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Protein interactions are essential for many biological functions to occur. ... Erika Lacy:  Cell Biology & Neuroscience
Protein interactions are essential for many biological functions to occur. ... Erika Lacy: Cell Biology & Neuroscience

... Fluorescent Probes for Detecting Protein Interactions in Bacteria Protein interactions are essential for many biological functions to occur. Bimolecular Fluorescence Complementation (BiFC) assay is a complementation-based technique used to study protein interactions. One benefit of this approach is ...
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10/14 - The Mathematical Institute, University of Oxford, Eprints Archive
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... investigated in Section 2. In Section 3, we consider the case α ≤ 1. The formula relating k1 with model parameters λ, ̺ and σ is derived as (2.12) for α > 1 (i.e. for σ > ̺) and as (3.4) for α ≤ 1 (i.e. for σ ≤ ̺). It is given as one equation for three unknowns λ, ̺ and σ. In particular, there is a ...
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ENGINEERING PROTEINS

... in just the right positions for hydrogen bonds to form. These can be seen in the DNA double helix. Compounds which have two functional groups e.g. amino acids have -NH2 and -COOH. A carbon centre within a molecule surrounded by four different groupings of atoms (=> non-superimposable mirror images). ...
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Multi-state modeling of biomolecules

Multi-state modeling of biomolecules refers to a series of techniques used to represent and compute the behaviour of biological molecules or complexes that can adopt a large number of possible functional states.Biological signaling systems often rely on complexes of biological macromolecules that can undergo several functionally significant modifications that are mutually compatible. Thus, they can exist in a very large number of functionally different states. Modeling such multi-state systems poses two problems: The problem of how to describe and specify a multi-state system (the ""specification problem"") and the problem of how to use a computer to simulate the progress of the system over time (the ""computation problem""). To address the specification problem, modelers have in recent years moved away from explicit specification of all possible states, and towards rule-based formalisms that allow for implicit model specification, including the κ-calculus, BioNetGen, the Allosteric Network Compiler and others. To tackle the computation problem, they have turned to particle-based methods that have in many cases proved more computationally efficient than population-based methods based on ordinary differential equations, partial differential equations, or the Gillespie stochastic simulation algorithm. Given current computing technology, particle-based methods are sometimes the only possible option. Particle-based simulators further fall into two categories: Non-spatial simulators such as StochSim, DYNSTOC, RuleMonkey, and NFSim and spatial simulators, including Meredys, SRSim and MCell. Modelers can thus choose from a variety of tools; the best choice depending on the particular problem. Development of faster and more powerful methods is ongoing, promising the ability to simulate ever more complex signaling processes in the future.
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