found, an allele of which causes a modification of some allozymes of the enzyme esterase 6 in Drosophila melanogaster." 3. Example of a gene mentioned in passing: "Fast and slow electrophoreti ...
Biol
... Could the characteristics followed in the pedigree be caused by an X-linked recessive allele? A. Yes, all individuals fit the X-linked recessive inheritance pattern. B. No, the offspring of I-1 and I-2 contradict an X-linked recessive inheritance. C. No, the offspring of I-3 and I-4 contradict an X- ...
... Could the characteristics followed in the pedigree be caused by an X-linked recessive allele? A. Yes, all individuals fit the X-linked recessive inheritance pattern. B. No, the offspring of I-1 and I-2 contradict an X-linked recessive inheritance. C. No, the offspring of I-3 and I-4 contradict an X- ...
Leukaemia Section t(5;14)(q35;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... type M5). In this second case, the t(5;14) appears to be secondary to a t(6;11)(q27;q23). Although molecular studies were not available at that time, it is likely that the patient, who have had a history of possible toxic exposure, who presented with a high blood count (above 50X109/l), and who did ...
... type M5). In this second case, the t(5;14) appears to be secondary to a t(6;11)(q27;q23). Although molecular studies were not available at that time, it is likely that the patient, who have had a history of possible toxic exposure, who presented with a high blood count (above 50X109/l), and who did ...
Teacher-submitted assessment ideas
... 4. Let’s think more about the two drawings you just created: How is it possible that mutations in certain locations within PTC gene (nucleotide positions 145, 785 and 886) affect tasting the PTC molecule but mutations in other regions of the PTC gene might not affect tasting PTC? You may answer this ...
... 4. Let’s think more about the two drawings you just created: How is it possible that mutations in certain locations within PTC gene (nucleotide positions 145, 785 and 886) affect tasting the PTC molecule but mutations in other regions of the PTC gene might not affect tasting PTC? You may answer this ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.