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letters Structure of -lactam synthetase reveals how to
letters Structure of -lactam synthetase reveals how to

Datasheet - LifeSensors
Datasheet - LifeSensors

... Interferon stimulated gene 15 (ISG15) is a member of the ubiquitin-like protein family whose expression is increased following stimulation with type 1 Interferons. ISG15-VME is synthesized by the conjugation of 4-amino-but-2-enoic acid methyl ester to the C-terminus of ISG15G156. Binding of ISG15-V ...
Biocatalysts in Cancer Tissue
Biocatalysts in Cancer Tissue

... at appreciable rates. Evidently the aerobic mechanisms are unable to keep pace with the adenosine triphosphate breakdown, and are thus unable to esterify the inorganic phosphate rapidly enough to have any appreciable slowing action on reactions 1 and 2. Now, if the concentration of aerobic enzymes w ...
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... By 1930 it was established that the addition of lactate, acetate succinate, malate, a-ketoglutaric acid (dicarboxylic acids) and citrate and isocitrate (tricarboxylic acids) when added to muscle mince that they stimulated oxygen consumption and release of CO2 1935Albert Szent-Gyorgyi showed that ...
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Slide 1
Slide 1

... chemical reactions a) The main catalysts of chemical reactions in organisms are specialized proteins called enzymes. 1) An enzyme doesn’t supply activation energy, but instead lowers the energy requirement barrier so that the reaction can proceed at normal cell temperatures 2) Each enzyme catalyzes ...
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Enzyme



Enzymes /ˈɛnzaɪmz/ are macromolecular biological catalysts. Enzymes accelerate, or catalyze, chemical reactions. The molecules at the beginning of the process are called substrates and the enzyme converts these into different molecules, called products. Almost all metabolic processes in the cell need enzymes in order to occur at rates fast enough to sustain life. The set of enzymes made in a cell determines which metabolic pathways occur in that cell. The study of enzymes is called enzymology.Enzymes are known to catalyze more than 5,000 biochemical reaction types. Most enzymes are proteins, although a few are catalytic RNA molecules. Enzymes' specificity comes from their unique three-dimensional structures.Like all catalysts, enzymes increase the rate of a reaction by lowering its activation energy. Some enzymes can make their conversion of substrate to product occur many millions of times faster. An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of years to occur in milliseconds. Chemically, enzymes are like any catalyst and are not consumed in chemical reactions, nor do they alter the equilibrium of a reaction. Enzymes differ from most other catalysts by being much more specific. Enzyme activity can be affected by other molecules: inhibitors are molecules that decrease enzyme activity, and activators are molecules that increase activity. Many drugs and poisons are enzyme inhibitors. An enzyme's activity decreases markedly outside its optimal temperature and pH.Some enzymes are used commercially, for example, in the synthesis of antibiotics. Some household products use enzymes to speed up chemical reactions: enzymes in biological washing powders break down protein, starch or fat stains on clothes, and enzymes in meat tenderizer break down proteins into smaller molecules, making the meat easier to chew.
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